Associate Professor Simone Schoenwaelder

Research Affiliate, FMH Medical Research Institutes / Heart Research Institute

Member of the Charles Perkins Centre

Telephone 02 8627 4117
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Biographical details

Simone Schoenwaelder is Associate Director of Research Management and Education of the Heart Research Institute, an Associate Professor (Research)at the Heart Research Institute and Charles Perkins Centre at the University of Sydney (NSW), Adjunct Associate Professor at Monash University (Victoria), and President of the Australian Vascular Biology Society.

Simone completed her undergraduate Bachelor of Science degree in 1992, receiving first class honours at Monash University in Victoria. This was followed by doctoral studies at Monash University. Following the completion of her Ph.D. in 1996, she spent several postdoctoral years at the University of North Carolina, Chapel Hill (USA) as an NHMRC CJ Martin Fellow in the Department of Cell Biology and Anatomy, in the laboratory of Professor Keith Burridge. During her time in the USA, Simone was awarded “Young Australian of the Year in Science and Technology” in her state of Victoria in 1997, and selected as a national finalist as “young Australian of the year for Science and Technology”. Upon completion of her postdoctoral studies in 1999, Simone returned to Australia as an NHMRC RD Wright and Monash University Logan Research Fellow, joining the Australian Centre for Blood Diseases (ACBD).

In 2015, Simone relocated to her current position at the Heart Research Institute and University of Sydney, NSW.

Simone Schoenwaelder is Associate Director of Research Management and Education of HRI, an Associate Professor (Research) at HRI and Charles Perkins Centre at the University of Sydney (NSW), Adjunct Associate Professor at Monash University (Victoria), and President of the Australian Vascular Biology Society.

Born in Melbourne, Simone completed her undergraduate Bachelor of Science degree in 1992, receiving first class honours at Monash University in Victoria. This was followed by doctoral studies at Monash University. Following the completion of her PhD in 1996, she spent several postdoctoral years at the University of North Carolina, Chapel Hill (USA) as a National Health and Medical Research Council (NHMRC) CJ Martin Fellow in the Department of Cell Biology and Anatomy, in the laboratory of Professor Keith Burridge.

During her time in the USA, Simone was awarded ‘Young Australian of the Year in Science and Technology’ in her state of Victoria in 1997, and selected as a national finalist as ‘Young Australian of the Year for Science and Technology’. Upon completion of her postdoctoral studies in 1999, Simone returned to Australia as an NHMRC RD Wright and Monash University Logan Research Fellow, joining the Australian Centre for Blood Diseases.

In 2015, Simone relocated to her current position at HRI and University of Sydney, NSW.

Simone Schoenwaelder is Associate Director of Research Management and Education of HRI, an Associate Professor (Research) at HRI and Charles Perkins Centre at the University of Sydney (NSW), Adjunct Associate Professor at Monash University (Victoria), and President of the Australian Vascular Biology Society.

Born in Melbourne, Simone completed her undergraduate Bachelor of Science degree in 1992, receiving first class honours at Monash University in Victoria. This was followed by doctoral studies at Monash University. Following the completion of her PhD in 1996, she spent several postdoctoral years at the University of North Carolina, Chapel Hill (USA) as a National Health and Medical Research Council (NHMRC) CJ Martin Fellow in the Department of Cell Biology and Anatomy, in the laboratory of Professor Keith Burridge.

During her time in the USA, Simone was awarded ‘Young Australian of the Year in Science and Technology’ in her state of Victoria in 1997, and selected as a national finalist as ‘Young Australian of the Year for Science and Technology’. Upon completion of her postdoctoral studies in 1999, Simone returned to Australia as an NHMRC RD Wright and Monash University Logan Research Fellow, joining the Australian Centre for Blood Diseases.

In 2015, Simone relocated to her current position at HRI and University of Sydney, NSW.

Simone Schoenwaelder is Associate Director of Research Management and Education of HRI, an Associate Professor (Research) at HRI and Charles Perkins Centre at the University of Sydney (NSW), Adjunct Associate Professor at Monash University (Victoria), and President of the Australian Vascular Biology Society.

Born in Melbourne, Simone completed her undergraduate Bachelor of Science degree in 1992, receiving first class honours at Monash University in Victoria. This was followed by doctoral studies at Monash University. Following the completion of her PhD in 1996, she spent several postdoctoral years at the University of North Carolina, Chapel Hill (USA) as a National Health and Medical Research Council (NHMRC) CJ Martin Fellow in the Department of Cell Biology and Anatomy, in the laboratory of Professor Keith Burridge.

