Associate Professor Simone Schoenwaelder

Research Affiliate, FMH Medical Research Institutes / Heart Research Institute

Member of the Charles Perkins Centre


Map

Selected grants

2018

  • Novel targets to facilitate thrombolytic therapy; Schoenwaelder S; DVC Research/Bridging Support Grant.

2017

  • CPC/HRI - Global Health Challenges - Cardiovascular Disease (Open Learning Environment - Undergraduate); Schoenwaelder S, Carroll M, Groocoe A; DVC Education/Small Educational Innovation Grant.

2015

  • PI3Kbeta and blood clot porosity; Schoenwaelder S, Jackson S; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Mitochondrial dynamics - a matter of platelet life or death; Schoenwaelder S, Josefsson E; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Ju, L., McFadyen, J., Al-Daher, S., Alwis, I., Chen, Y., Tonnesen, L., Maiocchi, S., Coulter, B., Calkin, A., Felner, E., Yuan, Y., Schoenwaelder, S., Jackson, S., et al (2018). Compression force sensing regulates integrin αiIbβ3adhesive function on diabetic platelets. Nature Communications, 9(1), 1-16. [More Information]
  • Pleines, I., Lebois, M., Gangatirkar, P., Au, A., Lane, R., Henley, K., Kauppi, M., Corbin, J., Cannon, P., Bernardini, J., Alwis, I., Jackson, S., Schoenwaelder, S., et al (2018). Intrinsic apoptosis circumvents the functional decline of circulating platelets, but does not cause the storage lesion. Blood, 132(2), 197-209. [More Information]
  • Samson, A., Alwis, I., Maclean, J., Priyananda, P., Hawkett, B., Schoenwaelder, S., Jackson, S. (2017). Endogenous fibrinolysis facilitates clot retraction in vivo. Blood, 130(23), 2453-2462. [More Information]
  • Schoenwaelder, S., Darbousset, R., Cranmer, S., Ramshaw, H., Orive, S., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J., Woodcock, J., Maclean, J., James, D., Jackson, S., et al (2016). 14-3-3z regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature Communications, 7, 1-15. [More Information]
  • Samson, A., Ho, B., Au, A., Schoenwaelder, S., Smyth, M., Bottomley, S., Kleifeld, O., Medcalf, R. (2016). Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells. Open Biology, 6(11), 1-12. [More Information]
  • Schoenwaelder, S., Jackson, S. (2015). Ferric chloride thrombosis model: unravelling the vascular effects of a highly corrosive oxidant. Blood, 126(24), 2652-2653. [More Information]
  • Samson, A., Ju, L., Ah KIm, H., Zhang, S., Maclean, J., Sturgeon, S., Sobey, C., Jackson, S., Schoenwaelder, S. (2015). MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents. Scientific Reports, 5, 1-11. [More Information]
  • Mountford, J., Petitjean, C., Putra, H., McCafferty, J., Setiabakti, N., Lee, H., Tønnesen, L., McFadyen, J., Schoenwaelder, S., Eckly, A., Jackson, S., et al (2015). The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function. Nature Communications, 6, 1-14. [More Information]
  • Kaplan, Z., Zarpellon, A., Alwis, I., Yuan, Y., McFadyen, J., Ghasemzadeh, M., Schoenwaelder, S., Ruggeri, Z., Jackson, S. (2015). Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4. Nature Communications, 6, 1-13. [More Information]
  • Hughan, S., Spring, C., Schoenwaelder, S., Sturgeon, S., Alwis, I., Yuan, Y., McFadyen, J., Westein, E., Goddard, D., Ono, A., Jackson, S., et al (2014). Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrinαIIbβ3 in mice. Journal of Biological Chemistry, 289(8), 5051-5060. [More Information]
  • Luo, L., Wall, A., Yeo, J., Condon, N., Norwood, S., Schoenwaelder, S., Chen, K., Jackson, S., Jenkins, B., Hartland, E., et al (2014). Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications, 5, 1-13. [More Information]
  • Qiao, J., Schoenwaelder, S., Mason, K., Tran, H., Davis, A., Kaplan, Z., Jackson, S., Kile, B., Andrews, R., et al (2013). Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263). Blood, 121(8), 1479-1481. [More Information]
  • Ghasemzadeh, M., Kaplan, Z., Alwis, I., Schoenwaelder, S., Ashworth, K., Westein, E., Hosseini, E., Salem, H., Slattery, R., McColl, S., et al (2013). The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood, 121(22), 4555-4566. [More Information]
  • Jackson, S., Schoenwaelder, S. (2012). Antithrombotic phosphoinositide 3-kinase B inhibitors in humans: a 'shear' delight!. Journal of Thrombosis and Haemostasis, 10(10), 2123-2126. [More Information]
  • Schoenwaelder, S., Jackson, S. (2012). Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function. Blood, 119(5), 1320-1321. [More Information]
  • Schoenwaelder, S., Jarman, K., Gardiner, E., Hua, M., Qiao, J., White, M., Josefsson, E., Alwis, I., Ono, A., Willcox, A., et al (2011). Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood, 118(6), 1663-1674. [More Information]
  • Calkin, A., Drew, B., Ono, A., Duffy, S., Gordon, M., Schoenwaelder, S., Sviridov, D., Cooper, M., Kingwell, B., Jackson, S. (2009). Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation, 120(21), 2095-2104. [More Information]

