Dr Sumit Sahni

Research Fellow
Leader, Tumour Micro-environment and Cancer Progression Group

Telephone +61-02-935-16150

Map

Current research students

Project title Research student
Glutathione-S-Transferase Machinery and its Role as a Novel Nitric Oxide Storage and Transport System in Macrophage Biology Taufik ABIDIN

Honours project opportunities

Selected grants

2018

  • Therapeutic Targeting of the Potent Metastasis Suppressor, NDRG1, in Pancreatic Cancer; Kovacevic Z, Kalinowski D, Apte M, Lee S, Sahni S; Avner Pancreatic Cancer Foundation/Research support.

2017

  • Molecular Role of the AMPK-Dependent Pathway in the Activity of Thiosemicarbazones Against Pancreatic Cancer.; Sahni S; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.
  • Development of Novel Agents that Target P-Glycoprotein Resistant Pancreatic Cancer; Richardson D, Jansson P, Kalinowski D, Sahni S; Avner Pancreatic Cancer Foundation/Research support.

2015

  • SMS ECR Scheme 2015; Sahni S; Sydney Medical School/New Staff - Early Career Researcher Scheme.

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho P, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

Selected publications

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Journals

  • Park, K., Menezes, S., Kalinowski, D., Sahni, S., Jansson, P., Kovacevic, Z., Richardson, D. (2018). Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1864 (8), 2644-2663. [More Information]
  • Sahni, S., Hickok, J., Thomas, D. (2018). Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes. Nitric Oxide: Biology And Chemistry, 76, 37-44. [More Information]
  • Al-Akra, L., Bae, D., Sahni, S., Huang, M., Park, K., Lane, D., Jansson, P., Richardson, D. (2018). Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones. Journal of Biological Chemistry, 293(10), 3562-3587. [More Information]
  • Palanimuthu, D., Poon, R., Sahni, S., Anjum, R., Hibbs, D., Lin, H., Bernhardt, P., Kalinowski, D., Richardson, D. (2017). A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 139, 612-632. [More Information]
  • Menezes, S., Sahni, S., Kovacevic, Z., Richardson, D. (2017). Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling. Journal of Biological Chemistry, 292(31), 12772-12782. [More Information]
  • Kovacevic, Z., Sahni, S., Lok, H., Davies, M., Wink, D., Richardson, D. (2017). Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1861 (5), 995-999. [More Information]
  • Sahni, S., Bae, D., Jansson, P., Richardson, D. (2017). The mechanistic role of chemically diverse metal ions in the induction of autophagy. Pharmacological Research, 119, 118-127. [More Information]
  • Lok, H., Sahni, S., Jansson, P., Kovacevic, Z., Hawkins, C., Richardson, D. (2016). A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity. Journal of Biological Chemistry, 291(53), 27042-27061. [More Information]
  • Park, K., Fouani, L., Jansson, P., Wooi, D., Sahni, S., Lane, D., Palanimuthu, D., Lok, H., Kovacevic, Z., Huang, M., Kalinowski, D., Richardson, D. (2016). Copper and conquer: Copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics. Metallomics, 8(9), 874-886. [More Information]
  • Kovacevic, Z., Sahni, S., Richardson, D. (2016). Copper that cancer with lysosomal love!. Aging, 8(2), 210-211.
  • Chiang, S., Kovacevic, Z., Sahni, S., Lane, D., Merlot, A., Kalinowski, D., Huang, M., Richardson, D. (2016). Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia. Clinical Science, 130(11), 853-870. [More Information]
  • Klionsky, D., Abdelmohsen, K., Akihisa, A., Abedin, M., Abeliovich, H., Acevedo-Arozena, A., Arozena, H., Adams, C., Adams, P., et al, Sue, C., Mihailidou, A., Bae, D., Gutierrez, E., Jansson, P., Lane, D., Merlot, A., Richardson, D., Sahni, S. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), 1-222. [More Information]
  • Merlot, A., Sahni, S., Lane, D., Richardson, V., Huang, M., Kalinowski, D., Richardson, D. (2016). Letter to the Editor: Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques"". International Journal of Molecular Sciences, 17(11), E1916. [More Information]
