Associate Professor Susan McLennan

Principal Research Fellow & Associate Professor
Medicine, Central Clinical School
Bosch Institute

Telephone 02 95155185
Fax 02 95161273

Map

Research interests

Diabetes and its complications

Selected grants

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Circulating monocyte phenotype: Is it altered in association with the development of diabetic complications?; McLennan S, Twigg S, Min D; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • The Role of the Hepatocyte and EMMPRIN in Liver Injury; Shackel N, McCaughan G, McLennan S; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Targeting proteases for a novel therapy for type 2 diabetes and liver complications.; Gorrell M, Twigg S, McLennan S, McCaughan G, Chowdhury S; Diabetes Australia Research Trust/Research Grants.
  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Role of Inflammation in Diabetic Cardiomyopathy; Twigg S, King N, McLennan S; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Preventing Adverse Effects of Matrix Metalloproteinases in Diabetic Wound Healing; McLennan S, Twigg S, Min D, Yue D; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Diabetes exacerbates non-alcoholic steato-hepatitis (NASH); Twigg S, McLennan S, Gorrell M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Connective Tissue Growth Factor in diabetic cardiomyopathy; Twigg S, McLennan S; Heart Foundation of Australia/Grants-in-Aid.
  • Funded Position; Yue D, McLennan S; Sydney South West Area Health Service/Research Support.

2008

  • Dako ACIS III Cellular Image Acquisition and Analysis System; Gorrell M, Grau G, Bishop A, Black J, Campbell I, McLennan S, Rodgers K, Seth D, Marsh D, Dong Q, Hambly B, Bao B, King N, Markham R, McDonald K, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • The role of the Hepatocyte in extracellular matrix interactions in Liver Fibrogenesis; Shackel N, McLennan S, Warner F; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Dako ACIS 111 Cellular Image Acquisition and Analysis System; Hambly B, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2007

  • Rotor-Gene 6000, 5-Plex HRM with desktop computer & Gene-Disc 100 Stater Kit; Halliday G, Yue D, Sharland A, Bishop A, Stocker R, Bao B, McLennan S, Matsumoto I, Hambly B, Rose B, Harbour C, Ho J, Lee C, Twigg S, Soon L, Richardson D, King N, Zreiqat H; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Novel regulators of fat cell differentiation; Twigg S, McLennan S, Baxter R; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Role and mechanism of connective tissue growth factor in diabetic cardiomyopathy; Twigg S, McLennan S, Allen T; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • A novel 3D quantitative mapping technique of angiogenesis in diabetes; McLennan S; Juvenile Diabetes Research Foundation International (JDRF)/Research Grant.

2004

  • Impaired wound healing in diabetes : role for combination growth factor therapies; McLennan S; Juvenile Diabetes Research Foundation International (JDRF)/Research Grant.

2003

  • Type I diabetes in baboons: The effects of inhibiting advanced glycation on diabetic complications; Yue D, McLennan S; Rebecca L Cooper/Medical Research Foundation.
  • 2 x leica microsystems imaging systems; 2 x Computer workstations; Black J, Pollard J, Yue D, McLennan S, Twigg S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • Type I diabetes in baboons: the effects of inhibiting advanced glycation on diabetic complications; Yue D, McLennan S; Juvenile Diabetes Fdn Internat/Research Grant.

Selected publications

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Book Chapters

  • Boughton, E., McLennan, S. (2013). Biomimetic scaffolds for skin tissue and wound repair. In Andrew J Ruys (Eds.), Biomimetic biomaterials: Structure and applications, (pp. 153-180). Cambridge: Woodhead Publishing Ltd.
  • Twigg, S., McLennan, S. (2012). Managing diabetes complications in the clinical arena. In Louise A. Baur, Stephen M. Twigg, Roger S.Magnusson (Eds.), A Modern Epidemic: Expert Perspectives on Obesity and Diabetes, (pp. 353-371). Sydney, Australia: Sydney University Press.

