Dr Subhodeep Sarker

BE, PhD
Visiting Scholar in Pharmacology
FWF Erwin Schroedinger Fellow
Associate Editor, Ecotoxicology (Springer Nature)
Discipline of Pharmacology

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Biographical details

Dr Subhodeep Sarker attended the Birla Institute of Technology, Mesra, India, earning a Bachelor of Engineering (BE) degree in Biotechnology in 2007. In 2010, he earned a Doctor of Philosophy (PhD) degree in Molecular Pharmacology from the Medical University of Vienna, Austria.

Currently, as Visiting Scholar in Pharmacology and FWF Erwin Schrödinger Fellow at The University of Sydney, Australia, Dr Subhodeep Sarker is developing novel lipid-based analgesics for the treatment of chronic pain. His previous research at the University of Veterinary Medicine (Vetmeduni) in Vienna, Austria explored therapeutic strategies to target salmonid whirling disease, for which there is currently no successful treatment (Sarker et al., 2015). He recently developed an RNA interference (RNAi)-based therapeutic strategy to target salmonid whirling disease in vivo (Sarker et al., 2017; Sarker and El-Matbouli, 2015). Concomitantly, Dr Sarker used a teleost model to investigate host-parasite interaction mechanisms at the molecular level (Kumar et al., 2015). Recently, he also contributed to unravelling the therapeutic potential of curcumin (a herbal antioxidant) for high-risk human papilloma virus (HPV)-infected oral cancers (Mishra et al., 2015). In addition, using an interdisciplinary approach, he is also assessing and evaluating the biological response of sentinel species to environmental pollution in coastal ecosystems [Sarker et al., 2018; Sarkar et al., 2017; Sarker et al., 2016; Sarkar et al., 2006, 2014; Gaitonde et al., 2006]. During his PhD with Dr Michael Freissmuth in the Cell Communication in Health and Disease (CCHD) PhD programme at the Medical University of Vienna, Austria, Dr Sarker proposed a model on the mechanism of tricyclic antidepressant (TCA) binding to mammalian neurotransmitter transporters (Sarker et al., 2010; Hasenhuetl et al., 2015). In addition, he also investigated the endoplasmic reticulum (ER) export of mammalian neurotransmitter transporters demonstrating that the surface expression and hence pre-synaptic enrichment of neurotransmitter transporters is in part regulated by their rate of concentrative ER export (Sucic et al., 2011). Thereafter, Dr Sarker conducted postdoctoral research on the pharmacology of G protein-coupled receptors and beta-arrestins at Duke University Medical Center in Durham, NC, USA (Sarker et al., 2011).

Current projects

Funding Organisation

Project Number

Role

Project Title

Duration

Amount

Austrian Science Fund (FWF)

J3982-B27

Schrödinger Programme

Project Leader

Bioactive lipid modulation of glycine transporter 2 (GlyT2)

04.04.2017 to 03.04.2019

80,500 EUR

Awards and honours

Erwin Schrödinger Fellowship, Austrian Science Fund (FWF) (2017 – 2019)

University of Veterinary Medicine (Vetmeduni Vienna) Postdoctoral Fellowship (2013 – 2017)

Vetmeduni Vienna Academic Staff Grants for Active Conference Participation Abroad (2014)

Duke University Postdoctoral Fellowship, Durham, NC, USA (2011 – 2012)

Molecular Medicine Predoctoral Fellowship (Medical University of Graz, Austria and FWF); I declined (2007 – 2010)

CCHD Predoctoral Fellowship (Medical University of Vienna, Austria and FWF) (2007 – 2010)

Indian Academy of Sciences Summer Visiting Student-Fellowship (2006)

iEARN-USA Scholarships, The John Templeton Foundation, USA (2000 & 2001)

1st DAN Black Belt in Shotokan Karate-Do, Japan Karate Association, Tokyo (1997)

In the media

EDITORIAL BOARD MEMBER

Associate Editor, Ecotoxicology (Springer Nature) (2016 – present)

PEER-REVIEWER (INTERNATIONAL JOURNALS): Ecotoxicology (Springer Nature), Ecotoxicology and Environmental Safety (Elsevier).

ORGANIZING COMMITTEE MEMBER 1st (February 20-21, 2008), 2nd (February 11-12, 2009) & 3rd (February 17-18, 2010) International Workshops on Cell Communication in Health & Disease, General Hospital (AKH der Stadt Wien), Vienna, Austria.


