Professor Stephen Twigg

Stan Clark Chair in Diabetes
Medicine, Central Clinical School
Bosch Institute

Telephone +61 2 9515 6150
Fax +61 2 9516 1273

Map

Research interests

Diabetes

PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

Selected grants

2014

  • Circulating monocyte phenotype: Is it altered in association with the development of diabetic complications?; McLennan S, Twigg S, Min D; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2013

  • Type 1 Diabetes and Exercise RCT of an On-Line Educational Tool; Twigg S; Juvenile Diabetes Research Foundation (Australia)/Pilot and Feasibility Grants.
  • A high-throughput, bright-field and fluorescence digital slide scanning platform and service that is both research and teaching-focused and available University-wide.; King N, Graeber M, Naylor M, Slapeta J, Quinnell R, Charles (nee Slaviero) K, Owens T, Bourne R, Braet F, Hambly B, Overall R, Stone J, Twigg S, Hardikar A, Halliday G, Richardson D, Byrne M, Keay K, Marsh D, Howell V, Pollock C, Chen X; DVC Research/Equipment Grant.

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Targeting proteases for a novel therapy for type 2 diabetes and liver complications.; Gorrell M, Twigg S, McLennan S, McCaughan G, Chowdhury S; Diabetes Australia Research Trust/Research Grants.
  • Incretins as Therapy in Diabetic Cardiomyopathy; Wang X, Twigg S; Diabetes Australia Research Trust/Research Grants.
  • Role of Inflammation in Diabetic Cardiomyopathy; Twigg S, King N, McLennan S; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Preventing Adverse Effects of Matrix Metalloproteinases in Diabetic Wound Healing; McLennan S, Twigg S, Min D, Yue D; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Diabetes exacerbates non-alcoholic steato-hepatitis (NASH); Twigg S, McLennan S, Gorrell M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Key role of connective tissue growth factor (CTGF) in familial cardiomyopathy and heart failure; Semsarian C, Twigg S, Tsoutsman T; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Metabolism Spec Fund; Twigg S, Head-of C; Sydney Local Health Network/Research Support.
  • Unlocking genetic factors predicting type 2 diabetes complications for clinical practice: The Field Study; Keech A, Best J, Jenkins A, Sullivan D, Twigg S; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Molecular Imager (PharosFX Plus) system for the Multi-use Molecular Biology Facility; Twigg S; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Connective Tissue Growth Factor in diabetic cardiomyopathy; Twigg S, McLennan S; Heart Foundation of Australia/Grants-in-Aid.

2007

  • Rotor-Gene 6000, 5-Plex HRM with desktop computer & Gene-Disc 100 Stater Kit; Halliday G, Yue D, Sharland A, Bishop A, Stocker R, Bao B, McLennan S, Matsumoto I, Hambly B, Rose B, Harbour C, Ho J, Lee C, Twigg S, Soon L, Richardson D, King N, Zreiqat H; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Novel regulators of fat cell differentiation; Twigg S, McLennan S, Baxter R; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Role and mechanism of connective tissue growth factor in diabetic cardiomyopathy; Twigg S, McLennan S, Allen T; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Role of profibrotic growth factors in the pathogenesis of fat cell differentiation in the metabolic syndrome; Twigg S; University of Sydney/Research & Development.

2005

  • Role of connective tissue growth factor in an experimental model of wound healing in Diabetes; Twigg S; Diabetes Australia Research Trust/Diabetes Research Grant Program.

2004

  • Fibrosis and diastolic dysfunction in diabetes mellitus; Celermajer D, Twigg S; Diabetes Australia/Research Grant.
  • Role of profibrotic growth factors in the metabolic syndrome; Twigg S; DVC Research/Research and Development Scheme: Newly Appointed Staff (NAS).
  • Research into Diabetic cardiomyopathy - detecting early changes and pathogenic associations; Twigg S; Diabetes Australia/Research Grant.
  • Real time RT-PCR unit with a robotic (automated) component; Twigg S; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.

2003

  • Novel regulators of connective tissue growth factor expression and bioactivity in diabetic complications; Twigg S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • 2 x leica microsystems imaging systems; 2 x Computer workstations; Black J, Pollard J, Yue D, McLennan S, Twigg S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • Abnormal interactions between peripheral blood monocytes and decidual endothelial cells in acute atherosis in human pregnancy; Gallery E, Morris J, Jackson C, Twigg S; Diabetes Australia/Research Grant.

2000

  • Growth factors regulating C-Cell hyperplasia and medullary thyroid cancer; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

Selected publications

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Books

  • Twigg, S., Craig, M., Cheung, N., Donaghue, K., Jenkins, A., Conn, J., Cameron, F. (2011). National Evidence-Based Clinical Care Guidelines for Type 1 Diabetes in Children, Adolescents and Adults. Australia: Australian Government Department of Health and Age , Australia.

Edited Books

  • Baur, L., Twigg, S., Magnusson, R. (2012). A Modern Epidemic: Expert Perspectives on Obesity and Diabetes. Sydney, Australia: Sydney University Press.

Book Chapters

  • Twigg, S., McLennan, S. (2012). Managing diabetes complications in the clinical arena. In Louise A. Baur, Stephen M. Twigg, Roger S.Magnusson (Eds.), A Modern Epidemic: Expert Perspectives on Obesity and Diabetes, (pp. 353-371). Sydney, Australia: Sydney University Press.

