Associate Professor Stephen Fuller

Associate Professor
Medicine, Nepean Clinical School

Telephone +61 2 4734 2613
Fax +61 2 4734 2614

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Selected grants

2013

  • Study of the Effect of Body Iron on Serum Fibroblast Growth Factor 23 Levels, Phosphate Homeostatsis and Bone Remodelling; Hibbert E, Fuller S; Nepean Medical Research Foundation/Project Grant.

2012

  • Study of the differential expession of P2X7 splice variants in normal B cells and chronic lymphocytic leukaemia cells; Fuller S; Nepean Medical Research Foundation/Project Grant.
  • Identification of genes responsible for familial predispositions to haematological malignancies; Scott H, Fuller S; University of Adelaide/Shared Research Support.

2011

  • BD FACSVerse Flow Cytometer; Peek M, Fuller S; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.

2010

  • Using familial predipostion to Chronic Lymphocytic Leukaemia to follow disease progression; Fuller S; Leukaemia Foundation of Australia/Grants in Aid.

2009

  • Analysis of chronic lymphocytic leukemia susceptibility genes in a large multi-generational family; Fuller S, Skarratt K; Nepean Medical Research Foundation/Project Grant.

Selected publications

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Journals

  • Gu, B., Sun, C., Fuller, S., Skarratt, K., Petrou, S., Wiley, J. (2014). A quantitative method for measuring innate phagocytosis by human monocytes using real-time flow cytometry. Cytometry Part A, 85(4), 313-321. [More Information]
  • Skarratt, K., Fuller, S. (2014). Quantitative real-time PCR eliminates false-positives in colony screening PCR. Journal of Microbiological Methods, 96(1), 99-100. [More Information]
  • Gu, B., Baird, P., Vessey, K., Skarratt, K., Fletcher, E., Fuller, S., Richardson, A., Guymer, R., Wiley, J. (2013). A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration. The FASEB Journal, 27(4), 1479-1487. [More Information]
  • Tow, J., Loh, H., Bui, C., Fuller, S., Mansberg, R. (2012). Multiple Intraabdominal Purulent Collections Demonstrated on FDG PET/CT in Staging of Non-Hodgkin Lymphoma. Clinical Nuclear Medicine, 37(2), 210-213. [More Information]
  • Fuller, S. (2012). New Insights into the Pathogenesis, Diagnosis, and Management of Mastocytosis. Hematology-Oncology Clinics of North America, 26(6), 1143-1168. [More Information]
  • Jorgensen, N., Husted, L., Skarratt, K., Stokes, L., Tofteng, C., Kvist, T., Jensen, J., Eiken, P., Brixen, K., Fuller, S., Clifton-Bligh, R., Wiley, J., et al (2012). Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures. European Journal of Human Genetics, 20(6), 675-681. [More Information]
  • Miller, C., Zakrzewski, A., Ikin, R., Boulter, N., Katrib, M., Lees, M., Fuller, S., Wiley, J., Smith, N. (2011). Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X7 receptor-deficient mice. International Journal for Parasitology, 41(3-4), 301-308. [More Information]
  • Wiley, J., Sluyter, R., Gu, B., Stokes, L., Fuller, S. (2011). The human P2X7 receptor and its role in innate immunity. Tissue Antigens: immune response genetics, 78(5), 321-332. [More Information]
  • Miller, C., Boulter, N., Fuller, S., Zakrzewski, A., Lees, M., Saunders, B., Wiley, J., Smith, N. (2011). The Role of the P2X(7) Receptor in Infectious Diseases. PLoS Pathogens, 7(11), 1-7. [More Information]
  • Jamieson, S., Peixoto-Rangel, A., Hargrave, A., de Roubaix, L., Mui, E., Boulter, N., Miller, E., Fuller, S., Wiley, J., Castellucci, L., et al (2010). Evidence for associations between the purinergic receptor P2X7 (P2RX7) and toxoplasmosis. Genes and Immunity, 11(5), 374-383. [More Information]
  • Sluyter, R., Stokes, L., Fuller, S., Gu, B., Wiley, J. (2010). Functional significance of P2RX7 polymorphisms associated with affective mood disorders. Journal of Psychiatric Research, 44(15), 1116-7. [More Information]
  • Lees, M., Fuller, S., McLeod, R., Boulter, N., Miller, C., Zakrzewski, A., Mui, E., Witola, W., Coyne, J., Hargrave, A., Wiley, J., et al (2010). P2X7 Receptor-Mediated Killing of an Intracellular Parasite, Toxoplasma gondii, by Human and Murine Macrophages. Journal of Immunology, 184(12), 7040-7046. [More Information]
  • Stokes, L., Fuller, S., Sluyter, R., Skarratt, K., Gu, B., Wiley, J. (2010). Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1{beta} secretion. The F A S E B Journal, 24(8), 2916-2927. [More Information]
  • Fuller, S., Stokes, L., Skarratt, K., Gu, B., Wiley, J. (2009). Genetics of the P2X7 receptor and human disease. Purinergic Signalling, 5(2), 257-262. [More Information]
