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Dr Slade Matthews

Senior Lecturer
Pharmacology, School of Medical Sciences
Sub-Dean Sydney Medical School (Stage 1)

Telephone +61 2 9351 6200

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Research interests

Slade's research is focussed on the effects of stress, heart disease and diabetes on heart rate variability, clinical factors affecting drug metabolism and disposition and computational techniques for non-clinical toxicity assessment. Machine learning algorithms and computational modelling, statistical analysis and analysis of heart rate variability are his key research techniques.

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Teaching and supervision

Slade is the coordinator of the 3rd year course, Toxicology, and his teaching is focussed in the areas of non-clinical regulatory toxicology, pharmacokinetics and data analysis for detection of toxicity.

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Awards and honours

Slade has two teaching awards for student-centred scholarly approach to teaching: the 2012 Sydney Medical School Award for Outstanding Teaching and the 2009 Coop Bookshop Excellence in teaching award.

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Selected grants

2014

  • Clinical observation and comprehensive psychophysiological recording and behavioural coding equipment; Guastella A, de Rosnay M, Einfeld S, Glozier N, Hawes D, Hickie I, Lagapolos J, Matthews S, Menzies R, Morley K, Naismith S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
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Selected publications

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Journals

  • Ebach, M., Michael, M., Shaw, W., Goff, J., Murphy, D., Matthews, S. (2016). Big data and the historical sciences: A critique. Geoforum, 71, 1-4. [More Information]
  • Lee, Y., Reidler, P., Jelinek, H., Lee, Y., Zhou, Y., Hambly, B., McCabe, J., Matthews, S., Ke, H., Assareh, H., et al (2016). Electrocardiogram derived QRS duration associations with elevated central aortic systolic pressure (CASP) in a rural Australian population. Clinical Hypertension, 22(6), 1-6. [More Information]
  • Marzbanrad, F., Khandoker, A., Hambly, B., Ng, E., Tamayo, M., Lu, Y., Matthews, S., Karmakar, C., Palaniswami, M., Jelinek, H., et al (2016). Methodological Comparisons of Heart Rate Variability Analysis in Patients With Type 2 Diabetes and Angiotensin Converting Enzyme Polymorphism. IEEE Journal of Biomedical and Health Informatics, 20(1), 55-63. [More Information]
  • Dixit, R., Matthews, S., Khandaker, G., Walker, K., Festa, M., Booy, R. (2016). Pharmacokinetics of oseltamivir in infants under the age of 1 year. Clinical and Translational Medicine, 5(1), 1-6. [More Information]
  • Gnjidic, D., Bennett, A., Le Couteur, D., Blyth, F., Cumming, R., Waite, L., Handelsman, D., Naganathan, V., Matthews, S., Hilmer, S. (2015). Ischemic heart disease, prescription of optimal medical therapy and geriatric syndromes in community-dwelling older men: A population-based study. International Journal of Cardiology, 192, 49-55. [More Information]
  • Qi, K., Reeve, E., Hilmer, S., Pearson, S., Matthews, S., Gnjidic, D. (2015). Older peoples' attitudes regarding polypharmacy, statin use and willingness to have statins deprescribed in Australia. International Journal of Clinical Pharmacy, 37(5), 949-957. [More Information]
  • Bennett, A., Gnjidic, D., Gillett, M., Carroll, P., Matthews, S., Johnell, K., Fastbom, J., Hilmer, S. (2014). Prevalence and impact of fall-risk-increasing drugs, polypharmacy, and drug-drug interactions in robust versus frail hospitalised falls patients: a prospective cohort study. Drugs and Aging, 31(3), 225-232. [More Information]
  • Johnston, C., Hilmer, S., McLachlan, A., Matthews, S., Carroll, P., Kirkpatrick, C. (2014). The impact of frailty on pharmacokinetics in older people: using gentamicin population pharmacokinetic modeling to investigate changes in renal drug clearance by glomerular filtration. European Journal of Clinical Pharmacology, 70(5), 549-555. [More Information]
  • Ng, E., Lu, Y., Hambly, B., Jelinek, H., Yu, B., Matthews, S., McLachlan, C. (2013). Angiotensin-converting enzyme gene DD genotype is associated with increased systolic blood pressure in an Australian Rural Type 2 Diabetic Cohort. Hypertension Research, 36(4), 381-382. [More Information]
  • Matthews, S. (2013). Letter to the Editor: One-tailed significance tests and the accounting for alpha. Clinical and Experimental Pharmacology and Physiology, 40(8), 594-594. [More Information]
