Dr Silke Rinkwitz

Senior Research Fellow
Brain & Mind Research Institute, School of Medical Sciences

Telephone +61 2 9351 0866
Fax +61 2 9351 0731

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Research interests

The zebrafish is established as a vertebrate model organism for forward and reverse genetic approaches. Extra-uterine development, transparency of the embryos and larvae and rapid differentiation make this organism especially suitable for studying the function of genes in developmental, physiological or behavioral processes. We are interested in genes that are associated with mental disorders and hypothalamic obesity, both developmental phenotypes, with the goal to establish the disease causing mechanisms for single gene mutations.

We create transgenenic zebrafish lines that use the regulatory sequences of genes to visualise and modify gene activity. Expressing fluorescent proteins these lines serve as morphological markers, but are also used to analyse the function of the genes.

Selected grants

2012

  • In vivo analysis of miRNAs associated with neurological diseases; Becker T, Rinkwitz S, Cairns M; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Cis regulatory and functional analysis of genomic loci with implication in hypothalamic obesity using the zebrafish as a model system; Rinkwitz S, Becker T; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Zebrafish as a model system for studying hypothalmic obesity; Rinkwitz S; DVC Research/Bridging Support Grant.

Selected publications

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Journals

  • Maley, D., Laird, A., Rinkwitz, S., Becker, T. (2013). A Simple and Efficient Protocol for the Treatment of Zebrafish Colonies Infected with Parasitic Nematodes. Zebrafish, 10(3), 447-450. [More Information]
  • Svahn, A., Graeber, M., Ellett, F., Lieschke, G., Rinkwitz, S., Bennett, M., Becker, T. (2013). Development of Ramified Microglia from Early Macrophages in the Zebrafish Optic Tectum. Developmental Neurobiology, 73(1), 60-71. [More Information]
  • Ishibashi, M., Mechaly Garcia, A., Becker, T., Rinkwitz, S. (2013). Using zebrafish transgenesis to test human genomic sequences for specific enhancer activity. Methods, 62(3), 216-225. [More Information]
  • Sundstrom, E., Komisarczuk, A., Jiang, L., Golovko, A., Navratilova, P., Rinkwitz, S., Becker, T., Andersson, L. (2012). Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horses. Pigment Cell & Melanoma Research, 25(1), 28-36. [More Information]
  • Becker, T., Rinkwitz, S. (2012). Zebrafish as a Genomics Model for Human Neurological and Polygenic Disorders. Developmental Neurobiology, 72(3), 415-428. [More Information]
  • Punnamoottil, B., Herrmann, C., Pascual-Anaya, J., D'Aniello, S., Garcia-Fernandez, J., Akalin, A., Becker, T., Rinkwitz, S. (2010). Cis-regulatory characterization of sequence conservation surrounding the Hox4 genes. Developmental Biology, 340(2), 269-282. [More Information]
  • Rinkwitz, S., Mourrain, P., Becker, T. (2010). Zebrafish: an integrative System for Neurogenomics and Neurosciences. Progress in Neurobiology, 93(2), 231-43. [More Information]
  • Ma, L., Punnamoottil, B., Rinkwitz, S., Baker, R. (2009). Mosaic hoxb4a neuronal pleiotropism in zebrafish caudal hindbrain. PloS One, 4(6), e5944-1-e5944-16. [More Information]
  • Punnamoottil, B., Kikuta, H., Pezeron, G., Erceg, J., Becker, T., Rinkwitz, S. (2008). Enhancer detection in zebrafish permits the identification of neuronal subtypes that express Hox4 paralogs. Developmental Dynamics, 237(8), 2195-2208. [More Information]
  • Freter, S., Muta, Y., Mak, S., Rinkwitz, S., Ladher, R. (2008). Progressive restriction of otic fate: the role of FGF and Wnt in resolving inner ear potential. Development (Cambridge) (Print), 135(20), 3415-3424. [More Information]
  • Kikuta, H., Fredman, D., Rinkwitz, S., Lenhard, B., Becker, T. (2007). Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - A fundamental feature of vertebrate genomes. Genome Biology, 8(SUPPL. 1, Article number S4), 1-13. [More Information]
  • Hadrys, T., Prince, V., Hunter, M., Baker, R., Rinkwitz, S. (2004). Comparative Genomic Analysis of Vertebrate Hox3 and Hox4 Genes. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 302(2), 147-164. [More Information]

2013

  • Maley, D., Laird, A., Rinkwitz, S., Becker, T. (2013). A Simple and Efficient Protocol for the Treatment of Zebrafish Colonies Infected with Parasitic Nematodes. Zebrafish, 10(3), 447-450. [More Information]
  • Svahn, A., Graeber, M., Ellett, F., Lieschke, G., Rinkwitz, S., Bennett, M., Becker, T. (2013). Development of Ramified Microglia from Early Macrophages in the Zebrafish Optic Tectum. Developmental Neurobiology, 73(1), 60-71. [More Information]
  • Ishibashi, M., Mechaly Garcia, A., Becker, T., Rinkwitz, S. (2013). Using zebrafish transgenesis to test human genomic sequences for specific enhancer activity. Methods, 62(3), 216-225. [More Information]

2012

  • Sundstrom, E., Komisarczuk, A., Jiang, L., Golovko, A., Navratilova, P., Rinkwitz, S., Becker, T., Andersson, L. (2012). Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horses. Pigment Cell & Melanoma Research, 25(1), 28-36. [More Information]
  • Becker, T., Rinkwitz, S. (2012). Zebrafish as a Genomics Model for Human Neurological and Polygenic Disorders. Developmental Neurobiology, 72(3), 415-428. [More Information]

2010

  • Punnamoottil, B., Herrmann, C., Pascual-Anaya, J., D'Aniello, S., Garcia-Fernandez, J., Akalin, A., Becker, T., Rinkwitz, S. (2010). Cis-regulatory characterization of sequence conservation surrounding the Hox4 genes. Developmental Biology, 340(2), 269-282. [More Information]
  • Rinkwitz, S., Mourrain, P., Becker, T. (2010). Zebrafish: an integrative System for Neurogenomics and Neurosciences. Progress in Neurobiology, 93(2), 231-43. [More Information]

2009

  • Ma, L., Punnamoottil, B., Rinkwitz, S., Baker, R. (2009). Mosaic hoxb4a neuronal pleiotropism in zebrafish caudal hindbrain. PloS One, 4(6), e5944-1-e5944-16. [More Information]

2008

  • Punnamoottil, B., Kikuta, H., Pezeron, G., Erceg, J., Becker, T., Rinkwitz, S. (2008). Enhancer detection in zebrafish permits the identification of neuronal subtypes that express Hox4 paralogs. Developmental Dynamics, 237(8), 2195-2208. [More Information]
  • Freter, S., Muta, Y., Mak, S., Rinkwitz, S., Ladher, R. (2008). Progressive restriction of otic fate: the role of FGF and Wnt in resolving inner ear potential. Development (Cambridge) (Print), 135(20), 3415-3424. [More Information]

2007

  • Kikuta, H., Fredman, D., Rinkwitz, S., Lenhard, B., Becker, T. (2007). Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - A fundamental feature of vertebrate genomes. Genome Biology, 8(SUPPL. 1, Article number S4), 1-13. [More Information]

2004

  • Hadrys, T., Prince, V., Hunter, M., Baker, R., Rinkwitz, S. (2004). Comparative Genomic Analysis of Vertebrate Hox3 and Hox4 Genes. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 302(2), 147-164. [More Information]

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