Dr Sue Firth

Honorary Associate
Medicine, Northern Clinical School
Kolling Institute of Medical Research

Telephone +61 2 9926 4707
Fax +61 2 9926 5908

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Selected grants

2012

  • IGFBP-3 enhances autophagy to promote breast cancer ceil survival during stress; Firth S; Cancer Institute New South Wales/Career Development Fellowship.

2011

  • Modulation of ER stress by IGFBPs; Firth S; DVC Research/Bridging Support Grant.

2008

  • The role of the M6P/IGF-11 receptor in regulating cellular function; Scott C, Firth S; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Novel interactions of IGFBP-3 with extracullular matrix components: Functional characterisation of the interactions in breast cancer; Firth S; University of Sydney/Cancer Research Fund.
  • Proteolysis of binding protein complexes regulates IGF bioavailability; Firth S, Baxter R; Australian Research Council (ARC)/Discovery Projects (DP).

2006

  • FAXSCalibur 4 -colour Flow Cytometer; Baxter R, Firth S, Marsh D, Schedlich L, Scott C, Martin J, Robinson B; Cancer Institute New South Wales/Research Grants Program - Category 2.
  • Fiberlite: Carbon fiber composite rotors; Firth S, Chen X, Marsh D, Benn D; University of Sydney/Research Support.

2005

  • Multifunction Imaging System; Firth S, McCracken S, Marsh D, Chen X; University of Sydney/Research Support.
  • Automated Precision Liquid Handling System; Benn D, Chen X, Chung L, Baxter R, Marsh D, Robinson B, Firth S; University of Sydney/Research Support.
  • Igfbp-3 As A Growth Inhibitor In Breast Cancer; Baxter R, Firth S, Martin J; Worldwide Cancer Research/Research Grants Scheme.
  • Cancer InstNSW Fell05-Firth; Firth S; Cancer Institute New South Wales/Research Grant.

2004

  • NanoDrop ND-1000 spectrometer plus computer; Marsh D, Firth S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2003

  • Structural elucidation and functional analysis of insulin-like growth factor binding protein-3 domains; Baxter R, Firth S; Australian Research Council (ARC)/Discovery Projects (DP).
  • Flexi-dry microprocessor controlled manifold freeze dryer; Baxter R, Firth S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • Beckman Optima XL-100K Ultracentrifuge; Firth S, Baxter R, Delhanty P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Interactions between IGFBP-3 and TGFbeta in the inhibition of breast cancer cell growth; Firth S, Baxter R; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Interactions between IGFBP-3 and transforming growth factor beta signalling in the inhibition of human breast cancer cell growth; Baxter R, Firth S; Leo and Jenny Leukaemia and Cancer Foundation/Cure Cancer Foundation.
  • Interactions between insulin-like growth factor binding protein-3 and transforming growth factor beta signalling in the inhibition of human breast cancer cell growth; Baxter R, Firth S; Cunningham Foundation/Research Project Grants.