  • Gutierrez, E., Seebacher, N., Arzuman, L., Kovacevic, Z., Lane, D., Richardson, V., Merlot, A., Lok, H., Kalinowski, D., Sahni, S., Jansson, P., Richardson, D. (2016). Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT). Biochimica et Biophysica Acta, 1863 (7 Pt A), 1665-1681. [More Information]
  • Merlot, A., Shafie, N., Yu, Y., Richardson, V., Jansson, P., Sahni, S., Lane, D., Kovacevic, Z., Kalinowski, D., Richardson, D. (2016). Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2[alpha], IRE1[alpha], ATF6 and calmodulin kinase. Biochemical Pharmacology, 109, 27-47. [More Information]
  • Al-Eisawi, Z., Stefani, C., Jansson, P., Arvind, A., Sharpe, P., Basha, M., Iskander, G., Kumar, N., Kovacevic, Z., Lane, D., Sahni, S., Richardson, D., Kalinowski, D., et al (2016). Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3- selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization. Journal of Medicinal Chemistry, 59(1), 294-312. [More Information]
  • Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Olynyk, J., Chua, A., Jansson, P., Sahni, S., Lane, D., Merlot, A., Kovacevic, Z., Huang, M., Richardson, D., et al (2016). Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica et Biophysica Acta, 1863 (4), 727-748. [More Information]
  • Paluncic, J., Kovacevic, Z., Jansson, P., Kalinowski, D., Merlot, A., Huang, M., Lok, H., Sahni, S., Lane, D., Richardson, D. (2016). Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling. Biochimica et Biophysica Acta, 1863 (4), 770-784. [More Information]
  • Sahni, S., Kovacevic, Z., Kalinowski, D., Huang, M., Menezes, S., Krishan, S., Lane, D., Jansson, P., Richardson, D. (2016). Targeting autophagy in antitumor agent design: Furthering the 'lysosomal love' strategy. Future Medicinal Chemistry, 8(7), 727-729. [More Information]
  • Wangpu, X., Lu, J., Xi, R., Yue, F., Sahni, S., Park, K., Menezes, S., Huang, M., Zheng, M., Kovacevic, Z., Richardson, D. (2016). Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling. Molecular Pharmacology, 89(5), 521-540. [More Information]
  • Krishan, S., Richardson, D., Sahni, S. (2016). The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells. Biochimica et Biophysica Acta, 1863 (12), 2916-2933. [More Information]
  • Kovacevic, Z., Menezes, S., Sahni, S., Kalinowski, D., Bae, D., Lane, D., Richardson, D. (2016). The metastasis suppressor, N-MYC downstream-regulated gene-1 (NDRG1), down-regulates the ErbB family of receptors to inhibit downstream oncogenic signaling pathways. Journal of Biological Chemistry, 291(3), 1029-1052. [More Information]
  • Krishan, S., Richardson, D., Sahni, S. (2015). Adenosine Monophosphate-Activated Kinase and Its Key Role in Catabolism: Structure, Regulation, Biological Activity and Pharmacological Activation. Molecular Pharmacology, 87(3), 363-377. [More Information]
  • Lane, D., Merlot, A., Huang, M., Bae, D., Jansson, P., Sahni, S., Kalinowski, D., Richardson, D. (2015). Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochimica et Biophysica Acta - General Subjects, 1853 (5), 1130-1144. [More Information]
  • Jansson, P., Yamagishi, T., Arvind, A., Seebacher, N., Gutierrez, E., Stacy, A., Maleki, S., Sharp, D., Sahni, S., Richardson, D. (2015). Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp). Journal of Biological Chemistry, 290(15), 9588-9603. [More Information]
  • Lane, D., Bae, D., Merlot, A., Sahni, S., Richardson, D. (2015). Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation. Nutrients, 7(4), 2274-2296. [More Information]
  • Potuckova, E., Roh, J., Machacek, M., Sahni, S., Stariat, J., Sestak, V., Jansova, H., Haskova, P., Jirkovska, A., Kalinowski, D., Richardson, D., et al (2015). In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites. PloS One, 10(10), 1-20. [More Information]
  • Krishan, S., Jansson, P., Gutierrez, E., Lane, D., Richardson, D., Sahni, S. (2015). Iron metabolism and autophagy: A poorly explored relationship that has important consequences for health and disease. Nagoya Journal of Medical Science, 77, 1-6.
