Dr Stuart Fraser

Senior Lecturer
Physiology, School of Medical Sciences

Telephone +61 2 9036 3313
Fax +61 2 9036 3316

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Biographical details

Dr. Fraser joined the Discipline of Physiology as Sesquicentenial lecturer in Molecular Embryology in April 2010. Prior to returning to Australia, Dr. Fraser was Assistant Professor in Hematology/Medical Oncology in the Mount Sinai School of Medicine in New York City for 6 years. Dr. Fraser also completed postdoctoral studies at the University of Mainz in Germany and spent 4 years at Kyoto University in Japan.

Research interests

Our main interests focus upon the mechanisms controlling the formation of the blood, or hematopoietic lineages, in the embryo and how these processes can go awry in the adult.

PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

International links

Japan

(Kyushu University) Collaboration with Dr. Daisuke Sugiyama

Selected grants

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • La Vision BioTec Ultramicroscope; Murphy C, Braet F, Byrne M, Chan-Ling T, Fraser S, Goldsbury C, Halliday G, Hambly B, Johnstone D, Keay K, Lovelace M, Lyons G, Mason R, Overall R, Owens T, Richardson D, Stone J, Weiss A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Chemotherapy transporters in breast cancer; Fraser S; National Breast Cancer Foundation/Novel Concept Awards.
  • A novel system for diagnosing and monitoring haemotropic mycoplasma infection in cats.; Fraser S; Feline Health Research Fund (FHRF)/Research Support.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • PyroMark Q96 ID system; Richardson D, Stone J, Black J, King N, Mason R, Hunt N, Kril J, Murray M, Scolyer R, Halliday G, Vandenberg R, McMinn P, Chadban S, Byrne M, Ryan R, Dong Q, Lee C, Bishop A, Haass N, Fraser S, Hambly B, Sharland A, Kalinowski D, Assinder S, Yu Y, Bao B, Ju Y, Lovejoy D, Buckland M, Lane D, Dos Remedios C, Kovacevic Z, Sutherland G, Zhang D, Morris B, Suryo Rahmanto A, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