  • Fuller, S., Papaemmanuil, E., McKinnon, L., Webb, E., Sellick, G., Dao-Ung, L., Skarratt, K., Crowther-Swanepoel, D., Houlston, R., Wiley, J. (2008). Analysis of a large multi-generational family provides insight into the genetics of chronic lymphocytic leukemia. British Journal of Haematology, 142(2), 238-245. [More Information]
  • Crowther-Swanepoel, D., Wild, R., Sellick, G., Dyer, M., Mauro, F., Cuthbert, R., Jonsson, V., Matutes, E., Dearden, C., Wiley, J., Fuller, S., et al (2008). Insight into the pathogenesis of chronic lymphocytic leukemia (CLL) through analysis of IgVH gene usage and mutation status in familial CLL. Blood, 111(12), 5691-5693. [More Information]
  • Sellick, G., Goldin, L., Wild, R., Slager, S., Ressenti, L., Strom, S., Dyer, M., Mauro, F., Marti, G., Fuller, S., et al (2007). A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia. Blood, 110, 3326-3333.
  • Jursik, C., Sluyter, R., Georgiou, J., Fuller, S., Wiley, J., Gu, B. (2007). A quantitative method for routine measurement of cell surface P2X(7) receptor function in leucocyte subsets by two-colour time-resolved flow cytometry. Journal of Immunological Methods, 325(1-2), 67-77. [More Information]
  • Al-Khawaja, D., Eslick, G., Fuller, S., Seex, K. (2007). Intracerebral hemorrhage after thrombolytic therapy managed with ventricular drainage. Journal of Clinical Neuroscience, 14(9), 898-900. [More Information]
  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2006). A Thr(357) to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X(7) function and impairs ATP-induced mycobacterial killing by macrophages. Journal of Biological Chemistry, 281(4), 2079-2086. [More Information]
  • Skarratt, K., Fuller, S., Sluyter, R., Dao-Ung, L., Gu, B., Wiley, J. (2005). A 50 intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1–2% of the Caucasian population. FEBS Letters, 579(12), 2675-2678. [More Information]
  • Sellick, G., Webb, E., Allinson, R., Matutes, E., Dyer, M., Jonsson, V., Langerak, A., Mauro, F., Fuller, S., Wiley, J., et al (2005). A high-density SNP genomewide linkage scan for chronic lymphocytic leukemia-susceptibility loci. American Journal of Human Genetics, 77(3), 420-429. [More Information]
  • Georgiou, J., Skarratt, K., Fuller, S., Martin, C., Christopherson, R., Wiley, J., Sluyter, R. (2005). Human Epidermal and Monocyte-Derived Langerhans Cells Express Functional P2X7 Receptors. The Journal of Investigative Dermatology, 125(3), 482-490. [More Information]
  • Gu, B., Sluyter, R., Skarratt, K., Shemon, A., Dao-Ung, L., Fuller, S., Barden, J., Clarke, A., Petrou, S., Wiley, J. (2004). An Arg307 To Gln Polymorphism Within The Atp-Binding Site Causes Loss Of Function Of The Human P2X7 Receptor. Journal of Biological Chemistry, 279(30), 31287-31295.
  • Dao-Ung, L., Fuller, S., Sluyter, R., Skarratt, K., Thunberg, U., Tobin, G., Byth Wilson, K., Ban, M., Rosenquist, R., Stewart, G., Wiley, J. (2004). Association of the 1513C polymorphism in the P2X7 gene with familial forms of chronic lymphocytic leukaemia. British Journal of Haematology, 125(6), 815-817.
  • Dao-Ung, L., Sluyter, R., Fuller, S., Taper, J., Wiley, J. (2004). CXCR4 but not CXCR3 expression correlates with lymphocyte counts in B-cell chronic lymphocytic leukemia. Annals of Hematology, 83(5), 326-327. [More Information]
  • Wiley, J., Dao-Ung, L., Li, C., Shemon, A., Gu, B., Smart, M., Fuller, S., Barden, J., Petrou, S., Sluyter, R. (2003). An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor. Journal of Biological Chemistry, 278(19), 17108-17113.
  • Fuller, S., Kumar, P., Weltman, M., Wiley, J. (2003). Autoimmune hemolysis associated with primary biliary cirrhosis responding to ursodeoxycholic acid as sole treatment. American Journal Of Hematology, 72(1), 31-33. [More Information]
  • Lee, D., Chitturi, S., Kench, J., George, J., Fuller, S., Bradstock, K., Lin, R., Wong, K., Young, N. (2003). Transjugular liver biopsy effecting changes in clinical management. Journal of Medical Imaging and Radiation Oncology, 47(2), 117-120. [More Information]

Conferences

  • Skarratt, K., Fuller, S., Sluyter, R., Dao-Ung, L., Gu, B., Wiley, J. (2005). A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2005). A Thr(357) to ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Sluyter, R., Georgiou, J., Skarratt, K., Fuller, S., Martin, C., Christopherson, R., Wiley, J. (2005). Human epidermal and monocyte-derived langerhans cells express functional P2X7 receptors. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.