2018

  • Ju, L., McFadyen, J., Al-Daher, S., Alwis, I., Chen, Y., Tonnesen, L., Maiocchi, S., Coulter, B., Calkin, A., Felner, E., Yuan, Y., Schoenwaelder, S., Jackson, S., et al (2018). Compression force sensing regulates integrin αiIbβ3adhesive function on diabetic platelets. Nature Communications, 9(1), 1-16. [More Information]
  • Pleines, I., Lebois, M., Gangatirkar, P., Au, A., Lane, R., Henley, K., Kauppi, M., Corbin, J., Cannon, P., Bernardini, J., Alwis, I., Jackson, S., Schoenwaelder, S., et al (2018). Intrinsic apoptosis circumvents the functional decline of circulating platelets, but does not cause the storage lesion. Blood, 132(2), 197-209. [More Information]

2017

  • Samson, A., Alwis, I., Maclean, J., Priyananda, P., Hawkett, B., Schoenwaelder, S., Jackson, S. (2017). Endogenous fibrinolysis facilitates clot retraction in vivo. Blood, 130(23), 2453-2462. [More Information]

2016

  • Schoenwaelder, S., Darbousset, R., Cranmer, S., Ramshaw, H., Orive, S., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J., Woodcock, J., Maclean, J., James, D., Jackson, S., et al (2016). 14-3-3z regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature Communications, 7, 1-15. [More Information]
  • Samson, A., Ho, B., Au, A., Schoenwaelder, S., Smyth, M., Bottomley, S., Kleifeld, O., Medcalf, R. (2016). Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells. Open Biology, 6(11), 1-12. [More Information]

2015

  • Schoenwaelder, S., Jackson, S. (2015). Ferric chloride thrombosis model: unravelling the vascular effects of a highly corrosive oxidant. Blood, 126(24), 2652-2653. [More Information]
  • Samson, A., Ju, L., Ah KIm, H., Zhang, S., Maclean, J., Sturgeon, S., Sobey, C., Jackson, S., Schoenwaelder, S. (2015). MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents. Scientific Reports, 5, 1-11. [More Information]
  • Mountford, J., Petitjean, C., Putra, H., McCafferty, J., Setiabakti, N., Lee, H., Tønnesen, L., McFadyen, J., Schoenwaelder, S., Eckly, A., Jackson, S., et al (2015). The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function. Nature Communications, 6, 1-14. [More Information]
  • Kaplan, Z., Zarpellon, A., Alwis, I., Yuan, Y., McFadyen, J., Ghasemzadeh, M., Schoenwaelder, S., Ruggeri, Z., Jackson, S. (2015). Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4. Nature Communications, 6, 1-13. [More Information]

2014

  • Hughan, S., Spring, C., Schoenwaelder, S., Sturgeon, S., Alwis, I., Yuan, Y., McFadyen, J., Westein, E., Goddard, D., Ono, A., Jackson, S., et al (2014). Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrinαIIbβ3 in mice. Journal of Biological Chemistry, 289(8), 5051-5060. [More Information]
  • Luo, L., Wall, A., Yeo, J., Condon, N., Norwood, S., Schoenwaelder, S., Chen, K., Jackson, S., Jenkins, B., Hartland, E., et al (2014). Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications, 5, 1-13. [More Information]

2013

  • Qiao, J., Schoenwaelder, S., Mason, K., Tran, H., Davis, A., Kaplan, Z., Jackson, S., Kile, B., Andrews, R., et al (2013). Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263). Blood, 121(8), 1479-1481. [More Information]
  • Ghasemzadeh, M., Kaplan, Z., Alwis, I., Schoenwaelder, S., Ashworth, K., Westein, E., Hosseini, E., Salem, H., Slattery, R., McColl, S., et al (2013). The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood, 121(22), 4555-4566. [More Information]

2012

  • Jackson, S., Schoenwaelder, S. (2012). Antithrombotic phosphoinositide 3-kinase B inhibitors in humans: a 'shear' delight!. Journal of Thrombosis and Haemostasis, 10(10), 2123-2126. [More Information]
  • Schoenwaelder, S., Jackson, S. (2012). Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function. Blood, 119(5), 1320-1321. [More Information]

2011

  • Schoenwaelder, S., Jarman, K., Gardiner, E., Hua, M., Qiao, J., White, M., Josefsson, E., Alwis, I., Ono, A., Willcox, A., et al (2011). Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood, 118(6), 1663-1674. [More Information]

2009

  • Calkin, A., Drew, B., Ono, A., Duffy, S., Gordon, M., Schoenwaelder, S., Sviridov, D., Cooper, M., Kingwell, B., Jackson, S. (2009). Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation, 120(21), 2095-2104. [More Information]

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