Journals

  • Azzi, M., Constantino, M., Pont, L., McGill, M., Twigg, S., Krass, I. (2014). Medication Safety: an audit of medication discrepancies in transferring type 2 diabetes mellitus (T2DM) patients from Australian primary care to tertiary ambulatory care. International Journal for Quality in Health Care, 26(4), 397-403. [More Information]
  • Keane, F., Tsun-Wen, Y., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]
  • Shun, C., Donaghue, K., Phelan, H., Twigg, S., Craig, M. (2014). Thyroid autoimmunity in Type 1 diabetes: systematic review and meta-analysis. Diabetic Medicine, 31(2), 126-135. [More Information]
  • Hibbert, E., Lambert, T., Carter, J., Learoyd, D., Twigg, S., Clarke, S. (2013). A randomized controlled pilot trial comparing the impact of access to clinical endocrinology video demonstrations with access to usual revision resources on medical student performance of clinical endocrinology skills. BMC Medical Education, 13(1), 1-10. [More Information]
  • Klocker, A., Phelan, H., Twigg, S., Craig, M. (2013). Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. Diabetic Medicine, 30(7), 818-824. [More Information]
  • Tsoutsman, T., Wang, X., Garchow, K., Riser, B., Twigg, S., Semsarian, C. (2013). CCN2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. Journal of Molecular and Cellular Cardiology, 62, 164-178. [More Information]
  • McLennan, S., Abdollahi, M., Twigg, S. (2013). Connective tissue growth factor, matrix regulation, and diabetic kidney disease. Current Opinion In Nephrology And Hypertension, 22(1), 85-92. [More Information]
  • Tan, J., McLennan, S., Williams, P., Rezaeizadeh, A., Lo, L., Bonner, J., Twigg, S. (2013). Connective tissue growth factor/CCN-2 is upregulated in epididymal and subcutaneous fat depots in a dietary-induced obesity model. American Journal of Physiology: Endocrinology and Metabolism, 304(12), E1291-E1302. [More Information]
  • Williams, K., Shackel, N., Gorrell, M., McLennan, S., Twigg, S. (2013). Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocrine Reviews, 34(1), 84-129. [More Information]
  • Constantino, M., Molyneaux, L., Limacher-Gisler, F., Al-Saaed, A., Luo, C., Wu, T., Twigg, S., Yue, D., Wong, J. (2013). Long-Term Complications and Mortality in Young-Onset Diabetes: Type 2 diabetes is more hazardous and lethal than type 1 diabetes. Diabetes Care, 36(12), 3863-3869. [More Information]
  • Min, D., Brooks, B., Wong, J., Salomon, R., Bao, W., Harrisberg, B., Twigg, S., Yue, D., McLennan, S. (2012). Alterations in Monocyte CD16 in Association with Diabetes Complications. Mediators of Inflammation, 2012, 1-10. [More Information]
  • de Silva, H., Firth, S., Twigg, S., Baxter, R. (2012). Interaction Between IGF Binding Protein-3 and TGFb in in the Regulation of Adipocyte Differentiation. Endocrinology, 153(10), 4799-4807. [More Information]
  • Ly, L., Twigg, S., Tran, D., Nguyen, K. (2012). Most type 1 diabetes presenting as diabetic ketoacidosis in Vietnamese people is negative for pancreatic islet cell autoantibodies. Diabetes Research and Clinical Practice, 96(3), e63-e65. [More Information]
  • Jiwa, M., Meng, X., Sriram, D., Hughes, J., Colagiuri, S., Twigg, S., Skinner, T., Shaw, T. (2012). The management of Type 2 diabetes: A survey of Australian general practitioners. Diabetes Research and Clinical Practice, 95(3), 326-332. [More Information]
  • d'Emden, M., Shaw, J., Colman, P., Colagiuri, S., Twigg, S., Jones, G., Goodall, I., Schneider, H., Australian Diabetes Society, A., Royal College of Pathologists of Australasia, R., Cheung, N., et al (2012). The role of HbA1c in the diagnosis of diabetes mellitus in Australia. Medical Journal of Australia, 197(4), 220-221. [More Information]
  • Zimmet, P., Campbell, L., Toomath, R., Twigg, S., Wittert, G., Proietto, J. (2011). Bariatric surgery to treat severely obese patients with type 2 diabetes: A consensus statement. Obesity Research and Clinical Practice, 5(1), e71-e78. [More Information]
  • Wang, X., McLennan, S., Twigg, S. (2011). CCN-2 is up-regulated by and mediates effects of matrix bound advanced glycated end-products in human renal mesangial cells. Journal of Cell Communication and Signaling, 5(3), 193-200. [More Information]
  • Jones, G., Barker, G., Goodall, I., Schneider, H., Shephard, M., Twigg, S. (2011). Change of HbA1c reporting to the new SI units. Medical Journal of Australia, 195(1), 45-46. [More Information]
  • Lo, L., McLennan, S., Williams, P., Bonner, J., Chowdhury, S., McCaughan, G., Gorrell, M., Yue, D., Twigg, S. (2011). Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis. Journal of Hepatology, 55(2), 435-444. [More Information]
  • Hart, S., Abraham, S., Franklin, R., Twigg, S., Russell, J. (2011). Hypoglycaemia following a mixed meal in eating disorder patients. Postgraduate Medical Journal, 87(1028), 405-409. [More Information]
  • Jones, G., Barker, G., Goodall, I., Schneider, H., Shephard, M., Twigg, S. (2011). Reply: Change of glycated haemoglobin (HbA1c) reporting to the new SI units. Medical Journal of Australia, 195(9), 514-515. [More Information]
  • Twigg, S., Irvine, S., Laesk, A., Perbal, B. (2011). Report on the 6th international workshop of the CCN family of genes. Journal of Cell Communication and Signaling, 5(1), 1-3. [More Information]
  • Perera, N., Molyneaux, L., Constantino, M., McGill, M., Yue, D., Twigg, S., Ross, G. (2011). Suboptimal Performance of Blood Glucose Meters in an Antenatal Diabetes Clinic. Diabetes Care, 34(2), 335-337. [More Information]
  • Perera, N., Stewart, P., Williams, P., Chua, E., Yue, D., Twigg, S. (2011). The danger of using inappropriate point-of-care glucose meters in patients on icodextrin dialysis. Diabetic Medicine, 28(10), 1272-1276. [More Information]
  • Perera, N., Harding, A., Constantino, M., Molyneaux, L., McGill, M., Chua, E., Twigg, S., Ross, G., Yue, D. (2011). Triple-B (basal-bolus-booster) subcutaneous insulin regimen: A pragmatic approach to managing hospital inpatient hyperglycaemia. Practical Diabetes, 28(6), 266-269. [More Information]
  • Thomson, S., McLennan, S., Hennessy, A., Boughton, P., Bonner, J., Zoellner, H., Yue, D., Twigg, S. (2010). A novel primate model of delayed wound healing in diabetes: dysregulation of connective tissue growth factor. Diabetologia: clinical and experimental diabetes and metabolism, 53, 572-583. [More Information]
  • Chadban, S., Howell, M., Twigg, S., Thomas, M., Cass, A., Campbell, D., Tong, A., Tong, A., Colagiuri, R., Colagiuri, S., Craig, J., et al (2010). Assessment of kidney function in type 2 diabetes. Nephrology, 15(S1), S146-S161. [More Information]
  • Wong, J., Molyneaux, L., Constantino, M., Twigg, S., Yue, D. (2010). Beyond ONTARGET: Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockade in Combination, a Lesser Evil in Some? Diabetes, Obesity and Metabolism, 12(12), 1072-1078. [More Information]
  • Chadban, S., Howell, M., Twigg, S., Thomas, M., Jerums, G., Cass, A., Campbell, D., Nicholls, K., Tong, A., Mangos, G., et al (2010). Cost-effectiveness and socioeconomic implications of prevention and management of chronic kidney disease in type 2 diabetes. Nephrology, 15(Sup 1), S195-S203. [More Information]
