Professor Simon Hawke

Honorary Professor
Pathology, School of Medical Sciences

Telephone +61 2 6362 0711

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Biographical details

Prion diseases such as Creutzfeldt-Jacob diseases in humans and bovine spongiform encephalopathy (BSE or Mad Cow Disease) in cattle are fatal neurodegenerativie disorders without effective treatment. Underlying these disorders is the transformation of normal cellular protein into infections proteins or prions. Prof Hawke and his colleagues are attempting to harness the immune system to inhibit this transformation and the replication of prions. Already, they have shown that prion replication outside the brain can be substantially inhibited by passively transferring monoclonal antibodies specific for prion protein. Studies are in progress aiming to control replication in the central nervous system.

Selected grants

2014

  • Characterizing plasma microparticle content in multiple sclerosis patients; Wheway J, Zinger A, Hawke S, Grau G, Combes V; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2011

  • Molecular characterization of blood brain barrier inflammation in multiple sclerosis; Hawke S, Ting K; Multiple Sclerosis Research Australia/Investigator Project Grants.

2009

  • The role of mutant TDP-43 in ALS.; Blair I, Nicholson G, Hawke S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Targeting prion protein with monoclonal antibodies and lentivirus delivered shRNA as treatment for prion diseases; Hawke S; DVC Research/Bridging Support Grant.

2008

  • To Create a Comprehensive Profile Of Somatic and Viral Gene Expression In Multiple Sclerosis (MS) Brain With Particular Attention to Cerebral Blood Vessels; Hawke S; Multiple Sclerosis Research Australia/Investigator Project Grants.

2005

  • Understanding the pathogenetic mechanisms of prion diseases & related disorders; Hawke S, Pollard J; University of Sydney/Internal Research Grant Allocations - Jessie Isabel Alberti Program Grants.

Selected publications

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Book Chapters

  • Hawke, S. (2009). Dementia in prion disorders. In Kurlan, Roger (Eds.), Handbook of Secondary Dementia, (pp. 57-72). New York: Taylor and Francis.

Journals

  • Oates, E., Reddel, S., Rodriguez, M., Gandolfo, L., Bahlo, M., Hawke, S., Lamande, S., Clarke, N., North, K. (2012). Autosomal dominant congenital spinal muscular atrophy: a true form of spinal muscular atrophy caused by early loss of anterior horn cells. Brain: a journal of neurology, 135(6), 1714-1723. [More Information]
  • Tayebi, M., David, M., Bate, C., Jones, D., Taylor, W., Morton-Chandra, R., Pollard, J., Hawke, S. (2010). Epitope specific anti-prion antibodies up-regulate apolipoprotein e and disrupt membrane cholesterol homeostasis. Journal of General Virology, 91(12), 3105-3115. [More Information]
  • Tayebi, M., Collinge, J., Hawke, S. (2009). Unswitched immunoglobulin M response prolongs mouse survival in prion disease. Journal of General Virology, 90(3), 777-782. [More Information]
  • Tayebi, M., Bate, C., Hawke, S., Williams, A. (2007). A role for B lymphocytes in anti-infective prion therapies? Expert Review of Anti-infective Therapy, 5(4), 631-638. [More Information]
  • Khalili-Shirazi, A., Kaisar, M., Mallinson, G., Jones, S., Bhelt, D., Fraser, C., Clarke, A., Hawke, S., Jackson, G., Collinge, J. (2007). β-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91-110 that recognise native PrPSc. Biochimica et Biophysica Acta. Proteins and Proteomics, 1774 (11), 1438-1450. [More Information]
  • Tayebi, M., Hawke, S. (2006). Antibody-mediated neuronal apoptosis: therapeutic implications for prion diseases. Immunology Letters, 105(2), 123-126. [More Information]
  • Khalili-Shirazi, A., Quaratino, S., Londei, M., Summers, L., Tayebi, M., Clarke, A., Hawke, S., Jackson, G., Collinge, J. (2005). Protein conformation significantly influences immune responses to prion protein. Journal of Immunology, 174(6), 3256-3263. [More Information]
  • Khalili-Shirazi, A., Summers, L., Linehan, J., Mallinson, G., Anstee, D., Hawke, S., Jackson, G., Collinge, J. (2005). PrP glycoforms are associated in a strain-specific ratio in native PrPSc. Journal of General Virology, 86(9), 2635-2644. [More Information]
  • Tayebi, M., Enever, P., Sattar, Z., Collinge, J., Hawke, S. (2004). Disease-associated prion protein elicits immunoglobulin M responses in vivo. Molecular Medicine, 10(7-12), 104-111.
  • Tuke, P., Hawke, S., Griffiths, P., Clark, D. (2004). Distribution and quantification of human herpesvirus 6 in multiple sclerosis and control brains. Multiple Sclerosis: clinical and laboratory research, 10(4), 355-359.
  • Beringue, V., Vilette, D., Mallinson, G., Archer, F., Kaisar, M., Tayebi, M., Jackson, G., Clarke, A., Laude, H., Collinge, J., Hawke, S. (2004). PrPSc binding antibodies are potent inhibitors of prion replication in cell lines. Journal of Biological Chemistry, 279(38), 39671-39676.
  • White, A., Hawke, S. (2003). Immunotherapy as a therapeutic treatment for neurodegenerative disorders. Journal of Neurochemistry, 87(4), 801-808.
  • White, A., Enever, P., Tayebi, M., Mushens, R., Linehan, J., Brandner, S., Anstee, D., Collinge, J., Hawke, S. (2003). Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature, 422(6927), 80-83.
  • Beringue, V., Mallinson, G., Kaisar, M., Tayebi, M., Sattar, Z., Jackson, G., Anstee, D., Collinge, J., Hawke, S. (2003). Regional heterogeneity of cellular prion protein isoforms in the mouse brain. Brain, 126(9), 2065-2073.
  • Vincent, T., Richardson, M., Mackworth-Young, C., Hawke, S., Venables, P. (2003). Sjögren's Syndrome-Associated Myelopathy: Response to Immunosuppressive Treatment. The American Journal of Medicine, 114(2), 145-148.

