Dr Susan Tomlinson

Senior Lecturer
Medicine, Central Clinical School

Telephone +61 2 9036 3091
Fax +61 2 9036 3092

Map

Biographical details

Dr Tomlinson trained in clinical neurology in Sydney and London, UK. She subsequently spent four years in full time research studying clinical, neurophysiological and genetic aspects of neurological ion channel disorders at the UCL Institute of Neurology, Queen Square, London. In 2010 she received an NHMRC grant to continue research in nerve excitability in genetic and idiopathic epilepsies.

Research interests

Nerve and muscle cell membranes are electrically active. This property is determined by the activity of ion channels, which are proteins that allow movement of charged particles (ions) across the cell membrane. Ion channel dysfunction can result in neurological disease e.g epilepsy, migraine, ataxia. By assessing peripheral nerve excitability in patients, insight can be obtained into nerve and muscle membrane potential and ion channel dysfunction in vivo. Dr Tomlinson┬┐s research interest involves assessing peripheral nerve excitability patients with genetic or acquired ion channel disorders in order to obtain a better understanding of how ion channel dysfunction results in disease.

International links

United States

(University of Rochester, NY, USA) CINCH (Consortium for Investigation of Neurological Channelopathies) is an international collaboration of investigators who undertake research in neurological ion channel disorders. Dr Tomlinson leads the Australian arm of the CINCH consortium. The research includes characterising natural history and clincal features of rare or uncommon diseases and conducting clinical trials.

Selected grants

2014

  • Aberrant nerve excitability: An in-depth study of HCN channel activity in neurological disorders (epilepsy and chronic neuropathic pain).; Tomlinson S; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

2011

  • The final common channel: measurement for nerve excitability in epilepsy; Tomlinson S, Burke D, Kiernan M; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Nerve excitability in genetic neurological ion channel disorders; Tomlinson S, Burke D; Sydney Foundation for Medical Research/Research Support.
  • Ion channel function in peripheral nerve of patients with genetic epilepsies; Tomlinson S, Burke D; Brain Foundation of Australia/Annual Research Awards.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Loy, C., Tomlinson, S., Brew, B. (2005). HIV-related neurological disease in the era of HAART and drug resistance. In Christopher Power, Richard Tidball Johnson (Eds.), Emerging Neurological Infections, (pp. 427-452). US: Taylor and Francis.

Journals

  • Tomlinson, S., Rajakulendran, S., Tan, S., Graves, T., Bamiou, D., Labrum, R., Burke, D., Sue, C., Giunti, P., Schorge, S., et al (2013). Clinical, genetic, neurophysiological and functional study of new mutations in episodic ataxia type 1. Journal of Neurology, Neurosurgery, and Psychiatry, 84(10), 1107-1112. [More Information]
  • Pitceathly, R., Tomlinson, S., Hargreaves, I., Bhardwaj, N., Holton, J., Morrow, J., Evans, J., Smith, C., Fratter, C., Woodward, C., et al (2013). Distal myopathy with cachexia: an unrecognised phenotype caused by dominantly-inherited mitochondrial polymerase (gamma) mutations. Journal of Neurology, Neurosurgery and Psychiatry, 84(1), 107-110. [More Information]
  • Burke, D., Howells, J., Tomlinson, S. (2013). HCN Channels: Function and clinical implications. Neurology, 81(5), 513-514. [More Information]
  • Tomlinson, S., Bostock, H., Grinton, B., Hanna, M., Kullmann, D., Kiernan, M., Scheffer, I., Berkovic, S., Burke, D. (2012). In vivo loss of slow potassium channel activity in individuals with benign familial neonatal epilepsy in remission. Brain: a journal of neurology, 135, 3144-3152. [More Information]
  • Munn, A., Tomlinson, S., Savage, T., Clauss, M. (2012). Retention of different-sized particles and derived gut fill estimate in tammar wallabies (Macropus eugenii): Physiological and methodological considerations. Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology, 161(2), 243-249. [More Information]
  • Trevillion, L., Howells, J., Tomlinson, S., Bostock, H., Burke, D. (2011). What makes some axons more excitable than others. Physiology News, 82, 32-35.
  • Tomlinson, S., Tan, V., Kullmann, D., Griggs, R., Burke, D., Hanna, M., Bostock, H. (2010). Nerve excitability studies characterize KV1.1 fast potassium channel dysfunction in patients with episodic ataxia type 1. Brain, 133, 1-11. [More Information]
  • Rajakulendran, S., Tan, C., Matthews, E., Tomlinson, S., Labrum, R., Sud, R., Kullmann, D., Schorge, S., Hanna, M. (2009). A patient with episodic ataxia and paramyotonia congenita due to mutations in KCNA1 and SCN4A. Neurology, 73(12), 993-995. [More Information]
  • Tomlinson, S., Hanna, M., Kullmann, D., Tan, V., Burke, D. (2009). Clinical neurophysiology of the episodic ataxias: insights into ion channel dysfunction in vivo. Clinical Neurophysiology, 120(10), 1768-1776. [More Information]
  • Tomlinson, S., Burke, D., Hanna, M., Koltzenburg, M., Bostock, H. (2009). In vivo assessment of HCN channel current (I(h)) in human motor axons. Muscle and Nerve, 10.1002/mus.21482, 1-11. [More Information]
  • Tomlinson, S., Hanna, M. (2007). Acute neurology. Clinical Medicine, 7(3), 272-277. [More Information]

