Associate Professor Stephen Alexander

Associate Professor
Paediatrics & Child Health, Children's Hospital, Westmead

Telephone +61 2 9845 3430
Fax +61 2 9845 3432

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Selected grants

2013

  • Building sustainable collaborations in diabetes and islet transplantation research and practice in Sydney and Shanghai; Hu M, Alexander S, Freckelton L, Hawthorne W, O'Connell P, Wang W, Ning G, Li X, Gu W, Dai J; DVC International/IPDF Grant.

2012

  • Defining the contribution of skin gamma delta T cells to cutaneous immunosurveillance, immunity and disease after HSV infection; Jones C, Alexander S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • TOLERANCE OR REJECTION - THE ROLE OF INNATE IMMUNITY IN DETERMINING THE FATE OF A KIDNEY ALLOGRAFT; Chadban S, Wu H, Alexander S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • ROLE OF PURINES IN RENAL AND TRANSPLANT INJURY; Alexander S, Dwyer K, Wang Y; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • The BD Influx High Speed Cell Sorter; Cunningham A, George J, Rizos H, Clarke C, Reddel R, Kefford R, North K, Stewart G, Jones C, Tam P, Alexander S, Gottlieb D, Bradstock K, Bryan T, Booth D, Bendall L, Brilot-Turville F, Hebbard L, Cooper S, Wang Y, Wang X; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • ION TORRENT PERSONAL GENOME MACHINE (PGM).; North K, Alexander I, Alexander S, Christodoulou J, Catchpoole D, Clarke N; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • The BD Influx High Speed Cell Sorter; Kefford R, Cunningham A, Bendall L, Clarke C, Harris D, Alexander S, Tam P, Sorrell T, Iredell J, Bryan T, Rizos H, Wang Y, Hebbard L; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Gene therapy, stress haematopoiesis and the risk of malignancy; Alexander I, Kuchel P, Rasko J, Alexander S, McCormack M, Thrasher A, Ginn S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Gamm-Delta Tregs, CD8 Tregs and selected natural Tregs to treat renal injury; Alexander S, Harris D, Wang Y, Wang Y; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • The role of primed T cells in graft rejection; Fazekas B, Alexander S, Levidiotis V; National Health and Medical Research Council (NHMRC)/Project Grants.
  • DNA vaccination using chemokine and costimulatory pathways as a treatment for chronic kidney disease; Harris D, Alexander S, Wang Y, Wang Y; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Kidney transplantation: Improving outcomes.; Alexander S, Bishop A, Sharland A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The effect of age on regulatory T cell control of the innate and adaptive antiviral immune response; Jones C, Cunningham A, Alexander S; Australian Research Council (ARC)/Discovery Projects (DP).

2007

  • Kidney transplantation; improving outcomes; Alexander S; University of Sydney/Bridging Support.
  • Treatment of Diverse Renal Diseases with Regulatory Cells; Harris D, Alexander S, Wang Y, Wang Y; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Flow Cytometry support; Alexander S, Braithwaite A, Bradstock K, Bendall L, Gunning P, Henderson B, Kefford R, Reddel R, Rizos H, Jones C, Byrne J; Cancer Institute New South Wales/Infrastructure Grant.

2004

  • Costimulation in progressive non-immune tubulointerstitial renal disease; Harris D, Alexander S, Wang Y; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Wang, Y., Alexander, S. (2014). DNA Vaccination as a Treatment for Chronic Kidney Disease. In Monica Rinaldi, Daniela Fioretti and Sandra Iurescia (Eds.), Methods in Molecular Biology: Vol 1143, DNA Vaccines, (pp. 297-304). New York: Springer Science+Business Media.
  • Hodson, E., Alexander, S., Graf, N. (2008). Steroid-sensitive nephrotic syndrome. In Denis F. Geary, Franz Schaefer (Eds.), Comprehensive Pediatric Nephrology. United States: Elsevier Ltd.