  • Kane, A., Mitchell, S., Carroll, P., Matthews, S., Hilmer, S. (2012). Characteristics of older and younger patients with suspected paracetamol toxicity. Australasian Journal on Ageing, 31(3), 190-193. [More Information]
  • Kemp, A., Quintana, D., Felmingham, K., Matthews, S., Jelinek, H. (2012). Depression, comorbid anxiety disorders, and heart rate variability in physically healthy, unmedicated patients: implications for cardiovascular risk. PloS One, 7(2), 1-8. [More Information]
  • Matthews, S., Succar, P., Jelinek, H., McParland, B., Buckland, M., McLachlan, C. (2012). Diagnosis of oligodendroglioma: Molecular and classical histological assessment in the twenty-first century. Asia-Pacific Journal of Clinical Oncology, 8(3), 213-216. [More Information]
  • Matthews, S., Jelinek, H., Vafaeiafraz, S., McLachlan, C. (2012). Heart rate stability and decreased parasympathetic heart rate variability in healthy young adults during perceived stress. International Journal of Cardiology, 156(3), 337-338. [More Information]
  • Johnston, C., Carroll, P., Matthews, S., Mitchell, S., Hilmer, S. (2011). 'You look like a 240 mg': Gentamicin dosing at a Sydney hospital. Journal of Pharmacy Practice and Research, 41(4), 275-277.
  • Hilmer, S., Tran, K., Rubie, P., Wright, J., Gnjidic, D., Mitchell, S., Matthews, S., Carroll, P. (2011). Gentamicin Pharmacokinetics in Old Age and Frailty. British Journal of Clinical Pharmacology, 71(2), 224-231. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2011). Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • McMahon, V., Matthews, S., Capper, H., Chudleigh, J., McLachlan, C. (2011). Understanding decision and enabling factors influencing clinical trial participation in australia: a view point. Asian Pacific Journal of Cancer Prevention, 12(11), 3153-3156. [More Information]
  • Wang, C., Almsherqi, Z., McLachlan, C., Matthews, S., Ramachandran, M., Tay, S., Deng, Y. (2010). Acute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function. Stress: the international Journal on the Biology of Stress, , 1-7. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2010). Hepatotoxicity of therapeutic short-course paracetamol inhospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • McLachlan, C., Ocsan, R., Spence, I., Hambly, B., Matthews, S., Wang, L., Jelinek, H. (2010). Increased total heart rate variability and enhanced cardiac vagal autonomic activity in healthy humans with sinus bradycardia. Baylor University Medical Center Proceedings, 23(4), 368-370. [More Information]
  • Taylor, C., Li, Y., Willenberg, L., Matthews, S., Glass, P., Myburgh, J. (2010). Severe falciparum malaria patients transferred late" to a high level ICU in India represents a difficult research capture point to comment on predictors of mortality and related organ dysfunction.". Singapore Medical Journal, 51(9), 752-753. [More Information]
  • Slack, K., Billing, R., Matthews, S., Allbutt, H., Einstein, R., Henderson, J. (2010). Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat. Parkinson's Disease, 2010, 1-10. [More Information]
  • Mitchell, S., Murnion, B., Matthews, S., Hilmer, S. (2009). Compliance with Paracetamol Prescribing Policies at a Sydney Hospital. Journal of Pharmacy Practice and Research, 39(2), 122-127.
  • Hilmer, S., Perera, V., Mitchell, S., Murnion, B., Dent, J., Bajorek, B., Matthews, S., Rolfson, D. (2009). The assessment of frailty in older people in acute care. Australasian Journal on Ageing, 28(4), 182-188. [More Information]
  • Perera, V., Bajorek, B., Matthews, S., Hilmer, S. (2009). The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation. Age and Ageing, 38(2), 156-162. [More Information]
  • Brancatisano, A., Wahlroos, S., Matthews, S., Brancatisano, R. (2008). Gastric banding for the treatment of type 2 diabetes mellitus in morbidly obese. Surgery for Obesity and Related Diseases, 4(3), 423-439. [More Information]
  • McLachlan, C., Almsherqi, Z., Deng, Y., Matthews, S., Mossop, P. (2008). Vitamin C and mitochondrial uncoupling protein in enhanced dobutamine myocardial contractility. American Heart Journal, 155(4), e29. [More Information]
  • Gething, L., Fethney, J., McKee, K., Persson, L., Goff, M., Churchward, M., Matthews, S., Halvarsson, M., Johannsson, I. (2004). Validation Of The Reactions To Ageing Questionnare: Assessing Similarities Across Several Countries. Journal of Gerontological Nursing, 30(9), 47-54.