  • Merlot, A., Kalinowski, D., Kovacevic, Z., Jansson, P., Lane, D., Sahni, S., Huang, M., Richardson, D. (2015). Making a case for albumin - a highly promising drug-delivery system. Future Medicinal Chemistry, 7(5), 553-556. [More Information]
  • Lui, G., Kovacevic, Z., Menezes, S., Kalinowski, D., Merlot, A., Sahni, S., Richardson, D. (2015). Novel Thiosemicarbazones Regulate the Signal Transducer and Activator of Transcription 3 (STAT3) Pathway: Inhibition of Constitutive and Interleukin 6-Induced Activation by Iron Depletion. Molecular Pharmacology, 87(3), 543-560. [More Information]
  • Merlot, A., Sahni, S., Lane, D., Fordham, A., Pantarat, N., Hibbs, D., Richardson, V., Doddareddy, M., Ong, J., Huang, M., Richardson, D., Kalinowski, D. (2015). Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells. Oncotarget, 6(12), 10374-10398. [More Information]
  • Liu, W., Kovacevic, Z., Peng, Z., Jin, R., Wang, P., Yue, F., Zheng, M., Huang, M., Jansson, P., Richardson, V., Kalinowski, D., Lane, D., Merlot, A., Sahni, S., Richardson, D. (2015). The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets. Oncotarget, 6(34), 35522-35541. [More Information]
  • Liu, W., Yue, F., Zheng, M., Merlot, A., Bae, D., Huang, M., Lane, D., Jansson, P., Lui, G., Richardson, V., Sahni, S., Kalinowski, D., Kovacevic, Z., Richardson, D. (2015). The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1. Oncotarget, 6(11), 8851-8874. [More Information]
  • Jansson, P., Kalinowski, D., Lane, D., Kovacevic, Z., Seebacher, N., Fouani, L., Sahni, S., Merlot, A., Richardson, D. (2015). The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones. Pharmacological Research, 100, 255-260. [More Information]
  • Sahni, S., Krishan, S., Palanimuthu, D., Richardson, D. (2015). The use of iron chelators in biocidal compositions: evaluation of patent, WO2014059417A1. Expert Opinion on Therapeutic Patents, 25(3), 367-372. [More Information]
  • Krishan, S., Richardson, D., Sahni, S. (2014). AMP kinase (PRKAA1). Journal of Clinical Pathology, 67(9), 758-763. [More Information]
  • Sahni, S., Merlot, A., Krishnan, S., Jansson, P., Richardson, D. (2014). Gene of the month: BECN1. Journal of Clinical Pathology, 67(8), 656-660. [More Information]
  • Lok, H., Sahni, S., Richardson, V., Kalinowski, D., Kovacevic, Z., Lane, D., Richardson, D. (2014). Glutathione S-Transferase and MRP1 Form an Integrated System Involved in the Storage and Transport of Dinitrosyl-Dithiolato Iron Complexes in Cells. Free Radical Biology and Medicine, 75, 14-29. [More Information]
  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014). Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1845 (1), 1-19. [More Information]
  • Sahni, S., Krishan, S., Richardson, D. (2014). NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: the case for developing inhibitors of metastasis. Future Medicinal Chemistry, 6(11), 1241-1244. [More Information]
  • Sahni, S., Bae, D., Lane, D., Kovacevic, Z., Kalinowski, D., Jansson, P., Richardson, D. (2014). The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. Journal of Biological Chemistry, 289(14), 9692-9709. [More Information]
  • Merlot, A., Pantarat, N., Menezes, S., Sahni, S., Richardson, D., Kalinowski, D. (2013). Cellular Uptake of the Antitumor Agent Dp44mT Occurs via a Carrier/Receptor-Mediated Mechanism. Molecular Pharmacology, 84(6), 911-924. [More Information]
  • Sun, J., Zhang, D., Bae, D., Sahni, S., Jansson, P., Zheng, Y., Zhao, Q., Yue, F., Zheng, M., Kovacevic, Z., Richardson, D. (2013). Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis, 34(9), 1943-1954. [More Information]
  • Yamagishi, T., Sahni, S., Sharp, D., Arvind, A., Jansson, P., Richardson, D. (2013). P-Glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration. Journal of Biological Chemistry, 288(44), 31761-31771. [More Information]
  • Bae, D., Jansson, P., Huang, M., Kovacevic, Z., Kalinowski, D., Lee, C., Sahni, S., Richardson, D. (2013). The role of NDRG1 in the pathology and potential treatment of human cancers. Journal of Clinical Pathology, 66(11), 911-917. [More Information]