  • Wang, B., Herman-Edelstein, M., Koh, P., Burns, W., Jandeleit-Dahm, K., Watson, A., Saleem, M., Goodall, G., Twigg, S., Cooper, M., et al (2010). E-Cadherin Expression Is Regulated by miR-192/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor-B. Diabetes, 59(7), 1794-1802. [More Information]
  • Fulcher, G., Colagiuri, S., Phillips, P., Prins, J., Sinha, A., Twigg, S., Dalton, B. (2010). Insulin Intensification for People with Type 2 Diabetes: A Practical Approach. The Australasian Medical Journal, 3(12), 808-813. [More Information]
  • Bao, W., Min, D., Twigg, S., Shackel, N., Warner, F., Yue, D., McLennan, S. (2010). Monocyte CD147 is induced by advanced glycation end products and high glucose concentration: possible role in diabetic complications. American Journal of Physiology: Cell Physiology, 299(5), C1212-C1219. [More Information]
  • Tu, E., Bagnall, R., Duflou, J., Lynch, M., Twigg, S., Semsarian, C. (2010). Post-mortem pathologic and genetic studies in "dead in bed syndrome" cases in type 1 diabetes mellitus. Human Pathology, 41(3), 392-400. [More Information]
  • Chadban, S., Howell, M., Twigg, S., Thomas, M., Jerums, G., Cass, A., Campbell, D., Nicholls, K., Tong, A., Mangos, G., et al (2010). Prevention and management of chronic kidney disease in type 2 diabetes. Nephrology, 15(S1), S162-S194. [More Information]
  • Wang, X., McLennan, S., Allen, T., Twigg, S. (2010). Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes. Journal of Cell Communication and Signaling, 4(1), 15-23. [More Information]
  • Ban, C., Twigg, S., Franjic, B., Brooks, B., Celermajer, D., Yue, D., McLennan, S. (2010). Serum MMP-7 is increased in diabetic renal disease and diabetic diastolic dysfunction. Diabetes Research and Clinical Practice, 87(3), 335-341. [More Information]
  • Tu, E., Twigg, S., Semsarian, C. (2010). Sudden death in type 1 diabetes: The mystery of the 'dead in bed' syndrome. International Journal of Cardiology, 138(1), 91-93. [More Information]
  • Baxter, R., Twigg, S. (2009). Actions of IGF binding proteins and related proteins in adipose tissue. Trends in Endocrinology and Metabolism, 20(10), 499-505. [More Information]
  • Wang, X., McLennan, S., Allen, T., Tsoutsman, T., Semsarian, C., Twigg, S. (2009). Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. American Journal of Physiology: Cell Physiology, 297(6), c1490-c1500. [More Information]
  • Loy, C., Twigg, S. (2009). Growth factors, AGEing, and the diabetes link in Alzheimer's disease. Journal of Alzheimer's Disease, 16(4), 823-831. [More Information]
  • Liu, Y., Min, D., Bolton, T., Nube, V., Twigg, S., Yue, D., McLennan, S. (2009). Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers. Diabetes Care, 32(1), 117-119. [More Information]
  • Chan, S., Schedlich, L., Twigg, S., Baxter, R. (2009). Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3. American Journal of Physiology: Endocrinology and Metabolism, 296(4), E654-E663. [More Information]
  • Min, D., Lyons, G., Bonner, J., Twigg, S., Yue, D., McLennan, S. (2009). Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathways: possible pathogenic role in diabetic nephropathy. American Journal of Physiology: Renal Physiology (Print), 297(5), F1229-F1237. [More Information]
  • Wong, J., McLennan, S., Molyneaux, L., Min, D., Twigg, S., Yue, D. (2009). Mitochondrial DNA content in peripheral blood monocytes: relationship with age of diabetes onsetand diabetic complications. Diabetologia: clinical and experimental diabetes and metabolism, 52, 1953-1961. [More Information]
  • Cheung, N., Conn, J., d'Emden, M., Gunton, J., Jenkins, A., Ross, G., Sinha, A., Andrikopoulos, S., Twigg, S. (2009). Position statement of the Australian Diabetes Society: individualisation of glycated haemoglobin targets for adults with diabetes mellitus. Medical Journal of Australia, 191(6), 339-344. [More Information]
  • Tu, E., Twigg, S., Duflou, J., Semsarian, C. (2008). Causes of death in young Australians with type 1 diabetes: a review of coronial postmortem examinations. Medical Journal of Australia, 188(12), 699-702. [More Information]
  • Tan, J., McLennan, S., Song (Wen Chao), W., Lo, L., Bonner, J., Williams, P., Twigg, S. (2008). Connective tissue growth factor inhibits adipocyte differentiation. American Journal of Physiology: Cell Physiology, 295(3), C740-C751. [More Information]
  • Brooks, B., McLennan, S., Twigg, S., Yue, D. (2008). Detection and characterisation of microcirculatory abnormalities in the skin of diabetic patients with microvascular complications. Diabetes and Vascular Disease Research, 5(1), 30-35. [More Information]
  • Wong, J., Molyneaux, L., Zhao, D., Constantino, M., Gray, R., Twigg, S., Xu, Z., Yue, D. (2008). Different accelerators to early-onset Type 2 diabetes: a comparison of Anglo-Celtic and Chinese patients. Journal of Diabetes and Its Complications, 22(6), 389-394. [More Information]
  • Ban, C., Twigg, S. (2008). Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers. Vascular health and risk management, 4(3), 575-596. [More Information]
  • Thomson, S., McLennan, S., Kirwan, P., Heffernan, S., Hennessy, A., Yue, D., Twigg, S. (2008). Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy. Journal of Diabetes and Its Complications, 22(4), 284-294. [More Information]
  • McLennan, S., Bonner, J., Milne, S., Lo, L., Charlton, A., Kurup, S., Jia, J., Yue, D., Twigg, S. (2008). The anti-inflammatory agent Propolis improves wound healing in a rodent model of experimental diabetes. Wound Repair and Regeneration, 16, 706-713. [More Information]
  • Brooks, B., Heffernan, S., Thomson, S., McLennan, S., Twigg, S., Yue, D. (2008). The Effects of Diabetes and Aminoguanidine Treatment on Endothelial Function in a Primate Model of Type 1 Diabetes. American Journal of Primatology, 70(8), 796-802. [More Information]
  • McGill, M., Molyneaux, L., Twigg, S., Yue, D. (2008). The metabolic syndrome in type 1 diabetes: does it exist and does it matter? Journal of Diabetes and Its Complications, 22(1), 18-23. [More Information]
  • Wong, J., Twigg, S., Molyneaux, L., Yue, D., Constantino, M. (2008). Timing is Everything: Age of Onset Influences Long-Term Retinopathy Risk in Type 2 Diabetes, Independent of Traditional Risk Factors. Diabetes Care, 31(10), 1985-1990. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia: clinical and experimental diabetes and metabolism, 50(9), 1969-1976. [More Information]
  • Xu, L., McLennan, S., Lo, L., Natfaji, A., Bolton, T., Liu, Y., Twigg, S., Yue, D. (2007). Bacterial load predicts healing rate in neuropathic diabetic foot ulcers. Diabetes Care, 30(2), 378-380. [More Information]
  • Brooks, B., Franjic, B., Ban, C., Swaraj, K., Yue, D., Celermajer, D., Twigg, S. (2007). Diastolic dysfunction and abnormalities of the microcirculation in type 2 diabetes. Diabetes, Obesity and Metabolism, online publication(doi: 10.1111/j.1463-1326.2007.00803.x), 1-8. [More Information]