Conferences

  • Marzbanrad, F., Hambly, B., Ng, E., Tamayo, M., Matthews, S., Karmakar, C., Khandoker, A., Palaniswami, M., Jelinek, H. (2014). Relationship Between Heart Rate Variability and Angiotensinogen Gene Polymorphism in Diabetic and control individuals. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014), Piscataway: (IEEE) Institute of Electrical and Electronics Engineers. [More Information]
  • Marzbanrad, F., Jelinek, H., Ng, E., Tamayo, M., Hambly, B., McLachlan, C., Matthews, S., Palaniswami, M., Khandoker, A. (2013). The Effect of Automated Preprocessing of RR Interval Tachogram on Discrimination Capability of Heart Rate Variability Parameters. 2013 40th Computing in Cardiology Conference (CinC 2013), Spain: IEEE.
  • Jelinek, H., Ahammer, H., Matthews, S., Succar, P., McLachlan, C., Buckland, M. (2012). Establishing a reference range for oligodendroglioma classification using Higuchi dimension analysis. 9th IASTED International Conference on Biomedical Engineering (BioMed 2012), Innsbruck: ACTA Press. [More Information]
  • Matthews, S., Spence, I., Jelinek, H., McLachlan, C. (2012). Neuron cell classification using machine learning algorithms: Methodological considerations. 9th IASTED International Conference on Biomedical Engineering (BioMed 2012), Innsbruck: ACTA Press. [More Information]
  • Ng, E., Hambly, B., Matthews, S., McLachlan, C., Jelinek, H. (2012). Weka machine learning classification in identifying autonomic dysfunction parameters associated with ACE insertion/deletion genotypes. 9th IASTED International Conference on Biomedical Engineering (BioMed 2012), Innsbruck: ACTA Press. [More Information]

2016

  • Ebach, M., Michael, M., Shaw, W., Goff, J., Murphy, D., Matthews, S. (2016). Big data and the historical sciences: A critique. Geoforum, 71, 1-4. [More Information]
  • Lee, Y., Reidler, P., Jelinek, H., Lee, Y., Zhou, Y., Hambly, B., McCabe, J., Matthews, S., Ke, H., Assareh, H., et al (2016). Electrocardiogram derived QRS duration associations with elevated central aortic systolic pressure (CASP) in a rural Australian population. Clinical Hypertension, 22(6), 1-6. [More Information]
  • Marzbanrad, F., Khandoker, A., Hambly, B., Ng, E., Tamayo, M., Lu, Y., Matthews, S., Karmakar, C., Palaniswami, M., Jelinek, H., et al (2016). Methodological Comparisons of Heart Rate Variability Analysis in Patients With Type 2 Diabetes and Angiotensin Converting Enzyme Polymorphism. IEEE Journal of Biomedical and Health Informatics, 20(1), 55-63. [More Information]
  • Dixit, R., Matthews, S., Khandaker, G., Walker, K., Festa, M., Booy, R. (2016). Pharmacokinetics of oseltamivir in infants under the age of 1 year. Clinical and Translational Medicine, 5(1), 1-6. [More Information]