During her time in the USA, Simone was awarded ‘Young Australian of the Year in Science and Technology’ in her state of Victoria in 1997, and selected as a national finalist as ‘Young Australian of the Year for Science and Technology’. Upon completion of her postdoctoral studies in 1999, Simone returned to Australia as an NHMRC RD Wright and Monash University Logan Research Fellow, joining the Australian Centre for Blood Diseases.

In 2015, Simone relocated to her current position at HRI and University of Sydney, NSW.

Research interests

Simone’s overarching research aim focusses on advancement in our understanding on the role of platelets in arterial thrombosis, through fundamental discovery research.Specific areas of focus include delineating the role of cell death pathways in blood clot formation, and the discovery and ongoing investigation of a novel regulator of blood clot formation – PI 3-kinase p110beta.

Her work continues to be published in high impact journals in the field, with 62 career publications (cumulative career h-index - 38; totalcitations -5090), in journals including Nature Medicine,NatureCommunications, Science Translational Medicine, Journal of Clinical Investigation, Blood, and Circulation.

She also has a keen interest in the translation of basic research findings from the lab, and in her part-time role as head of biology forKinaciaPty Ltd., she co-invented a new class of PI3K inhibitors (1999-2004) and directed their development (Jackson, Schoenwaelder et al, Nature Medicine, 2005).

Teaching and supervision

Contribution to research training: A/Prof Schoenwaelder has successfully supervised 11 honours students (all awarded H1), co-supervised 1 Masters student and supervised/co-supervised to completion 3 PhD students. She has developed summer scholarship and undergraduate training programs at Monash University, and has played a major role in coordinating/delivering undergraduate teaching programs at Monash University (Human Pathology HUP3011/HUP3022) as well as more recently at the University of Sydney.

Current research students

Project title Research student
Mechano-redox control of neutrophil function in thrombo-inflammation Alexander DUPUY

Current projects

Project 1. Development of novel antiplatelet and anticoagulant drugs for the treatment of stroke

Associations

Current Appointments:

  • Associate Professor (Research), Heart Research Institute
  • Conjoint Associate Professor, Department of Physiology, SOMS, University of Sydney
  • Associate Director, research management and education – Heart Research Institute (HRI)
  • Secretary – Australian Vascular Biology Society

Link to your ORCID page: https://orcid.org/0000-0003-0465-5840

Link to your PubMed page:https://www.ncbi.nlm.nih.gov/pubmed/?term=schoenwaelder+SM

Awards and honours

Prizes and Awards:

  • 1997 VictorianPremiers Award for Medical Research, Commendation
  • 1998 State winner (Victoria), Young Australian of the Year for 1999 –Eastern Energy Science and Technology Award.
  • 1999 National Finalist, Young Australian of the Year for 1999 – Eastern Energy Science and Technology Award.
  • 1999 City of Whitehorse Young Citizen of the Year for 1999
  • 2001 International Investigator Award – XVIII Congress of the International Society on Haemostasis and Thrombosis (ISTH), Paris, France.
  • 2001 Australian Society for Thrombosis and Haemostasis (ASTH) Scientific Medal – runner up (formerly the Ipsen Medal Award).
  • 2003 International Young Investigator Award – XIX Congress of the ISTH, Birmingham, UK.
  • 2007 ASTH Scientific Medal
  • 2015 ASMR MRW® XXIII NSW Scientific Meeting, Powerhouse Museum, Sydney. Awarded best postdoctoral oral presentation.
  • 2017 -Sydney Local Health District Mentor of the Year

Selected grants

2018

  • Novel targets to facilitate thrombolytic therapy; Schoenwaelder S; DVC Research/Bridging Support Grant.

2017

  • CPC/HRI - Global Health Challenges - Cardiovascular Disease (Open Learning Environment - Undergraduate); Schoenwaelder S, Carroll M, Groocoe A; DVC Education/Small Educational Innovation Grant.