Journals

  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, C., Wang, X., Lee, V., Wang, Y., Wang, Y., Zheng, G., Tan, T., Harris, D., et al (2014). Failed renoprotection by alternatively activated macrophages from bone marrow due to proliferation-dependent phenotype switch in vivo. Kidney International, 85(4), 794-806. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Tan, T., Lee, S., Zhang, J., Zhang, G., Hu, M., Wang, C., Cao, Q., Zhao, Y., Harris, D., et al (2014). Regulatory T cells require renal antigen recognition through the TCR to protect against injury in nephritis. International Journal of Clinical and Experimental Pathology, 7(1), 38-47.
  • Zhou, J., Wang, Y., Harris, D., Medbury, H., Williams, H., Durkan, A., Alexander, S., Lee, V., Tan, T., Hu, M., et al (2013). Adenine-induced Chronic Kidney Disease Is Associated with Arterial Macrophage Infiltration and Medial Vascular Calcification. Nephrology, 18(Supp 1), 52-52.
  • Wang, Y., Sawyer, A., Zhou, J., Zhang, G., Wang, Y., Hu, M., Roberts, V., Dwyer, K., Harris, D., Alexander, S. (2013). Analysis of Linkage of P2x7r to Balb/C Associated Kidney Injury in the Adriamycin Murine Model in F2 Mice. Nephrology, 18(Supp. 1), 60-60.
  • Hu, M., Fletcher, J., McCahon, E., Catchpoole, D., Zhang, G., Wang, Y., Algar, E., Alexander, S. (2013). Bilateral Wilms Tumor and Early Presentation in Pediatric Patients Is Associated with the Truncation of the Wilms Tumor 1 Protein. The Journal of Pediatrics, 163(1), 224-229. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Harris, D., Alexander, S., Durkan, A. (2013). Cx3cr1-dec205 dc-targeted dna Vaccine Induces Specific Antibodies and Limits Atherosclerosis and Macrophage Infiltration in the apo-e Knockout Mouse Model of Atherosclerosis. Nephrology, 18(Supp. 1), 16-16.
  • Wang, Y., Zhou, J., Wang, Y., Watson, D., Zhang, G., Hu, M., Wu, H., Zheng, G., Wang, Y., Durkan, A., Harris, D., Alexander, S. (2013). Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease. International Journal of Clinical and Experimental Pathology, 6(3), 326-333. [More Information]
  • Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V., Zheng, G., Tan, T., Wang, X., Harris, D., Wang, Y., et al (2013). Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney International, 84(4), 745-755. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Zhang, G., Zhou, J., Tan, T., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Harris, D., et al (2013). DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney International, 83(2), 223-232. [More Information]
  • Wang, Y., Alexander, S. (2013). IL-2/Anti-IL-2 Complex: A Novel Strategy of In Vivo Regulatory T Cell Expansion in Renal Injury. Journal of the American Society of Nephrology, 24(10), 1503-1504. [More Information]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • Wyburn, K., Chadban, S., Kwan, T., Alexander, S., Wu, H. (2013). Interleukin-18 binding protein therapy is protective in adriamycin nephropathy. AJP: Renal Physiology (Online), 304(1), F68-F76. [More Information]
  • Cao, Q., Wang, X., Wang, C., Lee, V., Ye, Q., Zheng, G., Zhao, Y., Alexander, S., Wang, Y., Harris, D. (2013). Kidney Cd103+ Dcs Exacerbate Renal Injury Through Activating Cd8+ T Cells in Adriamycin Nephropathy. Nephrology, 18(Supp. 1), 24-24.
  • Tan, T., Zheng, G., Hsu, T., Lee, S., Zhang, J., Zhao, Y., Tian, X., Wang, Y., Wang, Y., Cao, Q., Wang, Y., Lee, V., Wang, C., Zheng, D., Alexander, S., Harris, D., et al (2013). Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage. Laboratory Investigation, 93(4), 434-449. [More Information]
  • Wang, Y., Wang, C., Cao, Q., Ye, Q., Zheng, G., Alexander, S., Jones, D., Harris, D. (2013). Midkine Antibodies Prevent Renal Injury in Adriamycin Nephropathy. Nephrology, 18(Supp. 1), 59-59.
  • Alexander, S., Ingelfinger, J. (2013). One step closer to "Rejectostix". The New England Journal of Medicine, 369(1), 84-85. [More Information]
  • Wyld, M., Clayton, P., Jesudason, S., Chadban, S., Alexander, S. (2013). Pregnancy Outcomes for Kidney Transplant Recipients. American Journal of Transplantation, 13(12), 3173-3182. [More Information]
  • Fletcher, J., McDonald, S., Alexander, S. (2013). Prevalence of genetic renal disease in children. Pediatric Nephrology, 28(2), 251-256. [More Information]
  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013). Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation, 22(10), 1929-1941. [More Information]
  • Fernandez, M., YU, U., Zhang, G., White, R., Sparwasser, T., Alexander, S., Jones, C. (2013). Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection. Virology, 447(1-2), 9-20. [More Information]
  • Wu, H., Noordmans, G., O'Brien, M., Ma, J., Zhao, C., Zhang, G., Kwan, T., Alexander, S., Chadban, S. (2012). Absence of MyD88 Signaling Induces Donor-Specific Kidney Allograft Tolerance. Journal of the American Society of Nephrology, 23(10), 1701-1716. [More Information]
  • Wang, Y., Zhang, G., Hu, M., Polhill, T., Sawyer, A., Zhou, J., Saito, M., Watson, D., Wu, H., Wang, Y., Wang, X., Wang, Y., Harris, D., Alexander, S. (2012). CD8+ Regulatory T Cells Induced by T Cell Vaccination Protect Against Autoimmune Nephritis. Journal of the American Society of Nephrology, 23(6), 1058-1067. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Phoon, R., Zhang, G., Wang, Y., Tan, T., Hu, M., Wang, D., Saito, M., Harris, D., Durkan, A., et al (2012). DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. International Journal of Clinical and Experimental Medicine, 5(1), 24-33. [More Information]
  • Cowley, M., Weinberg, A., Zammit, N., Walters, S., Hawthorne, W., Loudovaris, T., Thomas, H., Kay, T., Gunton, J., Alexander, S., O'Connell, P., et al (2012). Human islets express a marked proinflammatory molecular signature prior to transplantation. Cell Transplantation, 21(9), 2063-2078. [More Information]
  • Polhill, T., Zhang, G., Hu, M., Sawyer, A., Zhou, J., Saito, M., Webster, K., Wang, Y., Wang, Y., Grey, S., Harris, D., Alexander, S., Wang, Y., et al (2012). IL-2/IL-2Ab Complexes Induce Regulatory T Cell Expansion and Protect against Proteinuric CKD. Journal of the American Society of Nephrology, 23(8), 1303-1308. [More Information]
  • Zheng, D., Cao, Q., Lee, V., Wang, Y., Zheng, G., Wang, Y., Tan, T., Wang, C., Alexander, S., Harris, D., Wang, Y. (2012). Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney International. [More Information]
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Harris, D., Alexander, S., et al (2012). Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology, 42(9), 2441-2451. [More Information]