Journals

  • Calabro, S., Maczurek, A., Morgan, A., Tu, T., Wen, V., Yee, C., Mridha, A., Lee, M., D'Avigdor, W., Locarnini, S., McCaughan, G., Warner, F., McLennan, S., Shackel, N. (2014). Hepatocyte Produced Matrix Metalloproteinases Are Regulated by CD147 in Liver Fibrogenesis. PLoS One, 9(7), e90571. [More Information]
  • McGrath, K., Li, X., Whitworth, P., Kasz, R., Tan, J., McLennan, S., Celermajer, D., Barter, P., Rye, K., Heather, A. (2014). High density lipoproteins improve insulin sensitivity in high-fat diet-fed mice by suppressing hepatic inflammation. Journal of Lipid Research (Online), 55(3), 421-430. [More Information]
  • Keane, F., Tsun-Wen, Y., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]
  • McLennan, S., Abdollahi, M., Twigg, S. (2013). Connective tissue growth factor, matrix regulation, and diabetic kidney disease. Current Opinion In Nephrology And Hypertension, 22(1), 85-92. [More Information]
  • Tan, J., McLennan, S., Williams, P., Rezaeizadeh, A., Lo, L., Bonner, J., Twigg, S. (2013). Connective tissue growth factor/CCN-2 is upregulated in epididymal and subcutaneous fat depots in a dietary-induced obesity model. American Journal of Physiology: Endocrinology and Metabolism, 304(12), E1291-E1302. [More Information]
  • Williams, K., Shackel, N., Gorrell, M., McLennan, S., Twigg, S. (2013). Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocrine Reviews, 34(1), 84-129. [More Information]
  • McLennan, S., Warner, F., Shackel, N. (2013). The role of CD147 in Liver Injury - "The truth is in the details" - letter to the editor. Journal of Hepatology, 58(4), 836-837. [More Information]
  • Min, D., Brooks, B., Wong, J., Salomon, R., Bao, W., Harrisberg, B., Twigg, S., Yue, D., McLennan, S. (2012). Alterations in Monocyte CD16 in Association with Diabetes Complications. Mediators of Inflammation, 2012, 1-10. [More Information]
  • Wang, X., McLennan, S., Twigg, S. (2011). CCN-2 is up-regulated by and mediates effects of matrix bound advanced glycated end-products in human renal mesangial cells. Journal of Cell Communication and Signaling, 5(3), 193-200. [More Information]
  • Lo, L., McLennan, S., Williams, P., Bonner, J., Chowdhury, S., McCaughan, G., Gorrell, M., Yue, D., Twigg, S. (2011). Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis. Journal of Hepatology, 55(2), 435-444. [More Information]
  • Thomson, S., McLennan, S., Hennessy, A., Boughton, P., Bonner, J., Zoellner, H., Yue, D., Twigg, S. (2010). A novel primate model of delayed wound healing in diabetes: dysregulation of connective tissue growth factor. Diabetologia: clinical and experimental diabetes and metabolism, 53, 572-583. [More Information]
  • Bao, W., Min, D., Twigg, S., Shackel, N., Warner, F., Yue, D., McLennan, S. (2010). Monocyte CD147 is induced by advanced glycation end products and high glucose concentration: possible role in diabetic complications. American Journal of Physiology: Cell Physiology, 299(5), C1212-C1219. [More Information]
  • Wang, X., McLennan, S., Allen, T., Twigg, S. (2010). Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes. Journal of Cell Communication and Signaling, 4(1), 15-23. [More Information]
  • Ban, C., Twigg, S., Franjic, B., Brooks, B., Celermajer, D., Yue, D., McLennan, S. (2010). Serum MMP-7 is increased in diabetic renal disease and diabetic diastolic dysfunction. Diabetes Research and Clinical Practice, 87(3), 335-341. [More Information]
  • Wang, X., McLennan, S., Allen, T., Tsoutsman, T., Semsarian, C., Twigg, S. (2009). Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. American Journal of Physiology: Cell Physiology, 297(6), c1490-c1500. [More Information]
  • Liu, Y., Min, D., Bolton, T., Nube, V., Twigg, S., Yue, D., McLennan, S. (2009). Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers. Diabetes Care, 32(1), 117-119. [More Information]
  • Min, D., Lyons, G., Bonner, J., Twigg, S., Yue, D., McLennan, S. (2009). Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathways: possible pathogenic role in diabetic nephropathy. American Journal of Physiology: Renal Physiology (Print), 297(5), F1229-F1237. [More Information]