2014

  • Gu, B., Sun, C., Fuller, S., Skarratt, K., Petrou, S., Wiley, J. (2014). A quantitative method for measuring innate phagocytosis by human monocytes using real-time flow cytometry. Cytometry Part A, 85(4), 313-321. [More Information]
  • Skarratt, K., Fuller, S. (2014). Quantitative real-time PCR eliminates false-positives in colony screening PCR. Journal of Microbiological Methods, 96(1), 99-100. [More Information]

2013

  • Gu, B., Baird, P., Vessey, K., Skarratt, K., Fletcher, E., Fuller, S., Richardson, A., Guymer, R., Wiley, J. (2013). A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration. The FASEB Journal, 27(4), 1479-1487. [More Information]

2012

  • Tow, J., Loh, H., Bui, C., Fuller, S., Mansberg, R. (2012). Multiple Intraabdominal Purulent Collections Demonstrated on FDG PET/CT in Staging of Non-Hodgkin Lymphoma. Clinical Nuclear Medicine, 37(2), 210-213. [More Information]
  • Fuller, S. (2012). New Insights into the Pathogenesis, Diagnosis, and Management of Mastocytosis. Hematology-Oncology Clinics of North America, 26(6), 1143-1168. [More Information]
  • Jorgensen, N., Husted, L., Skarratt, K., Stokes, L., Tofteng, C., Kvist, T., Jensen, J., Eiken, P., Brixen, K., Fuller, S., Clifton-Bligh, R., Wiley, J., et al (2012). Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures. European Journal of Human Genetics, 20(6), 675-681. [More Information]

2011

  • Miller, C., Zakrzewski, A., Ikin, R., Boulter, N., Katrib, M., Lees, M., Fuller, S., Wiley, J., Smith, N. (2011). Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X7 receptor-deficient mice. International Journal for Parasitology, 41(3-4), 301-308. [More Information]
  • Wiley, J., Sluyter, R., Gu, B., Stokes, L., Fuller, S. (2011). The human P2X7 receptor and its role in innate immunity. Tissue Antigens: immune response genetics, 78(5), 321-332. [More Information]
  • Miller, C., Boulter, N., Fuller, S., Zakrzewski, A., Lees, M., Saunders, B., Wiley, J., Smith, N. (2011). The Role of the P2X(7) Receptor in Infectious Diseases. PLoS Pathogens, 7(11), 1-7. [More Information]

2010

  • Jamieson, S., Peixoto-Rangel, A., Hargrave, A., de Roubaix, L., Mui, E., Boulter, N., Miller, E., Fuller, S., Wiley, J., Castellucci, L., et al (2010). Evidence for associations between the purinergic receptor P2X7 (P2RX7) and toxoplasmosis. Genes and Immunity, 11(5), 374-383. [More Information]
  • Sluyter, R., Stokes, L., Fuller, S., Gu, B., Wiley, J. (2010). Functional significance of P2RX7 polymorphisms associated with affective mood disorders. Journal of Psychiatric Research, 44(15), 1116-7. [More Information]
  • Lees, M., Fuller, S., McLeod, R., Boulter, N., Miller, C., Zakrzewski, A., Mui, E., Witola, W., Coyne, J., Hargrave, A., Wiley, J., et al (2010). P2X7 Receptor-Mediated Killing of an Intracellular Parasite, Toxoplasma gondii, by Human and Murine Macrophages. Journal of Immunology, 184(12), 7040-7046. [More Information]
  • Stokes, L., Fuller, S., Sluyter, R., Skarratt, K., Gu, B., Wiley, J. (2010). Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1{beta} secretion. The F A S E B Journal, 24(8), 2916-2927. [More Information]

2009

  • Fuller, S., Stokes, L., Skarratt, K., Gu, B., Wiley, J. (2009). Genetics of the P2X7 receptor and human disease. Purinergic Signalling, 5(2), 257-262. [More Information]