Selected publications

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Journals

  • Sarker, S., Vashistha, D., Sarker, S., Sarkar, A. (2018). DNA damage in marine rock oyster (Saccostrea Cucullata) exposed to environmentally available PAHs and heavy metals along the Arabian Sea coast. Ecotoxicology and Environmental Safety, 151, 132-143. [More Information]
  • Sarker, S., Menanteau-Ledouble, S., Kotob, M., El-Matbouli, M. (2017). A RNAi-based therapeutic proof of concept targets salmonid whirling disease in vivo. PloS One, 12(6), 1-21. [More Information]
  • Sarkar, A., Bhagat, J., Sarkar, M., Gaitonde, D., Sarker, S. (2017). Evaluation of the impact of bioaccumulation of PAH from the marine environment on DNA integrity and oxidative stress in marine rock oyster (Saccostrea cucullata) along the Arabian sea coast. Ecotoxicology, 26(8), 1105-1116. [More Information]
  • Sarker, S., Desai, S., Verlecar, X., Sarker, M., Sarkar, A. (2016). Mercury-induced genotoxicity in marine diatom (Chaetoceros tenuissimus). Environmental Science and Pollution Research, 23(3), 2770-2777. [More Information]
  • Sarker, S., El-Matbouli, M. (2015). Can RNAi Target Salmonid Whirling Disease In Vivo? Nucleic Acid Therapeutics, 25(5), 285-286. [More Information]
  • Mishra, A., Kumar, R., Tyagi, A., Kohaar, I., Hedau, S., Bharti, A., Sarker, S., Dey, D., Saluja, D., Das, B. (2015). Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer. ecancermedicalscience, 9, 525. [More Information]
  • Hasenhuetl, P., Schicker, K., Koenig, X., Li, Y., Sarker, S., Stockner, T., Sucic, S., Sitte, H., Freissmuth, M., Sandtner, W. (2015). Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction. Molecular Pharmacology, 88(1), 12-18. [More Information]
  • Kumar, G., Sarker, S., Menanteau-Ledouble, S., El-Matbouli, M. (2015). Tetracapsuloides bryosalmonae infection affects the expression of genes involved in cellular signal transduction and iron metabolism in the kidney of the brown trout Salmo trutta. Parasitology Research, 114(6), 2301-2308. [More Information]
  • Sarker, S., Kallert, D., Hedrick, R., El-Matbouli, M. (2015). Whirling disease revisited: pathogenesis, parasite biology and disease intervention. Diseases of Aquatic Organisms, 114(2), 155-175. [More Information]
  • Sarkar, A., Bhagat, J., Sarker, S. (2014). Evaluation of impairment of DNA in marine gastropod, Morula granulata as a biomarker of marine pollution. Ecotoxicology and Environmental Safety, 106, 253-261. [More Information]
  • Sarker, S., Xiao, K., Shenoy, S. (2011). A tale of two sites: How ubiquitination of a G protein-coupled receptor is coupled to its lysosomal trafficking from distinct receptor domains. Communicative and Integrative Biology, 4(5), 528-531. [More Information]
  • Sucic, S., El-Kasaby, A., Kudlacek, O., Sarker, S., Sitte, H., Marin, P., Freissmuth, M. (2011). The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C. Journal of Biological Chemistry, 286(18), 16482-16490. [More Information]
  • Sarker, S., Weissensteiner, R., Steiner, I., Sitte, H., Ecker, G., Freissmuth, M., Sucic, S. (2010). The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter. Molecular Pharmacology, 78(6), 1026-1035. [More Information]

2018

  • Sarker, S., Vashistha, D., Sarker, S., Sarkar, A. (2018). DNA damage in marine rock oyster (Saccostrea Cucullata) exposed to environmentally available PAHs and heavy metals along the Arabian Sea coast. Ecotoxicology and Environmental Safety, 151, 132-143. [More Information]

2017

  • Sarker, S., Menanteau-Ledouble, S., Kotob, M., El-Matbouli, M. (2017). A RNAi-based therapeutic proof of concept targets salmonid whirling disease in vivo. PloS One, 12(6), 1-21. [More Information]
  • Sarkar, A., Bhagat, J., Sarkar, M., Gaitonde, D., Sarker, S. (2017). Evaluation of the impact of bioaccumulation of PAH from the marine environment on DNA integrity and oxidative stress in marine rock oyster (Saccostrea cucullata) along the Arabian sea coast. Ecotoxicology, 26(8), 1105-1116. [More Information]

2016

  • Sarker, S., Desai, S., Verlecar, X., Sarker, M., Sarkar, A. (2016). Mercury-induced genotoxicity in marine diatom (Chaetoceros tenuissimus). Environmental Science and Pollution Research, 23(3), 2770-2777. [More Information]

2015

  • Sarker, S., El-Matbouli, M. (2015). Can RNAi Target Salmonid Whirling Disease In Vivo? Nucleic Acid Therapeutics, 25(5), 285-286. [More Information]
  • Mishra, A., Kumar, R., Tyagi, A., Kohaar, I., Hedau, S., Bharti, A., Sarker, S., Dey, D., Saluja, D., Das, B. (2015). Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer. ecancermedicalscience, 9, 525. [More Information]
  • Hasenhuetl, P., Schicker, K., Koenig, X., Li, Y., Sarker, S., Stockner, T., Sucic, S., Sitte, H., Freissmuth, M., Sandtner, W. (2015). Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction. Molecular Pharmacology, 88(1), 12-18. [More Information]
  • Kumar, G., Sarker, S., Menanteau-Ledouble, S., El-Matbouli, M. (2015). Tetracapsuloides bryosalmonae infection affects the expression of genes involved in cellular signal transduction and iron metabolism in the kidney of the brown trout Salmo trutta. Parasitology Research, 114(6), 2301-2308. [More Information]
  • Sarker, S., Kallert, D., Hedrick, R., El-Matbouli, M. (2015). Whirling disease revisited: pathogenesis, parasite biology and disease intervention. Diseases of Aquatic Organisms, 114(2), 155-175. [More Information]

2014

  • Sarkar, A., Bhagat, J., Sarker, S. (2014). Evaluation of impairment of DNA in marine gastropod, Morula granulata as a biomarker of marine pollution. Ecotoxicology and Environmental Safety, 106, 253-261. [More Information]

2011

  • Sarker, S., Xiao, K., Shenoy, S. (2011). A tale of two sites: How ubiquitination of a G protein-coupled receptor is coupled to its lysosomal trafficking from distinct receptor domains. Communicative and Integrative Biology, 4(5), 528-531. [More Information]
  • Sucic, S., El-Kasaby, A., Kudlacek, O., Sarker, S., Sitte, H., Marin, P., Freissmuth, M. (2011). The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C. Journal of Biological Chemistry, 286(18), 16482-16490. [More Information]

2010

  • Sarker, S., Weissensteiner, R., Steiner, I., Sitte, H., Ecker, G., Freissmuth, M., Sucic, S. (2010). The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter. Molecular Pharmacology, 78(6), 1026-1035. [More Information]

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