Dr Sudarshini Ramanathan

BSc (Med) MBBS (Hons) FRACP PhD
Neurologist and Neuroimmunologist, Westmead Hospital
Clinical Lecturer, University of Sydney
Postdoctoral Research Fellow, Institute For Neuroscience and Muscle Research and The University of Sydney


Map

Biographical details

Dr Darshi Ramanathan is a neurologist and early career clinician-scientist based at the Westmead Hospital Campus in Sydney. She has a subspecialty interest in neuroimmunology, and is focused on clinical and laboratory research related to antibody-mediated neurological disorders, including demyelination and autoimmune encephalitis; as well as the management of patients with multiple sclerosis. She is a neurologist/ neuroimmunologist affiliated with the Department of Neurology at Westmead Hospital, a Clinical Lecturer at the University of Sydney, and a postdoctoral research fellow with the Brain Autoimmunity Group, Institute For Neuroscience and Muscle Research at the Children's Hospital at Westmead.

She has been recently awarded the NHMRC Neil Hamilton Fairley Early Career Fellowship and will be undertaking a postdoctoral fellowship in Oxford exploring mechanisms of disease pathogenesis in autoimmune encephalitis, with the Autoimmune Neurology Group at the John Radcliffe Hospital/ University of Oxford for 2 years (2018 and 2019), before returning to Sydney.

Research interests

Dr Ramanathan completed her PhD on the clinical phenotypes, radiological characterisation, therapeutic responses, and outcomes in myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination. In 2016, she established and is now the lead investigator of the Australasian and New Zealand MOG Study Group. This is a unique collaborative platform of over 100 adult and paediatric neurologists from over 40 tertiary, metropolitan, rural, and remote centres throughout Australasia, with the goal of better understanding and treating antibody-associated demyelination. This collaboration has assisted in the diagnosis of over 1500 adults with antibody-associated demyelination and has led to a number of publications which elaborate on the phenotype and management of these patients. Dr Ramanathan has been the chief investigator for scholarships and grants providing research funding from the National Health and Medical Research Council (NHMRC) and the Brain Foundation.

Dr Ramanathan is committed to translational research from basic science projects which help us better understand underlying mechanisms of disease pathogenesis, to clinical projects which enable us to identify and treat patients with antibody-mediated neurological disorders in order to ultimately improve their outcomes.

Teaching and supervision

Dr Ramanathan is actively involved in medical student and basic physician trainee teaching and examination.

