Professor Tailoi Ling

Professor of Neurobiology & Visual Science
Anatomy & Histology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9351 2596
Fax +61 2 9351 6556

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Research interests

Dr Chan-Ling has made a sustained contribution to the understanding of glial-vascular biology during normal CNS development as well as key understanding to the disease processes in Retinopathy of Prematurity (the leading cause of infant blindness in the world) animal models of multiple sclerosis, cerebral malaria and inflammation.

International links

Australia

(Canberra Hospital, Australian National University) Collaborative work with Professor Jane Dahlstrom - Histopathologist. Publications arising: Cellular and molecular mechanisms of formation of the human choroidal and retinal vasculature. Papers arising: Chan-Ling T, Baxter LC, Sterling RA, Dahlstrom J, Bean EG, Hughes S, Human choroidal formation takes place via hematopoietic differentiation, vasculogenesis and angiogenesis Submitted for publication.

United Kingdom

(Department of Opthalmology & Visual Science, Queens University Belfast.) Dr Tom Gardiner - Collaborative studies utilising transmission electron microscopy to characterise changes in pericyte and smooth muscle cell ensheathment of retinal and choroidal blood vessels during normal development, in disease and in aging. Publications arising. Chan-Ling T, Page M, Gardiner T, Baxter L and Hughes S, Desmin Ensheathment ratio (DER) as an indicator of vessel stability: Evidence in normal development and in Retinopathy of prematurity (2004) 165(4) American Journal of Pathology 1301. Hughes S, Gardiner T, Hu P, Baxter E, Rosinova E and Chan-Ling T, Altered pericyte-endothelial relationship during physiological aging: Implications for vessel stability (2006) 27(12) Neurobiology of Aging 1838. E article, available, Nov 2005. http://linkinghub.elsevier.com/retrieve/pii/S0197458005003490 Hughes S, Gardiner T, Baxter L, Chan-Ling T, Changes in pericytes and smooth muscle cells in the kitten model of Retinopathy of Prematurity (ROP): Implications for plus disease (2007) 48 Investigative Ophthalmology and Visual Science 1368-1379.

United States

(Department of Neurology, University of Washington) Undertook lab visit in January 2008 to gain training in the application of the Helios Gene Gun for complete visualisation of cell morphology. Future visits will provide further experience with HPLC and imaging of ion sensitive dyes with the aim of gaining insights into glial, neuronal and vascular interactions using the rat retinal wholemount preparation. Calcium imaging and hemichannels on human fetal astrocytes. Publication arising: Co-authored a comprehensive review of astrocyte developmental biology and astrocyte function, Ransom and Chan-Ling, In Youmans Neurological Surgery, 2004.

United States

(Department of Pharmacology & Therapeutics, University of Florida) Professor Maria Grant - Collaborative studies to maximise the repair functions of hematopoietic stem cells in stemming vision loss. Two grants awarded to Professor Chan-Ling (International Science Linkages grant, Department of Education, Science and Technology). Publications arising: Chan-Ling T, Baxter L, Afzal A, Sengupta N, Caballero S, Rosinova E and Grant MB, Hematopoietic stem cells provide repair functions after laser-induced Bruchs membrane rupture model of choroidal neovascularisation (2006) 168 American Journal of Pathology 1031. Chang KH, Chan-Ling T, McFarland EL, Afzal A, Pan H, Baxter LC, Shaw LC, Caballero S, Sengupta N, Calzi SL, Sullivan SM, and Grant MB, IGF Binding Protein-3 Regulates Hematopoietic Stem and Endothelial Precursor Cell Differentiation, Migration and Retinal Development (2007) 104 Proceedings of the National Academy of Sciences (PNAS) 10595 Kielczewski JL, McFarland EL, Jarajapu Y, Afzal A, Calzi S, Chang KH, Lydic T, Shaw LC, Busik J, Hughes J, Cardounel AJ, Wilson K, Lyons TJ, Cai J, Boulton ME, Mames RN, Gardiner T, Chan-Ling T, and Grant MB, Insulin-like growth factor binding protein-3 (IGFBP-3) mediates vascular repair by enhancing nitric oxide generation. (2009) J Circulation Research. Accepted

United States

(Harkness Eye Institute, Columbia University) Professor John Flynn - Understanding Retinopathy of Prematurity: The Gift of Sight. Professor Chan-Ling currently holds the appointment of Adjunct Professor of Ophthalmic Science(Ophthalmology),Harkness Eye Institute, Columbia University Medical Center New York, USA Publication arising: ROP, Two distinct mechanisms underlying Zone 1 Zone 2 disease (2006) 142 American Journal of Ophthalmology 46

Selected grants

2014

  • CNS Inflammation & Bone Marrow Neuropathy in Diabetes; Chan-Ling T; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Evidence for existence of lymphatics in the human choroid. Normal development & Pathology; Chan-Ling T; DVC Research/Bridging Support Grant.
  • Stereotaxic frame; Arnold J, Christie M, Collins M, Sawatari A, Leamey C, Stone J, van Nieuwenhuijzen P, Chan-Ling T, Balle T; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • La Vision BioTec Ultramicroscope; Murphy C, Braet F, Byrne M, Chan-Ling T, Fraser S, Goldsbury C, Halliday G, Hambly B, Johnstone D, Keay K, Lovelace M, Lyons G, Mason R, Overall R, Owens T, Richardson D, Stone J, Weiss A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.