2018

  • Park, K., Menezes, S., Kalinowski, D., Sahni, S., Jansson, P., Kovacevic, Z., Richardson, D. (2018). Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1864 (8), 2644-2663. [More Information]
  • Sahni, S., Hickok, J., Thomas, D. (2018). Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes. Nitric Oxide: Biology And Chemistry, 76, 37-44. [More Information]
  • Al-Akra, L., Bae, D., Sahni, S., Huang, M., Park, K., Lane, D., Jansson, P., Richardson, D. (2018). Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones. Journal of Biological Chemistry, 293(10), 3562-3587. [More Information]

2017

  • Palanimuthu, D., Poon, R., Sahni, S., Anjum, R., Hibbs, D., Lin, H., Bernhardt, P., Kalinowski, D., Richardson, D. (2017). A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 139, 612-632. [More Information]
  • Menezes, S., Sahni, S., Kovacevic, Z., Richardson, D. (2017). Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling. Journal of Biological Chemistry, 292(31), 12772-12782. [More Information]
  • Kovacevic, Z., Sahni, S., Lok, H., Davies, M., Wink, D., Richardson, D. (2017). Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1861 (5), 995-999. [More Information]
  • Sahni, S., Bae, D., Jansson, P., Richardson, D. (2017). The mechanistic role of chemically diverse metal ions in the induction of autophagy. Pharmacological Research, 119, 118-127. [More Information]

2016

  • Lok, H., Sahni, S., Jansson, P., Kovacevic, Z., Hawkins, C., Richardson, D. (2016). A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity. Journal of Biological Chemistry, 291(53), 27042-27061. [More Information]
  • Park, K., Fouani, L., Jansson, P., Wooi, D., Sahni, S., Lane, D., Palanimuthu, D., Lok, H., Kovacevic, Z., Huang, M., Kalinowski, D., Richardson, D. (2016). Copper and conquer: Copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics. Metallomics, 8(9), 874-886. [More Information]
  • Kovacevic, Z., Sahni, S., Richardson, D. (2016). Copper that cancer with lysosomal love!. Aging, 8(2), 210-211.
  • Chiang, S., Kovacevic, Z., Sahni, S., Lane, D., Merlot, A., Kalinowski, D., Huang, M., Richardson, D. (2016). Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia. Clinical Science, 130(11), 853-870. [More Information]
  • Klionsky, D., Abdelmohsen, K., Akihisa, A., Abedin, M., Abeliovich, H., Acevedo-Arozena, A., Arozena, H., Adams, C., Adams, P., et al, Sue, C., Mihailidou, A., Bae, D., Gutierrez, E., Jansson, P., Lane, D., Merlot, A., Richardson, D., Sahni, S. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), 1-222. [More Information]
  • Merlot, A., Sahni, S., Lane, D., Richardson, V., Huang, M., Kalinowski, D., Richardson, D. (2016). Letter to the Editor: Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques"". International Journal of Molecular Sciences, 17(11), E1916. [More Information]
  • Gutierrez, E., Seebacher, N., Arzuman, L., Kovacevic, Z., Lane, D., Richardson, V., Merlot, A., Lok, H., Kalinowski, D., Sahni, S., Jansson, P., Richardson, D. (2016). Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT). Biochimica et Biophysica Acta, 1863 (7 Pt A), 1665-1681. [More Information]
  • Merlot, A., Shafie, N., Yu, Y., Richardson, V., Jansson, P., Sahni, S., Lane, D., Kovacevic, Z., Kalinowski, D., Richardson, D. (2016). Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2[alpha], IRE1[alpha], ATF6 and calmodulin kinase. Biochemical Pharmacology, 109, 27-47. [More Information]
  • Al-Eisawi, Z., Stefani, C., Jansson, P., Arvind, A., Sharpe, P., Basha, M., Iskander, G., Kumar, N., Kovacevic, Z., Lane, D., Sahni, S., Richardson, D., Kalinowski, D., et al (2016). Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3- selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization. Journal of Medicinal Chemistry, 59(1), 294-312. [More Information]
  • Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Olynyk, J., Chua, A., Jansson, P., Sahni, S., Lane, D., Merlot, A., Kovacevic, Z., Huang, M., Richardson, D., et al (2016). Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica et Biophysica Acta, 1863 (4), 727-748. [More Information]
  • Paluncic, J., Kovacevic, Z., Jansson, P., Kalinowski, D., Merlot, A., Huang, M., Lok, H., Sahni, S., Lane, D., Richardson, D. (2016). Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling. Biochimica et Biophysica Acta, 1863 (4), 770-784. [More Information]
  • Sahni, S., Kovacevic, Z., Kalinowski, D., Huang, M., Menezes, S., Krishan, S., Lane, D., Jansson, P., Richardson, D. (2016). Targeting autophagy in antitumor agent design: Furthering the 'lysosomal love' strategy. Future Medicinal Chemistry, 8(7), 727-729. [More Information]
  • Wangpu, X., Lu, J., Xi, R., Yue, F., Sahni, S., Park, K., Menezes, S., Huang, M., Zheng, M., Kovacevic, Z., Richardson, D. (2016). Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling. Molecular Pharmacology, 89(5), 521-540. [More Information]
  • Krishan, S., Richardson, D., Sahni, S. (2016). The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells. Biochimica et Biophysica Acta, 1863 (12), 2916-2933. [More Information]
  • Kovacevic, Z., Menezes, S., Sahni, S., Kalinowski, D., Bae, D., Lane, D., Richardson, D. (2016). The metastasis suppressor, N-MYC downstream-regulated gene-1 (NDRG1), down-regulates the ErbB family of receptors to inhibit downstream oncogenic signaling pathways. Journal of Biological Chemistry, 291(3), 1029-1052. [More Information]