  • Wong, J., McLennan, S., Molyneaux, L., Min, D., Twigg, S., Yue, D. (2009). Mitochondrial DNA content in peripheral blood monocytes: relationship with age of diabetes onsetand diabetic complications. Diabetologia: clinical and experimental diabetes and metabolism, 52, 1953-1961. [More Information]
  • Tan, J., McLennan, S., Song (Wen Chao), W., Lo, L., Bonner, J., Williams, P., Twigg, S. (2008). Connective tissue growth factor inhibits adipocyte differentiation. American Journal of Physiology: Cell Physiology, 295(3), C740-C751. [More Information]
  • Brooks, B., McLennan, S., Twigg, S., Yue, D. (2008). Detection and characterisation of microcirculatory abnormalities in the skin of diabetic patients with microvascular complications. Diabetes and Vascular Disease Research, 5(1), 30-35. [More Information]
  • McLennan, S., Min, D., Zaman, S. (2008). Matrix metalloproteinases: their role in poor wound healing in diabetes. Wound Practice & Research, 16, 116-120.
  • Thomson, S., McLennan, S., Kirwan, P., Heffernan, S., Hennessy, A., Yue, D., Twigg, S. (2008). Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy. Journal of Diabetes and Its Complications, 22(4), 284-294. [More Information]
  • McLennan, S., Bonner, J., Milne, S., Lo, L., Charlton, A., Kurup, S., Jia, J., Yue, D., Twigg, S. (2008). The anti-inflammatory agent Propolis improves wound healing in a rodent model of experimental diabetes. Wound Repair and Regeneration, 16, 706-713. [More Information]
  • Brooks, B., Heffernan, S., Thomson, S., McLennan, S., Twigg, S., Yue, D. (2008). The Effects of Diabetes and Aminoguanidine Treatment on Endothelial Function in a Primate Model of Type 1 Diabetes. American Journal of Primatology, 70(8), 796-802. [More Information]
  • McLennan, S., Kelly, D., Schache, M., Waltham, M., Dy, V., Langham, R., Yue, D., Gilbert, R. (2007). Advanced glycation end products decrease mesangial cell MMP-7: A role in matrix accumulation in diabetic nephropathy? Kidney International, 72(4), 481-488. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia: clinical and experimental diabetes and metabolism, 50(9), 1969-1976. [More Information]
  • Xu, L., McLennan, S., Lo, L., Natfaji, A., Bolton, T., Liu, Y., Twigg, S., Yue, D. (2007). Bacterial load predicts healing rate in neuropathic diabetic foot ulcers. Diabetes Care, 30(2), 378-380. [More Information]
  • McLennan, S., McGill, M., Twigg, S., Yue, D. (2007). Improving wound-healing outcomes in diabetic foot ulcers. Expert Review of Endocrinology and Metabolism, 2, 205-213.
  • Min, D., Lyons, G., Jia, J., Lo, L., McLennan, S. (2006). 2-Methoxy-2,4-diphenyl-3(2H)-furanone-labeled gelatin zymography and reverse zymography: a rapid real-time method for quantification of matrix metalloproteinases-2 and -9 and tissue inhibitors of metalloproteinases. Electrophoresis, 27(2), 357-364. [More Information]
  • Thomson, S., McLennan, S., Twigg, S. (2006). Growth factors in diabetic complications. Expert Review of Clinical Immunology, 2(3), 403-18. [More Information]
  • Young, A., McLennan, S., Smith, M., Smith, S., Cake, M., Read, R., Melrose, J., Sonnabend, D., Flannery, C., Little, C. (2006). Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Research and Therapy, 8(2), 1-6. [More Information]
  • McLennan, S., Wang, X., Moreno, V., Yue, D., Twigg, S. (2004). Connective Tissue Growth Factor Mediates High Glucose Effects On Matrix Degradation Through Tissue Inhibitor Of Matrix Metalloproteinase Type 1: Implications For Diabetic Nephropathy. Endocrinology, 145(12), 5646-5655.
  • Prasan, A., McCarron, H., White, M., McLennan, S., Tchen, A., Hambly, B., Jeremy, R. (2002). Duration of ischaemia determines matrix metalloproteinase-2 activation in the reperfused rabbit heart. Proteomics, 2, 1204-1210.
  • Birrell, A., Heffernan, S., Ansselin, A., McLennan, S., Church, D., Gillin, A., Yue, D. (2000). Functional and structural abnormalities in the nerves of Type 1 diabetic baboons: aminoguanidine treatment does not improve nerve function. Diabetologia: clinical and experimental diabetes and metabolism, 43, 110-116.

