Associate Professor Stephen Assinder

Senior Lecturer
Physiology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9036 3614
Fax +61 2 9351 8400

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Research interests

The work of Andrology Research Group is concerned with two significant issues of male health, namely prostate disease and environmental endocrine disruption of male fertility.

Prostate Disease: Prostate cancer is the most commonly diagnosed cancer in Australia, and is the second leading cause of cancer death in men. More than 2,700 men die of prostate cancer in Australia each year. It was estimated that in the year 2000, there were 513,000 new cases worldwide. Benign prostatic hyperplasia is the most common benign tumour in men, resulting in severe morbidity. Research of the group is focused on: 1. Understanding how the loss of structural proteins involved in organization of the cell cytoskeleton contribute to the development of prostate cancer phenotypes. 2. Hormone regulation of prostate cell proliferation. In particular we are interested in how the hormones usually associated with females, namely oestrogen and oxytocin, are associated with abnormal growth of the prostate. Endocrine disruption of male fertility: It is of increasing concern that human sperm quality is declining. Many environmental factors have been implicated in this decline, including phytoestrogens. Since phytoestrogens were first associated with the disruption of mammalian fertility there has been considerable interest in their effects on sexual development and reproductive function. This is particularly pertinent given the increasing advocacy for the use of phytoestrogens as bioprotective agents against disease (eg. cardiovascular disease, prostate cancer). Work has recently demonstrated that exposure to phytoestrogen in adulthood can disrupt factors that determine fertility. In an attempt to understand the mechanisms involved, the group is developing transgenic models to determine the roles of oestrogen in spermatogenesis.

Selected grants

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • PyroMark Q96 ID system; Richardson D, Stone J, Black J, King N, Mason R, Hunt N, Kril J, Murray M, Scolyer R, Halliday G, Vandenberg R, McMinn P, Chadban S, Byrne M, Ryan R, Dong Q, Lee C, Bishop A, Haass N, Fraser S, Hambly B, Sharland A, Kalinowski D, Assinder S, Yu Y, Bao B, Ju Y, Lovejoy D, Buckland M, Lane D, Dos Remedios C, Kovacevic Z, Sutherland G, Zhang D, Morris B, Suryo Rahmanto A, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Integration of ecogenic and tumour suppresive pathways in prostate cancer and investigation of their potential roles in treatment; Richardson D, Assinder S; DVC Research/Cancer Research Fund.
  • Pharmacological Targeting via AKT, PTEN, and TGF-beta Pathway Integration using Novel Therapeutics; Richardson D, Assinder S, Dong Q; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • PHERAstar and POLARstar Optima multi-functional plate readers with robotic high throughput screening system for multi-disciplinary cancer research; Halliday G, Ho J, Conigrave A, Iland H, Lee C, Joshua D, Cook D, Richardson D, Reichardt J, Grau G, Lovejoy D, Hunt N, King N, Mason R, Murphy C, Sharland A, Assinder S, Dong Q, Bishop A; Cancer Institute New South Wales/Infrastructure Grant.

Selected publications

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Book Chapters

  • Assinder, S. (2009). Oxytocin in the Pathophysiology of Prostate Cancer. In Hugo Jastrow, Daniela Feuerbach (Eds.), Handbook of Oxytocin Research: Synthesis, Storage and Release, Actions and Drug Forms, (pp. 155-170). New York, USA: Nova Science Publishers.
  • Assinder, S., Glover, A. (2008). Endocrine disruption of male fertility by dietary oestrogens. Research Advances in Reproduction 1. Kerala, India: Global Research Publications.
  • Nicholson, H., Assinder, S. (2008). Male gametogenesis. In Steven Fleming, Simon Cooke (Eds.), Textbook of Assisted Reproduction for Scientists in Reproductive Technology: Scientists in Reproductive Technology (SIRT); Fertility Society of Australia, (pp. 3-29). Australia: VIVID Publishing.
  • Nicholson, H., Assinder, S. (2007). Physiology of the prostate. In Fouad R. Kandeel (Eds.), Male Reproductive Dysfunction: Pathophysiology and treatment, (pp. 81-91). New York: Informa Healthcare.
  • Assinder, S., Nicholson, H. (2007). Prostate Disease: Prostate Hyperplasia, Prostate Cancer and Prostatitis. In Fouad R. Kandeel (Eds.), Male Reproductive Dysfunction: Pathophysiology and treatment, (pp. 499-518). New York: Informa Healthcare.