2015

  • Krishan, S., Richardson, D., Sahni, S. (2015). Adenosine Monophosphate-Activated Kinase and Its Key Role in Catabolism: Structure, Regulation, Biological Activity and Pharmacological Activation. Molecular Pharmacology, 87(3), 363-377. [More Information]
  • Lane, D., Merlot, A., Huang, M., Bae, D., Jansson, P., Sahni, S., Kalinowski, D., Richardson, D. (2015). Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochimica et Biophysica Acta - General Subjects, 1853 (5), 1130-1144. [More Information]
  • Jansson, P., Yamagishi, T., Arvind, A., Seebacher, N., Gutierrez, E., Stacy, A., Maleki, S., Sharp, D., Sahni, S., Richardson, D. (2015). Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp). Journal of Biological Chemistry, 290(15), 9588-9603. [More Information]
  • Lane, D., Bae, D., Merlot, A., Sahni, S., Richardson, D. (2015). Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation. Nutrients, 7(4), 2274-2296. [More Information]
  • Potuckova, E., Roh, J., Machacek, M., Sahni, S., Stariat, J., Sestak, V., Jansova, H., Haskova, P., Jirkovska, A., Kalinowski, D., Richardson, D., et al (2015). In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites. PloS One, 10(10), 1-20. [More Information]
  • Krishan, S., Jansson, P., Gutierrez, E., Lane, D., Richardson, D., Sahni, S. (2015). Iron metabolism and autophagy: A poorly explored relationship that has important consequences for health and disease. Nagoya Journal of Medical Science, 77, 1-6.
  • Merlot, A., Kalinowski, D., Kovacevic, Z., Jansson, P., Lane, D., Sahni, S., Huang, M., Richardson, D. (2015). Making a case for albumin - a highly promising drug-delivery system. Future Medicinal Chemistry, 7(5), 553-556. [More Information]
  • Lui, G., Kovacevic, Z., Menezes, S., Kalinowski, D., Merlot, A., Sahni, S., Richardson, D. (2015). Novel Thiosemicarbazones Regulate the Signal Transducer and Activator of Transcription 3 (STAT3) Pathway: Inhibition of Constitutive and Interleukin 6-Induced Activation by Iron Depletion. Molecular Pharmacology, 87(3), 543-560. [More Information]
  • Merlot, A., Sahni, S., Lane, D., Fordham, A., Pantarat, N., Hibbs, D., Richardson, V., Doddareddy, M., Ong, J., Huang, M., Richardson, D., Kalinowski, D. (2015). Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells. Oncotarget, 6(12), 10374-10398. [More Information]
  • Liu, W., Kovacevic, Z., Peng, Z., Jin, R., Wang, P., Yue, F., Zheng, M., Huang, M., Jansson, P., Richardson, V., Kalinowski, D., Lane, D., Merlot, A., Sahni, S., Richardson, D. (2015). The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets. Oncotarget, 6(34), 35522-35541. [More Information]
  • Liu, W., Yue, F., Zheng, M., Merlot, A., Bae, D., Huang, M., Lane, D., Jansson, P., Lui, G., Richardson, V., Sahni, S., Kalinowski, D., Kovacevic, Z., Richardson, D. (2015). The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1. Oncotarget, 6(11), 8851-8874. [More Information]
  • Jansson, P., Kalinowski, D., Lane, D., Kovacevic, Z., Seebacher, N., Fouani, L., Sahni, S., Merlot, A., Richardson, D. (2015). The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones. Pharmacological Research, 100, 255-260. [More Information]
  • Sahni, S., Krishan, S., Palanimuthu, D., Richardson, D. (2015). The use of iron chelators in biocidal compositions: evaluation of patent, WO2014059417A1. Expert Opinion on Therapeutic Patents, 25(3), 367-372. [More Information]