  • Chapman, J., Alexander, S. (2012). The Candle Illuminating the Pathway to Tolerance? American Journal of Kidney Diseases, 60(4), 521-523. [More Information]
  • Bishop, A., Ierino, F., Sharland, A., Hall, B., Alexander, S., Sandrin, M., Coates, P., McCaughan, G. (2011). Approaching the promise of operational tolerance in clinical transplantation. Transplantation, 91(10), 1065-1074. [More Information]
  • Schwensen, K., Burgess, J., Graf, N., Alexander, S., Harris, D., Phillips, J., Rangan, G. (2011). Early Cyst Growth Is Associated with the Increased Nuclear Expression of Cyclin D1/Rb Protein in an Autosomal-Recessive Polycystic Kidney Disease Rat Model. Nephron Experimental Nephrology, 117(4), e93-e103. [More Information]
  • Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011). IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology, 22(7), 1229-1239. [More Information]
  • Bishop, A., Sharland, A., Ierino, F., Sandrin, M., Hall, B., Alexander, S., Coates, P., McCaughan, G. (2011). Operational Tolerance in Organ Transplantation Versus Tissue Engineering: Into the Future. Transplantation, 92(8), e39-e39. [More Information]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]
  • Zheng, D., Wang, Y., Cao, Q., Lee, V., Zheng, G., Sun, Y., Tan, T., Wang, Y., Alexander, S., Harris, D. (2011). Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus. Nephron Experimental Nephrology, 118(4), e87-e99. [More Information]
  • Sedger, L., Katewa, A., Petterson, A., Osvath, S., Farrell, G., Stewart, G., Bendall, L., Alexander, S. (2010). Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL- and TRAIL-double deficient mice. Blood, 115(16), 3258-3268. [More Information]
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010). IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology, 21(6), 933-942. [More Information]
  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010). Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular Therapy, 18(5), 965-976. [More Information]
  • Nankivell (Nankievell), B., Alexander, S. (2010). Rejection of the Kidney Allograft. New England Journal of Medicine, 363(15), 1451-1462. [More Information]
  • Lee, V., Qin, X., Wang, Y., Zheng, G., Wang, Y., Wang, Y., Ince, J., Tan, T., Kairaitis, L., Alexander, S., Harris, D. (2010). The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrology, Dialysis, Transplantation, 25(3), 717-730. [More Information]
  • Watson, D., Zheng, G., Wu, H., Wang, Y., Wang, Y., Harris, D., Alexander, S. (2009). CCL2 DNA vaccine to treat renal disease. The International Journal of Biochemistry and Cell Biology, 41(4), 729-732. [More Information]
  • Wang, Y., Alexander, S. (2009). CD8 regulatory T cells: what's old is now new. Immunology and Cell Biology. [More Information]
  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009). Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American Journal of Pathology: cellular and molecular biology of disease, 175(2), 580-591. [More Information]
  • Zhang, G., Hu, M., Wang, Y., Alexander, S. (2009). FOXP3 as a marker of tolerance induction versus rejection. Current Opinion in Organ Transplantation, 14(1), 40-45. [More Information]
  • Albaramki, J., Teo, J., Alexander, S. (2009). Rituximab therapy in two children with autoimmune thrombotic thrombocytopenic purpura. Pediatric Nephrology, 24(9), 1749-52. [More Information]
  • Pattullo, V., Bourke, M., Tran, K., McLeod, D., Williams, S., Bailey, A., Alexander, S., Mishra, A., Co, J. (2009). The suction pseudopolyp technique: a novel method for the removal of small flat nonpolypoid lesions of the colon and rectum. Endoscopy, 41(12), 1032-7. [More Information]
  • Watson, D., Hu, M., Zhang, G., Wang, Y., Alexander, S. (2009). Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies. Current Opinion in Organ Transplantation, 14(4), 357-363. [More Information]
  • Alexander, S., Smith, N., Hu, M., Verran, D., Shun, A., Dorney, S., Smith, A., Webster, B., Shaw, P., Lammi, A., Stormon, M. (2008). Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant. New England Journal of Medicine, 358(4), 369-374. [More Information]
  • Fletcher, J., Nankivell (Nankievell), B., Alexander, S. (2008). Chronic allograft nephropathy. Pediatric Nephrology, DOI 10.1007/s00467-008-0869-z, 1-7. [More Information]
  • Alexander, S., Bourke, M., Williams, S., Bailey, A., Gill, A. (2008). Diagnosis of autoimmune pancreatitis with intraductal biliary biopsy and treatment of stricture with serial placement of multiple biliary stents. Gastrointestinal Endoscopy, 68(2), 396-9. [More Information]
  • Pattullo, V., Bourke, M., Alexander, S., Co, J. (2008). Endoscopic evolution of a caustic injury to the gastric antrum. Gastrointestinal Endoscopy, 69(3), 583-5. [More Information]
  • Hodson, E., Alexander, S. (2008). Evaluation and management of steroid-sensitive nephrotic syndrome. Current Opinion in Pediatrics, 20(2), 145-150. [More Information]
  • Hu, M., Watson, D., Zhang, G., Graf, N., Wang, Y., Sartor, M., Howden, B., Fletcher, J., Alexander, S. (2008). Long-term cardiac allograft survival across an MHC mismatch after "pruning" of alloreactive CD4 T cells. Journal of Immunology, 180(10), 6593-6603. [More Information]
  • Lee, V., Wang, Y., Wang, Y., Zheng, D., Polhill, T., Cao, Q., Wu, H., Alexander, I., Alexander, S., Harris, D. (2008). Regulatory immune cells in kidney disease. American Journal of Physiology: Renal Physiology (Print), 295(2), F335-F342. [More Information]
  • Wang, Y., Hu, M., Wang, Y., Polhill, T., Zhang, G., Wang, Y., Lee, V., Harris, D., Alexander, S. (2008). Regulatory T Cells in Renal Disease. International Journal of Clinical and Experimental Medicine, 1(4), 294-304. [More Information]
  • Fernandez, M., Puttur, F., Wang, Y., Howden, W., Alexander, S., Jones, C. (2008). T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. Journal of Immunology, 180(3), 1556-1564. [More Information]
  • Williams, G., Fletcher, J., Alexander, S., Craig, J. (2008). Vesicoureteral Reflux. Journal of the American Society of Nephrology, 19, 847-862. [More Information]
  • Huiling, W., Wang, Y., Wang, Y., Hu, M., Zhang, G., Knight, J., Harris, D., Alexander, S. (2007). Depletion of gammadelta T cells exacerbates murine adriamycin nephropathy. Journal of the American Society of Nephrology, 18(4), 1180-1189. [More Information]
  • Wang, Y., Wang, Y., Zheng, G., Lee, V., Ouyang, L., Chang, D., Mahajan, D., Coombs, J., Wang, Y., Alexander, S., Harris, D. (2007). Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney International, 72(3), 290-299. [More Information]