Journals

  • Velonas, V., Woo, H., Dos Remedios, C., Assinder, S. (2013). Current Status of Biomarkers for Prostate Cancer. International Journal of Molecular Sciences, 14(6), 11034-11060. [More Information]
  • Hua, S., Yao, M., Vignarajan, S., Witting, P., Hejazi, L., Gong, Z., Teng, Y., Niknami, M., Assinder, S., Richardson, D., Dong, Q. (2013). Cytosolic phospholipase A2alpha sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1831 (6), 1146-1157. [More Information]
  • Dixon, K., Lui, G., Kovacevic, Z., Zhang, D., Yao, M., Chen, Z., Dong, Q., Assinder, S., Richardson, D. (2013). Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells. British Journal of Cancer, 108(2), 409-419. [More Information]
  • Ghalayini, M., Dong, Q., Richardson, D., Assinder, S. (2013). Proteolytic cleavage and truncation of NDRG1 in human prostate cancer cells, but not normal prostate epithelial cells. Bioscience Reports, 33(3), 451-464. [More Information]
  • Sanchez-Perez, A., Brown, G., Malik, R., Assinder, S., Cantlon, K., Gotsis, C., Dunbar, S., Fraser, S. (2013). Rapid detection of haemotropic mycoplasma infection of feline erythrocytes using a novel flow cytometric approach. Parasites and Vectors, 6(1), 1-7. [More Information]
  • Wee, N., Weinstein, D., Fraser, S., Assinder, S. (2013). The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease. The International Journal of Biochemistry and Cell Biology, 45(5), 960-963. [More Information]
  • Bower, N., Garcia de la serrana, D., Cole, N., Hollway, G., Lee, H., Assinder, S., Johnston, I. (2012). Stac3 Is Required for Myotube Formation and Myogenic Differentiation in Vertebrate Skeletal Muscle. Journal of Biological Chemistry, 287(52), 43936-43949. [More Information]
  • Assinder, S., Cole, N. (2011). Does TGF-β induced formation of actin stress fibres reinforce Smad dependent TGF-β signalling in the prostate? Medical Hypotheses, 76(6), 802-804. [More Information]
  • Assinder, S. (2011). TAGLN (transgelin). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 15(6), 477-479. [More Information]
  • Assinder, S., Au, E., Dong, Q., Winnick, C. (2010). A novel splice variant of the beta-tropomyosin (TPM2) gene in prostate cancer. Molecular Carcinogenesis, 49(6), 525-531. [More Information]
  • Prasad, P., Stanton, J., Assinder, S. (2010). Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer. Cell and Tissue Research, 339(2), 337-347. [More Information]
  • Tom, N., Assinder, S. (2010). Oxytocin in health and disease. The International Journal of Biochemistry and Cell Biology, 42(2), 202-5. [More Information]
  • Tom, N., Assinder, S. (2010). Oxytocin: Recent developments. Biomolecular Concepts, 1(5-6), 367-380. [More Information]
  • Assinder, S., Dong, Q., Mangs, A., Richardson, D. (2009). Pharmacological targeting of the integrated protein kinase B, phosphatase and tensin homolog deleted on chromosome 10, and transforming growth Factor-β pathways in prostate cancer. Molecular Pharmacology, 75(3), 429-436. [More Information]
  • Assinder, S., Dong, Q., Kovacevic, Z., Richardson, D. (2009). The TGF-beta, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer. Biochemical Journal, 417(2), 411-421. [More Information]
  • Assinder, S., Stanton, J., Prasad, P. (2009). Transgelin: An actin-binding protein and tumour suppressor. The International Journal of Biochemistry and Cell Biology, 41(3), 482-486. [More Information]
  • Assinder, S. (2008). Oxytocin increases 5alpha-reductase activity of human prostate epithelial cells, but not stromal cells. The Prostate, 68, 115-121. [More Information]
  • Assinder, S., Davis, R., Fenwick, M., Glover, A. (2007). Adult-only exposure of male rats to a diet of high phytoestrogen content increases apoptosis of meiotic and post-meiotic germ cells. Reproduction, Fertility and Development, 133(1), 11-19. [More Information]
  • Whittington, K., Connors, B., King, K., Assinder, S., Hogarth, K., Nicholson, H. (2007). The effect of oxytocin on cell proliferation in the human prostate is modulated by gonadal steroids: implications for benign prostatic hyperplasia and carcinoma of the prostate. The Prostate, 67(10), 1132-1142. [More Information]
  • Glover, A., Assinder, S. (2006). Acute exposure of adult male rats to dietary phytoestrogens reduces fecundity and alters epididymal steroid hormone receptor expression. Journal of Endocrinology, 189(3), 565-573. [More Information]
  • King, K., Nicholson, H., Assinder, S. (2006). Effect of Increasing Ratio of Estrogen:Androgen on Proliferation of Normal Human Prostate Stromal and Epithelial Cells, and the Malignant Cell Line LNCaP. The Prostate, 66(1), 105-114. [More Information]
  • Assinder, S. (2005). Familial risks in testicular cancer as aetiological clues (comment at end of article). International Journal Of Andrology, 29, 210-210.
  • Fink, J., McLeod, B., Assinder, S., Parry, L., Nicholson, H. (2005). Seasonal Changes in Mesotocin and Localization of Its Receptor in the Prostate of the Brushtail Possum (Trichosurus vulpecula). Biology Of Reproduction, 72(2), 470-478. [More Information]
  • Assinder, S., Nicholson, H. (2004). Effects of steroids on oxytocin secretion by the human prostate in vitro. International Journal Of Andrology, 27(1), 12-18.
  • Whittington, K., Assinder, S., Gould, M., Nicholson, H. (2004). Oxytocin, oxytocin-associated neurophysin and the oxytocin receptor in the human prostate. Cell and Tissue Research, 318(2), 375-382.
  • Assinder, S., Johnson, C., King, K., Nicholson, H. (2004). Regulation of 5α-Reductase Isoforms by Oxytocin in the Rat Ventral Prostate. Endocrinology, 145(12), 5767-5773.

