Professor Stephen Hunyor

Professor
Medicine, Northern Clinical School
Kolling Institute of Medical Research

Telephone 02 9926 4905
Fax 02 9901 4097

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Research interests

Heart Injury and Repair; Heart Assist Devices R&D; Stem Cell Therapy for the Heart; Heart Failure; Heart "energetics"

Selected grants

2014

  • ECM stiffness driven cardiac induction of stem cells; Choi Y, Hunyor S, Cooper-White J, Engler A; Heart Research Australia/Research Support.

2012

  • Aortic stiffness, ventriculo-arterial coupling, heart mechanics and coronary supply: A novel sheep model of heart failure with preserved ejection fraction (HFPEF); Hunyor S, Paterson H, Puttaswamy V, Avolio A; North Shore Heart Research Foundation/Research Support.

2009

  • Stem Cell treatment for tendon degeneration; Smith M, Little C, Smith M, Sonnabend D, Appleyard R, Melrose J, Hunyor S; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • University of Sydney - Bridging Support Grant; Hunyor S; University of Sydney/Bridging Support.

2004

  • Development of a chronically implantable miniatured device for monitoring ventricular function to assist tracking and management of heart failure patients; Hunyor S; National Health and Medical Research Council (NHMRC)/Development Grants.

Selected publications

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Journals

  • Bassin, L., Yong, A., Kilpatrick, D., Hunyor, S. (2014). Arrhythmogenicity of Hypothermia - A Large Animal Model of Hypothermia. Heart, Lung and Circulation, 23, 82-87. [More Information]
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]
  • Bailey, E., Bailey, D., Hunyor, S., Ladd, L., Bautovich, G. (2013). Translation of Methodology Used In Human Myocardial Imaging to a Sheep Model of Acute Myocardial Infarction. Asia Oceania Journal of Nuclear Medicine & Biology, 1(2), 10-21.
  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]
  • Mau, J., Menzie, S., Huang, Y., Ward, M., Hunyor, S. (2011). Nonsurround, nonuniform, biventricular-capable direct cardiac compression provides Frank-Starling recruitment independent of left ventricular septal damage. The Journal of Thoracic and Cardiovascular Surgery, 142(1), 209-215. [More Information]
  • Hunyor, S., Jackson, C. (2010). Microenvironment and Macroenvironment in Hypertensive Hearts. Boundaries and Silos-Can We Pick and Treat Diastolic Heart Failure? Hypertension, 55(6), 1312-3. [More Information]
  • Grieve, S., Bhindi, R., Seow, J., Doyle, A., Turner, A., Tomka, J., Lay, W., Gill, A., Hunyor, S., Figtree, G. (2010). Microvascular obstruction by intracoronary delivery of mesenchymal stem cells and quantification of resulting myocardial infarction by cardiac magnetic resonance. Circulation. Heart Failure, 3(3), e5-e6. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]
  • Mau, J., Menzie, S., Huang, Y., Ward, M., Hunyor, S. (2009). Chronic septal infarction confers right ventricular protection during mechanical left ventricular unloading. The Journal of Thoracic and Cardiovascular Surgery, 138(1), 172-178. [More Information]
  • Weir, C., Morel-Kopp, M., Gill, A., Tinworth, K., Ladd, L., Hunyor, S., Ward, C. (2008). Mesenchymal Stem Cells: Isolation, Characterisation and In Vivo Fluorescent Dye Tracking. Heart, Lung and Circulation, 17(5), 395-403. [More Information]
  • Joseph, A., Hunyor, S. (2008). The Royal North Shore Hospital inquiry: an analysis of the recommendations and the implications for quality and safety in Australian public hospitals. Medical Journal of Australia, 188(8), 469-472. [More Information]
  • Gallagher, G., Huang, Y., Zielinski, R., Morita, S., Hunyor, S. (2007). Effect of direct cardiac compression on left ventricular axial dynamics in sheep. ASAIO Journal, 53(3), 292-297. [More Information]
  • Gallagher, G., Huang, Y., Morita, S., Zielinski, R., Hunyor, S. (2007). Efficacy and mechanisms of biventricular and left/right direct cardiac compression in acute heart failure sheep. Artificial Organs: replacement, recovery, and regeneration, 31(1), 39-44. [More Information]
  • Gallagher, G., Jackson, C., Hunyor, S. (2007). Myocardial extracellular matrix remodelling in ischemic heart failure. Frontiers in Bioscience, 12(4), 1410-1419. [More Information]
  • Mau, J., Menzie, S., Ward, M., Bundgaard, H., Hunyor, S. (2007). Time-dependent response of both ventricles after septal ablation: implications for biventricular support after left ventricular assist device placement. The Journal of Thoracic and Cardiovascular Surgery, 134(3), 579-586. [More Information]
  • Gallagher, G., Menzie, S., Huang, Y., Jackson, C., Hunyor, S. (2006). Regional cardiac dysfunction is associated with specific alterations in inflammatory cytokines and matrix metalloproteinases after acute myocardial infarction in sheep. Basic Research in Cardiology. [More Information]
  • Ramanathan, T., Morita, S., Huang, Y., Shirota, K., Nishimura, T., Zheng, X., Hunyor, S. (2004). Glucose-Insulin-Potassium Solution Improves Left Ventricular Energetics In Chronic Ovine Diabetes. The Annals of Thoracic Surgery, 77(4), 1408-1414.
  • Huang, Y., Hunyor, S., Jiang, L., Kawaguchi, O., Shirota, K., Ikeda, Y., Yuasa, T., Gallagher, G., Zeng, B., Zheng, X. (2004). Remodeling Of The Chronic Severely Failing Ischemic Sheep Heart After Coronary Microembolization: Functional, Energetic, Structural, And Cellular Responses. American Journal of Physiology: Heart and Circulatory Physiology, 286(6), H2141-H2150.