Selected publications

Download citations: PDF RTF Endnote

Journals

  • Dale, R., Ramanathan, S. (2017). Cell surface antibody-associated neurodegeneration: The case of anti-IgLON5 antibodies. Neurology, 88(18), 1688-1690. [More Information]
  • Ramanathan, S., Dale, R., Brilot-Turville, F. (2016). Anti-MOG antibody: The history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination. Autoimmunity Reviews, 15(4), 307-324. [More Information]
  • Ramanathan, S., Sato, S., Matsushita, T., Masaki, K., Yamasaki, R., Dale, R., Kira, J., Brilot-Turville, F. (2016). Antibodies to myelin oligodendrocyte glycoprotein are uncommon in Japanese opticospinal multiple sclerosis. Multiple Sclerosis Journal, 22(1), 127-128. [More Information]
  • Kothur, K., Wienholt, L., Tantsis, E., Earl, J., Bandodkar, S., Prelog, K., Tea, F., Ramanathan, S., Brilot-Turville, F., Dale, R. (2016). B Cell, Th17, and Neutrophil Related Cerebrospinal Fluid Cytokine/Chemokines Are Elevated in MOG Antibody Associated Demyelination. PloS One, 11(2), 1-16. [More Information]
  • Sinmaz, N., Tea, F., Pilli, D., Zou, A., Amatoury, M., Nguyen, T., Merheb, V., Ramanathan, S., Cooper, S., Dale, R., Brilot-Turville, F. (2016). Dopamine-2 receptor extracellular N-terminus regulates receptor surface availability and is the target of human pathogenic antibodies from children with movement and psychiatric disorders. Acta Neuropathologica Communications, 4, 1-18. [More Information]
  • Ramanathan, S., Prelog, K., Barnes, E., Tantsis, E., Reddel, S., Henderson, A., Vucic, S., Gorman, M., Benson, L., Alper, G., Barnett, M., Parratt, J., Hardy, T., Merheb, V., Nosadini, M., Fung, V., Brilot-Turville, F., Dale, R., et al (2016). Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis. Multiple Sclerosis Journal, 22(4), 470-482. [More Information]
  • Nosadini, M., Alper, G., Riney, C., Benson, L., Mohammad, S., Ramanathan, S., Nolan, M., Appleton, R., Leventer, R., Deiva, K., Brilot-Turville, F., Dale, R., et al (2016). Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder. Neurology: Neuroimmunology and Neuroinflammation, 3(1), 1-10. [More Information]
  • Pathmanandavel, K., Starling, J., Merheb, V., Ramanathan, S., Sinmaz, N., Dale, R., Brilot-Turville, F. (2015). Antibodies to Surface Dopamine-2 Receptor and N-Methyl-D-Aspartate Receptor in the First Episode of Acute Psychosis in Children. Biological Psychiatry, 77(6), 537-547. [More Information]
  • Sinmaz, N., Amatoury, M., Merheb, V., Ramanathan, S., Dale, R., Brilot-Turville, F. (2015). Autoantibodies in movement and psychiatric disorders: Updated concepts in detection methods, pathogenicity, and CNS entry. Annals of the New York Academy of Sciences, 1351 (1), 22-38. [More Information]
  • Ramanathan, S., Langguth, D., Hardy, T., Garg, N., Bundell, C., Rojana-udomsart, A., Dale, R., Robertson, T., Mammen, A., Reddel, S. (2015). Clinical course and treatment of anti-HMGCR antibody-associated necrotizing autoimmune myopathy. Neurology: Neuroimmunology and Neuroinflammation, 2(3), 1-8. [More Information]
  • Pillai, S., Tantsis, E., Prelog, K., Ramanathan, S., Webster, R., Ouvrier, R., Kesson, A., Brilot-Turville, F., Dale, R. (2015). Confirmed enterovirus encephalitis with associated steroid-responsive acute disseminated encephalomyelitis: An overlapping infection and inflammation syndrome. European Journal of Paediatric Neurology, 19(2), 266-270. [More Information]
  • Ramanathan, S., Fung, V., Bielich, A., Masters, L., Russo, R., Buckland, M., Sarros, S., Klug, G., Collins, S., Reddel, S. (2015). Hyperekplexia as the presenting symptom of Creutzfeldt-Jakob disease. Neurology: Clinical Practice, 5(6), 498-501. [More Information]
  • Nosadini, M., Mohammad, S., Ramanathan, S., Brilot, F., Dale, R. (2015). Immune therapy in autoimmune encephalitis: a systematic review. Expert Review of Neurotherapeutics, 15(12), 1391-1419. [More Information]
  • Dale, R., Tantsis, E., Merheb, V., Kumaran, R., Sinmaz, N., Pathmanandavel, K., Ramanathan, S., Booth, D., Wienholt, L., Prelog, K., Mathey, E., Brilot-Turville, F., et al (2014). Antibodies to MOG have a demyelination phenotype and affect oligodendrocyte cytoskeleton. Neurology: Neuroimmunology and Neuroinflammation, 2014 (1), 1-10. [More Information]
  • Ramanathan, S., Reddel, S., Henderson, A., Parratt, J., Barnett, M., Gatt, P., Merheb, V., Kumaran, R., Pathmanandavel, K., Sinmaz, N., Yiannikas, K., Vucic, S., Stewart, G., Booth, D., Dale, R., Brilot-Turville, F., et al (2014). Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritis. Neurology: Neuroimmunology and Neuroinflammation, 1(4), 1-12. [More Information]
  • Mohammad, S., Wallace, G., Ramanathan, S., Brilot-Turville, F., Dale, R. (2014). Antipsychotic-induced akathisia and neuroleptic malignant syndrome in anti-NMDAR encephalitis. Annals of Clinical Psychiatry, 26(4), 297-298.
  • Ramanathan, S., Mohammad, S., Brilot-Turville, F., Dale, R. (2014). Autoimmune encephalitis: Recent updates and emerging challenges. Journal of Clinical Neuroscience, 21(5), 722-730. [More Information]
  • Ramanathan, S., Bleasel, A., Parratt, J., Orr, C., Dale, R., Vincent, A., Fung, V. (2014). Characterisation of a syndrome of autoimmune adult onset focal epilepsy and encephalitis. Journal of Clinical Neuroscience, 21(7), 1169-1175. [More Information]
  • Mohammad, S., Fung, V., Grattan-Smith, P., Gill, D., Pillai, S., Ramanathan, S., Brilot-Turville, F., Dale, R. (2014). Movement disorders in children with anti-NMDAR encephalitis and other autoimmune encephalopathies. Movement Disorders, 29(12), 1539-1542. [More Information]
  • Ramanathan, S., Wong, C., Rahman, Z., Dale, R., Fulcher, D., Bleasel, A. (2014). Myoclonic status epilepticus as a presentation of caspr2 antibody-associated autoimmune encephalitis. Epileptic Disorders, 16(4), 477-481. [More Information]
  • Mohammad, S., Ramanathan, S., Brilot-Turville, F., Dale, R. (2013). Autoantibody-Associated Movement Disorders. Neuropediatrics, 44(6), 336-345. [More Information]
  • Ramanathan, S., Wong, C., Fung, V. (2013). Long duration between presentation of probable anti-N-methyl-D-aspartate receptor encephalitis and either clinical relapse or positive serum autoantibodies. Journal of Clinical Neuroscience, 20(9), 1322-2653. [More Information]
  • Ramanathan, S., Lenton, K., Burke, T., Gomes, L., Storchenegger, K., Yiannikas, C., Vucic, S. (2013). The utility of multimodal evoked potentials in multiple sclerosis prognostication. Journal of Clinical Neuroscience, 20(11), 1576-1581. [More Information]
  • Vucic, S., Burke, T., Lenton, K., Ramanathan, S., Gomes, L., Yannikas, C., Kiernan, M. (2012). Cortical dysfunction underlies disability in multiple sclerosis. Multiple Sclerosis Journal, 18(4), 425-432. [More Information]