  • Ganesan, P., Alexander, S., Watson, D., Logan, G., Zhang, G., Alexander, I. (2007). Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression. Cancer Immunology, Immunotherapy: other biological response modifications, 56(12), 1955-1965. [More Information]
  • Wu, H., Chen, G., Wyburn, K., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007). TLR4 activation mediates kidney ischemia/reperfusion injury. Journal of Clinical Investigation, 117(10), 2847-2859. [More Information]
  • McTaggart, S., Alexander, S., Craig, J. (2007). Use of darbepoetin alfa (Aranesp) in pediatric kidney disease. Pediatric Nephrology, 22, 1472.
  • Qin, X., Lee, V., Wang, Y., Zheng, G., Wang, Y., Alexander, S., Harris, D. (2006). A protective role for programmed death 1 in progression of murine adriamycin nephropathy. Kidney International, 70, 1244-1250. [More Information]
  • Lee, V., Wang, Y., Qin, X., Wang, Y., Zheng, G., Mahajan, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrology, Dialysis, Transplantation. [More Information]
  • Mahajan, D., Wang, Y., Qin, X., Wang, Y., Zheng, G., Wang, Y., Alexander, S., Harris, D. (2006). CD4+CD25+ Regulatory T Cells Protect against Injury in an Innate Murine Model of Chronic Kidney Disease. Journal of the American Society of Nephrology, 17(10), 2731-2741. [More Information]
  • Alexander, S., Fletcher, J., Nankivell (Nankievell), B. (2006). Chronic allograft nephropathy in paediatric renal transplantation. Pediatric Nephrology, 22(1), 17-23. [More Information]
  • Zheng, G., Wang, Y., XIANG, S., Tay, Y., Wu, H., Watson, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury. Journal of the American Society of Nephrology, 17(2), 465-474. [More Information]
  • Wang, C., Cordoba, S., Bertolino, P., Alexander, S., Wu, M., Allen, R., McCaughan, G., Bishop, A. (2006). Examination of the immune mechanism of spontaneous tolerance of renal allografts in a mouse model. Immunology and Cell Biology, 84(1), A29-30.
  • Seddiki, N., Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S., Nanan, R., Fazekas, B., et al (2006). Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. The Journal of Experimental Medicine, 203(7), 1693-1700. [More Information]
  • Wang, Y., Zhang, G., Wang, Y., Hu, M., Wu, H., Watson, D., Hori, S., Alexander, I., Harris, D., Alexander, S. (2006). Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin. Journal of the American Society of Nephrology, 17(3), 697-706. [More Information]
  • Hu, M., Kramer, B., Zhang, G., McCowage, G., Alexander, I., Gunning, P., Alexander, S. (2006). Long term skin allograft survival in mice with MGMT chimeric bone marrow engraftment. Immunology and Cell Biology, 84 (Suppl.)(3), A29-A29.
  • Fletcher, J., Graf, N., Scarman, A., Saleh, H., Alexander, S. (2006). Nephrotoxicity with cyclooxygenase 2 inhibitor use in children. Pediatric Nephrology, 21, 1893-7. [More Information]
  • Zheng, G., Zheng, L., Wang, Y., Wu, H., Kairaitis, L., Zhang, C., Tay, Y., Wang, Y., Alexander, S., Harris, D. (2006). NK cells do not mediate renal injury in murine adriamycin nephropathy. Kidney International, 69(7), 1159-1165. [More Information]
  • Seddiki, N., Nanan, B., Tangye, S., Alexander, S., Solomon, M., Soon, L., Nanan, R., Fazekas, B. (2006). Persistence of naive CD45RA(+) regulatory T cells in adult life. Blood, 107(7), 2830-2838. [More Information]
  • Allen, W., Alexander, S. (2005). Adenovirus associated haematuria. Archives of Disease in Childhood, 90(3), 305-6. [More Information]
  • Wu, H., Wang, Y., Tay, Y., Zheng, G., Zhang, C., Alexander, S., Harris, D. (2005). DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Kidney International, 67(6), 2178-2186. [More Information]
  • Hu, M., Wang, C., Cordoba, S., Zhang, G., Wang, Y., Watson, D., Bishop, A., Alexander, S. (2005). Foxp3 expression correlates with tolerance in a mouse allograft model of cardiac rejection and renal tolerance. Immunology and Cell Biology, 83(4), A21-A21.
  • Fletcher, J., Hu, M., Berman, Y., Collins, F., Grigg, J., McIver, M., Juppner, H., Alexander, S. (2005). Multicystic dysplastic kidney and variable phenotype in a family with a novel deletion mutation of PAX2. Journal of the American Society of Nephrology, 16(9), 2754-2761. [More Information]
  • Zheng, G., Wang, Y., Mahajan, D., Qin, X., Wang, Y., Wang, Y., Alexander, S., Harris, D. (2005). The role of tubulointerstitial inflammation. Kidney International, 67(S94), S96-S100. [More Information]
  • Ginn, S., Curtin, J., Kramer, B., Smyth, C., Wong, M., Kakakios, A., McCowage, G., Watson, D., Alexander, S., Latham, M., Rowe, P., Alexander, I., et al (2005). Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia. Medical Journal of Australia, 182(9), 458-463. [More Information]
  • Watson, D., Zhang, G., Sartor, M., Alexander, S. (2004). "Pruning" Of Alloreactive Cd4+ T Cells Using 5- (And 6-)Carboxyfluorescein Diacetate Succinimidyl Ester Prolongs Skin Allograft Survival. Journal of Immunology, 173(11), 6574-6582.
  • Hu, M., Craig, J., Howard, N., Kan, A., Chaitow, J., Little, D., Alexander, S. (2004). A Novel Mutation Of WT1 Exon 9 In A Patient With Denys-Drash Syndrome And Pyloric Stenosis. Pediatric Nephrology, 19(10), 1160-1163. [More Information]
  • Logan, G., Spinoulas, A., Alexander, S., Smythe, J., Alexander, I. (2004). CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection. Immunology and Cell Biology, 82(2), 132-135.
  • Foster, A., Marangolo, M., Sartor, M., Alexander, S., Hu, M., Bradstock, K., Gottlieb, D. (2004). Human Cd62L- Memory T Cells Are Less Responsive To Alloantigen Stimulation Than Cd62L+ Naive T Cells: Potential For Adoptive Immunotherapy And Allodepletion. Blood, 104(8), 2403-2409.
  • Hu, M., Zhang, G., Walters, G., Sartor, M., Watson, D., Knight, J., Alexander, S. (2004). Matching T-Cell Receptors Identified In Renal Biopsies And Urine At The Time Of Acute Rejection In Pediatric Renal Transplant Patients. American Journal Of Transplantation, 4(11), 1859-1868.
  • Hu, M., Zhang, G., Arbuckle, S., Graf, N., Shun, A., Silink, M., Lewis, D., Alexander, S. (2004). Prophylactic Bilateral Nephrectomies In Two Paediatric Patients With Missense Mutations In The Wt1 Gene. Nephrology, Dialysis, Transplantation, 19(1), 223-226.
  • Wu, H., Knight, J., Alexander, S. (2004). Regulatory Gamma Delta T Cells In Heymann Nephritis Express An Invariant Vgamma6/Vdelta1 With A Canonical Cdr3 Sequence. European Journal of Immunology, 34(8), 2322-2330. [More Information]