Selected publications

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Journals

  • Zhang, H., Nieves, J., Fraser, S., Isern, J., Douvaras, P., Papatsenko, D., D'Souza, S., Lemischka, I., Dyer, M., Baron, M. (2014). Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells, 32(1), 191-203. [More Information]
  • Acosta, J., Goldsbury, C., Winnick, C., Badrock, A., Fraser, S., Laird, A., Hall, T., Don, E., Fifita, J., Blair, I., Nicholson, G., Cole, N. (2014). Mutant Human FUS Is Ubiquitously Mislocalized and Generates Persistent Stress Granules in Primary Cultured Transgenic Zebrafish Cells. PLoS One, 9(6), 1-9. [More Information]
  • Vacaru, A., Isern, J., Fraser, S., Baron, M. (2013). Analysis of Primitive Erythroid Cell Proliferation and Enucleation Using a Cyan Fluorescent Reporter in Transgenic Mice. Genesis, 51(11), 751-762. [More Information]
  • Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Tam, P., et al (2013). Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology, 33(15), 2976-2987. [More Information]
  • Antas, V., Al-Drees, M., Prudence, A., Sugiyama, D., Fraser, S. (2013). Hemogenic Endothelium: A Vessel For Blood Production. The International Journal of Biochemistry and Cell Biology, 45(3), 692-695. [More Information]
  • Guiu, J., Shimizu, R., D'Altri, T., Fraser, S., Hatakeyama, J., Bresnick, E., Kageyama, R., Dzierzak, E., Yamamoto, M., Espinosa, L., et al (2013). Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. The Journal of Experimental Medicine, 210(1), 71-84. [More Information]
  • Sanchez-Perez, A., Brown, G., Malik, R., Assinder, S., Cantlon, K., Gotsis, C., Dunbar, S., Fraser, S. (2013). Rapid detection of haemotropic mycoplasma infection of feline erythrocytes using a novel flow cytometric approach. Parasites and Vectors, 6(1), 1-7. [More Information]
  • Wee, N., Weinstein, D., Fraser, S., Assinder, S. (2013). The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease. The International Journal of Biochemistry and Cell Biology, 45(5), 960-963. [More Information]
  • Fraser, S. (2013). The Modern Primitives: Applying New Technological Approaches to Explore the Biology of the Earliest Red Blood Cells. ISRN Hematology, 2013, 1-21. [More Information]
  • Mizuochi, C., Fraser, S., Biasch, K., Horio, Y., Kikushige, Y., Tani, K., Akashi, K., Tavian, M., Sugiyama, D. (2012). Intra-Aortic Clusters Undergo Endothelial to Hematopoietic Phenotypic Transition during Early Embryogenesis. PLoS One, 7(4), 1-10. [More Information]
  • Funnell, A., Norton, L., Mak, K., Burdach, J., Artuz, C., Twine, N., Wilkins, M., Power, C., Hung, T., Perdomo, J., Bell-Anderson, K., Fraser, S., et al (2012). The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo. Molecular and Cellular Biology, 32(16), 3281-3292. [More Information]
  • Baron, M., Isern, J., Fraser, S. (2012). The embryonic origins of erythropoiesis in mammals. Blood, 119(21), 4828-4837. [More Information]
  • Sugiyama, D., Inoue-Yokoo, T., Fraser, S., Kelkeaw, K., Mizuochi, C., Horio, Y. (2011). Embryonic regulation of the mouse hematopoietic niche. The Scientific World Journal, 11, 1770-1780. [More Information]
  • Fraser, S., Midwinter, R., Berger, B., Stocker, R. (2011). Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development. Advances in Hematology, 2011, Article ID 473709 - 1-Article ID 473709 - 6. [More Information]
  • Isern, J., He, Z., Fraser, S., Nowotschin, S., Ferrer-Vaquer, A., Moore, R., Hadjantonakis, A., Schulz, V., Tuck, D., Gallagher, P., et al (2011). Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood, 117(18), 4924-4934. [More Information]
  • Isern, J., Fraser, S., He, Z., Baron, M. (2010). Developmental niches for embryonic erythroid cells. Blood Cells, Molecules and Diseases, 44(4), 207-208. [More Information]
  • Isern, J., Fraser, S., He, Z., Zhang, H., Baron, M. (2010). Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf. Blood, 116(19), 3972-3980. [More Information]
  • Fraser, S., Isern, J., Baron, M. (2010). Use of transgenic fluorescent reporter mouse lines to monitor hematopoietic and erythroid development during embryogenesis. Methods in Enzymology, 476, 403-427. [More Information]
  • Fraser, S., Baron, M. (2009). Embryonic Fates for Extraembryonic Lineages: New Perspectives. Journal Of Cellular Biochemistry, 107(4), 586-591. [More Information]
  • Zhang, H., Fraser, S., Papazoglu, C., Hoatlin, M., Baron, M. (2009). Transcriptional Activation by the Mixl1 Homeodomain Protein in Differentiating Mouse Embryonic Stem Cells. Stem Cells: the international journal of cell differentiation and proliferation, 27(12), 2884-2895. [More Information]
  • Isern, J., Fraser, S., He, Z., Baron, M. (2008). The fetal liver is a niche for maturation of primitive erythroid cells. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 105(18), 6662-6667. [More Information]
  • Fraser, S., Isern, J., Baron, M. (2007). Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression. Blood, 109(1), 343-352. [More Information]
  • Roos, W., Christmann, M., Fraser, S., Kaina, B. (2007). Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O6-methylguanine due to high E2F1 regulated mismatch repair. Cell Death and Differentiation, 14(8), 1422-1432. [More Information]
  • Haremaki, T., Fraser, S., Kuo, Y., Baron, M., Weinstein, D. (2007). Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 104(29), 12029-12034. [More Information]
  • Willey, S., Fraser, S., Ayuso-Sacido, A., Zhang, H., Sahr, K., Adlam, M., Kyba, M., Daley, G., Keller, G., Baron, M. (2006). Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor. Blood, 107(8), 3122-3130. [More Information]
  • Kwon, G., Fraser, S., Eakin, G., Mangano, M., Isern, J., Sahr, K., Hadjantonakis, A., Baron, M. (2006). Tg(Afp-GFP) Expression Marks Primitive and Definitive Endoderm Lineages During Mouse Development. Developmental Dynamics, 235(9), 2549-2558. [More Information]
  • Baron, M., Fraser, S. (2005). The specification of early hematopoiesis in the mammal. Current Opinion In Hematology, 12(3), 217-221. [More Information]
  • Fraser, S., Hadjantonakis, A., Sahr, K., Willey, S., Kelly, O., Jones, E., Dickinson, M., Baron, M. (2005). Using a Histone Yellow Fluorescent Protein Fusion for Tagging and Tracking Endothelial Cells in ES Cells and Mice. Genesis, 42(3), 162-171. [More Information]