2014

  • Krishan, S., Richardson, D., Sahni, S. (2014). AMP kinase (PRKAA1). Journal of Clinical Pathology, 67(9), 758-763. [More Information]
  • Sahni, S., Merlot, A., Krishnan, S., Jansson, P., Richardson, D. (2014). Gene of the month: BECN1. Journal of Clinical Pathology, 67(8), 656-660. [More Information]
  • Lok, H., Sahni, S., Richardson, V., Kalinowski, D., Kovacevic, Z., Lane, D., Richardson, D. (2014). Glutathione S-Transferase and MRP1 Form an Integrated System Involved in the Storage and Transport of Dinitrosyl-Dithiolato Iron Complexes in Cells. Free Radical Biology and Medicine, 75, 14-29. [More Information]
  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014). Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1845 (1), 1-19. [More Information]
  • Sahni, S., Krishan, S., Richardson, D. (2014). NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: the case for developing inhibitors of metastasis. Future Medicinal Chemistry, 6(11), 1241-1244. [More Information]
  • Sahni, S., Bae, D., Lane, D., Kovacevic, Z., Kalinowski, D., Jansson, P., Richardson, D. (2014). The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. Journal of Biological Chemistry, 289(14), 9692-9709. [More Information]

2013

  • Merlot, A., Pantarat, N., Menezes, S., Sahni, S., Richardson, D., Kalinowski, D. (2013). Cellular Uptake of the Antitumor Agent Dp44mT Occurs via a Carrier/Receptor-Mediated Mechanism. Molecular Pharmacology, 84(6), 911-924. [More Information]
  • Sun, J., Zhang, D., Bae, D., Sahni, S., Jansson, P., Zheng, Y., Zhao, Q., Yue, F., Zheng, M., Kovacevic, Z., Richardson, D. (2013). Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis, 34(9), 1943-1954. [More Information]
  • Yamagishi, T., Sahni, S., Sharp, D., Arvind, A., Jansson, P., Richardson, D. (2013). P-Glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration. Journal of Biological Chemistry, 288(44), 31761-31771. [More Information]
  • Bae, D., Jansson, P., Huang, M., Kovacevic, Z., Kalinowski, D., Lee, C., Sahni, S., Richardson, D. (2013). The role of NDRG1 in the pathology and potential treatment of human cancers. Journal of Clinical Pathology, 66(11), 911-917. [More Information]

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