  • McLennan, S., McGill, M., Twigg, S., Yue, D. (2007). Improving wound-healing outcomes in diabetic foot ulcers. Expert Review of Endocrinology and Metabolism, 2, 205-213.
  • Xie, L., Galettis, A., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2007). Intercellular adhesion molecule-1 (ICAM-1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy. Diabetes - Metabolism: Research and Reviews, Online: 7 Nov 2007, 1-9. [More Information]
  • Twigg, S., Kamp, M., Davis, T., Neylon, E., Flack, J. (2007). Prediabetes: a position statement from the Australian Diabetes Society and Australian Diabetes Educators Association. Medical Journal of Australia, 186(9), 461-465. [More Information]
  • Qi, W., Chen, X., Twigg, S., Zhang, Y., Gilbert, R., Kelly, D., Pollock, C. (2007). The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1. Nephrology, 12(3), 267-274. [More Information]
  • Burgess, J., Ge, Q., Poniris, M., Boustany, S., Twigg, S., Black, J., Johnson, P. (2006). Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix. American Journal of Physiology: Lung Cellular and Molecular Physiology, 290(1), L153-L161. [More Information]
  • Johnson, P., Burgess, J., Ge, Q., Poniris, M., Boustany, S., Twigg, S., Black, J. (2006). Connective tissue growth factor induces extracellular matrix in asthmatic airway smooth muscle. American Journal of Respiratory and Critical Care Medicine, 173(1), 32-41. [More Information]
  • Burns, W., Twigg, S., Forbes, J., Pete, J., Tikellis, C., Thallas-Bonke, V., Thomas, M., Cooper, M., Kantharidis, P. (2006). Connective Tissue Growth Factor Plays an Important Role in Advanced Glycation End Product-Induced Tubular Epithelial-to-Mesenchymal Transition: Implications for Diabetic Renal Disease. Journal of the American Society of Nephrology, 17(9), 2484-2494. [More Information]
  • Thomson, S., McLennan, S., Twigg, S. (2006). Growth factors in diabetic complications. Expert Review of Clinical Immunology, 2(3), 403-18. [More Information]
  • Samaras, K., McElduff, A., Twigg, S., Proietto, J., Prins, J., Welborn, T., Zimmet, P., Chisholm, D., Campbell, L. (2006). Insulin levels in insulin resistance: phantom of the metabolic opera? Medical Journal of Australia, 185(3), 159-161. [More Information]
  • Ong, C., Molyneaux, L., Constantino, M., Twigg, S., Yue, D. (2006). Long-term efficacy of metformin therapy in nonobese individuals with type 2 diabetes. Diabetes Care, 29(11), 2361-2364. [More Information]
  • Qi, W., Chen, X., Polhill, T., Sumual, S., Twigg, S., Gilbert, R., Pollock, C. (2006). TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. American Journal of Physiology: Renal Physiology (Print), 290(3), F703-F709. [More Information]
  • Molyneaux, L., Twigg, S., Yue, D., Constantino, M., Wong, J. (2006). The metabolic syndrome in type 2 diabetes: When does it matter? Diabetes, Obesity and Metabolism, 8(6), 690-697. [More Information]
  • Qi, W., Chen, X., Twigg, S., Polhill, T., Gilbert, R., Pollock, C. (2006). Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells. Kidney International, 69(6), 989-995. [More Information]
  • Qi, W., Twigg, S., Pollock, C., Holian, J., Mreich, E., Gilbert, R., Chen, X. (2006). Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells. American Journal of Physiology: Renal Physiology (Print), 291, F1070-F1077. [More Information]
  • Dean, R., Balding, L., Candido, R., Burns, W., Cao, Z., Twigg, S., Burrell, L. (2005). Connective tissue growth factor and cardiac fibrosis after myocardial infarction. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 53(10), 1245-1256. [More Information]
  • Chan, S., Twigg, S., Firth, S., Baxter, R. (2005). Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes. Journal of Clinical Endocrinology and Metabolism, 90(12), 6588-6595. [More Information]
  • Qi, W., Twigg, S., Chen, X., Polhill, T., Poronnik, P., Gilbert, R., Pollock, C. (2005). Integrated actions of transforming growth factor-beta(1) and connective tissue growth factor in renal fibrosis. American Journal of Physiology: Renal Physiology (Print), 288(4), F800-F809.
  • McLennan, S., Wang, X., Moreno, V., Yue, D., Twigg, S. (2004). Connective Tissue Growth Factor Mediates High Glucose Effects On Matrix Degradation Through Tissue Inhibitor Of Matrix Metalloproteinase Type 1: Implications For Diabetic Nephropathy. Endocrinology, 145(12), 5646-5655.
  • Galettis, A., Campbell, S., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2004). Monocyte adhesion to decidual endothelial cells is increased in pregnancies complicated by Type 1 diabetes but not by gestational diabetes. Diabetes Care, 27(10), 2514-2515.
  • Twigg, S., Cooper, M. (2004). The time has come to target connective tissue growth factor in diabetic complications. Diabetologia: clinical and experimental diabetes and metabolism, 47(6), 965-968.
  • Candido, R., Forbes, J., Thomas, M., Thallas, V., Dean, R., Burns, W., Tikellis, C., Ritchie, R., Twigg, S., Cooper, M., et al (2003). A breaker of advanced Glycation end products attenuates diabetes-induced myocardial structural changes. Circulation Research, 92(7), 785-792.
  • Tikellis, C., Cooper, M., Twigg, S., Burns, W., Tolcos, M. (2003). Connective tissue growth factor is up-regulated in the diabetic retina: amelioration by angiotensin-converting enzyme inhibition. Endocrinology, 145(2), 860-866.
  • Cooper, L., Clifton-Bligh, P., Nery, M., Figtree, G., Twigg, S., Hibbert, E., Robinson, B. (2003). Vitamin D supplementation and bone mineral density in early postmenopausal women. American Journal of Clinical Nutrition, 77(5), 1324-1329.
  • Tsubaki, J., Hwa, V., Twigg, S., Rosenfeld, R. (2002). Differential Activation of the IGF Binding Protein-3 Promoter by Butyrate in Prostate Cancer Cells. Endocrinology, 143(5), 1778-1788.
  • Dwight, T., Philips, J., Robinson, B., Twigg, S., Kytola, S., Delbridge, L., Teh, B., Marsh, D., Theodosopoulos, G., Nelson, A., et al (2002). Genetic analysis of lithium-associated parathyroid tumors. European Journal of Endocrinology, 146(5), 619-627.
  • Candido, R., Jandeleit-Dahm, K., Zemin, C., Nesteroff, S., Burns, W., Twigg, S., Dilley, R., Cooper, M., Allen, T. (2002). Prevention of Accelerated Atherosclerosis by Angiotensin-Converting Enzyme Inhibition in Diabetic Apolipoprotein E-Deficient Mice. Circulation, 106(2), 246-253.
  • Twigg, S., Zemin, C., McLennan, S., Burns, W., Brammar, G., Forbes, J., Cooper, M. (2002). Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Endocrinology, 143(12), 4907-4915.
  • Twigg, S., Chen, M., Joly, A., Chakrapani, S., Tsubaki, J., Kim,, H., Oh,, Y., Rosenfeld, R. (2001). Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: a potential mechanism for expansion of extacellular matrix in diabetes mellitus. Endocrinology, 142(5), 1760-1769.
  • Twigg, S., Tsubaki, J., Choi,, W., Ingermann, A., Kim,, H., Rosenfeld, R., Oh,, Y. (2001). Effects of sodium butyrate on expression of members of the IGF-binding protein superfamily in human mammary epithelial cells. Journal of Endocrinology, 169, 97-110.