Conferences

  • Hu, M., Kramer, B., Zhang, G., McCowage, G., Alexander, I., Gunning, P., Alexander, S. (2006). Long term skin allograft survival in mice with MGMT chimeric bone marrow engraftment. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Wang, Y., Zhang, G., Wang, Y., Hu, M., Wu, H., Watson, D., Harris, D., Alexander, S. (2006). T cell vaccination protects against active Heymann nephritis: A CD8 T cell mechanism. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Wu, H., Chen, G., Wyburn, K., Afifi, M., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2006). TLR4 activation mediates kidney ischemia reperfusion injury. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Sedger, L., Bendall, L., Gottlieb, D., Alexander, S., Osvath, S. (2005). A novel mechanism of viral subversion of TNF-R signalling by the poxvirus TNF-R like protein, T2. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Zhang, G., Hu, M., Wang, Y., Osvath, S., Sedger, L., Alexander, S. (2005). IL-15 required for DST induced tolerance across a major class I mismatch. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and it''s ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and its ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.

2014

  • Wang, Y., Alexander, S. (2014). DNA Vaccination as a Treatment for Chronic Kidney Disease. In Monica Rinaldi, Daniela Fioretti and Sandra Iurescia (Eds.), Methods in Molecular Biology: Vol 1143, DNA Vaccines, (pp. 297-304). New York: Springer Science+Business Media.
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, C., Wang, X., Lee, V., Wang, Y., Wang, Y., Zheng, G., Tan, T., Harris, D., et al (2014). Failed renoprotection by alternatively activated macrophages from bone marrow due to proliferation-dependent phenotype switch in vivo. Kidney International, 85(4), 794-806. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Tan, T., Lee, S., Zhang, J., Zhang, G., Hu, M., Wang, C., Cao, Q., Zhao, Y., Harris, D., et al (2014). Regulatory T cells require renal antigen recognition through the TCR to protect against injury in nephritis. International Journal of Clinical and Experimental Pathology, 7(1), 38-47.

2013

  • Zhou, J., Wang, Y., Harris, D., Medbury, H., Williams, H., Durkan, A., Alexander, S., Lee, V., Tan, T., Hu, M., et al (2013). Adenine-induced Chronic Kidney Disease Is Associated with Arterial Macrophage Infiltration and Medial Vascular Calcification. Nephrology, 18(Supp 1), 52-52.
  • Wang, Y., Sawyer, A., Zhou, J., Zhang, G., Wang, Y., Hu, M., Roberts, V., Dwyer, K., Harris, D., Alexander, S. (2013). Analysis of Linkage of P2x7r to Balb/C Associated Kidney Injury in the Adriamycin Murine Model in F2 Mice. Nephrology, 18(Supp. 1), 60-60.
  • Hu, M., Fletcher, J., McCahon, E., Catchpoole, D., Zhang, G., Wang, Y., Algar, E., Alexander, S. (2013). Bilateral Wilms Tumor and Early Presentation in Pediatric Patients Is Associated with the Truncation of the Wilms Tumor 1 Protein. The Journal of Pediatrics, 163(1), 224-229. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Harris, D., Alexander, S., Durkan, A. (2013). Cx3cr1-dec205 dc-targeted dna Vaccine Induces Specific Antibodies and Limits Atherosclerosis and Macrophage Infiltration in the apo-e Knockout Mouse Model of Atherosclerosis. Nephrology, 18(Supp. 1), 16-16.
  • Wang, Y., Zhou, J., Wang, Y., Watson, D., Zhang, G., Hu, M., Wu, H., Zheng, G., Wang, Y., Durkan, A., Harris, D., Alexander, S. (2013). Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease. International Journal of Clinical and Experimental Pathology, 6(3), 326-333. [More Information]
  • Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V., Zheng, G., Tan, T., Wang, X., Harris, D., Wang, Y., et al (2013). Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney International, 84(4), 745-755. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Zhang, G., Zhou, J., Tan, T., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Harris, D., et al (2013). DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney International, 83(2), 223-232. [More Information]
  • Wang, Y., Alexander, S. (2013). IL-2/Anti-IL-2 Complex: A Novel Strategy of In Vivo Regulatory T Cell Expansion in Renal Injury. Journal of the American Society of Nephrology, 24(10), 1503-1504. [More Information]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • Wyburn, K., Chadban, S., Kwan, T., Alexander, S., Wu, H. (2013). Interleukin-18 binding protein therapy is protective in adriamycin nephropathy. AJP: Renal Physiology (Online), 304(1), F68-F76. [More Information]
  • Cao, Q., Wang, X., Wang, C., Lee, V., Ye, Q., Zheng, G., Zhao, Y., Alexander, S., Wang, Y., Harris, D. (2013). Kidney Cd103+ Dcs Exacerbate Renal Injury Through Activating Cd8+ T Cells in Adriamycin Nephropathy. Nephrology, 18(Supp. 1), 24-24.
  • Tan, T., Zheng, G., Hsu, T., Lee, S., Zhang, J., Zhao, Y., Tian, X., Wang, Y., Wang, Y., Cao, Q., Wang, Y., Lee, V., Wang, C., Zheng, D., Alexander, S., Harris, D., et al (2013). Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage. Laboratory Investigation, 93(4), 434-449. [More Information]
  • Wang, Y., Wang, C., Cao, Q., Ye, Q., Zheng, G., Alexander, S., Jones, D., Harris, D. (2013). Midkine Antibodies Prevent Renal Injury in Adriamycin Nephropathy. Nephrology, 18(Supp. 1), 59-59.
  • Alexander, S., Ingelfinger, J. (2013). One step closer to "Rejectostix". The New England Journal of Medicine, 369(1), 84-85. [More Information]
  • Wyld, M., Clayton, P., Jesudason, S., Chadban, S., Alexander, S. (2013). Pregnancy Outcomes for Kidney Transplant Recipients. American Journal of Transplantation, 13(12), 3173-3182. [More Information]
  • Fletcher, J., McDonald, S., Alexander, S. (2013). Prevalence of genetic renal disease in children. Pediatric Nephrology, 28(2), 251-256. [More Information]
  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013). Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation, 22(10), 1929-1941. [More Information]
  • Fernandez, M., YU, U., Zhang, G., White, R., Sparwasser, T., Alexander, S., Jones, C. (2013). Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection. Virology, 447(1-2), 9-20. [More Information]