Conferences

  • Thomson, S., McLennan, S., Hennessy, A., Bonner, J., Zoellner, H., Yue, D., Twigg, S. (2007). Dysregulated inflammation predicts reduced connective tissue growth factor expression in a baboon wound healing model of type 1 diabetes. The 43rd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Young, A., McLennan, S., Smith, S., Smith, M., Melrose, J., Cake, M., Flannery, C., Sonnabend, D., Little, C. (2006). Changes in expression and immunolcalization of proteoglycan 4 / lubricin in cartilage in an ovine model of early osteoarthritis. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • McLennan, S., Jia, J., Milne, S., Lo, L., Bonner, J., Yue, D., Twigg, S. (2006). Propolis, the anti-inflammatory bee hive protectant improves wound healing in experimental diabetes. 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.

2014

  • Calabro, S., Maczurek, A., Morgan, A., Tu, T., Wen, V., Yee, C., Mridha, A., Lee, M., D'Avigdor, W., Locarnini, S., McCaughan, G., Warner, F., McLennan, S., Shackel, N. (2014). Hepatocyte Produced Matrix Metalloproteinases Are Regulated by CD147 in Liver Fibrogenesis. PLoS One, 9(7), e90571. [More Information]
  • McGrath, K., Li, X., Whitworth, P., Kasz, R., Tan, J., McLennan, S., Celermajer, D., Barter, P., Rye, K., Heather, A. (2014). High density lipoproteins improve insulin sensitivity in high-fat diet-fed mice by suppressing hepatic inflammation. Journal of Lipid Research (Online), 55(3), 421-430. [More Information]
  • Keane, F., Tsun-Wen, Y., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]

2013

  • Boughton, E., McLennan, S. (2013). Biomimetic scaffolds for skin tissue and wound repair. In Andrew J Ruys (Eds.), Biomimetic biomaterials: Structure and applications, (pp. 153-180). Cambridge: Woodhead Publishing Ltd.
  • McLennan, S., Abdollahi, M., Twigg, S. (2013). Connective tissue growth factor, matrix regulation, and diabetic kidney disease. Current Opinion In Nephrology And Hypertension, 22(1), 85-92. [More Information]
  • Tan, J., McLennan, S., Williams, P., Rezaeizadeh, A., Lo, L., Bonner, J., Twigg, S. (2013). Connective tissue growth factor/CCN-2 is upregulated in epididymal and subcutaneous fat depots in a dietary-induced obesity model. American Journal of Physiology: Endocrinology and Metabolism, 304(12), E1291-E1302. [More Information]
  • Williams, K., Shackel, N., Gorrell, M., McLennan, S., Twigg, S. (2013). Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocrine Reviews, 34(1), 84-129. [More Information]
  • McLennan, S., Warner, F., Shackel, N. (2013). The role of CD147 in Liver Injury - "The truth is in the details" - letter to the editor. Journal of Hepatology, 58(4), 836-837. [More Information]

2012

  • Min, D., Brooks, B., Wong, J., Salomon, R., Bao, W., Harrisberg, B., Twigg, S., Yue, D., McLennan, S. (2012). Alterations in Monocyte CD16 in Association with Diabetes Complications. Mediators of Inflammation, 2012, 1-10. [More Information]
  • Twigg, S., McLennan, S. (2012). Managing diabetes complications in the clinical arena. In Louise A. Baur, Stephen M. Twigg, Roger S.Magnusson (Eds.), A Modern Epidemic: Expert Perspectives on Obesity and Diabetes, (pp. 353-371). Sydney, Australia: Sydney University Press.