2013

  • Velonas, V., Woo, H., Dos Remedios, C., Assinder, S. (2013). Current Status of Biomarkers for Prostate Cancer. International Journal of Molecular Sciences, 14(6), 11034-11060. [More Information]
  • Hua, S., Yao, M., Vignarajan, S., Witting, P., Hejazi, L., Gong, Z., Teng, Y., Niknami, M., Assinder, S., Richardson, D., Dong, Q. (2013). Cytosolic phospholipase A2alpha sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1831 (6), 1146-1157. [More Information]
  • Dixon, K., Lui, G., Kovacevic, Z., Zhang, D., Yao, M., Chen, Z., Dong, Q., Assinder, S., Richardson, D. (2013). Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells. British Journal of Cancer, 108(2), 409-419. [More Information]
  • Ghalayini, M., Dong, Q., Richardson, D., Assinder, S. (2013). Proteolytic cleavage and truncation of NDRG1 in human prostate cancer cells, but not normal prostate epithelial cells. Bioscience Reports, 33(3), 451-464. [More Information]
  • Sanchez-Perez, A., Brown, G., Malik, R., Assinder, S., Cantlon, K., Gotsis, C., Dunbar, S., Fraser, S. (2013). Rapid detection of haemotropic mycoplasma infection of feline erythrocytes using a novel flow cytometric approach. Parasites and Vectors, 6(1), 1-7. [More Information]
  • Wee, N., Weinstein, D., Fraser, S., Assinder, S. (2013). The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease. The International Journal of Biochemistry and Cell Biology, 45(5), 960-963. [More Information]

2012

  • Bower, N., Garcia de la serrana, D., Cole, N., Hollway, G., Lee, H., Assinder, S., Johnston, I. (2012). Stac3 Is Required for Myotube Formation and Myogenic Differentiation in Vertebrate Skeletal Muscle. Journal of Biological Chemistry, 287(52), 43936-43949. [More Information]

2011

  • Assinder, S., Cole, N. (2011). Does TGF-β induced formation of actin stress fibres reinforce Smad dependent TGF-β signalling in the prostate? Medical Hypotheses, 76(6), 802-804. [More Information]
  • Assinder, S. (2011). TAGLN (transgelin). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 15(6), 477-479. [More Information]

2010

  • Assinder, S., Au, E., Dong, Q., Winnick, C. (2010). A novel splice variant of the beta-tropomyosin (TPM2) gene in prostate cancer. Molecular Carcinogenesis, 49(6), 525-531. [More Information]
  • Prasad, P., Stanton, J., Assinder, S. (2010). Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer. Cell and Tissue Research, 339(2), 337-347. [More Information]
  • Tom, N., Assinder, S. (2010). Oxytocin in health and disease. The International Journal of Biochemistry and Cell Biology, 42(2), 202-5. [More Information]
  • Tom, N., Assinder, S. (2010). Oxytocin: Recent developments. Biomolecular Concepts, 1(5-6), 367-380. [More Information]