2012

  • Wu, H., Noordmans, G., O'Brien, M., Ma, J., Zhao, C., Zhang, G., Kwan, T., Alexander, S., Chadban, S. (2012). Absence of MyD88 Signaling Induces Donor-Specific Kidney Allograft Tolerance. Journal of the American Society of Nephrology, 23(10), 1701-1716. [More Information]
  • Wang, Y., Zhang, G., Hu, M., Polhill, T., Sawyer, A., Zhou, J., Saito, M., Watson, D., Wu, H., Wang, Y., Wang, X., Wang, Y., Harris, D., Alexander, S. (2012). CD8+ Regulatory T Cells Induced by T Cell Vaccination Protect Against Autoimmune Nephritis. Journal of the American Society of Nephrology, 23(6), 1058-1067. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Phoon, R., Zhang, G., Wang, Y., Tan, T., Hu, M., Wang, D., Saito, M., Harris, D., Durkan, A., et al (2012). DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. International Journal of Clinical and Experimental Medicine, 5(1), 24-33. [More Information]
  • Cowley, M., Weinberg, A., Zammit, N., Walters, S., Hawthorne, W., Loudovaris, T., Thomas, H., Kay, T., Gunton, J., Alexander, S., O'Connell, P., et al (2012). Human islets express a marked proinflammatory molecular signature prior to transplantation. Cell Transplantation, 21(9), 2063-2078. [More Information]
  • Polhill, T., Zhang, G., Hu, M., Sawyer, A., Zhou, J., Saito, M., Webster, K., Wang, Y., Wang, Y., Grey, S., Harris, D., Alexander, S., Wang, Y., et al (2012). IL-2/IL-2Ab Complexes Induce Regulatory T Cell Expansion and Protect against Proteinuric CKD. Journal of the American Society of Nephrology, 23(8), 1303-1308. [More Information]
  • Zheng, D., Cao, Q., Lee, V., Wang, Y., Zheng, G., Wang, Y., Tan, T., Wang, C., Alexander, S., Harris, D., Wang, Y. (2012). Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney International. [More Information]
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Harris, D., Alexander, S., et al (2012). Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology, 42(9), 2441-2451. [More Information]
  • Chapman, J., Alexander, S. (2012). The Candle Illuminating the Pathway to Tolerance? American Journal of Kidney Diseases, 60(4), 521-523. [More Information]

2011

  • Bishop, A., Ierino, F., Sharland, A., Hall, B., Alexander, S., Sandrin, M., Coates, P., McCaughan, G. (2011). Approaching the promise of operational tolerance in clinical transplantation. Transplantation, 91(10), 1065-1074. [More Information]
  • Schwensen, K., Burgess, J., Graf, N., Alexander, S., Harris, D., Phillips, J., Rangan, G. (2011). Early Cyst Growth Is Associated with the Increased Nuclear Expression of Cyclin D1/Rb Protein in an Autosomal-Recessive Polycystic Kidney Disease Rat Model. Nephron Experimental Nephrology, 117(4), e93-e103. [More Information]
  • Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011). IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology, 22(7), 1229-1239. [More Information]
  • Bishop, A., Sharland, A., Ierino, F., Sandrin, M., Hall, B., Alexander, S., Coates, P., McCaughan, G. (2011). Operational Tolerance in Organ Transplantation Versus Tissue Engineering: Into the Future. Transplantation, 92(8), e39-e39. [More Information]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]
  • Zheng, D., Wang, Y., Cao, Q., Lee, V., Zheng, G., Sun, Y., Tan, T., Wang, Y., Alexander, S., Harris, D. (2011). Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus. Nephron Experimental Nephrology, 118(4), e87-e99. [More Information]

2010

  • Sedger, L., Katewa, A., Petterson, A., Osvath, S., Farrell, G., Stewart, G., Bendall, L., Alexander, S. (2010). Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL- and TRAIL-double deficient mice. Blood, 115(16), 3258-3268. [More Information]
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010). IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology, 21(6), 933-942. [More Information]
  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010). Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular Therapy, 18(5), 965-976. [More Information]
  • Nankivell (Nankievell), B., Alexander, S. (2010). Rejection of the Kidney Allograft. New England Journal of Medicine, 363(15), 1451-1462. [More Information]
  • Lee, V., Qin, X., Wang, Y., Zheng, G., Wang, Y., Wang, Y., Ince, J., Tan, T., Kairaitis, L., Alexander, S., Harris, D. (2010). The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrology, Dialysis, Transplantation, 25(3), 717-730. [More Information]

2009

  • Watson, D., Zheng, G., Wu, H., Wang, Y., Wang, Y., Harris, D., Alexander, S. (2009). CCL2 DNA vaccine to treat renal disease. The International Journal of Biochemistry and Cell Biology, 41(4), 729-732. [More Information]
  • Wang, Y., Alexander, S. (2009). CD8 regulatory T cells: what's old is now new. Immunology and Cell Biology. [More Information]
  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009). Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American Journal of Pathology: cellular and molecular biology of disease, 175(2), 580-591. [More Information]
  • Zhang, G., Hu, M., Wang, Y., Alexander, S. (2009). FOXP3 as a marker of tolerance induction versus rejection. Current Opinion in Organ Transplantation, 14(1), 40-45. [More Information]
  • Albaramki, J., Teo, J., Alexander, S. (2009). Rituximab therapy in two children with autoimmune thrombotic thrombocytopenic purpura. Pediatric Nephrology, 24(9), 1749-52. [More Information]
  • Pattullo, V., Bourke, M., Tran, K., McLeod, D., Williams, S., Bailey, A., Alexander, S., Mishra, A., Co, J. (2009). The suction pseudopolyp technique: a novel method for the removal of small flat nonpolypoid lesions of the colon and rectum. Endoscopy, 41(12), 1032-7. [More Information]
  • Watson, D., Hu, M., Zhang, G., Wang, Y., Alexander, S. (2009). Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies. Current Opinion in Organ Transplantation, 14(4), 357-363. [More Information]

