Dr Siva Purushothuman

PhD, Grad Cert Mgmt, BSc (Hons), BPsych, BSc
Research Fellow
Central Clinical School

Member of the Brain and Mind Centre

Telephone 93510759

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International links

United States

(Philadelphia College of Osteopathic Med, U.S.A) Role of Noggin/MyoD cells in eye & brain development and degeneration

Selected grants

2016

  • Lewy bodies in patients with dementia - Determining common and unique mechanisms in relation to Alzheimer's disease; Purushothuman S; National Health and Medical Research Council (NHMRC)/NHMRC-ARC Dementia Research Development Fellowships.

Selected publications

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Journals

  • Kim, B., Brandli, A., Mitrofanis, J., Stone, J., Purushothuman, S., Johnstone, D. (2017). Remote tissue conditioning � An emerging approach for inducing body-wide protection against diseases of ageing. Ageing Research Reviews, 37, 69-78. [More Information]
  • Brandli, A., Gerhart, J., Sutera, C., Purushothuman, S., George-Weinstein, M., Stone, J., Bravo-Nuevo, A. (2017). Role of Myo/Nog cells in neuroprotection: Evidence from the light damaged retina. PloS One, 12(1), 1-15. [More Information]
  • Shahandeh, A., Purushothuman, S., Martin, K., Graham, M., Johnstone, D., Milward, E. (2015). Anti-oxidant Phytochemicals as Potential Treatments for Age-Related Macular Degeneration. Antioxidant Activity, 1(1), 29-41. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasenaa,, C., van Eersel, J., Ittner, L., Mitrofanis, J., Stone, J. (2015). Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia. Neuroscience Letters, 591, 155-159. [More Information]
  • Purushothuman, S. (2015). Oxidative stress in neurodegenerative conditions and the protective potential of a natural antioxidant, dietary saffron. Oxidants and Antioxidants in Medical Science, 4(3), 112-118. [More Information]
  • Purushothuman, S., Stone, J. (2015). The reaction of cerebral cortex to a nearby lesion: Damage, survival, self-protection. Brain Research, 1601, 52-63. [More Information]
  • Johnstone, D., El Massri, N., Moro, C., Spana, S., Wang, X., Torres, N., Chabrol, C., de Jaeger, X., Reinhart, F., Purushothuman, S., Stone, J., Mitrofanis, J., et al (2014). Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect. Neuroscience, 274, 93-101. [More Information]
  • Moro, C., El Massri, N., Torres, N., Ratel, D., de Jaeger, X., Chabrol, C., Perraut, F., Bourgerette, A., Berger, M., Purushothuman, S., Johnstone, D., Stone, J., Mitrofanis, J., et al (2014). Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice. Journal of Neurosurgery, 120(3), 670-683. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasena, S., Mitrofanis, J., Stone, J. (2014). Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models. Alzheimers Research & Therapy, 6(1), 1-13. [More Information]
  • Purushothuman, S., Nandasena, C., Peoples, C., El Massri, N., Johnstone, D., Mitrofanis, J., Stone, J. (2013). Saffron Pre-Treatment Offers Neuroprotection to Nigral and Retinal Dopaminergic Cells of MPTP-Treated mice. Journal of Parkinson's Disease, 3(1), 77-83. [More Information]
  • Purushothuman, S., Nandasena, S., Johnstone, D., Stone, J., Mitrofanis, J. (2013). The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain Research, 1535, 61-70. [More Information]
  • Purushothuman, S., Marotte, L., Stowe, S., Johnstone, D., Stone, J. (2013). The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model. PloS One, 8(3), 1-18. [More Information]
  • Di Marco, F., Romeo, S., Nandasena, S., Purushothuman, S., Adams, C., Bisti, S., Stone, J. (2013). The time course of action of two neuroprotectants, dietary saffron and photobiomodulation, assessed in the rat retina. American Journal of Neurodegenerative Disease, 2(3), 208-220.

2017

  • Kim, B., Brandli, A., Mitrofanis, J., Stone, J., Purushothuman, S., Johnstone, D. (2017). Remote tissue conditioning � An emerging approach for inducing body-wide protection against diseases of ageing. Ageing Research Reviews, 37, 69-78. [More Information]
  • Brandli, A., Gerhart, J., Sutera, C., Purushothuman, S., George-Weinstein, M., Stone, J., Bravo-Nuevo, A. (2017). Role of Myo/Nog cells in neuroprotection: Evidence from the light damaged retina. PloS One, 12(1), 1-15. [More Information]

2015

  • Shahandeh, A., Purushothuman, S., Martin, K., Graham, M., Johnstone, D., Milward, E. (2015). Anti-oxidant Phytochemicals as Potential Treatments for Age-Related Macular Degeneration. Antioxidant Activity, 1(1), 29-41. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasenaa,, C., van Eersel, J., Ittner, L., Mitrofanis, J., Stone, J. (2015). Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia. Neuroscience Letters, 591, 155-159. [More Information]
  • Purushothuman, S. (2015). Oxidative stress in neurodegenerative conditions and the protective potential of a natural antioxidant, dietary saffron. Oxidants and Antioxidants in Medical Science, 4(3), 112-118. [More Information]
  • Purushothuman, S., Stone, J. (2015). The reaction of cerebral cortex to a nearby lesion: Damage, survival, self-protection. Brain Research, 1601, 52-63. [More Information]

2014

  • Johnstone, D., El Massri, N., Moro, C., Spana, S., Wang, X., Torres, N., Chabrol, C., de Jaeger, X., Reinhart, F., Purushothuman, S., Stone, J., Mitrofanis, J., et al (2014). Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect. Neuroscience, 274, 93-101. [More Information]
  • Moro, C., El Massri, N., Torres, N., Ratel, D., de Jaeger, X., Chabrol, C., Perraut, F., Bourgerette, A., Berger, M., Purushothuman, S., Johnstone, D., Stone, J., Mitrofanis, J., et al (2014). Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice. Journal of Neurosurgery, 120(3), 670-683. [More Information]
  • Purushothuman, S., Johnstone, D., Nandasena, S., Mitrofanis, J., Stone, J. (2014). Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models. Alzheimers Research & Therapy, 6(1), 1-13. [More Information]

2013

  • Purushothuman, S., Nandasena, C., Peoples, C., El Massri, N., Johnstone, D., Mitrofanis, J., Stone, J. (2013). Saffron Pre-Treatment Offers Neuroprotection to Nigral and Retinal Dopaminergic Cells of MPTP-Treated mice. Journal of Parkinson's Disease, 3(1), 77-83. [More Information]
  • Purushothuman, S., Nandasena, S., Johnstone, D., Stone, J., Mitrofanis, J. (2013). The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain Research, 1535, 61-70. [More Information]
  • Purushothuman, S., Marotte, L., Stowe, S., Johnstone, D., Stone, J. (2013). The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model. PloS One, 8(3), 1-18. [More Information]
  • Di Marco, F., Romeo, S., Nandasena, S., Purushothuman, S., Adams, C., Bisti, S., Stone, J. (2013). The time course of action of two neuroprotectants, dietary saffron and photobiomodulation, assessed in the rat retina. American Journal of Neurodegenerative Disease, 2(3), 208-220.

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