2012

  • Oates, E., Reddel, S., Rodriguez, M., Gandolfo, L., Bahlo, M., Hawke, S., Lamande, S., Clarke, N., North, K. (2012). Autosomal dominant congenital spinal muscular atrophy: a true form of spinal muscular atrophy caused by early loss of anterior horn cells. Brain: a journal of neurology, 135(6), 1714-1723. [More Information]

2010

  • Tayebi, M., David, M., Bate, C., Jones, D., Taylor, W., Morton-Chandra, R., Pollard, J., Hawke, S. (2010). Epitope specific anti-prion antibodies up-regulate apolipoprotein e and disrupt membrane cholesterol homeostasis. Journal of General Virology, 91(12), 3105-3115. [More Information]

2009

  • Hawke, S. (2009). Dementia in prion disorders. In Kurlan, Roger (Eds.), Handbook of Secondary Dementia, (pp. 57-72). New York: Taylor and Francis.
  • Tayebi, M., Collinge, J., Hawke, S. (2009). Unswitched immunoglobulin M response prolongs mouse survival in prion disease. Journal of General Virology, 90(3), 777-782. [More Information]

2007

  • Tayebi, M., Bate, C., Hawke, S., Williams, A. (2007). A role for B lymphocytes in anti-infective prion therapies? Expert Review of Anti-infective Therapy, 5(4), 631-638. [More Information]
  • Khalili-Shirazi, A., Kaisar, M., Mallinson, G., Jones, S., Bhelt, D., Fraser, C., Clarke, A., Hawke, S., Jackson, G., Collinge, J. (2007). β-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91-110 that recognise native PrPSc. Biochimica et Biophysica Acta. Proteins and Proteomics, 1774 (11), 1438-1450. [More Information]

2006

  • Tayebi, M., Hawke, S. (2006). Antibody-mediated neuronal apoptosis: therapeutic implications for prion diseases. Immunology Letters, 105(2), 123-126. [More Information]

2005

  • Khalili-Shirazi, A., Quaratino, S., Londei, M., Summers, L., Tayebi, M., Clarke, A., Hawke, S., Jackson, G., Collinge, J. (2005). Protein conformation significantly influences immune responses to prion protein. Journal of Immunology, 174(6), 3256-3263. [More Information]
  • Khalili-Shirazi, A., Summers, L., Linehan, J., Mallinson, G., Anstee, D., Hawke, S., Jackson, G., Collinge, J. (2005). PrP glycoforms are associated in a strain-specific ratio in native PrPSc. Journal of General Virology, 86(9), 2635-2644. [More Information]

2004

  • Tayebi, M., Enever, P., Sattar, Z., Collinge, J., Hawke, S. (2004). Disease-associated prion protein elicits immunoglobulin M responses in vivo. Molecular Medicine, 10(7-12), 104-111.
  • Tuke, P., Hawke, S., Griffiths, P., Clark, D. (2004). Distribution and quantification of human herpesvirus 6 in multiple sclerosis and control brains. Multiple Sclerosis: clinical and laboratory research, 10(4), 355-359.
  • Beringue, V., Vilette, D., Mallinson, G., Archer, F., Kaisar, M., Tayebi, M., Jackson, G., Clarke, A., Laude, H., Collinge, J., Hawke, S. (2004). PrPSc binding antibodies are potent inhibitors of prion replication in cell lines. Journal of Biological Chemistry, 279(38), 39671-39676.

2003

  • White, A., Hawke, S. (2003). Immunotherapy as a therapeutic treatment for neurodegenerative disorders. Journal of Neurochemistry, 87(4), 801-808.
  • White, A., Enever, P., Tayebi, M., Mushens, R., Linehan, J., Brandner, S., Anstee, D., Collinge, J., Hawke, S. (2003). Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature, 422(6927), 80-83.
  • Beringue, V., Mallinson, G., Kaisar, M., Tayebi, M., Sattar, Z., Jackson, G., Anstee, D., Collinge, J., Hawke, S. (2003). Regional heterogeneity of cellular prion protein isoforms in the mouse brain. Brain, 126(9), 2065-2073.
  • Vincent, T., Richardson, M., Mackworth-Young, C., Hawke, S., Venables, P. (2003). Sjögren's Syndrome-Associated Myelopathy: Response to Immunosuppressive Treatment. The American Journal of Medicine, 114(2), 145-148.

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