Conferences

  • Ladd, L., Tinworth, K., Bailey, D., Bautovich, G., Bailey, E., Roach, P., Hunyor, S. (2006). SPECT/CT imaging for tracking myocardial infarction (MI) in an ovine model. 30th Annual Meeting of the Australiasian Section of the International Society of Heart Research (ISHR), United Kingdom: Academic Press. United Kingdom.

2014

  • Bassin, L., Yong, A., Kilpatrick, D., Hunyor, S. (2014). Arrhythmogenicity of Hypothermia - A Large Animal Model of Hypothermia. Heart, Lung and Circulation, 23, 82-87. [More Information]

2013

  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]
  • Bailey, E., Bailey, D., Hunyor, S., Ladd, L., Bautovich, G. (2013). Translation of Methodology Used In Human Myocardial Imaging to a Sheep Model of Acute Myocardial Infarction. Asia Oceania Journal of Nuclear Medicine & Biology, 1(2), 10-21.

2012

  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]

2011

  • Mau, J., Menzie, S., Huang, Y., Ward, M., Hunyor, S. (2011). Nonsurround, nonuniform, biventricular-capable direct cardiac compression provides Frank-Starling recruitment independent of left ventricular septal damage. The Journal of Thoracic and Cardiovascular Surgery, 142(1), 209-215. [More Information]

2010

  • Hunyor, S., Jackson, C. (2010). Microenvironment and Macroenvironment in Hypertensive Hearts. Boundaries and Silos-Can We Pick and Treat Diastolic Heart Failure? Hypertension, 55(6), 1312-3. [More Information]
  • Grieve, S., Bhindi, R., Seow, J., Doyle, A., Turner, A., Tomka, J., Lay, W., Gill, A., Hunyor, S., Figtree, G. (2010). Microvascular obstruction by intracoronary delivery of mesenchymal stem cells and quantification of resulting myocardial infarction by cardiac magnetic resonance. Circulation. Heart Failure, 3(3), e5-e6. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]

2009

  • Mau, J., Menzie, S., Huang, Y., Ward, M., Hunyor, S. (2009). Chronic septal infarction confers right ventricular protection during mechanical left ventricular unloading. The Journal of Thoracic and Cardiovascular Surgery, 138(1), 172-178. [More Information]

2008

  • Weir, C., Morel-Kopp, M., Gill, A., Tinworth, K., Ladd, L., Hunyor, S., Ward, C. (2008). Mesenchymal Stem Cells: Isolation, Characterisation and In Vivo Fluorescent Dye Tracking. Heart, Lung and Circulation, 17(5), 395-403. [More Information]
  • Joseph, A., Hunyor, S. (2008). The Royal North Shore Hospital inquiry: an analysis of the recommendations and the implications for quality and safety in Australian public hospitals. Medical Journal of Australia, 188(8), 469-472. [More Information]

2007

  • Gallagher, G., Huang, Y., Zielinski, R., Morita, S., Hunyor, S. (2007). Effect of direct cardiac compression on left ventricular axial dynamics in sheep. ASAIO Journal, 53(3), 292-297. [More Information]
  • Gallagher, G., Huang, Y., Morita, S., Zielinski, R., Hunyor, S. (2007). Efficacy and mechanisms of biventricular and left/right direct cardiac compression in acute heart failure sheep. Artificial Organs: replacement, recovery, and regeneration, 31(1), 39-44. [More Information]
  • Gallagher, G., Jackson, C., Hunyor, S. (2007). Myocardial extracellular matrix remodelling in ischemic heart failure. Frontiers in Bioscience, 12(4), 1410-1419. [More Information]
  • Mau, J., Menzie, S., Ward, M., Bundgaard, H., Hunyor, S. (2007). Time-dependent response of both ventricles after septal ablation: implications for biventricular support after left ventricular assist device placement. The Journal of Thoracic and Cardiovascular Surgery, 134(3), 579-586. [More Information]

2006

  • Gallagher, G., Menzie, S., Huang, Y., Jackson, C., Hunyor, S. (2006). Regional cardiac dysfunction is associated with specific alterations in inflammatory cytokines and matrix metalloproteinases after acute myocardial infarction in sheep. Basic Research in Cardiology. [More Information]
  • Ladd, L., Tinworth, K., Bailey, D., Bautovich, G., Bailey, E., Roach, P., Hunyor, S. (2006). SPECT/CT imaging for tracking myocardial infarction (MI) in an ovine model. 30th Annual Meeting of the Australiasian Section of the International Society of Heart Research (ISHR), United Kingdom: Academic Press. United Kingdom.

2004

  • Ramanathan, T., Morita, S., Huang, Y., Shirota, K., Nishimura, T., Zheng, X., Hunyor, S. (2004). Glucose-Insulin-Potassium Solution Improves Left Ventricular Energetics In Chronic Ovine Diabetes. The Annals of Thoracic Surgery, 77(4), 1408-1414.
  • Huang, Y., Hunyor, S., Jiang, L., Kawaguchi, O., Shirota, K., Ikeda, Y., Yuasa, T., Gallagher, G., Zeng, B., Zheng, X. (2004). Remodeling Of The Chronic Severely Failing Ischemic Sheep Heart After Coronary Microembolization: Functional, Energetic, Structural, And Cellular Responses. American Journal of Physiology: Heart and Circulatory Physiology, 286(6), H2141-H2150.

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