2000

  • Structure-function relationships in IGF binding protein (IGFBP)-3 and IGFBP-5 complexes; Baxter R, Firth S; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Grkovic, S., O'Reilly, V., Han, S., Hong, M., Baxter, R., Firth, S. (2013). IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments. Oncogene, 32(19), 2412-2420. [More Information]
  • de Silva, H., Firth, S., Twigg, S., Baxter, R. (2012). Interaction Between IGF Binding Protein-3 and TGFb in in the Regulation of Adipocyte Differentiation. Endocrinology, 153(10), 4799-4807. [More Information]
  • Jarajapu, Y., Cai, J., Yan, Y., Calzi, S., Kielczewski, J., Hu, P., Shaw, L., Firth, S., Chan-Ling, T., Boulton, M., Baxter, R., et al (2012). Protection of Blood Retinal Barrier and Systemic Vasculature by Insulin-Like Growth Factor Binding Protein-3. PLoS One, 7(7), 1-16. [More Information]
  • Firth, S., Yan, X., Baxter, R. (2011). D440N Mutation in the Acid-Labile Subunit of Insulin-Like Growth Factor Complexes Inhibits Secretion and Complex Formation. Molecular Endocrinology, 25(2), 307-314. [More Information]
  • Kielczewski, J., Calzi, S., Shaw, L., Cai, J., Qi, X., Ruan, Q., Wu, L., Liu, L., Hu, P., Chan-Ling, T., Firth, S., Baxter, R., et al (2011). Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase). Investigative Ophthalmology and Visual Science, 52(11), 8278-8286. [More Information]
  • Lin, Z., Natesan, V., Shi, H., Hamik, A., Kawanami, D., Hao, C., Mahabaleshwar, G., Wang, W., Jin, Z., Atkins, G., Firth, S., et al (2010). A novel role of CCN3 in regulating endothelial inflammation. Journal of Cell Communication and Signaling, 4, 141-153. [More Information]
  • Yan, X., Baxter, R., Firth, S. (2010). Involvement of pregnancy-associated plasma protein-A2 in insulin-like growth factor (IGF) binding protein-5 proteolysis during pregnancy: a potential mechanism for increasing IGF bioavailability. Journal of Clinical Endocrinology and Metabolism, 95(3), 1412-1420. [More Information]
  • Yan, X., Payet, L., Baxter, R., Firth, S. (2009). Activity of human pregnancy insulin-like growth factor binding protein-3: determination by reconstituting recombinant complexes. Endocrinology, 150(11), 4968-4976. [More Information]
  • Schedlich, L., Graham, L., O'Han, M., Muthukaruppan, A., Yan, X., Firth, S., Baxter, R. (2007). Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: Role in modulation of RAR-signaling. Archives of Biochemistry and Biophysics, 465(2), 359-369. [More Information]
  • Graham, M., Kilby, D., Firth, S., Robinson, P., Baxter, R. (2007). The in vivo phosphorylation and glycosylation of human insulin-like growth factor binding protein-5. Molecular and Cellular Proteomics, 6(8), 1392-1405. [More Information]
  • Fukunaga-Kalabis, M., Martinez, G., Liu, Z., Kalabis, J., Mrass, P., Planque, N., Firth, S., Perbal, B., Herlyn, M., Weninger, W. (2006). CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1. The Journal of Cell Biology, 175(4), 563-569. [More Information]
  • Santer, F., Bacher, N., Moser, B., Morandell, D., Ressler, S., Firth, S., Spoden, G., Sergi, C., Baxter, R., Jansen-Durr, P., et al (2006). Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin/proteasome-dependent proteolysis. Cancer Research, 66(6), 3024-3033. [More Information]
  • Yan, X., Baxter, R., Perbal, B., Firth, S. (2006). The aminoterminal insulin-like growth factor (IGF) binding domain of IGF binding protein-3 cannot be functionally substituted by the structurally homologous domain of CCN3. Endocrinology, 147(11), 5268-5274. [More Information]
