Dr Sonia Saad

Senior Research Fellow
Medicine, Northern Clinical School

Telephone +61 2 99264782
Fax 0299265715

Map

Biographical details

sdfsdfvsdfv

Research interests

My primary research focus is in the area of PPAR? agonists as they relate to the kidney and vasculature. My project will define differences between pioglitazone and rosiglitazone which are relevant to effect on microvascular and macrovascular complications of diabetes, including nephropathy and endothelial dysfunction. By defining potential mechanisms underpinning these differences further refinement of drug targets will be possible.

Selected grants

2010

  • Distinct ligands of PPARg mediate divergent inflammatory and fibrotic effects in endolthelium and proximal tubule; Saad S, Pollock C; Ramsay Healthcare/RNSH Bridging Support for Senior Scientist.

2007

  • The role of peroxisome proliferator-activated receptor gamma in sodium transport in human proximal tubule cells; Pollock C, Saad S; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

Download citations: PDF RTF Endnote

Journals

  • Chen, H., Simar, D., Pegg, K., Saad, S., Palmer, C., Morris, M. (2014). Exendin-4 is effective against metabolic disorders induced by intrauterine and postnatal overnutrition in rodents. Diabetologia: clinical and experimental diabetes and metabolism, 57(3), 614-622. [More Information]
  • Al-Odat, I., Chen, H., Chan, Y., Amgad, S., Wong, M., Gill, A., Pollock, C., Saad, S. (2014). The Impact of Maternal Cigarette Smoke Exposure in a Rodent Model on Renal Development in the Offspring. PLoS One, 9(7), e103443. [More Information]
  • Pegg, K., Zhang, J., Pollock, C., Saad, S. (2013). Combined effects of PPARĪ³ agonists and epidermal growth factor receptor inhibitors in human proximal tubule cells. PPAR Research, 2013, 1-8. [More Information]
  • Chen, H., Al-Odat, I., Pollock, C., Saad, S. (2013). Fetal Programming of Renal Development - Influence of Maternal Smoking. Journal of Diabetes & Metabolism, 2013 (S9), 1-7. [More Information]
  • Chen, H., Dorrigan, A., Saad, S., Hare, D., Cortie, M., Valenzuela, S. (2013). In Vivo Study of Spherical Gold Nanoparticles: Inflammatory Effects and Distribution in Mice. PLoS One, 8(2), 1-8. [More Information]
  • Yong, R., Chen, X., Shen, S., Vijayaraj, S., Ma, Q., Pollock, C., Saad, S. (2013). Plumbagin Ameliorates Diabetic Nephropathy via Interruption of Pathways that Include NOX4 Signalling. PLoS One, 8(8), 1-13. [More Information]
  • Saad, S., Zhang, J., Yong, R., Yaghobian, D., Wong, M., Kelly, D., Chen, X., Pollock, C. (2013). Role of the EGF receptor in PPARgamma-mediated sodium and water transport in human proximal tubule cells. Diabetologia: clinical and experimental diabetes and metabolism, 56(5), 1174-1182. [More Information]
  • Wong, M., Saad, S., Pollock, C., Wong, M. (2013). Semicarbazide-sensitive amine oxidase and kidney disease. American Journal of Physiology: Renal Physiology (Print), 305(12), F1637-F1644. [More Information]
  • Chen, H., Saad, S., Sandow, S., Bertrand, P. (2012). Cigarette Smoking and Brain Regulation of Energy Homeostasis. Frontiers in Pharmacology, 3, 1-8. [More Information]
  • Panchapakesan, U., Pollock, C., Saad, S. (2011). Renal epidermal growth factor receptor: Its role in sodium and water homeostasis in diabetic nephropathy. Clinical and Experimental Pharmacology and Physiology, 38(2), 84-88. [More Information]
  • Sumual, S., Saad, S., Tang, O., Yong, R., McGinn, C., Chen, X., Pollock, C. (2010). Differential Regulation of Snail by Hypoxia and Hyperglycemia in Human Proximal Tubule Cells. The International Journal of Biochemistry and Cell Biology, 42(10), 1689-1697. [More Information]
  • Saad, S., Stanners, S., Yong, R., Tang, O., Pollock, C. (2010). Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor. The International Journal of Biochemistry and Cell Biology, 42(7), 1115-1122. [More Information]
  • Panchapakesan, U., Pollock, C., Saad, S. (2009). Review Article: Importance of the kidney proximal tubular cells in thiazolidinedione-mediated sodium and water uptake. Nephrology, 14(3), 298-301. [More Information]
  • Stevens, V., Saad, S., Poronnik, P., Fenton Lee, C., Polhill, T., Pollock, C. (2008). The role of SGK-1 in angiotensin II-mediated sodium reabsorption in human proximal tubular cells. Nephrology, Dialysis, Transplantation, 23(6), 1834-1843. [More Information]
  • Saad, S., Agapiou, D., Chen, X., Stevens, V., Pollock, C. (2008). The role of Sgk-1 in the upregulation of transport proteins by PPAR-{gamma} agonists in human proximal tubule cells. Nephrology, Dialysis, Transplantation, doi: 10.1093/ndt/gfn614, 1-12. [More Information]
  • Stevens, V., Saad, S., Chen, X., Pollock, C. (2007). The interdependence of EGF-R and SGK-1 in fibronectin expression in primary kidney cortical fibroblast cells. The International Journal of Biochemistry and Cell Biology, 39(5), 1047-1054. [More Information]
  • Zafiriou, S., Stanners, S., Saad, S., Polhill, T., Poronnik, P., Pollock, C. (2005). Pioglitazone Inhibits Cell Growth and Reduces Matrix Production in Human Kidney Fibroblasts. Journal of the American Society of Nephrology, 16(3), 638-645. [More Information]
  • McGowan, E., Saad, S., Bendall, L., Bradstock, K., Clarke, C. (2004). Effect Of Progesterone Receptor A Predominance On Breast Cancer Cell Migration Into Bone Marrow Fibroblasts. Breast Cancer Research and Treatment, 83(3), 211-220.
  • McGinn, C., Saad, S., Poronnik, P., Pollock, C. (2003). High glucose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase. American Journal of Physiology: Endocrinology and Metabolism, 285, E708-E717.
  • Saad, S., Bendall, L., James, A., Gottlieb, D., Bradstock, K. (2000). Induction of matrix metalloproteinases MMP-1 and MMP-2 by co-culture of breast cancer cells and bone marrow fibroblasts. Breast Cancer Research and Treatment, 63(2), 105-115.