2017

  • Dale, R., Ramanathan, S. (2017). Cell surface antibody-associated neurodegeneration: The case of anti-IgLON5 antibodies. Neurology, 88(18), 1688-1690. [More Information]

2016

  • Ramanathan, S., Dale, R., Brilot-Turville, F. (2016). Anti-MOG antibody: The history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination. Autoimmunity Reviews, 15(4), 307-324. [More Information]
  • Ramanathan, S., Sato, S., Matsushita, T., Masaki, K., Yamasaki, R., Dale, R., Kira, J., Brilot-Turville, F. (2016). Antibodies to myelin oligodendrocyte glycoprotein are uncommon in Japanese opticospinal multiple sclerosis. Multiple Sclerosis Journal, 22(1), 127-128. [More Information]
  • Kothur, K., Wienholt, L., Tantsis, E., Earl, J., Bandodkar, S., Prelog, K., Tea, F., Ramanathan, S., Brilot-Turville, F., Dale, R. (2016). B Cell, Th17, and Neutrophil Related Cerebrospinal Fluid Cytokine/Chemokines Are Elevated in MOG Antibody Associated Demyelination. PloS One, 11(2), 1-16. [More Information]
  • Sinmaz, N., Tea, F., Pilli, D., Zou, A., Amatoury, M., Nguyen, T., Merheb, V., Ramanathan, S., Cooper, S., Dale, R., Brilot-Turville, F. (2016). Dopamine-2 receptor extracellular N-terminus regulates receptor surface availability and is the target of human pathogenic antibodies from children with movement and psychiatric disorders. Acta Neuropathologica Communications, 4, 1-18. [More Information]
  • Ramanathan, S., Prelog, K., Barnes, E., Tantsis, E., Reddel, S., Henderson, A., Vucic, S., Gorman, M., Benson, L., Alper, G., Barnett, M., Parratt, J., Hardy, T., Merheb, V., Nosadini, M., Fung, V., Brilot-Turville, F., Dale, R., et al (2016). Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis. Multiple Sclerosis Journal, 22(4), 470-482. [More Information]
  • Nosadini, M., Alper, G., Riney, C., Benson, L., Mohammad, S., Ramanathan, S., Nolan, M., Appleton, R., Leventer, R., Deiva, K., Brilot-Turville, F., Dale, R., et al (2016). Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder. Neurology: Neuroimmunology and Neuroinflammation, 3(1), 1-10. [More Information]