  • Chan, S., Twigg, S., Firth, S., Baxter, R. (2005). Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes. Journal of Clinical Endocrinology and Metabolism, 90(12), 6588-6595. [More Information]
  • Butt, A., Martin, J., Dickson, K., McDougall, F., Firth, S., Baxter, R. (2004). Insulin-Like Growth Factor Binding Protein-3 Expression Is Associated With Growth Stimulation Of T47D Human Breast Cancer Cells: The Role Of Altered Epidermal Growth Factor Signaling. Journal of Clinical Endocrinology and Metabolism, 89(4), 1950-1956.
  • Yan, X., Forbes, B., McNeil, K., Baxter, R., Firth, S. (2004). Role Of N- And C-Terminal Residues Of Insulin-Like Growth Factor (IGF)-Binding Protein-3 In Regulating IGF Complex Formation And Receptor Activation. Journal of Biological Chemistry, 279(51), 53232-53240.
  • Payet, L., Firth, S., Baxter, R. (2004). The Role Of The Acid-Labile Subunit In Regulating Insulin-Like Growth Factor Transport Across Human Umbilical Vein Endothelial Cell Monolayers. Journal of Clinical Endocrinology and Metabolism, 89(5), 2382-2389.
  • Firth, S., Scott, C. (2004). The Role Of The M6P/Igf-Ii Receptor In Cancer: Tumor Suppression Or Garbage Disposal? Hormone And Metabolic Research, 36(5), 261-271.
  • Payet, L., Wang, X., Baxter, R., Firth, S. (2003). Amino-and carboxyl-terminal fragments of insulin-like growth factor (IGF) binding protein-3 cooperate to bind IGFs with high affinity and inhibit IGF receptor interactions. Endocrinology, 144(7), 2797-2806.
  • Kricker, J., Towne, C., Firth, S., Herington, A., Upton, Z. (2003). Structural and functional evidence for the interaction of insulin-like growth factors (IGFs) and IGF binding proteins with vitronectin. Endocrinology, 144(7), 2807-2815.
  • Firth, S., Baxter, R. (2002). Cellular Actions of the Insulin-like Growth Factor Binding Proteins. Endocrine Reviews, 23(6), 824-854.
  • Butt, A., Fraley, K., Firth, S., Baxter, R. (2002). IGF-Binding Protein-3-Induced Growth Inhibition and Apoptosis Do Not Require Cell Surface Binding and Nuclear Translocation in Human Breast Cancer Cells. Endocrinology, 143(7), 2693-2699.
  • Firth, S., McDougall, F., McLachlan, A., Baxter, R. (2002). Impaired Blockade of Insulin-Like Growth Factor I (IGF-I)-Induced Hypoglycemia by IGF Binding Protein-3 Analog with Reduced Ternary Complex-Forming Ability. Endocrinology, 143(5), 1669-1676.
  • O'Gorman, D., Weiss, J., Firth, S., Hettiaratchi, A., Scott, C. (2002). Insulin-like Growth Factor-II/Mannose 6-Phosphate Receptor Overexpression Reduces Growth of Choriocarcinoma Cells in Vitro and in Vivo. Endocrinology, 143(11), 4287-4294.
  • Baxter, R., Meka, S., Firth, S. (2002). Molecular Distribution of IGF Binding Protein-5 in Human Serum. Journal of Clinical Endocrinology and Metabolism, 87(1), 271-276.
  • Kong, S., Firth, S., Baxter, R., Delhanty, P. (2002). Regulation of the acid-labile subunit in sustained endotoxemia. American Journal of Physiology: Endocrinology and Metabolism, , 692-701.
  • Fanayan, S., Firth, S., Baxter, R. (2002). Signaling through the Smad Pathway by Insulin-like Growth Factor-binding Protein-3 in Breast Cancer Cells: Relationship to transforming growth factor -β1 signaling. Journal of Biological Chemistry, 277(9), 7255-7261.
  • Firth, S., Baxter, R., Galanis, M., Bond,, J., Nathanielsz, A., Kortt, A., Hudson,, P. (2001). Ligand-binding characteristics of recombinant amino-and carboxyl-terminal fragments of human insulin-like growth factor-binding protein-3. Journal of Endocrinology, 169, 123-133.
  • Firth, S., Baxter, R., Clemmons,, D. (2001). Mutagenesis of basic amino acids in the carboxyl-terminal region of insulin-like growth factor binding protein-5 affects acid-labile subunit binding. Endocrinology, 142(5), 2147-2150.