2008

  • Fuller, S., Papaemmanuil, E., McKinnon, L., Webb, E., Sellick, G., Dao-Ung, L., Skarratt, K., Crowther-Swanepoel, D., Houlston, R., Wiley, J. (2008). Analysis of a large multi-generational family provides insight into the genetics of chronic lymphocytic leukemia. British Journal of Haematology, 142(2), 238-245. [More Information]
  • Crowther-Swanepoel, D., Wild, R., Sellick, G., Dyer, M., Mauro, F., Cuthbert, R., Jonsson, V., Matutes, E., Dearden, C., Wiley, J., Fuller, S., et al (2008). Insight into the pathogenesis of chronic lymphocytic leukemia (CLL) through analysis of IgVH gene usage and mutation status in familial CLL. Blood, 111(12), 5691-5693. [More Information]

2007

  • Sellick, G., Goldin, L., Wild, R., Slager, S., Ressenti, L., Strom, S., Dyer, M., Mauro, F., Marti, G., Fuller, S., et al (2007). A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia. Blood, 110, 3326-3333.
  • Jursik, C., Sluyter, R., Georgiou, J., Fuller, S., Wiley, J., Gu, B. (2007). A quantitative method for routine measurement of cell surface P2X(7) receptor function in leucocyte subsets by two-colour time-resolved flow cytometry. Journal of Immunological Methods, 325(1-2), 67-77. [More Information]
  • Al-Khawaja, D., Eslick, G., Fuller, S., Seex, K. (2007). Intracerebral hemorrhage after thrombolytic therapy managed with ventricular drainage. Journal of Clinical Neuroscience, 14(9), 898-900. [More Information]

2006

  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2006). A Thr(357) to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X(7) function and impairs ATP-induced mycobacterial killing by macrophages. Journal of Biological Chemistry, 281(4), 2079-2086. [More Information]

2005

  • Skarratt, K., Fuller, S., Sluyter, R., Dao-Ung, L., Gu, B., Wiley, J. (2005). A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Skarratt, K., Fuller, S., Sluyter, R., Dao-Ung, L., Gu, B., Wiley, J. (2005). A 50 intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1–2% of the Caucasian population. FEBS Letters, 579(12), 2675-2678. [More Information]
  • Sellick, G., Webb, E., Allinson, R., Matutes, E., Dyer, M., Jonsson, V., Langerak, A., Mauro, F., Fuller, S., Wiley, J., et al (2005). A high-density SNP genomewide linkage scan for chronic lymphocytic leukemia-susceptibility loci. American Journal of Human Genetics, 77(3), 420-429. [More Information]
  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2005). A Thr(357) to ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Georgiou, J., Skarratt, K., Fuller, S., Martin, C., Christopherson, R., Wiley, J., Sluyter, R. (2005). Human Epidermal and Monocyte-Derived Langerhans Cells Express Functional P2X7 Receptors. The Journal of Investigative Dermatology, 125(3), 482-490. [More Information]
  • Sluyter, R., Georgiou, J., Skarratt, K., Fuller, S., Martin, C., Christopherson, R., Wiley, J. (2005). Human epidermal and monocyte-derived langerhans cells express functional P2X7 receptors. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.

2004

  • Gu, B., Sluyter, R., Skarratt, K., Shemon, A., Dao-Ung, L., Fuller, S., Barden, J., Clarke, A., Petrou, S., Wiley, J. (2004). An Arg307 To Gln Polymorphism Within The Atp-Binding Site Causes Loss Of Function Of The Human P2X7 Receptor. Journal of Biological Chemistry, 279(30), 31287-31295.
  • Dao-Ung, L., Fuller, S., Sluyter, R., Skarratt, K., Thunberg, U., Tobin, G., Byth Wilson, K., Ban, M., Rosenquist, R., Stewart, G., Wiley, J. (2004). Association of the 1513C polymorphism in the P2X7 gene with familial forms of chronic lymphocytic leukaemia. British Journal of Haematology, 125(6), 815-817.
  • Dao-Ung, L., Sluyter, R., Fuller, S., Taper, J., Wiley, J. (2004). CXCR4 but not CXCR3 expression correlates with lymphocyte counts in B-cell chronic lymphocytic leukemia. Annals of Hematology, 83(5), 326-327. [More Information]

2003

  • Wiley, J., Dao-Ung, L., Li, C., Shemon, A., Gu, B., Smart, M., Fuller, S., Barden, J., Petrou, S., Sluyter, R. (2003). An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor. Journal of Biological Chemistry, 278(19), 17108-17113.
  • Fuller, S., Kumar, P., Weltman, M., Wiley, J. (2003). Autoimmune hemolysis associated with primary biliary cirrhosis responding to ursodeoxycholic acid as sole treatment. American Journal Of Hematology, 72(1), 31-33. [More Information]
  • Lee, D., Chitturi, S., Kench, J., George, J., Fuller, S., Bradstock, K., Lin, R., Wong, K., Young, N. (2003). Transjugular liver biopsy effecting changes in clinical management. Journal of Medical Imaging and Radiation Oncology, 47(2), 117-120. [More Information]

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