2008

  • Alexander, S., Smith, N., Hu, M., Verran, D., Shun, A., Dorney, S., Smith, A., Webster, B., Shaw, P., Lammi, A., Stormon, M. (2008). Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant. New England Journal of Medicine, 358(4), 369-374. [More Information]
  • Fletcher, J., Nankivell (Nankievell), B., Alexander, S. (2008). Chronic allograft nephropathy. Pediatric Nephrology, DOI 10.1007/s00467-008-0869-z, 1-7. [More Information]
  • Alexander, S., Bourke, M., Williams, S., Bailey, A., Gill, A. (2008). Diagnosis of autoimmune pancreatitis with intraductal biliary biopsy and treatment of stricture with serial placement of multiple biliary stents. Gastrointestinal Endoscopy, 68(2), 396-9. [More Information]
  • Pattullo, V., Bourke, M., Alexander, S., Co, J. (2008). Endoscopic evolution of a caustic injury to the gastric antrum. Gastrointestinal Endoscopy, 69(3), 583-5. [More Information]
  • Hodson, E., Alexander, S. (2008). Evaluation and management of steroid-sensitive nephrotic syndrome. Current Opinion in Pediatrics, 20(2), 145-150. [More Information]
  • Hu, M., Watson, D., Zhang, G., Graf, N., Wang, Y., Sartor, M., Howden, B., Fletcher, J., Alexander, S. (2008). Long-term cardiac allograft survival across an MHC mismatch after "pruning" of alloreactive CD4 T cells. Journal of Immunology, 180(10), 6593-6603. [More Information]
  • Lee, V., Wang, Y., Wang, Y., Zheng, D., Polhill, T., Cao, Q., Wu, H., Alexander, I., Alexander, S., Harris, D. (2008). Regulatory immune cells in kidney disease. American Journal of Physiology: Renal Physiology (Print), 295(2), F335-F342. [More Information]
  • Wang, Y., Hu, M., Wang, Y., Polhill, T., Zhang, G., Wang, Y., Lee, V., Harris, D., Alexander, S. (2008). Regulatory T Cells in Renal Disease. International Journal of Clinical and Experimental Medicine, 1(4), 294-304. [More Information]
  • Hodson, E., Alexander, S., Graf, N. (2008). Steroid-sensitive nephrotic syndrome. In Denis F. Geary, Franz Schaefer (Eds.), Comprehensive Pediatric Nephrology. United States: Elsevier Ltd.
  • Fernandez, M., Puttur, F., Wang, Y., Howden, W., Alexander, S., Jones, C. (2008). T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice. Journal of Immunology, 180(3), 1556-1564. [More Information]
  • Williams, G., Fletcher, J., Alexander, S., Craig, J. (2008). Vesicoureteral Reflux. Journal of the American Society of Nephrology, 19, 847-862. [More Information]

2007

  • Huiling, W., Wang, Y., Wang, Y., Hu, M., Zhang, G., Knight, J., Harris, D., Alexander, S. (2007). Depletion of gammadelta T cells exacerbates murine adriamycin nephropathy. Journal of the American Society of Nephrology, 18(4), 1180-1189. [More Information]
  • Wang, Y., Wang, Y., Zheng, G., Lee, V., Ouyang, L., Chang, D., Mahajan, D., Coombs, J., Wang, Y., Alexander, S., Harris, D. (2007). Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney International, 72(3), 290-299. [More Information]
  • Ganesan, P., Alexander, S., Watson, D., Logan, G., Zhang, G., Alexander, I. (2007). Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression. Cancer Immunology, Immunotherapy: other biological response modifications, 56(12), 1955-1965. [More Information]
  • Wu, H., Chen, G., Wyburn, K., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007). TLR4 activation mediates kidney ischemia/reperfusion injury. Journal of Clinical Investigation, 117(10), 2847-2859. [More Information]
  • McTaggart, S., Alexander, S., Craig, J. (2007). Use of darbepoetin alfa (Aranesp) in pediatric kidney disease. Pediatric Nephrology, 22, 1472.

2006

  • Qin, X., Lee, V., Wang, Y., Zheng, G., Wang, Y., Alexander, S., Harris, D. (2006). A protective role for programmed death 1 in progression of murine adriamycin nephropathy. Kidney International, 70, 1244-1250. [More Information]
  • Lee, V., Wang, Y., Qin, X., Wang, Y., Zheng, G., Mahajan, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrology, Dialysis, Transplantation. [More Information]
  • Mahajan, D., Wang, Y., Qin, X., Wang, Y., Zheng, G., Wang, Y., Alexander, S., Harris, D. (2006). CD4+CD25+ Regulatory T Cells Protect against Injury in an Innate Murine Model of Chronic Kidney Disease. Journal of the American Society of Nephrology, 17(10), 2731-2741. [More Information]
  • Alexander, S., Fletcher, J., Nankivell (Nankievell), B. (2006). Chronic allograft nephropathy in paediatric renal transplantation. Pediatric Nephrology, 22(1), 17-23. [More Information]
  • Zheng, G., Wang, Y., XIANG, S., Tay, Y., Wu, H., Watson, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury. Journal of the American Society of Nephrology, 17(2), 465-474. [More Information]
  • Wang, C., Cordoba, S., Bertolino, P., Alexander, S., Wu, M., Allen, R., McCaughan, G., Bishop, A. (2006). Examination of the immune mechanism of spontaneous tolerance of renal allografts in a mouse model. Immunology and Cell Biology, 84(1), A29-30.
  • Seddiki, N., Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S., Nanan, R., Fazekas, B., et al (2006). Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. The Journal of Experimental Medicine, 203(7), 1693-1700. [More Information]
  • Wang, Y., Zhang, G., Wang, Y., Hu, M., Wu, H., Watson, D., Hori, S., Alexander, I., Harris, D., Alexander, S. (2006). Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin. Journal of the American Society of Nephrology, 17(3), 697-706. [More Information]
  • Hu, M., Kramer, B., Zhang, G., McCowage, G., Alexander, I., Gunning, P., Alexander, S. (2006). Long term skin allograft survival in mice with MGMT chimeric bone marrow engraftment. Immunology and Cell Biology, 84 (Suppl.)(3), A29-A29.
  • Hu, M., Kramer, B., Zhang, G., McCowage, G., Alexander, I., Gunning, P., Alexander, S. (2006). Long term skin allograft survival in mice with MGMT chimeric bone marrow engraftment. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Fletcher, J., Graf, N., Scarman, A., Saleh, H., Alexander, S. (2006). Nephrotoxicity with cyclooxygenase 2 inhibitor use in children. Pediatric Nephrology, 21, 1893-7. [More Information]
  • Zheng, G., Zheng, L., Wang, Y., Wu, H., Kairaitis, L., Zhang, C., Tay, Y., Wang, Y., Alexander, S., Harris, D. (2006). NK cells do not mediate renal injury in murine adriamycin nephropathy. Kidney International, 69(7), 1159-1165. [More Information]
  • Seddiki, N., Nanan, B., Tangye, S., Alexander, S., Solomon, M., Soon, L., Nanan, R., Fazekas, B. (2006). Persistence of naive CD45RA(+) regulatory T cells in adult life. Blood, 107(7), 2830-2838. [More Information]
  • Wang, Y., Zhang, G., Wang, Y., Hu, M., Wu, H., Watson, D., Harris, D., Alexander, S. (2006). T cell vaccination protects against active Heymann nephritis: A CD8 T cell mechanism. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Wu, H., Chen, G., Wyburn, K., Afifi, M., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2006). TLR4 activation mediates kidney ischemia reperfusion injury. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.