2013

  • Grkovic, S., O'Reilly, V., Han, S., Hong, M., Baxter, R., Firth, S. (2013). IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments. Oncogene, 32(19), 2412-2420. [More Information]

2012

  • de Silva, H., Firth, S., Twigg, S., Baxter, R. (2012). Interaction Between IGF Binding Protein-3 and TGFb in in the Regulation of Adipocyte Differentiation. Endocrinology, 153(10), 4799-4807. [More Information]
  • Jarajapu, Y., Cai, J., Yan, Y., Calzi, S., Kielczewski, J., Hu, P., Shaw, L., Firth, S., Chan-Ling, T., Boulton, M., Baxter, R., et al (2012). Protection of Blood Retinal Barrier and Systemic Vasculature by Insulin-Like Growth Factor Binding Protein-3. PLoS One, 7(7), 1-16. [More Information]

2011

  • Firth, S., Yan, X., Baxter, R. (2011). D440N Mutation in the Acid-Labile Subunit of Insulin-Like Growth Factor Complexes Inhibits Secretion and Complex Formation. Molecular Endocrinology, 25(2), 307-314. [More Information]
  • Kielczewski, J., Calzi, S., Shaw, L., Cai, J., Qi, X., Ruan, Q., Wu, L., Liu, L., Hu, P., Chan-Ling, T., Firth, S., Baxter, R., et al (2011). Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase). Investigative Ophthalmology and Visual Science, 52(11), 8278-8286. [More Information]

2010

  • Lin, Z., Natesan, V., Shi, H., Hamik, A., Kawanami, D., Hao, C., Mahabaleshwar, G., Wang, W., Jin, Z., Atkins, G., Firth, S., et al (2010). A novel role of CCN3 in regulating endothelial inflammation. Journal of Cell Communication and Signaling, 4, 141-153. [More Information]
  • Yan, X., Baxter, R., Firth, S. (2010). Involvement of pregnancy-associated plasma protein-A2 in insulin-like growth factor (IGF) binding protein-5 proteolysis during pregnancy: a potential mechanism for increasing IGF bioavailability. Journal of Clinical Endocrinology and Metabolism, 95(3), 1412-1420. [More Information]

2009

  • Yan, X., Payet, L., Baxter, R., Firth, S. (2009). Activity of human pregnancy insulin-like growth factor binding protein-3: determination by reconstituting recombinant complexes. Endocrinology, 150(11), 4968-4976. [More Information]

2007

  • Schedlich, L., Graham, L., O'Han, M., Muthukaruppan, A., Yan, X., Firth, S., Baxter, R. (2007). Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: Role in modulation of RAR-signaling. Archives of Biochemistry and Biophysics, 465(2), 359-369. [More Information]
  • Graham, M., Kilby, D., Firth, S., Robinson, P., Baxter, R. (2007). The in vivo phosphorylation and glycosylation of human insulin-like growth factor binding protein-5. Molecular and Cellular Proteomics, 6(8), 1392-1405. [More Information]

2006

  • Fukunaga-Kalabis, M., Martinez, G., Liu, Z., Kalabis, J., Mrass, P., Planque, N., Firth, S., Perbal, B., Herlyn, M., Weninger, W. (2006). CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1. The Journal of Cell Biology, 175(4), 563-569. [More Information]
  • Santer, F., Bacher, N., Moser, B., Morandell, D., Ressler, S., Firth, S., Spoden, G., Sergi, C., Baxter, R., Jansen-Durr, P., et al (2006). Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin/proteasome-dependent proteolysis. Cancer Research, 66(6), 3024-3033. [More Information]
  • Yan, X., Baxter, R., Perbal, B., Firth, S. (2006). The aminoterminal insulin-like growth factor (IGF) binding domain of IGF binding protein-3 cannot be functionally substituted by the structurally homologous domain of CCN3. Endocrinology, 147(11), 5268-5274. [More Information]

2005

  • Chan, S., Twigg, S., Firth, S., Baxter, R. (2005). Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes. Journal of Clinical Endocrinology and Metabolism, 90(12), 6588-6595. [More Information]