Conferences

  • Monkaresi, H., Calvo, R., Chow, K., Mullan, B., Lam, M., Twigg, S., Cook, D. (2013). Intelligent Diabetes Lifestyle Coach. 25th Australian Computer-Human Interaction Conference: Augmentation, Application, Innovation, Collaboration (OzCHI 2013), Adelaide, Australia: Association for Computing Machinery (ACM).
  • Thomson, S., McLennan, S., Hennessy, A., Bonner, J., Zoellner, H., Yue, D., Twigg, S. (2007). Dysregulated inflammation predicts reduced connective tissue growth factor expression in a baboon wound healing model of type 1 diabetes. The 43rd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Ferreira, S., Ramachandran, A., Aschner, P., Chan, J., Hancu, N., Baik, S., Ilkova, H., Twigg, S., Gagliardino, J. (2006). Basic characteristics and treatment regimens in people with type 1 diabetes in the international diabetes management practices study (IDMPS). 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Hancu, N., Baik, S., Ferreira, S., Gagliardino, J., Chan, J., Aschner, P., Ramachandran, A., Twigg, S., Ilkova, H. (2006). Basic characteristics and treatment regimens in people with type 2 diabetes in the international diabetes management practices study (IDMPS). 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Ramachandran, A., Aschner, P., Chan, J., Hancu, N., Baik, S., Ferreira, S., Ilkova, H., Twigg, S., Gagliardino, J. (2006). Complications and cardiovascular risk factors in people with type 1 diabetes in the International Diabetes Management Practices Study (IDMPS). 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Gagliardino, J., Aschner, P., Baik, S., Chan, J., Ferreira, S., Hancu, N., Ilkova, H., Twigg, S., Ramachandran, A. (2006). Hypoglycaemia and self-monitoring blood glucose are predictive factors for achieving glycaemic control in people with diabetes. 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • McLennan, S., Jia, J., Milne, S., Lo, L., Bonner, J., Yue, D., Twigg, S. (2006). Propolis, the anti-inflammatory bee hive protectant improves wound healing in experimental diabetes. 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Qi, W., Chen, X., Holian, J., Twigg, S., Gilbert, R., Pollock, C. (2006). Transforming growth factor-beta1 differentially mediates fibrosis and immunomodulation in kidney tubular cells. XLIII ERA-EDTA Congress, United Kingdom: Oxford University Press.

Patents

  • Chadban, S., Howell, M., Twigg, S., Thomas, M., Jerums, G., Nicholls, K., Mangos, G., Tong, A., Stack, A., McIsaac, R., Girgis, S., Colagiuri, S., Colagiuri, R., Craig, J. (2009).

2014

  • Azzi, M., Constantino, M., Pont, L., McGill, M., Twigg, S., Krass, I. (2014). Medication Safety: an audit of medication discrepancies in transferring type 2 diabetes mellitus (T2DM) patients from Australian primary care to tertiary ambulatory care. International Journal for Quality in Health Care, 26(4), 397-403. [More Information]
  • Keane, F., Tsun-Wen, Y., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]
  • Shun, C., Donaghue, K., Phelan, H., Twigg, S., Craig, M. (2014). Thyroid autoimmunity in Type 1 diabetes: systematic review and meta-analysis. Diabetic Medicine, 31(2), 126-135. [More Information]

2013

  • Hibbert, E., Lambert, T., Carter, J., Learoyd, D., Twigg, S., Clarke, S. (2013). A randomized controlled pilot trial comparing the impact of access to clinical endocrinology video demonstrations with access to usual revision resources on medical student performance of clinical endocrinology skills. BMC Medical Education, 13(1), 1-10. [More Information]
  • Klocker, A., Phelan, H., Twigg, S., Craig, M. (2013). Blood β-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes: a systematic review. Diabetic Medicine, 30(7), 818-824. [More Information]
  • Tsoutsman, T., Wang, X., Garchow, K., Riser, B., Twigg, S., Semsarian, C. (2013). CCN2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. Journal of Molecular and Cellular Cardiology, 62, 164-178. [More Information]
  • McLennan, S., Abdollahi, M., Twigg, S. (2013). Connective tissue growth factor, matrix regulation, and diabetic kidney disease. Current Opinion In Nephrology And Hypertension, 22(1), 85-92. [More Information]
  • Tan, J., McLennan, S., Williams, P., Rezaeizadeh, A., Lo, L., Bonner, J., Twigg, S. (2013). Connective tissue growth factor/CCN-2 is upregulated in epididymal and subcutaneous fat depots in a dietary-induced obesity model. American Journal of Physiology: Endocrinology and Metabolism, 304(12), E1291-E1302. [More Information]
  • Williams, K., Shackel, N., Gorrell, M., McLennan, S., Twigg, S. (2013). Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocrine Reviews, 34(1), 84-129. [More Information]
  • Monkaresi, H., Calvo, R., Chow, K., Mullan, B., Lam, M., Twigg, S., Cook, D. (2013). Intelligent Diabetes Lifestyle Coach. 25th Australian Computer-Human Interaction Conference: Augmentation, Application, Innovation, Collaboration (OzCHI 2013), Adelaide, Australia: Association for Computing Machinery (ACM).
  • Constantino, M., Molyneaux, L., Limacher-Gisler, F., Al-Saaed, A., Luo, C., Wu, T., Twigg, S., Yue, D., Wong, J. (2013). Long-Term Complications and Mortality in Young-Onset Diabetes: Type 2 diabetes is more hazardous and lethal than type 1 diabetes. Diabetes Care, 36(12), 3863-3869. [More Information]

2012

  • Baur, L., Twigg, S., Magnusson, R. (2012). A Modern Epidemic: Expert Perspectives on Obesity and Diabetes. Sydney, Australia: Sydney University Press.
  • Min, D., Brooks, B., Wong, J., Salomon, R., Bao, W., Harrisberg, B., Twigg, S., Yue, D., McLennan, S. (2012). Alterations in Monocyte CD16 in Association with Diabetes Complications. Mediators of Inflammation, 2012, 1-10. [More Information]
  • de Silva, H., Firth, S., Twigg, S., Baxter, R. (2012). Interaction Between IGF Binding Protein-3 and TGFb in in the Regulation of Adipocyte Differentiation. Endocrinology, 153(10), 4799-4807. [More Information]
  • Twigg, S., McLennan, S. (2012). Managing diabetes complications in the clinical arena. In Louise A. Baur, Stephen M. Twigg, Roger S.Magnusson (Eds.), A Modern Epidemic: Expert Perspectives on Obesity and Diabetes, (pp. 353-371). Sydney, Australia: Sydney University Press.
  • Ly, L., Twigg, S., Tran, D., Nguyen, K. (2012). Most type 1 diabetes presenting as diabetic ketoacidosis in Vietnamese people is negative for pancreatic islet cell autoantibodies. Diabetes Research and Clinical Practice, 96(3), e63-e65. [More Information]
  • Jiwa, M., Meng, X., Sriram, D., Hughes, J., Colagiuri, S., Twigg, S., Skinner, T., Shaw, T. (2012). The management of Type 2 diabetes: A survey of Australian general practitioners. Diabetes Research and Clinical Practice, 95(3), 326-332. [More Information]
  • d'Emden, M., Shaw, J., Colman, P., Colagiuri, S., Twigg, S., Jones, G., Goodall, I., Schneider, H., Australian Diabetes Society, A., Royal College of Pathologists of Australasia, R., Cheung, N., et al (2012). The role of HbA1c in the diagnosis of diabetes mellitus in Australia. Medical Journal of Australia, 197(4), 220-221. [More Information]