2013

  • Tomlinson, S., Rajakulendran, S., Tan, S., Graves, T., Bamiou, D., Labrum, R., Burke, D., Sue, C., Giunti, P., Schorge, S., et al (2013). Clinical, genetic, neurophysiological and functional study of new mutations in episodic ataxia type 1. Journal of Neurology, Neurosurgery, and Psychiatry, 84(10), 1107-1112. [More Information]
  • Pitceathly, R., Tomlinson, S., Hargreaves, I., Bhardwaj, N., Holton, J., Morrow, J., Evans, J., Smith, C., Fratter, C., Woodward, C., et al (2013). Distal myopathy with cachexia: an unrecognised phenotype caused by dominantly-inherited mitochondrial polymerase (gamma) mutations. Journal of Neurology, Neurosurgery and Psychiatry, 84(1), 107-110. [More Information]
  • Burke, D., Howells, J., Tomlinson, S. (2013). HCN Channels: Function and clinical implications. Neurology, 81(5), 513-514. [More Information]

2012

  • Tomlinson, S., Bostock, H., Grinton, B., Hanna, M., Kullmann, D., Kiernan, M., Scheffer, I., Berkovic, S., Burke, D. (2012). In vivo loss of slow potassium channel activity in individuals with benign familial neonatal epilepsy in remission. Brain: a journal of neurology, 135, 3144-3152. [More Information]
  • Munn, A., Tomlinson, S., Savage, T., Clauss, M. (2012). Retention of different-sized particles and derived gut fill estimate in tammar wallabies (Macropus eugenii): Physiological and methodological considerations. Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology, 161(2), 243-249. [More Information]

2011

  • Trevillion, L., Howells, J., Tomlinson, S., Bostock, H., Burke, D. (2011). What makes some axons more excitable than others. Physiology News, 82, 32-35.

2010

  • Tomlinson, S., Tan, V., Kullmann, D., Griggs, R., Burke, D., Hanna, M., Bostock, H. (2010). Nerve excitability studies characterize KV1.1 fast potassium channel dysfunction in patients with episodic ataxia type 1. Brain, 133, 1-11. [More Information]

2009

  • Rajakulendran, S., Tan, C., Matthews, E., Tomlinson, S., Labrum, R., Sud, R., Kullmann, D., Schorge, S., Hanna, M. (2009). A patient with episodic ataxia and paramyotonia congenita due to mutations in KCNA1 and SCN4A. Neurology, 73(12), 993-995. [More Information]
  • Tomlinson, S., Hanna, M., Kullmann, D., Tan, V., Burke, D. (2009). Clinical neurophysiology of the episodic ataxias: insights into ion channel dysfunction in vivo. Clinical Neurophysiology, 120(10), 1768-1776. [More Information]
  • Tomlinson, S., Burke, D., Hanna, M., Koltzenburg, M., Bostock, H. (2009). In vivo assessment of HCN channel current (I(h)) in human motor axons. Muscle and Nerve, 10.1002/mus.21482, 1-11. [More Information]

2007

  • Tomlinson, S., Hanna, M. (2007). Acute neurology. Clinical Medicine, 7(3), 272-277. [More Information]

2005

  • Loy, C., Tomlinson, S., Brew, B. (2005). HIV-related neurological disease in the era of HAART and drug resistance. In Christopher Power, Richard Tidball Johnson (Eds.), Emerging Neurological Infections, (pp. 427-452). US: Taylor and Francis.

To update your profile click here. For support on your academic profile contact .