2014

  • Chen, H., Simar, D., Pegg, K., Saad, S., Palmer, C., Morris, M. (2014). Exendin-4 is effective against metabolic disorders induced by intrauterine and postnatal overnutrition in rodents. Diabetologia: clinical and experimental diabetes and metabolism, 57(3), 614-622. [More Information]
  • Al-Odat, I., Chen, H., Chan, Y., Amgad, S., Wong, M., Gill, A., Pollock, C., Saad, S. (2014). The Impact of Maternal Cigarette Smoke Exposure in a Rodent Model on Renal Development in the Offspring. PLoS One, 9(7), e103443. [More Information]

2013

  • Pegg, K., Zhang, J., Pollock, C., Saad, S. (2013). Combined effects of PPARĪ³ agonists and epidermal growth factor receptor inhibitors in human proximal tubule cells. PPAR Research, 2013, 1-8. [More Information]
  • Chen, H., Al-Odat, I., Pollock, C., Saad, S. (2013). Fetal Programming of Renal Development - Influence of Maternal Smoking. Journal of Diabetes & Metabolism, 2013 (S9), 1-7. [More Information]
  • Chen, H., Dorrigan, A., Saad, S., Hare, D., Cortie, M., Valenzuela, S. (2013). In Vivo Study of Spherical Gold Nanoparticles: Inflammatory Effects and Distribution in Mice. PLoS One, 8(2), 1-8. [More Information]
  • Yong, R., Chen, X., Shen, S., Vijayaraj, S., Ma, Q., Pollock, C., Saad, S. (2013). Plumbagin Ameliorates Diabetic Nephropathy via Interruption of Pathways that Include NOX4 Signalling. PLoS One, 8(8), 1-13. [More Information]
  • Saad, S., Zhang, J., Yong, R., Yaghobian, D., Wong, M., Kelly, D., Chen, X., Pollock, C. (2013). Role of the EGF receptor in PPARgamma-mediated sodium and water transport in human proximal tubule cells. Diabetologia: clinical and experimental diabetes and metabolism, 56(5), 1174-1182. [More Information]
  • Wong, M., Saad, S., Pollock, C., Wong, M. (2013). Semicarbazide-sensitive amine oxidase and kidney disease. American Journal of Physiology: Renal Physiology (Print), 305(12), F1637-F1644. [More Information]