2011

  • Zimmet, P., Campbell, L., Toomath, R., Twigg, S., Wittert, G., Proietto, J. (2011). Bariatric surgery to treat severely obese patients with type 2 diabetes: A consensus statement. Obesity Research and Clinical Practice, 5(1), e71-e78. [More Information]
  • Wang, X., McLennan, S., Twigg, S. (2011). CCN-2 is up-regulated by and mediates effects of matrix bound advanced glycated end-products in human renal mesangial cells. Journal of Cell Communication and Signaling, 5(3), 193-200. [More Information]
  • Jones, G., Barker, G., Goodall, I., Schneider, H., Shephard, M., Twigg, S. (2011). Change of HbA1c reporting to the new SI units. Medical Journal of Australia, 195(1), 45-46. [More Information]
  • Lo, L., McLennan, S., Williams, P., Bonner, J., Chowdhury, S., McCaughan, G., Gorrell, M., Yue, D., Twigg, S. (2011). Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis. Journal of Hepatology, 55(2), 435-444. [More Information]
  • Hart, S., Abraham, S., Franklin, R., Twigg, S., Russell, J. (2011). Hypoglycaemia following a mixed meal in eating disorder patients. Postgraduate Medical Journal, 87(1028), 405-409. [More Information]
  • Twigg, S., Craig, M., Cheung, N., Donaghue, K., Jenkins, A., Conn, J., Cameron, F. (2011). National Evidence-Based Clinical Care Guidelines for Type 1 Diabetes in Children, Adolescents and Adults. Australia: Australian Government Department of Health and Age , Australia.
  • Jones, G., Barker, G., Goodall, I., Schneider, H., Shephard, M., Twigg, S. (2011). Reply: Change of glycated haemoglobin (HbA1c) reporting to the new SI units. Medical Journal of Australia, 195(9), 514-515. [More Information]
  • Twigg, S., Irvine, S., Laesk, A., Perbal, B. (2011). Report on the 6th international workshop of the CCN family of genes. Journal of Cell Communication and Signaling, 5(1), 1-3. [More Information]
  • Perera, N., Molyneaux, L., Constantino, M., McGill, M., Yue, D., Twigg, S., Ross, G. (2011). Suboptimal Performance of Blood Glucose Meters in an Antenatal Diabetes Clinic. Diabetes Care, 34(2), 335-337. [More Information]
  • Perera, N., Stewart, P., Williams, P., Chua, E., Yue, D., Twigg, S. (2011). The danger of using inappropriate point-of-care glucose meters in patients on icodextrin dialysis. Diabetic Medicine, 28(10), 1272-1276. [More Information]
  • Perera, N., Harding, A., Constantino, M., Molyneaux, L., McGill, M., Chua, E., Twigg, S., Ross, G., Yue, D. (2011). Triple-B (basal-bolus-booster) subcutaneous insulin regimen: A pragmatic approach to managing hospital inpatient hyperglycaemia. Practical Diabetes, 28(6), 266-269. [More Information]

2010

  • Thomson, S., McLennan, S., Hennessy, A., Boughton, P., Bonner, J., Zoellner, H., Yue, D., Twigg, S. (2010). A novel primate model of delayed wound healing in diabetes: dysregulation of connective tissue growth factor. Diabetologia: clinical and experimental diabetes and metabolism, 53, 572-583. [More Information]
  • Chadban, S., Howell, M., Twigg, S., Thomas, M., Cass, A., Campbell, D., Tong, A., Tong, A., Colagiuri, R., Colagiuri, S., Craig, J., et al (2010). Assessment of kidney function in type 2 diabetes. Nephrology, 15(S1), S146-S161. [More Information]
  • Wong, J., Molyneaux, L., Constantino, M., Twigg, S., Yue, D. (2010). Beyond ONTARGET: Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockade in Combination, a Lesser Evil in Some? Diabetes, Obesity and Metabolism, 12(12), 1072-1078. [More Information]
  • Chadban, S., Howell, M., Twigg, S., Thomas, M., Jerums, G., Cass, A., Campbell, D., Nicholls, K., Tong, A., Mangos, G., et al (2010). Cost-effectiveness and socioeconomic implications of prevention and management of chronic kidney disease in type 2 diabetes. Nephrology, 15(Sup 1), S195-S203. [More Information]
  • Wang, B., Herman-Edelstein, M., Koh, P., Burns, W., Jandeleit-Dahm, K., Watson, A., Saleem, M., Goodall, G., Twigg, S., Cooper, M., et al (2010). E-Cadherin Expression Is Regulated by miR-192/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor-B. Diabetes, 59(7), 1794-1802. [More Information]
  • Fulcher, G., Colagiuri, S., Phillips, P., Prins, J., Sinha, A., Twigg, S., Dalton, B. (2010). Insulin Intensification for People with Type 2 Diabetes: A Practical Approach. The Australasian Medical Journal, 3(12), 808-813. [More Information]
  • Bao, W., Min, D., Twigg, S., Shackel, N., Warner, F., Yue, D., McLennan, S. (2010). Monocyte CD147 is induced by advanced glycation end products and high glucose concentration: possible role in diabetic complications. American Journal of Physiology: Cell Physiology, 299(5), C1212-C1219. [More Information]
  • Tu, E., Bagnall, R., Duflou, J., Lynch, M., Twigg, S., Semsarian, C. (2010). Post-mortem pathologic and genetic studies in "dead in bed syndrome" cases in type 1 diabetes mellitus. Human Pathology, 41(3), 392-400. [More Information]
  • Chadban, S., Howell, M., Twigg, S., Thomas, M., Jerums, G., Cass, A., Campbell, D., Nicholls, K., Tong, A., Mangos, G., et al (2010). Prevention and management of chronic kidney disease in type 2 diabetes. Nephrology, 15(S1), S162-S194. [More Information]
  • Wang, X., McLennan, S., Allen, T., Twigg, S. (2010). Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes. Journal of Cell Communication and Signaling, 4(1), 15-23. [More Information]
  • Ban, C., Twigg, S., Franjic, B., Brooks, B., Celermajer, D., Yue, D., McLennan, S. (2010). Serum MMP-7 is increased in diabetic renal disease and diabetic diastolic dysfunction. Diabetes Research and Clinical Practice, 87(3), 335-341. [More Information]
  • Tu, E., Twigg, S., Semsarian, C. (2010). Sudden death in type 1 diabetes: The mystery of the 'dead in bed' syndrome. International Journal of Cardiology, 138(1), 91-93. [More Information]