2015

  • Pathmanandavel, K., Starling, J., Merheb, V., Ramanathan, S., Sinmaz, N., Dale, R., Brilot-Turville, F. (2015). Antibodies to Surface Dopamine-2 Receptor and N-Methyl-D-Aspartate Receptor in the First Episode of Acute Psychosis in Children. Biological Psychiatry, 77(6), 537-547. [More Information]
  • Sinmaz, N., Amatoury, M., Merheb, V., Ramanathan, S., Dale, R., Brilot-Turville, F. (2015). Autoantibodies in movement and psychiatric disorders: Updated concepts in detection methods, pathogenicity, and CNS entry. Annals of the New York Academy of Sciences, 1351 (1), 22-38. [More Information]
  • Ramanathan, S., Langguth, D., Hardy, T., Garg, N., Bundell, C., Rojana-udomsart, A., Dale, R., Robertson, T., Mammen, A., Reddel, S. (2015). Clinical course and treatment of anti-HMGCR antibody-associated necrotizing autoimmune myopathy. Neurology: Neuroimmunology and Neuroinflammation, 2(3), 1-8. [More Information]
  • Pillai, S., Tantsis, E., Prelog, K., Ramanathan, S., Webster, R., Ouvrier, R., Kesson, A., Brilot-Turville, F., Dale, R. (2015). Confirmed enterovirus encephalitis with associated steroid-responsive acute disseminated encephalomyelitis: An overlapping infection and inflammation syndrome. European Journal of Paediatric Neurology, 19(2), 266-270. [More Information]
  • Ramanathan, S., Fung, V., Bielich, A., Masters, L., Russo, R., Buckland, M., Sarros, S., Klug, G., Collins, S., Reddel, S. (2015). Hyperekplexia as the presenting symptom of Creutzfeldt-Jakob disease. Neurology: Clinical Practice, 5(6), 498-501. [More Information]
  • Nosadini, M., Mohammad, S., Ramanathan, S., Brilot, F., Dale, R. (2015). Immune therapy in autoimmune encephalitis: a systematic review. Expert Review of Neurotherapeutics, 15(12), 1391-1419. [More Information]

2014

  • Dale, R., Tantsis, E., Merheb, V., Kumaran, R., Sinmaz, N., Pathmanandavel, K., Ramanathan, S., Booth, D., Wienholt, L., Prelog, K., Mathey, E., Brilot-Turville, F., et al (2014). Antibodies to MOG have a demyelination phenotype and affect oligodendrocyte cytoskeleton. Neurology: Neuroimmunology and Neuroinflammation, 2014 (1), 1-10. [More Information]
  • Ramanathan, S., Reddel, S., Henderson, A., Parratt, J., Barnett, M., Gatt, P., Merheb, V., Kumaran, R., Pathmanandavel, K., Sinmaz, N., Yiannikas, K., Vucic, S., Stewart, G., Booth, D., Dale, R., Brilot-Turville, F., et al (2014). Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritis. Neurology: Neuroimmunology and Neuroinflammation, 1(4), 1-12. [More Information]
  • Mohammad, S., Wallace, G., Ramanathan, S., Brilot-Turville, F., Dale, R. (2014). Antipsychotic-induced akathisia and neuroleptic malignant syndrome in anti-NMDAR encephalitis. Annals of Clinical Psychiatry, 26(4), 297-298.
  • Ramanathan, S., Mohammad, S., Brilot-Turville, F., Dale, R. (2014). Autoimmune encephalitis: Recent updates and emerging challenges. Journal of Clinical Neuroscience, 21(5), 722-730. [More Information]
  • Ramanathan, S., Bleasel, A., Parratt, J., Orr, C., Dale, R., Vincent, A., Fung, V. (2014). Characterisation of a syndrome of autoimmune adult onset focal epilepsy and encephalitis. Journal of Clinical Neuroscience, 21(7), 1169-1175. [More Information]
  • Mohammad, S., Fung, V., Grattan-Smith, P., Gill, D., Pillai, S., Ramanathan, S., Brilot-Turville, F., Dale, R. (2014). Movement disorders in children with anti-NMDAR encephalitis and other autoimmune encephalopathies. Movement Disorders, 29(12), 1539-1542. [More Information]
  • Ramanathan, S., Wong, C., Rahman, Z., Dale, R., Fulcher, D., Bleasel, A. (2014). Myoclonic status epilepticus as a presentation of caspr2 antibody-associated autoimmune encephalitis. Epileptic Disorders, 16(4), 477-481. [More Information]

2013

  • Mohammad, S., Ramanathan, S., Brilot-Turville, F., Dale, R. (2013). Autoantibody-Associated Movement Disorders. Neuropediatrics, 44(6), 336-345. [More Information]
  • Ramanathan, S., Wong, C., Fung, V. (2013). Long duration between presentation of probable anti-N-methyl-D-aspartate receptor encephalitis and either clinical relapse or positive serum autoantibodies. Journal of Clinical Neuroscience, 20(9), 1322-2653. [More Information]
  • Ramanathan, S., Lenton, K., Burke, T., Gomes, L., Storchenegger, K., Yiannikas, C., Vucic, S. (2013). The utility of multimodal evoked potentials in multiple sclerosis prognostication. Journal of Clinical Neuroscience, 20(11), 1576-1581. [More Information]

2012

  • Vucic, S., Burke, T., Lenton, K., Ramanathan, S., Gomes, L., Yannikas, C., Kiernan, M. (2012). Cortical dysfunction underlies disability in multiple sclerosis. Multiple Sclerosis Journal, 18(4), 425-432. [More Information]

To update your profile click here. For support on your academic profile contact .