2005

  • Sedger, L., Bendall, L., Gottlieb, D., Alexander, S., Osvath, S. (2005). A novel mechanism of viral subversion of TNF-R signalling by the poxvirus TNF-R like protein, T2. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Allen, W., Alexander, S. (2005). Adenovirus associated haematuria. Archives of Disease in Childhood, 90(3), 305-6. [More Information]
  • Wu, H., Wang, Y., Tay, Y., Zheng, G., Zhang, C., Alexander, S., Harris, D. (2005). DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Kidney International, 67(6), 2178-2186. [More Information]
  • Hu, M., Wang, C., Cordoba, S., Zhang, G., Wang, Y., Watson, D., Bishop, A., Alexander, S. (2005). Foxp3 expression correlates with tolerance in a mouse allograft model of cardiac rejection and renal tolerance. Immunology and Cell Biology, 83(4), A21-A21.
  • Zhang, G., Hu, M., Wang, Y., Osvath, S., Sedger, L., Alexander, S. (2005). IL-15 required for DST induced tolerance across a major class I mismatch. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.
  • Fletcher, J., Hu, M., Berman, Y., Collins, F., Grigg, J., McIver, M., Juppner, H., Alexander, S. (2005). Multicystic dysplastic kidney and variable phenotype in a family with a novel deletion mutation of PAX2. Journal of the American Society of Nephrology, 16(9), 2754-2761. [More Information]
  • Zheng, G., Wang, Y., Mahajan, D., Qin, X., Wang, Y., Wang, Y., Alexander, S., Harris, D. (2005). The role of tubulointerstitial inflammation. Kidney International, 67(S94), S96-S100. [More Information]
  • Ginn, S., Curtin, J., Kramer, B., Smyth, C., Wong, M., Kakakios, A., McCowage, G., Watson, D., Alexander, S., Latham, M., Rowe, P., Alexander, I., et al (2005). Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia. Medical Journal of Australia, 182(9), 458-463. [More Information]
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and it''s ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.
  • Wu, H., Wyburn, K., Yin, J., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2005). Upregulation of NKG2D and its ligand RAE-1 in renal allografts may provide a link between innate and adaptive immunity in acute rejection. 23rd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Australia: Wiley-Blackwell Publishing Asia Pty Ltd.

2004

  • Watson, D., Zhang, G., Sartor, M., Alexander, S. (2004). "Pruning" Of Alloreactive Cd4+ T Cells Using 5- (And 6-)Carboxyfluorescein Diacetate Succinimidyl Ester Prolongs Skin Allograft Survival. Journal of Immunology, 173(11), 6574-6582.
  • Hu, M., Craig, J., Howard, N., Kan, A., Chaitow, J., Little, D., Alexander, S. (2004). A Novel Mutation Of WT1 Exon 9 In A Patient With Denys-Drash Syndrome And Pyloric Stenosis. Pediatric Nephrology, 19(10), 1160-1163. [More Information]
  • Logan, G., Spinoulas, A., Alexander, S., Smythe, J., Alexander, I. (2004). CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection. Immunology and Cell Biology, 82(2), 132-135.
  • Foster, A., Marangolo, M., Sartor, M., Alexander, S., Hu, M., Bradstock, K., Gottlieb, D. (2004). Human Cd62L- Memory T Cells Are Less Responsive To Alloantigen Stimulation Than Cd62L+ Naive T Cells: Potential For Adoptive Immunotherapy And Allodepletion. Blood, 104(8), 2403-2409.
  • Hu, M., Zhang, G., Walters, G., Sartor, M., Watson, D., Knight, J., Alexander, S. (2004). Matching T-Cell Receptors Identified In Renal Biopsies And Urine At The Time Of Acute Rejection In Pediatric Renal Transplant Patients. American Journal Of Transplantation, 4(11), 1859-1868.
  • Hu, M., Zhang, G., Arbuckle, S., Graf, N., Shun, A., Silink, M., Lewis, D., Alexander, S. (2004). Prophylactic Bilateral Nephrectomies In Two Paediatric Patients With Missense Mutations In The Wt1 Gene. Nephrology, Dialysis, Transplantation, 19(1), 223-226.
  • Wu, H., Knight, J., Alexander, S. (2004). Regulatory Gamma Delta T Cells In Heymann Nephritis Express An Invariant Vgamma6/Vdelta1 With A Canonical Cdr3 Sequence. European Journal of Immunology, 34(8), 2322-2330. [More Information]

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