2009

  • Baxter, R., Twigg, S. (2009). Actions of IGF binding proteins and related proteins in adipose tissue. Trends in Endocrinology and Metabolism, 20(10), 499-505. [More Information]
  • Wang, X., McLennan, S., Allen, T., Tsoutsman, T., Semsarian, C., Twigg, S. (2009). Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. American Journal of Physiology: Cell Physiology, 297(6), c1490-c1500. [More Information]
  • Loy, C., Twigg, S. (2009). Growth factors, AGEing, and the diabetes link in Alzheimer's disease. Journal of Alzheimer's Disease, 16(4), 823-831. [More Information]
  • Chadban, S., Howell, M., Twigg, S., Thomas, M., Jerums, G., Nicholls, K., Mangos, G., Tong, A., Stack, A., McIsaac, R., Girgis, S., Colagiuri, S., Colagiuri, R., Craig, J. (2009).
  • Liu, Y., Min, D., Bolton, T., Nube, V., Twigg, S., Yue, D., McLennan, S. (2009). Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers. Diabetes Care, 32(1), 117-119. [More Information]
  • Chan, S., Schedlich, L., Twigg, S., Baxter, R. (2009). Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3. American Journal of Physiology: Endocrinology and Metabolism, 296(4), E654-E663. [More Information]
  • Min, D., Lyons, G., Bonner, J., Twigg, S., Yue, D., McLennan, S. (2009). Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathways: possible pathogenic role in diabetic nephropathy. American Journal of Physiology: Renal Physiology (Print), 297(5), F1229-F1237. [More Information]
  • Wong, J., McLennan, S., Molyneaux, L., Min, D., Twigg, S., Yue, D. (2009). Mitochondrial DNA content in peripheral blood monocytes: relationship with age of diabetes onsetand diabetic complications. Diabetologia: clinical and experimental diabetes and metabolism, 52, 1953-1961. [More Information]
  • Cheung, N., Conn, J., d'Emden, M., Gunton, J., Jenkins, A., Ross, G., Sinha, A., Andrikopoulos, S., Twigg, S. (2009). Position statement of the Australian Diabetes Society: individualisation of glycated haemoglobin targets for adults with diabetes mellitus. Medical Journal of Australia, 191(6), 339-344. [More Information]

2008

  • Tu, E., Twigg, S., Duflou, J., Semsarian, C. (2008). Causes of death in young Australians with type 1 diabetes: a review of coronial postmortem examinations. Medical Journal of Australia, 188(12), 699-702. [More Information]
  • Tan, J., McLennan, S., Song (Wen Chao), W., Lo, L., Bonner, J., Williams, P., Twigg, S. (2008). Connective tissue growth factor inhibits adipocyte differentiation. American Journal of Physiology: Cell Physiology, 295(3), C740-C751. [More Information]
  • Brooks, B., McLennan, S., Twigg, S., Yue, D. (2008). Detection and characterisation of microcirculatory abnormalities in the skin of diabetic patients with microvascular complications. Diabetes and Vascular Disease Research, 5(1), 30-35. [More Information]
  • Wong, J., Molyneaux, L., Zhao, D., Constantino, M., Gray, R., Twigg, S., Xu, Z., Yue, D. (2008). Different accelerators to early-onset Type 2 diabetes: a comparison of Anglo-Celtic and Chinese patients. Journal of Diabetes and Its Complications, 22(6), 389-394. [More Information]
  • Ban, C., Twigg, S. (2008). Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers. Vascular health and risk management, 4(3), 575-596. [More Information]
  • Thomson, S., McLennan, S., Kirwan, P., Heffernan, S., Hennessy, A., Yue, D., Twigg, S. (2008). Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy. Journal of Diabetes and Its Complications, 22(4), 284-294. [More Information]
  • McLennan, S., Bonner, J., Milne, S., Lo, L., Charlton, A., Kurup, S., Jia, J., Yue, D., Twigg, S. (2008). The anti-inflammatory agent Propolis improves wound healing in a rodent model of experimental diabetes. Wound Repair and Regeneration, 16, 706-713. [More Information]
  • Brooks, B., Heffernan, S., Thomson, S., McLennan, S., Twigg, S., Yue, D. (2008). The Effects of Diabetes and Aminoguanidine Treatment on Endothelial Function in a Primate Model of Type 1 Diabetes. American Journal of Primatology, 70(8), 796-802. [More Information]
  • McGill, M., Molyneaux, L., Twigg, S., Yue, D. (2008). The metabolic syndrome in type 1 diabetes: does it exist and does it matter? Journal of Diabetes and Its Complications, 22(1), 18-23. [More Information]
  • Wong, J., Twigg, S., Molyneaux, L., Yue, D., Constantino, M. (2008). Timing is Everything: Age of Onset Influences Long-Term Retinopathy Risk in Type 2 Diabetes, Independent of Traditional Risk Factors. Diabetes Care, 31(10), 1985-1990. [More Information]

2007

  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia: clinical and experimental diabetes and metabolism, 50(9), 1969-1976. [More Information]
  • Xu, L., McLennan, S., Lo, L., Natfaji, A., Bolton, T., Liu, Y., Twigg, S., Yue, D. (2007). Bacterial load predicts healing rate in neuropathic diabetic foot ulcers. Diabetes Care, 30(2), 378-380. [More Information]
  • Brooks, B., Franjic, B., Ban, C., Swaraj, K., Yue, D., Celermajer, D., Twigg, S. (2007). Diastolic dysfunction and abnormalities of the microcirculation in type 2 diabetes. Diabetes, Obesity and Metabolism, online publication(doi: 10.1111/j.1463-1326.2007.00803.x), 1-8. [More Information]
  • Thomson, S., McLennan, S., Hennessy, A., Bonner, J., Zoellner, H., Yue, D., Twigg, S. (2007). Dysregulated inflammation predicts reduced connective tissue growth factor expression in a baboon wound healing model of type 1 diabetes. The 43rd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • McLennan, S., McGill, M., Twigg, S., Yue, D. (2007). Improving wound-healing outcomes in diabetic foot ulcers. Expert Review of Endocrinology and Metabolism, 2, 205-213.
  • Xie, L., Galettis, A., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2007). Intercellular adhesion molecule-1 (ICAM-1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy. Diabetes - Metabolism: Research and Reviews, Online: 7 Nov 2007, 1-9. [More Information]
  • Twigg, S., Kamp, M., Davis, T., Neylon, E., Flack, J. (2007). Prediabetes: a position statement from the Australian Diabetes Society and Australian Diabetes Educators Association. Medical Journal of Australia, 186(9), 461-465. [More Information]
  • Qi, W., Chen, X., Twigg, S., Zhang, Y., Gilbert, R., Kelly, D., Pollock, C. (2007). The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1. Nephrology, 12(3), 267-274. [More Information]