2015

  • Gnjidic, D., Bennett, A., Le Couteur, D., Blyth, F., Cumming, R., Waite, L., Handelsman, D., Naganathan, V., Matthews, S., Hilmer, S. (2015). Ischemic heart disease, prescription of optimal medical therapy and geriatric syndromes in community-dwelling older men: A population-based study. International Journal of Cardiology, 192, 49-55. [More Information]
  • Qi, K., Reeve, E., Hilmer, S., Pearson, S., Matthews, S., Gnjidic, D. (2015). Older peoples' attitudes regarding polypharmacy, statin use and willingness to have statins deprescribed in Australia. International Journal of Clinical Pharmacy, 37(5), 949-957. [More Information]

2014

  • Bennett, A., Gnjidic, D., Gillett, M., Carroll, P., Matthews, S., Johnell, K., Fastbom, J., Hilmer, S. (2014). Prevalence and impact of fall-risk-increasing drugs, polypharmacy, and drug-drug interactions in robust versus frail hospitalised falls patients: a prospective cohort study. Drugs and Aging, 31(3), 225-232. [More Information]
  • Marzbanrad, F., Hambly, B., Ng, E., Tamayo, M., Matthews, S., Karmakar, C., Khandoker, A., Palaniswami, M., Jelinek, H. (2014). Relationship Between Heart Rate Variability and Angiotensinogen Gene Polymorphism in Diabetic and control individuals. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2014), Piscataway: (IEEE) Institute of Electrical and Electronics Engineers. [More Information]
  • Johnston, C., Hilmer, S., McLachlan, A., Matthews, S., Carroll, P., Kirkpatrick, C. (2014). The impact of frailty on pharmacokinetics in older people: using gentamicin population pharmacokinetic modeling to investigate changes in renal drug clearance by glomerular filtration. European Journal of Clinical Pharmacology, 70(5), 549-555. [More Information]

2013

  • Ng, E., Lu, Y., Hambly, B., Jelinek, H., Yu, B., Matthews, S., McLachlan, C. (2013). Angiotensin-converting enzyme gene DD genotype is associated with increased systolic blood pressure in an Australian Rural Type 2 Diabetic Cohort. Hypertension Research, 36(4), 381-382. [More Information]
  • Matthews, S. (2013). Letter to the Editor: One-tailed significance tests and the accounting for alpha. Clinical and Experimental Pharmacology and Physiology, 40(8), 594-594. [More Information]
  • Marzbanrad, F., Jelinek, H., Ng, E., Tamayo, M., Hambly, B., McLachlan, C., Matthews, S., Palaniswami, M., Khandoker, A. (2013). The Effect of Automated Preprocessing of RR Interval Tachogram on Discrimination Capability of Heart Rate Variability Parameters. 2013 40th Computing in Cardiology Conference (CinC 2013), Spain: IEEE.

2012

  • Kane, A., Mitchell, S., Carroll, P., Matthews, S., Hilmer, S. (2012). Characteristics of older and younger patients with suspected paracetamol toxicity. Australasian Journal on Ageing, 31(3), 190-193. [More Information]
  • Kemp, A., Quintana, D., Felmingham, K., Matthews, S., Jelinek, H. (2012). Depression, comorbid anxiety disorders, and heart rate variability in physically healthy, unmedicated patients: implications for cardiovascular risk. PloS One, 7(2), 1-8. [More Information]
  • Matthews, S., Succar, P., Jelinek, H., McParland, B., Buckland, M., McLachlan, C. (2012). Diagnosis of oligodendroglioma: Molecular and classical histological assessment in the twenty-first century. Asia-Pacific Journal of Clinical Oncology, 8(3), 213-216. [More Information]
  • Jelinek, H., Ahammer, H., Matthews, S., Succar, P., McLachlan, C., Buckland, M. (2012). Establishing a reference range for oligodendroglioma classification using Higuchi dimension analysis. 9th IASTED International Conference on Biomedical Engineering (BioMed 2012), Innsbruck: ACTA Press. [More Information]
  • Matthews, S., Jelinek, H., Vafaeiafraz, S., McLachlan, C. (2012). Heart rate stability and decreased parasympathetic heart rate variability in healthy young adults during perceived stress. International Journal of Cardiology, 156(3), 337-338. [More Information]
  • Matthews, S., Spence, I., Jelinek, H., McLachlan, C. (2012). Neuron cell classification using machine learning algorithms: Methodological considerations. 9th IASTED International Conference on Biomedical Engineering (BioMed 2012), Innsbruck: ACTA Press. [More Information]
  • Ng, E., Hambly, B., Matthews, S., McLachlan, C., Jelinek, H. (2012). Weka machine learning classification in identifying autonomic dysfunction parameters associated with ACE insertion/deletion genotypes. 9th IASTED International Conference on Biomedical Engineering (BioMed 2012), Innsbruck: ACTA Press. [More Information]