2014

  • Zhang, H., Nieves, J., Fraser, S., Isern, J., Douvaras, P., Papatsenko, D., D'Souza, S., Lemischka, I., Dyer, M., Baron, M. (2014). Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells, 32(1), 191-203. [More Information]
  • Acosta, J., Goldsbury, C., Winnick, C., Badrock, A., Fraser, S., Laird, A., Hall, T., Don, E., Fifita, J., Blair, I., Nicholson, G., Cole, N. (2014). Mutant Human FUS Is Ubiquitously Mislocalized and Generates Persistent Stress Granules in Primary Cultured Transgenic Zebrafish Cells. PLoS One, 9(6), 1-9. [More Information]

2013

  • Vacaru, A., Isern, J., Fraser, S., Baron, M. (2013). Analysis of Primitive Erythroid Cell Proliferation and Enucleation Using a Cyan Fluorescent Reporter in Transgenic Mice. Genesis, 51(11), 751-762. [More Information]
  • Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Tam, P., et al (2013). Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology, 33(15), 2976-2987. [More Information]
  • Antas, V., Al-Drees, M., Prudence, A., Sugiyama, D., Fraser, S. (2013). Hemogenic Endothelium: A Vessel For Blood Production. The International Journal of Biochemistry and Cell Biology, 45(3), 692-695. [More Information]
  • Guiu, J., Shimizu, R., D'Altri, T., Fraser, S., Hatakeyama, J., Bresnick, E., Kageyama, R., Dzierzak, E., Yamamoto, M., Espinosa, L., et al (2013). Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. The Journal of Experimental Medicine, 210(1), 71-84. [More Information]
  • Sanchez-Perez, A., Brown, G., Malik, R., Assinder, S., Cantlon, K., Gotsis, C., Dunbar, S., Fraser, S. (2013). Rapid detection of haemotropic mycoplasma infection of feline erythrocytes using a novel flow cytometric approach. Parasites and Vectors, 6(1), 1-7. [More Information]
  • Wee, N., Weinstein, D., Fraser, S., Assinder, S. (2013). The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease. The International Journal of Biochemistry and Cell Biology, 45(5), 960-963. [More Information]
  • Fraser, S. (2013). The Modern Primitives: Applying New Technological Approaches to Explore the Biology of the Earliest Red Blood Cells. ISRN Hematology, 2013, 1-21. [More Information]

2012

  • Mizuochi, C., Fraser, S., Biasch, K., Horio, Y., Kikushige, Y., Tani, K., Akashi, K., Tavian, M., Sugiyama, D. (2012). Intra-Aortic Clusters Undergo Endothelial to Hematopoietic Phenotypic Transition during Early Embryogenesis. PLoS One, 7(4), 1-10. [More Information]
  • Funnell, A., Norton, L., Mak, K., Burdach, J., Artuz, C., Twine, N., Wilkins, M., Power, C., Hung, T., Perdomo, J., Bell-Anderson, K., Fraser, S., et al (2012). The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo. Molecular and Cellular Biology, 32(16), 3281-3292. [More Information]
  • Baron, M., Isern, J., Fraser, S. (2012). The embryonic origins of erythropoiesis in mammals. Blood, 119(21), 4828-4837. [More Information]