2011

  • Wang, X., McLennan, S., Twigg, S. (2011). CCN-2 is up-regulated by and mediates effects of matrix bound advanced glycated end-products in human renal mesangial cells. Journal of Cell Communication and Signaling, 5(3), 193-200. [More Information]
  • Lo, L., McLennan, S., Williams, P., Bonner, J., Chowdhury, S., McCaughan, G., Gorrell, M., Yue, D., Twigg, S. (2011). Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis. Journal of Hepatology, 55(2), 435-444. [More Information]

2010

  • Thomson, S., McLennan, S., Hennessy, A., Boughton, P., Bonner, J., Zoellner, H., Yue, D., Twigg, S. (2010). A novel primate model of delayed wound healing in diabetes: dysregulation of connective tissue growth factor. Diabetologia: clinical and experimental diabetes and metabolism, 53, 572-583. [More Information]
  • Bao, W., Min, D., Twigg, S., Shackel, N., Warner, F., Yue, D., McLennan, S. (2010). Monocyte CD147 is induced by advanced glycation end products and high glucose concentration: possible role in diabetic complications. American Journal of Physiology: Cell Physiology, 299(5), C1212-C1219. [More Information]
  • Wang, X., McLennan, S., Allen, T., Twigg, S. (2010). Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes. Journal of Cell Communication and Signaling, 4(1), 15-23. [More Information]
  • Ban, C., Twigg, S., Franjic, B., Brooks, B., Celermajer, D., Yue, D., McLennan, S. (2010). Serum MMP-7 is increased in diabetic renal disease and diabetic diastolic dysfunction. Diabetes Research and Clinical Practice, 87(3), 335-341. [More Information]

2009

  • Wang, X., McLennan, S., Allen, T., Tsoutsman, T., Semsarian, C., Twigg, S. (2009). Adverse effects of high glucose and free fatty acid on cardiomyocytes are mediated by connective tissue growth factor. American Journal of Physiology: Cell Physiology, 297(6), c1490-c1500. [More Information]
  • Liu, Y., Min, D., Bolton, T., Nube, V., Twigg, S., Yue, D., McLennan, S. (2009). Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers. Diabetes Care, 32(1), 117-119. [More Information]
  • Min, D., Lyons, G., Bonner, J., Twigg, S., Yue, D., McLennan, S. (2009). Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathways: possible pathogenic role in diabetic nephropathy. American Journal of Physiology: Renal Physiology (Print), 297(5), F1229-F1237. [More Information]
  • Wong, J., McLennan, S., Molyneaux, L., Min, D., Twigg, S., Yue, D. (2009). Mitochondrial DNA content in peripheral blood monocytes: relationship with age of diabetes onsetand diabetic complications. Diabetologia: clinical and experimental diabetes and metabolism, 52, 1953-1961. [More Information]

2008

  • Tan, J., McLennan, S., Song (Wen Chao), W., Lo, L., Bonner, J., Williams, P., Twigg, S. (2008). Connective tissue growth factor inhibits adipocyte differentiation. American Journal of Physiology: Cell Physiology, 295(3), C740-C751. [More Information]
  • Brooks, B., McLennan, S., Twigg, S., Yue, D. (2008). Detection and characterisation of microcirculatory abnormalities in the skin of diabetic patients with microvascular complications. Diabetes and Vascular Disease Research, 5(1), 30-35. [More Information]
  • McLennan, S., Min, D., Zaman, S. (2008). Matrix metalloproteinases: their role in poor wound healing in diabetes. Wound Practice & Research, 16, 116-120.
  • Thomson, S., McLennan, S., Kirwan, P., Heffernan, S., Hennessy, A., Yue, D., Twigg, S. (2008). Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy. Journal of Diabetes and Its Complications, 22(4), 284-294. [More Information]
  • McLennan, S., Bonner, J., Milne, S., Lo, L., Charlton, A., Kurup, S., Jia, J., Yue, D., Twigg, S. (2008). The anti-inflammatory agent Propolis improves wound healing in a rodent model of experimental diabetes. Wound Repair and Regeneration, 16, 706-713. [More Information]
  • Brooks, B., Heffernan, S., Thomson, S., McLennan, S., Twigg, S., Yue, D. (2008). The Effects of Diabetes and Aminoguanidine Treatment on Endothelial Function in a Primate Model of Type 1 Diabetes. American Journal of Primatology, 70(8), 796-802. [More Information]