2015

  • PI3Kbeta and blood clot porosity; Schoenwaelder S, Jackson S; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Mitochondrial dynamics - a matter of platelet life or death; Schoenwaelder S, Josefsson E; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Jackson, S., Darbousset, R., Schoenwaelder, S. (2019). Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms. Blood, 133(9), 906-918. [More Information]
  • Ju, L., McFadyen, J., Al-Daher, S., Alwis, I., Chen, Y., Tonnesen, L., Maiocchi, S., Coulter, B., Calkin, A., Felner, E., Yuan, Y., Schoenwaelder, S., Jackson, S., et al (2018). Compression force sensing regulates integrin alpha(IIb)beta(3) adhesive function on diabetic platelets. Nature Communications, 9(1), 1-16. [More Information]
  • Pleines, I., Lebois, M., Gangatirkar, P., Au, A., Lane, R., Henley, K., Kauppi, M., Corbin, J., Cannon, P., Bernardini, J., Alwis, I., Jackson, S., Schoenwaelder, S., et al (2018). Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion. Blood, 132(2), 197-209. [More Information]
  • Samson, A., Alwis, I., Maclean, J., Priyananda, P., Hawkett, B., Schoenwaelder, S., Jackson, S. (2017). Endogenous fibrinolysis facilitates clot retraction in vivo. Blood, 130(23), 2453-2462. [More Information]
  • Schoenwaelder, S., Darbousset, R., Cranmer, S., Ramshaw, H., Orive, S., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J., Woodcock, J., Maclean, J., James, D., Jackson, S., et al (2016). 14-3-3z regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature Communications, 7, 1-15. [More Information]
  • Samson, A., Ho, B., Au, A., Schoenwaelder, S., Smyth, M., Bottomley, S., Kleifeld, O., Medcalf, R. (2016). Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells. Open Biology, 6(11), 1-12. [More Information]
  • Schoenwaelder, S., Jackson, S. (2015). Ferric chloride thrombosis model: unravelling the vascular effects of a highly corrosive oxidant. Blood, 126(24), 2652-2653. [More Information]
  • Samson, A., Ju, L., Ah KIm, H., Zhang, S., Maclean, J., Sturgeon, S., Sobey, C., Jackson, S., Schoenwaelder, S. (2015). MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents. Scientific Reports, 5, 1-11. [More Information]
  • Mountford, J., Petitjean, C., Putra, H., McCafferty, J., Setiabakti, N., Lee, H., Tønnesen, L., McFadyen, J., Schoenwaelder, S., Eckly, A., Jackson, S., et al (2015). The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function. Nature Communications, 6, 1-14. [More Information]
  • Kaplan, Z., Zarpellon, A., Alwis, I., Yuan, Y., McFadyen, J., Ghasemzadeh, M., Schoenwaelder, S., Ruggeri, Z., Jackson, S. (2015). Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4. Nature Communications, 6, 1-13. [More Information]
  • Hughan, S., Spring, C., Schoenwaelder, S., Sturgeon, S., Alwis, I., Yuan, Y., McFadyen, J., Westein, E., Goddard, D., Ono, A., Jackson, S., et al (2014). Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrinαIIbβ3 in mice. Journal of Biological Chemistry, 289(8), 5051-5060. [More Information]
  • Luo, L., Wall, A., Yeo, J., Condon, N., Norwood, S., Schoenwaelder, S., Chen, K., Jackson, S., Jenkins, B., Hartland, E., et al (2014). Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications, 5, 1-13. [More Information]
  • Qiao, J., Schoenwaelder, S., Mason, K., Tran, H., Davis, A., Kaplan, Z., Jackson, S., Kile, B., Andrews, R., et al (2013). Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263). Blood, 121(8), 1479-1481. [More Information]
  • Ghasemzadeh, M., Kaplan, Z., Alwis, I., Schoenwaelder, S., Ashworth, K., Westein, E., Hosseini, E., Salem, H., Slattery, R., McColl, S., et al (2013). The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood, 121(22), 4555-4566. [More Information]
  • Jackson, S., Schoenwaelder, S. (2012). Antithrombotic phosphoinositide 3-kinase B inhibitors in humans: a 'shear' delight!. Journal of Thrombosis and Haemostasis, 10(10), 2123-2126. [More Information]
  • Schoenwaelder, S., Jackson, S. (2012). Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function. Blood, 119(5), 1320-1321. [More Information]
  • Schoenwaelder, S., Jarman, K., Gardiner, E., Hua, M., Qiao, J., White, M., Josefsson, E., Alwis, I., Ono, A., Willcox, A., et al (2011). Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood, 118(6), 1663-1674. [More Information]
  • Calkin, A., Drew, B., Ono, A., Duffy, S., Gordon, M., Schoenwaelder, S., Sviridov, D., Cooper, M., Kingwell, B., Jackson, S. (2009). Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation, 120(21), 2095-2104. [More Information]

2019

  • Jackson, S., Darbousset, R., Schoenwaelder, S. (2019). Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms. Blood, 133(9), 906-918. [More Information]