2006

  • Ferreira, S., Ramachandran, A., Aschner, P., Chan, J., Hancu, N., Baik, S., Ilkova, H., Twigg, S., Gagliardino, J. (2006). Basic characteristics and treatment regimens in people with type 1 diabetes in the international diabetes management practices study (IDMPS). 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Hancu, N., Baik, S., Ferreira, S., Gagliardino, J., Chan, J., Aschner, P., Ramachandran, A., Twigg, S., Ilkova, H. (2006). Basic characteristics and treatment regimens in people with type 2 diabetes in the international diabetes management practices study (IDMPS). 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Ramachandran, A., Aschner, P., Chan, J., Hancu, N., Baik, S., Ferreira, S., Ilkova, H., Twigg, S., Gagliardino, J. (2006). Complications and cardiovascular risk factors in people with type 1 diabetes in the International Diabetes Management Practices Study (IDMPS). 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Burgess, J., Ge, Q., Poniris, M., Boustany, S., Twigg, S., Black, J., Johnson, P. (2006). Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix. American Journal of Physiology: Lung Cellular and Molecular Physiology, 290(1), L153-L161. [More Information]
  • Johnson, P., Burgess, J., Ge, Q., Poniris, M., Boustany, S., Twigg, S., Black, J. (2006). Connective tissue growth factor induces extracellular matrix in asthmatic airway smooth muscle. American Journal of Respiratory and Critical Care Medicine, 173(1), 32-41. [More Information]
  • Burns, W., Twigg, S., Forbes, J., Pete, J., Tikellis, C., Thallas-Bonke, V., Thomas, M., Cooper, M., Kantharidis, P. (2006). Connective Tissue Growth Factor Plays an Important Role in Advanced Glycation End Product-Induced Tubular Epithelial-to-Mesenchymal Transition: Implications for Diabetic Renal Disease. Journal of the American Society of Nephrology, 17(9), 2484-2494. [More Information]
  • Thomson, S., McLennan, S., Twigg, S. (2006). Growth factors in diabetic complications. Expert Review of Clinical Immunology, 2(3), 403-18. [More Information]
  • Gagliardino, J., Aschner, P., Baik, S., Chan, J., Ferreira, S., Hancu, N., Ilkova, H., Twigg, S., Ramachandran, A. (2006). Hypoglycaemia and self-monitoring blood glucose are predictive factors for achieving glycaemic control in people with diabetes. 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Samaras, K., McElduff, A., Twigg, S., Proietto, J., Prins, J., Welborn, T., Zimmet, P., Chisholm, D., Campbell, L. (2006). Insulin levels in insulin resistance: phantom of the metabolic opera? Medical Journal of Australia, 185(3), 159-161. [More Information]
  • Ong, C., Molyneaux, L., Constantino, M., Twigg, S., Yue, D. (2006). Long-term efficacy of metformin therapy in nonobese individuals with type 2 diabetes. Diabetes Care, 29(11), 2361-2364. [More Information]
  • McLennan, S., Jia, J., Milne, S., Lo, L., Bonner, J., Yue, D., Twigg, S. (2006). Propolis, the anti-inflammatory bee hive protectant improves wound healing in experimental diabetes. 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Qi, W., Chen, X., Polhill, T., Sumual, S., Twigg, S., Gilbert, R., Pollock, C. (2006). TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. American Journal of Physiology: Renal Physiology (Print), 290(3), F703-F709. [More Information]
  • Molyneaux, L., Twigg, S., Yue, D., Constantino, M., Wong, J. (2006). The metabolic syndrome in type 2 diabetes: When does it matter? Diabetes, Obesity and Metabolism, 8(6), 690-697. [More Information]
  • Qi, W., Chen, X., Twigg, S., Polhill, T., Gilbert, R., Pollock, C. (2006). Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells. Kidney International, 69(6), 989-995. [More Information]
  • Qi, W., Twigg, S., Pollock, C., Holian, J., Mreich, E., Gilbert, R., Chen, X. (2006). Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells. American Journal of Physiology: Renal Physiology (Print), 291, F1070-F1077. [More Information]
  • Qi, W., Chen, X., Holian, J., Twigg, S., Gilbert, R., Pollock, C. (2006). Transforming growth factor-beta1 differentially mediates fibrosis and immunomodulation in kidney tubular cells. XLIII ERA-EDTA Congress, United Kingdom: Oxford University Press.

2005

  • Dean, R., Balding, L., Candido, R., Burns, W., Cao, Z., Twigg, S., Burrell, L. (2005). Connective tissue growth factor and cardiac fibrosis after myocardial infarction. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 53(10), 1245-1256. [More Information]
  • Chan, S., Twigg, S., Firth, S., Baxter, R. (2005). Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes. Journal of Clinical Endocrinology and Metabolism, 90(12), 6588-6595. [More Information]
  • Qi, W., Twigg, S., Chen, X., Polhill, T., Poronnik, P., Gilbert, R., Pollock, C. (2005). Integrated actions of transforming growth factor-beta(1) and connective tissue growth factor in renal fibrosis. American Journal of Physiology: Renal Physiology (Print), 288(4), F800-F809.

2004

  • McLennan, S., Wang, X., Moreno, V., Yue, D., Twigg, S. (2004). Connective Tissue Growth Factor Mediates High Glucose Effects On Matrix Degradation Through Tissue Inhibitor Of Matrix Metalloproteinase Type 1: Implications For Diabetic Nephropathy. Endocrinology, 145(12), 5646-5655.
  • Galettis, A., Campbell, S., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2004). Monocyte adhesion to decidual endothelial cells is increased in pregnancies complicated by Type 1 diabetes but not by gestational diabetes. Diabetes Care, 27(10), 2514-2515.
  • Twigg, S., Cooper, M. (2004). The time has come to target connective tissue growth factor in diabetic complications. Diabetologia: clinical and experimental diabetes and metabolism, 47(6), 965-968.

2003

  • Candido, R., Forbes, J., Thomas, M., Thallas, V., Dean, R., Burns, W., Tikellis, C., Ritchie, R., Twigg, S., Cooper, M., et al (2003). A breaker of advanced Glycation end products attenuates diabetes-induced myocardial structural changes. Circulation Research, 92(7), 785-792.
  • Tikellis, C., Cooper, M., Twigg, S., Burns, W., Tolcos, M. (2003). Connective tissue growth factor is up-regulated in the diabetic retina: amelioration by angiotensin-converting enzyme inhibition. Endocrinology, 145(2), 860-866.
  • Cooper, L., Clifton-Bligh, P., Nery, M., Figtree, G., Twigg, S., Hibbert, E., Robinson, B. (2003). Vitamin D supplementation and bone mineral density in early postmenopausal women. American Journal of Clinical Nutrition, 77(5), 1324-1329.

2002

  • Tsubaki, J., Hwa, V., Twigg, S., Rosenfeld, R. (2002). Differential Activation of the IGF Binding Protein-3 Promoter by Butyrate in Prostate Cancer Cells. Endocrinology, 143(5), 1778-1788.
  • Dwight, T., Philips, J., Robinson, B., Twigg, S., Kytola, S., Delbridge, L., Teh, B., Marsh, D., Theodosopoulos, G., Nelson, A., et al (2002). Genetic analysis of lithium-associated parathyroid tumors. European Journal of Endocrinology, 146(5), 619-627.
  • Candido, R., Jandeleit-Dahm, K., Zemin, C., Nesteroff, S., Burns, W., Twigg, S., Dilley, R., Cooper, M., Allen, T. (2002). Prevention of Accelerated Atherosclerosis by Angiotensin-Converting Enzyme Inhibition in Diabetic Apolipoprotein E-Deficient Mice. Circulation, 106(2), 246-253.
  • Twigg, S., Zemin, C., McLennan, S., Burns, W., Brammar, G., Forbes, J., Cooper, M. (2002). Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Endocrinology, 143(12), 4907-4915.

2001

  • Twigg, S., Chen, M., Joly, A., Chakrapani, S., Tsubaki, J., Kim,, H., Oh,, Y., Rosenfeld, R. (2001). Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: a potential mechanism for expansion of extacellular matrix in diabetes mellitus. Endocrinology, 142(5), 1760-1769.
  • Twigg, S., Tsubaki, J., Choi,, W., Ingermann, A., Kim,, H., Rosenfeld, R., Oh,, Y. (2001). Effects of sodium butyrate on expression of members of the IGF-binding protein superfamily in human mammary epithelial cells. Journal of Endocrinology, 169, 97-110.

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