2004

  • Butt, A., Martin, J., Dickson, K., McDougall, F., Firth, S., Baxter, R. (2004). Insulin-Like Growth Factor Binding Protein-3 Expression Is Associated With Growth Stimulation Of T47D Human Breast Cancer Cells: The Role Of Altered Epidermal Growth Factor Signaling. Journal of Clinical Endocrinology and Metabolism, 89(4), 1950-1956.
  • Yan, X., Forbes, B., McNeil, K., Baxter, R., Firth, S. (2004). Role Of N- And C-Terminal Residues Of Insulin-Like Growth Factor (IGF)-Binding Protein-3 In Regulating IGF Complex Formation And Receptor Activation. Journal of Biological Chemistry, 279(51), 53232-53240.
  • Payet, L., Firth, S., Baxter, R. (2004). The Role Of The Acid-Labile Subunit In Regulating Insulin-Like Growth Factor Transport Across Human Umbilical Vein Endothelial Cell Monolayers. Journal of Clinical Endocrinology and Metabolism, 89(5), 2382-2389.
  • Firth, S., Scott, C. (2004). The Role Of The M6P/Igf-Ii Receptor In Cancer: Tumor Suppression Or Garbage Disposal? Hormone And Metabolic Research, 36(5), 261-271.

2003

  • Payet, L., Wang, X., Baxter, R., Firth, S. (2003). Amino-and carboxyl-terminal fragments of insulin-like growth factor (IGF) binding protein-3 cooperate to bind IGFs with high affinity and inhibit IGF receptor interactions. Endocrinology, 144(7), 2797-2806.
  • Kricker, J., Towne, C., Firth, S., Herington, A., Upton, Z. (2003). Structural and functional evidence for the interaction of insulin-like growth factors (IGFs) and IGF binding proteins with vitronectin. Endocrinology, 144(7), 2807-2815.

2002

  • Firth, S., Baxter, R. (2002). Cellular Actions of the Insulin-like Growth Factor Binding Proteins. Endocrine Reviews, 23(6), 824-854.
  • Butt, A., Fraley, K., Firth, S., Baxter, R. (2002). IGF-Binding Protein-3-Induced Growth Inhibition and Apoptosis Do Not Require Cell Surface Binding and Nuclear Translocation in Human Breast Cancer Cells. Endocrinology, 143(7), 2693-2699.
  • Firth, S., McDougall, F., McLachlan, A., Baxter, R. (2002). Impaired Blockade of Insulin-Like Growth Factor I (IGF-I)-Induced Hypoglycemia by IGF Binding Protein-3 Analog with Reduced Ternary Complex-Forming Ability. Endocrinology, 143(5), 1669-1676.
  • O'Gorman, D., Weiss, J., Firth, S., Hettiaratchi, A., Scott, C. (2002). Insulin-like Growth Factor-II/Mannose 6-Phosphate Receptor Overexpression Reduces Growth of Choriocarcinoma Cells in Vitro and in Vivo. Endocrinology, 143(11), 4287-4294.
  • Baxter, R., Meka, S., Firth, S. (2002). Molecular Distribution of IGF Binding Protein-5 in Human Serum. Journal of Clinical Endocrinology and Metabolism, 87(1), 271-276.
  • Kong, S., Firth, S., Baxter, R., Delhanty, P. (2002). Regulation of the acid-labile subunit in sustained endotoxemia. American Journal of Physiology: Endocrinology and Metabolism, , 692-701.
  • Fanayan, S., Firth, S., Baxter, R. (2002). Signaling through the Smad Pathway by Insulin-like Growth Factor-binding Protein-3 in Breast Cancer Cells: Relationship to transforming growth factor -β1 signaling. Journal of Biological Chemistry, 277(9), 7255-7261.

2001

  • Firth, S., Baxter, R., Galanis, M., Bond,, J., Nathanielsz, A., Kortt, A., Hudson,, P. (2001). Ligand-binding characteristics of recombinant amino-and carboxyl-terminal fragments of human insulin-like growth factor-binding protein-3. Journal of Endocrinology, 169, 123-133.
  • Firth, S., Baxter, R., Clemmons,, D. (2001). Mutagenesis of basic amino acids in the carboxyl-terminal region of insulin-like growth factor binding protein-5 affects acid-labile subunit binding. Endocrinology, 142(5), 2147-2150.

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