2018

  • Ju, L., McFadyen, J., Al-Daher, S., Alwis, I., Chen, Y., Tonnesen, L., Maiocchi, S., Coulter, B., Calkin, A., Felner, E., Yuan, Y., Schoenwaelder, S., Jackson, S., et al (2018). Compression force sensing regulates integrin alpha(IIb)beta(3) adhesive function on diabetic platelets. Nature Communications, 9(1), 1-16. [More Information]
  • Pleines, I., Lebois, M., Gangatirkar, P., Au, A., Lane, R., Henley, K., Kauppi, M., Corbin, J., Cannon, P., Bernardini, J., Alwis, I., Jackson, S., Schoenwaelder, S., et al (2018). Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion. Blood, 132(2), 197-209. [More Information]

2017

  • Samson, A., Alwis, I., Maclean, J., Priyananda, P., Hawkett, B., Schoenwaelder, S., Jackson, S. (2017). Endogenous fibrinolysis facilitates clot retraction in vivo. Blood, 130(23), 2453-2462. [More Information]

2016

  • Schoenwaelder, S., Darbousset, R., Cranmer, S., Ramshaw, H., Orive, S., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J., Woodcock, J., Maclean, J., James, D., Jackson, S., et al (2016). 14-3-3z regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nature Communications, 7, 1-15. [More Information]
  • Samson, A., Ho, B., Au, A., Schoenwaelder, S., Smyth, M., Bottomley, S., Kleifeld, O., Medcalf, R. (2016). Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells. Open Biology, 6(11), 1-12. [More Information]

2015

  • Schoenwaelder, S., Jackson, S. (2015). Ferric chloride thrombosis model: unravelling the vascular effects of a highly corrosive oxidant. Blood, 126(24), 2652-2653. [More Information]
  • Samson, A., Ju, L., Ah KIm, H., Zhang, S., Maclean, J., Sturgeon, S., Sobey, C., Jackson, S., Schoenwaelder, S. (2015). MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents. Scientific Reports, 5, 1-11. [More Information]
  • Mountford, J., Petitjean, C., Putra, H., McCafferty, J., Setiabakti, N., Lee, H., Tønnesen, L., McFadyen, J., Schoenwaelder, S., Eckly, A., Jackson, S., et al (2015). The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function. Nature Communications, 6, 1-14. [More Information]
  • Kaplan, Z., Zarpellon, A., Alwis, I., Yuan, Y., McFadyen, J., Ghasemzadeh, M., Schoenwaelder, S., Ruggeri, Z., Jackson, S. (2015). Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4. Nature Communications, 6, 1-13. [More Information]

2014

  • Hughan, S., Spring, C., Schoenwaelder, S., Sturgeon, S., Alwis, I., Yuan, Y., McFadyen, J., Westein, E., Goddard, D., Ono, A., Jackson, S., et al (2014). Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrinαIIbβ3 in mice. Journal of Biological Chemistry, 289(8), 5051-5060. [More Information]
  • Luo, L., Wall, A., Yeo, J., Condon, N., Norwood, S., Schoenwaelder, S., Chen, K., Jackson, S., Jenkins, B., Hartland, E., et al (2014). Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications, 5, 1-13. [More Information]

2013

  • Qiao, J., Schoenwaelder, S., Mason, K., Tran, H., Davis, A., Kaplan, Z., Jackson, S., Kile, B., Andrews, R., et al (2013). Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263). Blood, 121(8), 1479-1481. [More Information]
  • Ghasemzadeh, M., Kaplan, Z., Alwis, I., Schoenwaelder, S., Ashworth, K., Westein, E., Hosseini, E., Salem, H., Slattery, R., McColl, S., et al (2013). The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood, 121(22), 4555-4566. [More Information]

2012

  • Jackson, S., Schoenwaelder, S. (2012). Antithrombotic phosphoinositide 3-kinase B inhibitors in humans: a 'shear' delight!. Journal of Thrombosis and Haemostasis, 10(10), 2123-2126. [More Information]
  • Schoenwaelder, S., Jackson, S. (2012). Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function. Blood, 119(5), 1320-1321. [More Information]

2011

  • Schoenwaelder, S., Jarman, K., Gardiner, E., Hua, M., Qiao, J., White, M., Josefsson, E., Alwis, I., Ono, A., Willcox, A., et al (2011). Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood, 118(6), 1663-1674. [More Information]

2009

  • Calkin, A., Drew, B., Ono, A., Duffy, S., Gordon, M., Schoenwaelder, S., Sviridov, D., Cooper, M., Kingwell, B., Jackson, S. (2009). Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation, 120(21), 2095-2104. [More Information]

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