Dr Shweta Tikoo

Postdoctoral Fellow
Immune Imaging Program
Centenary Institute of Cancer Medicine and Cell Biology

Conjoint Lecturer
Sydney Medical School

Telephone +61451469241

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Current research students

Project title Research student
Targeting melanoma protein trafficking pathways. Dajiang GUO

Current projects

1. Deciphering the ontogeny of macrophage development in health and disease

2. Elucidating the role of perivascular macrophages in breast cancer development and metastasis

3. Imaging the dynamics of immune cells in melanoma tumour microenvironment

4. Understanding the role of perivascular macrophages in contact hypersensitivity

5. Targeting protein trafficking pathways in melanoma

Awards and honours

2018 Bank of Queensland - Early Career Researcher - Gender Equity Award

2017 The Spruson & Ferguson ECR Award – Runner-Up

2017 Centenary Travel Award to attend Keystone Conference – Austin, Texas, USA

2016 Centenary Travel Award to attend Cell Press Symposia – Sicily, Italy

2015 3rd Place, Centenary Institute Scientific Image of the Year Prize

2011 Best poster, International Ageing Conference, New Delhi

2007 Gold Medal, M.Sc. Biotechnology, Jammu University, Jammu and Kashmir, India

In the media

Selected grants

2019

  • Targeting Invadopodia to prevent melanoma spread; Tikoo S; Tour de Cure Ltd/Pioneering Research Grant.

2016

  • Targeting breast cancer metastasis: Delineating the role of 'Perivascular Macrophages' in tumour cell metastasis; Tikoo S; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.
  • Targeting perivascular macrophages in breast cancer to combat tumour angiogenesis and metastasis; Tikoo S; University of Sydney/Kickstart Grants Program.

Selected publications

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Book Chapters

  • Jain, R., Tikoo, S., Egawa, G., Weninger, W. (2016). Effector T Lymphocyte Migration to and Within Non-Lymphoid Tissues. In M. Ratcliffe (Eds.), Encyclopedia of Immunobiology, (pp. 493-504). US: Elsevier. [More Information]

Journals

  • Roediger, B., Lee, Q., Tikoo, S., Cobbin, J., Henderson, J., Jormakka, M., O'Rourke, M., Padula, M., Pinello, N., Henry, M., Wynne, M., Lisowski, L., Tay, S., Harris, D., Bertolino, P., Wong, J., Gorrell, M., Holmes, E., Jolly, C., Weninger, W., et al (2018). An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. Cell, 175(2), 530-540. [More Information]
  • Lim, H., Lim, S., Tan, C., Thiam, C., Goh, C., Carbajo, D., Chew, S., See, P., Chakarov, S., Wang, X., et al (2018). Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen. Immunity, 49(2), 326-341. [More Information]
  • Tikoo, S., Barki, N., Jain, R., Zulkhernain, N., Buhner, S., Schemann, M., Weninger, W. (2018). Imaging of mast cells. Immunological Reviews, 282(1), 58-72. [More Information]
  • Tikoo, S., Jain, R., Kurz, A., Weninger, W. (2018). The lymphoid cell network in the skin. Immunology and Cell Biology, 96(5), 485-496. [More Information]
  • Kumari, J., Hussain, M., De, S., Chandra, S., Modi, P., Tikoo, S., Singh, A., Sagar, C., Sepuri, N., Sengupta, S. (2016). Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion. Journal of Cell Science, 129(7), 1312-1318. [More Information]
  • Kharat, S., Tripathi, V., Damodaran, A., Priyadarshini, R., Chandra, S., Tikoo, S., Nandhakumar, R., Srivastava, V., Priya, S., Hussain, M., et al (2016). Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability. Oncogene, 35(8), 1025-1038. [More Information]
  • Jain, R., Tikoo, S., Weninger, W. (2016). Recent advances in microscopic techniques for visualizing leukocytes in vivo. F1000Research, 5, 1-10. [More Information]
  • Tikoo, S., Haass, N. (2015). Friends or foes: IL-10 and TGF-β in melanoma. Experimental Dermatology, 24(4), 254-255. [More Information]
  • Abtin, A., Jain, R., Mitchell, A., Roediger, B., Brzoska, A., Tikoo, S., Cheng, Q., Ng, L., Cavanagh, L., von Andrian, U., Firth, N., et al (2014). Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection. Nature Immunology, 15(1), 45-53. [More Information]
  • Tay, S., Roediger, B., Tong, P., Tikoo, S., Weninger, W. (2014). The Skin-Resident Immune Network. Current Dermatology Reports, 3, 13-22. [More Information]
  • Chandra, S., Priyadarshini, R., Madhavan, V., Tikoo, S., Hussain, M., Mudgal, R., Modi, P., Srivastava, V., Sengupta, S. (2013). Enhancement of c-Myc degradation by BLM helicase leads to delayed tumor initiation. Journal of Cell Science, 126(16), 3782-3795. [More Information]
  • Tikoo, S., Madhavan, V., Hussain, M., Miller, E., Arora, P., Zlatanou, A., Modi, P., Townsend, K., Stewart, G., Sengupta, S. (2013). Ubiquitin-dependent recruitment of the Bloom Syndrome helicase upon replication stress is required to suppress homologous recombination. EMBO Journal, 32(12), 1778-1792. [More Information]
  • Kumar, A., Tikoo, S., Maity, S., Sengupta, S., Sengupta, S., Kaur, A., Bachhawat, A. (2012). Mammalian proapoptotic factor ChaC1 and its homologues function as (gamma)-glutamyl cyclotransferases acting specifically on glutathione. EMBO Reports, 13(12), 1095-1101. [More Information]
  • Kaur, S., Modi, P., Srivastava, V., Mudgal, R., Tikoo, S., Arora, P., Mohanty, D., Sengupta, S. (2010). Chk1-Dependent Constitutive Phosphorylation of BLM Helicase at Serine 646 Decreases after DNA Damage. Molecular Cancer Research, 8(9), 1234-1247. [More Information]
  • Tikoo, S., Sengupta, S. (2010). Time to Bloom. Genome Integrity, 1, 1-7. [More Information]