2009

  • Assinder, S. (2009). Oxytocin in the Pathophysiology of Prostate Cancer. In Hugo Jastrow, Daniela Feuerbach (Eds.), Handbook of Oxytocin Research: Synthesis, Storage and Release, Actions and Drug Forms, (pp. 155-170). New York, USA: Nova Science Publishers.
  • Assinder, S., Dong, Q., Mangs, A., Richardson, D. (2009). Pharmacological targeting of the integrated protein kinase B, phosphatase and tensin homolog deleted on chromosome 10, and transforming growth Factor-β pathways in prostate cancer. Molecular Pharmacology, 75(3), 429-436. [More Information]
  • Assinder, S., Dong, Q., Kovacevic, Z., Richardson, D. (2009). The TGF-beta, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer. Biochemical Journal, 417(2), 411-421. [More Information]
  • Assinder, S., Stanton, J., Prasad, P. (2009). Transgelin: An actin-binding protein and tumour suppressor. The International Journal of Biochemistry and Cell Biology, 41(3), 482-486. [More Information]

2008

  • Assinder, S., Glover, A. (2008). Endocrine disruption of male fertility by dietary oestrogens. Research Advances in Reproduction 1. Kerala, India: Global Research Publications.
  • Nicholson, H., Assinder, S. (2008). Male gametogenesis. In Steven Fleming, Simon Cooke (Eds.), Textbook of Assisted Reproduction for Scientists in Reproductive Technology: Scientists in Reproductive Technology (SIRT); Fertility Society of Australia, (pp. 3-29). Australia: VIVID Publishing.
  • Assinder, S. (2008). Oxytocin increases 5alpha-reductase activity of human prostate epithelial cells, but not stromal cells. The Prostate, 68, 115-121. [More Information]

2007

  • Assinder, S., Davis, R., Fenwick, M., Glover, A. (2007). Adult-only exposure of male rats to a diet of high phytoestrogen content increases apoptosis of meiotic and post-meiotic germ cells. Reproduction, Fertility and Development, 133(1), 11-19. [More Information]
  • Nicholson, H., Assinder, S. (2007). Physiology of the prostate. In Fouad R. Kandeel (Eds.), Male Reproductive Dysfunction: Pathophysiology and treatment, (pp. 81-91). New York: Informa Healthcare.
  • Assinder, S., Nicholson, H. (2007). Prostate Disease: Prostate Hyperplasia, Prostate Cancer and Prostatitis. In Fouad R. Kandeel (Eds.), Male Reproductive Dysfunction: Pathophysiology and treatment, (pp. 499-518). New York: Informa Healthcare.
  • Whittington, K., Connors, B., King, K., Assinder, S., Hogarth, K., Nicholson, H. (2007). The effect of oxytocin on cell proliferation in the human prostate is modulated by gonadal steroids: implications for benign prostatic hyperplasia and carcinoma of the prostate. The Prostate, 67(10), 1132-1142. [More Information]

2006

  • Glover, A., Assinder, S. (2006). Acute exposure of adult male rats to dietary phytoestrogens reduces fecundity and alters epididymal steroid hormone receptor expression. Journal of Endocrinology, 189(3), 565-573. [More Information]
  • King, K., Nicholson, H., Assinder, S. (2006). Effect of Increasing Ratio of Estrogen:Androgen on Proliferation of Normal Human Prostate Stromal and Epithelial Cells, and the Malignant Cell Line LNCaP. The Prostate, 66(1), 105-114. [More Information]

2005

  • Assinder, S. (2005). Familial risks in testicular cancer as aetiological clues (comment at end of article). International Journal Of Andrology, 29, 210-210.
  • Fink, J., McLeod, B., Assinder, S., Parry, L., Nicholson, H. (2005). Seasonal Changes in Mesotocin and Localization of Its Receptor in the Prostate of the Brushtail Possum (Trichosurus vulpecula). Biology Of Reproduction, 72(2), 470-478. [More Information]

2004

  • Assinder, S., Nicholson, H. (2004). Effects of steroids on oxytocin secretion by the human prostate in vitro. International Journal Of Andrology, 27(1), 12-18.
  • Whittington, K., Assinder, S., Gould, M., Nicholson, H. (2004). Oxytocin, oxytocin-associated neurophysin and the oxytocin receptor in the human prostate. Cell and Tissue Research, 318(2), 375-382.
  • Assinder, S., Johnson, C., King, K., Nicholson, H. (2004). Regulation of 5α-Reductase Isoforms by Oxytocin in the Rat Ventral Prostate. Endocrinology, 145(12), 5767-5773.

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