2011

  • Johnston, C., Carroll, P., Matthews, S., Mitchell, S., Hilmer, S. (2011). 'You look like a 240 mg': Gentamicin dosing at a Sydney hospital. Journal of Pharmacy Practice and Research, 41(4), 275-277.
  • Hilmer, S., Tran, K., Rubie, P., Wright, J., Gnjidic, D., Mitchell, S., Matthews, S., Carroll, P. (2011). Gentamicin Pharmacokinetics in Old Age and Frailty. British Journal of Clinical Pharmacology, 71(2), 224-231. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2011). Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • McMahon, V., Matthews, S., Capper, H., Chudleigh, J., McLachlan, C. (2011). Understanding decision and enabling factors influencing clinical trial participation in australia: a view point. Asian Pacific Journal of Cancer Prevention, 12(11), 3153-3156. [More Information]

2010

  • Wang, C., Almsherqi, Z., McLachlan, C., Matthews, S., Ramachandran, M., Tay, S., Deng, Y. (2010). Acute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function. Stress: the international Journal on the Biology of Stress, , 1-7. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2010). Hepatotoxicity of therapeutic short-course paracetamol inhospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • McLachlan, C., Ocsan, R., Spence, I., Hambly, B., Matthews, S., Wang, L., Jelinek, H. (2010). Increased total heart rate variability and enhanced cardiac vagal autonomic activity in healthy humans with sinus bradycardia. Baylor University Medical Center Proceedings, 23(4), 368-370. [More Information]
  • Taylor, C., Li, Y., Willenberg, L., Matthews, S., Glass, P., Myburgh, J. (2010). Severe falciparum malaria patients transferred late" to a high level ICU in India represents a difficult research capture point to comment on predictors of mortality and related organ dysfunction.". Singapore Medical Journal, 51(9), 752-753. [More Information]
  • Slack, K., Billing, R., Matthews, S., Allbutt, H., Einstein, R., Henderson, J. (2010). Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat. Parkinson's Disease, 2010, 1-10. [More Information]

2009

  • Mitchell, S., Murnion, B., Matthews, S., Hilmer, S. (2009). Compliance with Paracetamol Prescribing Policies at a Sydney Hospital. Journal of Pharmacy Practice and Research, 39(2), 122-127.
  • Hilmer, S., Perera, V., Mitchell, S., Murnion, B., Dent, J., Bajorek, B., Matthews, S., Rolfson, D. (2009). The assessment of frailty in older people in acute care. Australasian Journal on Ageing, 28(4), 182-188. [More Information]
  • Perera, V., Bajorek, B., Matthews, S., Hilmer, S. (2009). The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation. Age and Ageing, 38(2), 156-162. [More Information]

2008

  • Brancatisano, A., Wahlroos, S., Matthews, S., Brancatisano, R. (2008). Gastric banding for the treatment of type 2 diabetes mellitus in morbidly obese. Surgery for Obesity and Related Diseases, 4(3), 423-439. [More Information]
  • McLachlan, C., Almsherqi, Z., Deng, Y., Matthews, S., Mossop, P. (2008). Vitamin C and mitochondrial uncoupling protein in enhanced dobutamine myocardial contractility. American Heart Journal, 155(4), e29. [More Information]

2004

  • Gething, L., Fethney, J., McKee, K., Persson, L., Goff, M., Churchward, M., Matthews, S., Halvarsson, M., Johannsson, I. (2004). Validation Of The Reactions To Ageing Questionnare: Assessing Similarities Across Several Countries. Journal of Gerontological Nursing, 30(9), 47-54.
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