2007

  • McLennan, S., Kelly, D., Schache, M., Waltham, M., Dy, V., Langham, R., Yue, D., Gilbert, R. (2007). Advanced glycation end products decrease mesangial cell MMP-7: A role in matrix accumulation in diabetic nephropathy? Kidney International, 72(4), 481-488. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia: clinical and experimental diabetes and metabolism, 50(9), 1969-1976. [More Information]
  • Xu, L., McLennan, S., Lo, L., Natfaji, A., Bolton, T., Liu, Y., Twigg, S., Yue, D. (2007). Bacterial load predicts healing rate in neuropathic diabetic foot ulcers. Diabetes Care, 30(2), 378-380. [More Information]
  • Thomson, S., McLennan, S., Hennessy, A., Bonner, J., Zoellner, H., Yue, D., Twigg, S. (2007). Dysregulated inflammation predicts reduced connective tissue growth factor expression in a baboon wound healing model of type 1 diabetes. The 43rd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • McLennan, S., McGill, M., Twigg, S., Yue, D. (2007). Improving wound-healing outcomes in diabetic foot ulcers. Expert Review of Endocrinology and Metabolism, 2, 205-213.

2006

  • Min, D., Lyons, G., Jia, J., Lo, L., McLennan, S. (2006). 2-Methoxy-2,4-diphenyl-3(2H)-furanone-labeled gelatin zymography and reverse zymography: a rapid real-time method for quantification of matrix metalloproteinases-2 and -9 and tissue inhibitors of metalloproteinases. Electrophoresis, 27(2), 357-364. [More Information]
  • Young, A., McLennan, S., Smith, S., Smith, M., Melrose, J., Cake, M., Flannery, C., Sonnabend, D., Little, C. (2006). Changes in expression and immunolcalization of proteoglycan 4 / lubricin in cartilage in an ovine model of early osteoarthritis. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Thomson, S., McLennan, S., Twigg, S. (2006). Growth factors in diabetic complications. Expert Review of Clinical Immunology, 2(3), 403-18. [More Information]
  • McLennan, S., Jia, J., Milne, S., Lo, L., Bonner, J., Yue, D., Twigg, S. (2006). Propolis, the anti-inflammatory bee hive protectant improves wound healing in experimental diabetes. 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Germany: Springer-Verlag.
  • Young, A., McLennan, S., Smith, M., Smith, S., Cake, M., Read, R., Melrose, J., Sonnabend, D., Flannery, C., Little, C. (2006). Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Research and Therapy, 8(2), 1-6. [More Information]

2004

  • McLennan, S., Wang, X., Moreno, V., Yue, D., Twigg, S. (2004). Connective Tissue Growth Factor Mediates High Glucose Effects On Matrix Degradation Through Tissue Inhibitor Of Matrix Metalloproteinase Type 1: Implications For Diabetic Nephropathy. Endocrinology, 145(12), 5646-5655.

2002

  • Prasan, A., McCarron, H., White, M., McLennan, S., Tchen, A., Hambly, B., Jeremy, R. (2002). Duration of ischaemia determines matrix metalloproteinase-2 activation in the reperfused rabbit heart. Proteomics, 2, 1204-1210.

2000

  • Birrell, A., Heffernan, S., Ansselin, A., McLennan, S., Church, D., Gillin, A., Yue, D. (2000). Functional and structural abnormalities in the nerves of Type 1 diabetic baboons: aminoguanidine treatment does not improve nerve function. Diabetologia: clinical and experimental diabetes and metabolism, 43, 110-116.

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