2018

  • Roediger, B., Lee, Q., Tikoo, S., Cobbin, J., Henderson, J., Jormakka, M., O'Rourke, M., Padula, M., Pinello, N., Henry, M., Wynne, M., Lisowski, L., Tay, S., Harris, D., Bertolino, P., Wong, J., Gorrell, M., Holmes, E., Jolly, C., Weninger, W., et al (2018). An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. Cell, 175(2), 530-540. [More Information]
  • Lim, H., Lim, S., Tan, C., Thiam, C., Goh, C., Carbajo, D., Chew, S., See, P., Chakarov, S., Wang, X., et al (2018). Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen. Immunity, 49(2), 326-341. [More Information]
  • Tikoo, S., Barki, N., Jain, R., Zulkhernain, N., Buhner, S., Schemann, M., Weninger, W. (2018). Imaging of mast cells. Immunological Reviews, 282(1), 58-72. [More Information]
  • Tikoo, S., Jain, R., Kurz, A., Weninger, W. (2018). The lymphoid cell network in the skin. Immunology and Cell Biology, 96(5), 485-496. [More Information]

2016

  • Jain, R., Tikoo, S., Egawa, G., Weninger, W. (2016). Effector T Lymphocyte Migration to and Within Non-Lymphoid Tissues. In M. Ratcliffe (Eds.), Encyclopedia of Immunobiology, (pp. 493-504). US: Elsevier. [More Information]
  • Kumari, J., Hussain, M., De, S., Chandra, S., Modi, P., Tikoo, S., Singh, A., Sagar, C., Sepuri, N., Sengupta, S. (2016). Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion. Journal of Cell Science, 129(7), 1312-1318. [More Information]
  • Kharat, S., Tripathi, V., Damodaran, A., Priyadarshini, R., Chandra, S., Tikoo, S., Nandhakumar, R., Srivastava, V., Priya, S., Hussain, M., et al (2016). Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability. Oncogene, 35(8), 1025-1038. [More Information]
  • Jain, R., Tikoo, S., Weninger, W. (2016). Recent advances in microscopic techniques for visualizing leukocytes in vivo. F1000Research, 5, 1-10. [More Information]

2015

  • Tikoo, S., Haass, N. (2015). Friends or foes: IL-10 and TGF-β in melanoma. Experimental Dermatology, 24(4), 254-255. [More Information]

2014

  • Abtin, A., Jain, R., Mitchell, A., Roediger, B., Brzoska, A., Tikoo, S., Cheng, Q., Ng, L., Cavanagh, L., von Andrian, U., Firth, N., et al (2014). Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection. Nature Immunology, 15(1), 45-53. [More Information]
  • Tay, S., Roediger, B., Tong, P., Tikoo, S., Weninger, W. (2014). The Skin-Resident Immune Network. Current Dermatology Reports, 3, 13-22. [More Information]

2013

  • Chandra, S., Priyadarshini, R., Madhavan, V., Tikoo, S., Hussain, M., Mudgal, R., Modi, P., Srivastava, V., Sengupta, S. (2013). Enhancement of c-Myc degradation by BLM helicase leads to delayed tumor initiation. Journal of Cell Science, 126(16), 3782-3795. [More Information]
  • Tikoo, S., Madhavan, V., Hussain, M., Miller, E., Arora, P., Zlatanou, A., Modi, P., Townsend, K., Stewart, G., Sengupta, S. (2013). Ubiquitin-dependent recruitment of the Bloom Syndrome helicase upon replication stress is required to suppress homologous recombination. EMBO Journal, 32(12), 1778-1792. [More Information]

2012

  • Kumar, A., Tikoo, S., Maity, S., Sengupta, S., Sengupta, S., Kaur, A., Bachhawat, A. (2012). Mammalian proapoptotic factor ChaC1 and its homologues function as (gamma)-glutamyl cyclotransferases acting specifically on glutathione. EMBO Reports, 13(12), 1095-1101. [More Information]

2010

  • Kaur, S., Modi, P., Srivastava, V., Mudgal, R., Tikoo, S., Arora, P., Mohanty, D., Sengupta, S. (2010). Chk1-Dependent Constitutive Phosphorylation of BLM Helicase at Serine 646 Decreases after DNA Damage. Molecular Cancer Research, 8(9), 1234-1247. [More Information]
  • Tikoo, S., Sengupta, S. (2010). Time to Bloom. Genome Integrity, 1, 1-7. [More Information]

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