2012

  • Chen, H., Saad, S., Sandow, S., Bertrand, P. (2012). Cigarette Smoking and Brain Regulation of Energy Homeostasis. Frontiers in Pharmacology, 3, 1-8. [More Information]

2011

  • Panchapakesan, U., Pollock, C., Saad, S. (2011). Renal epidermal growth factor receptor: Its role in sodium and water homeostasis in diabetic nephropathy. Clinical and Experimental Pharmacology and Physiology, 38(2), 84-88. [More Information]

2010

  • Sumual, S., Saad, S., Tang, O., Yong, R., McGinn, C., Chen, X., Pollock, C. (2010). Differential Regulation of Snail by Hypoxia and Hyperglycemia in Human Proximal Tubule Cells. The International Journal of Biochemistry and Cell Biology, 42(10), 1689-1697. [More Information]
  • Saad, S., Stanners, S., Yong, R., Tang, O., Pollock, C. (2010). Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor. The International Journal of Biochemistry and Cell Biology, 42(7), 1115-1122. [More Information]

2009

  • Panchapakesan, U., Pollock, C., Saad, S. (2009). Review Article: Importance of the kidney proximal tubular cells in thiazolidinedione-mediated sodium and water uptake. Nephrology, 14(3), 298-301. [More Information]

2008

  • Stevens, V., Saad, S., Poronnik, P., Fenton Lee, C., Polhill, T., Pollock, C. (2008). The role of SGK-1 in angiotensin II-mediated sodium reabsorption in human proximal tubular cells. Nephrology, Dialysis, Transplantation, 23(6), 1834-1843. [More Information]
  • Saad, S., Agapiou, D., Chen, X., Stevens, V., Pollock, C. (2008). The role of Sgk-1 in the upregulation of transport proteins by PPAR-{gamma} agonists in human proximal tubule cells. Nephrology, Dialysis, Transplantation, doi: 10.1093/ndt/gfn614, 1-12. [More Information]

2007

  • Stevens, V., Saad, S., Chen, X., Pollock, C. (2007). The interdependence of EGF-R and SGK-1 in fibronectin expression in primary kidney cortical fibroblast cells. The International Journal of Biochemistry and Cell Biology, 39(5), 1047-1054. [More Information]

2005

  • Zafiriou, S., Stanners, S., Saad, S., Polhill, T., Poronnik, P., Pollock, C. (2005). Pioglitazone Inhibits Cell Growth and Reduces Matrix Production in Human Kidney Fibroblasts. Journal of the American Society of Nephrology, 16(3), 638-645. [More Information]

2004

  • McGowan, E., Saad, S., Bendall, L., Bradstock, K., Clarke, C. (2004). Effect Of Progesterone Receptor A Predominance On Breast Cancer Cell Migration Into Bone Marrow Fibroblasts. Breast Cancer Research and Treatment, 83(3), 211-220.

2003

  • McGinn, C., Saad, S., Poronnik, P., Pollock, C. (2003). High glucose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase. American Journal of Physiology: Endocrinology and Metabolism, 285, E708-E717.

2000

  • Saad, S., Bendall, L., James, A., Gottlieb, D., Bradstock, K. (2000). Induction of matrix metalloproteinases MMP-1 and MMP-2 by co-culture of breast cancer cells and bone marrow fibroblasts. Breast Cancer Research and Treatment, 63(2), 105-115.

To update your profile click here. For support on your academic profile contact .