2011

  • Sugiyama, D., Inoue-Yokoo, T., Fraser, S., Kelkeaw, K., Mizuochi, C., Horio, Y. (2011). Embryonic regulation of the mouse hematopoietic niche. The Scientific World Journal, 11, 1770-1780. [More Information]
  • Fraser, S., Midwinter, R., Berger, B., Stocker, R. (2011). Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development. Advances in Hematology, 2011, Article ID 473709 - 1-Article ID 473709 - 6. [More Information]
  • Isern, J., He, Z., Fraser, S., Nowotschin, S., Ferrer-Vaquer, A., Moore, R., Hadjantonakis, A., Schulz, V., Tuck, D., Gallagher, P., et al (2011). Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood, 117(18), 4924-4934. [More Information]

2010

  • Isern, J., Fraser, S., He, Z., Baron, M. (2010). Developmental niches for embryonic erythroid cells. Blood Cells, Molecules and Diseases, 44(4), 207-208. [More Information]
  • Isern, J., Fraser, S., He, Z., Zhang, H., Baron, M. (2010). Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf. Blood, 116(19), 3972-3980. [More Information]
  • Fraser, S., Isern, J., Baron, M. (2010). Use of transgenic fluorescent reporter mouse lines to monitor hematopoietic and erythroid development during embryogenesis. Methods in Enzymology, 476, 403-427. [More Information]

2009

  • Fraser, S., Baron, M. (2009). Embryonic Fates for Extraembryonic Lineages: New Perspectives. Journal Of Cellular Biochemistry, 107(4), 586-591. [More Information]
  • Zhang, H., Fraser, S., Papazoglu, C., Hoatlin, M., Baron, M. (2009). Transcriptional Activation by the Mixl1 Homeodomain Protein in Differentiating Mouse Embryonic Stem Cells. Stem Cells: the international journal of cell differentiation and proliferation, 27(12), 2884-2895. [More Information]

2008

  • Isern, J., Fraser, S., He, Z., Baron, M. (2008). The fetal liver is a niche for maturation of primitive erythroid cells. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 105(18), 6662-6667. [More Information]

2007

  • Fraser, S., Isern, J., Baron, M. (2007). Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression. Blood, 109(1), 343-352. [More Information]
  • Roos, W., Christmann, M., Fraser, S., Kaina, B. (2007). Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O6-methylguanine due to high E2F1 regulated mismatch repair. Cell Death and Differentiation, 14(8), 1422-1432. [More Information]
  • Haremaki, T., Fraser, S., Kuo, Y., Baron, M., Weinstein, D. (2007). Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 104(29), 12029-12034. [More Information]

2006

  • Willey, S., Fraser, S., Ayuso-Sacido, A., Zhang, H., Sahr, K., Adlam, M., Kyba, M., Daley, G., Keller, G., Baron, M. (2006). Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor. Blood, 107(8), 3122-3130. [More Information]
  • Kwon, G., Fraser, S., Eakin, G., Mangano, M., Isern, J., Sahr, K., Hadjantonakis, A., Baron, M. (2006). Tg(Afp-GFP) Expression Marks Primitive and Definitive Endoderm Lineages During Mouse Development. Developmental Dynamics, 235(9), 2549-2558. [More Information]

2005

  • Baron, M., Fraser, S. (2005). The specification of early hematopoiesis in the mammal. Current Opinion In Hematology, 12(3), 217-221. [More Information]
  • Fraser, S., Hadjantonakis, A., Sahr, K., Willey, S., Kelly, O., Jones, E., Dickinson, M., Baron, M. (2005). Using a Histone Yellow Fluorescent Protein Fusion for Tagging and Tracking Endothelial Cells in ES Cells and Mice. Genesis, 42(3), 162-171. [More Information]

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