2012

  • Stemming vision loss with Stem Cells; Chan-Ling T; Perpetual Trustees Charitable Trusts/Research Support.
  • Cheque sent to Cashier on 23/08/2012; Chan-Ling T; Perpetual Trustees Charitable Trusts/Research Support.
  • Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Development of ageing of human choroidal vasculature: Role of stem cells, lymphangiogenesis and novel pro-and anti angiogenic growth factors as targets in treating Wet Age Related Macular Degeneration (MD); Chan-Ling T; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • An investigation of purinergic nucleotides in directing the differentiation of human neural precursor cell populations: application to cell therapy for Parkinsons disease.; Chan-Ling T, Lovelace M; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2011

  • Rationale for non-invasive treatment of Retinopathy of Prematurity: Dark Rearing as a means of mimicking physiological vascularisation; Chan-Ling T; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Retinopathy of Prematurity: A Ray of Hope; Chan-Ling T; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2010

  • Elucidating the role of astrocytes in glaucoma; Chan-Ling T, Lovelace M; International Retinal Research Foundation/Charles D Kelman Postdoctoral Scholar.
  • Advanced Focused Ion Beam (FIB) / Scanning Electron Microscopes (SEM) for Nanometre Scale Characterisation and Fabrication; Cairney J, Munroe P, Ringer S, Ferry M, Mai Y, Liao X, McKenzie D, Wenham S, Dzurak A, Stevens-Kalceff M, Spinks G, Dou S, Valanoor N, Liu Z, Proust G, Young D, Braet F, Chan-Ling T, Maschmeyer T, Chan K, Traini D, Swain M, Harris A, Crawford J, Potts D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Rationale for non-invasive treatment of retinopathy of prematurity: dark rearing mimics physiological vascularisation; Chan-Ling T; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • A live cell imaging-based investigation of novel physiological functions of neural stem cells; Chan-Ling T, Lovelace M; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2009

  • Stemming vision loss with stem cells and growth factors; Chan-Ling T; Perpetual Trustees Charitable Trusts/Research Support.
  • Frequency of endothelial progenitor cells in peripheral blood - predictive indicator of progression to wet age-related macular degeneration (ARMD); Chan-Ling T; Optometrists Registration Board (NSW)/Optometry Best Practice Grant.
  • Retinopathy of Prematurity: A Ray of Hope; Chan-Ling T, Flynn J, Berrocal A, Korlimbinis A; Bonnie Babes Foundation/Research Grant.
  • Principal Research Fellowship - 6th year extension; Chan-Ling T; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.
  • Automated cell counter; Chan-Ling T; Macular Vision Loss Support Society of Australia Inc/Research Support.
  • Stemming Vision Loss With Stem Cells; Korlimbinis A, Chan-Ling T; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • The 3-D Visualisation of Neural Stem Cells Transplanted into Acute Spinal Cord Injuries; Weible M, Chan-Ling T; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Hemichannels and gap junctional communication in astrocytes: The supportive cells in the central nervous systems; Chan-Ling T; DVC International/IPDF Grant.

2008

  • Insulin-like growth factor binding protein-3 as a potential therapy in maximising repair functions of hematopoietic stem cells in stemming vision loss; Chan-Ling T, Baxter L, Grant M, Afzal A; Department of Innovation, Industry, Science and Research (Federal)/International Science Linkages (ISL) Competitive Grants.
  • Stereology setup; Chan-Ling T, Allbutt H; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Isolation and purification of human oligodentrocyte precursor cells; Weible M, Chan-Ling T; Multiple Sclerosis Australia/Seeding Grant.

2007

  • Cellular and molecular mechanisms of human choroidal and retinal vascularisation; Chan-Ling T; Perpetual Trustees Charitable Trusts/Research Support.
  • Cellular and molecular mechanisms of human choroidal and retinal vascularisation; Chan-Ling T; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Maximising repair functions of hematopoietic stem cells in stemming vision loss; Chan-Ling T; Perpetual Trustees Charitable Trusts/Research Grants.

2006

  • Maximising repair functions of hematopoietic stem cells in stemming vision loss; Chan-Ling T; DEST/International Science Linkages Competitive Grants.
  • NHMRC - Equipment Grant; Chan-Ling T; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Retinopathy of prematurity: vasculogenesis and mural cell development; Chan-Ling T; Baxter Charitable Foundation/Baxter Perpetual Research Grant.
  • Rebecca Cooper Medical Research Foundation - Research Grants Program; Chan-Ling T; Rebecca Cooper Medical Research Foundation/Rebecca Cooper Medical Research Foundation.
  • University of Sydney - Bridging Support Grant; Chan-Ling T; University of Sydney/Bridging Support.

2004

  • Microvascular, inflammatory and cellular changes in the retina during ageing; Chan-Ling T; Rebecca L Cooper/Medical Research Foundation.
  • Understanding retinopathy of prematurity (ROP) : the gift of sight; Chan-Ling T, McLean A; Financial Markets Foundation for Children/Financial Markets Foundation for Children Research Grants.
  • Microvascular, inflammatory and cellular changes in the retina during ageing; Chan-Ling T; Baxter Charitable Foundation/Research Grant.
  • Understanding retinopathy of prematurity : the gift of sight; Chan-Ling T; RG Arnott Foundation/Research Grant.

2003

  • Characterisation and purification of human astrocyte precurser cells: applications in regenerative medicine; Chan-Ling T; DVC Research/Research and Development Scheme: Research and Development (R&D).
  • Astrocytes and mural cells: normal development and pathophysiology in ageing; Chan-Ling T; Rebecca L Cooper/Medical Research Foundation.

2001

  • Characterisation of age-related changes in the retinal microvasculature: pathogenic mechanisms; Chan-Ling T; Rebecca L Cooper/Medical Research Foundation.
  • Astrocytes and mural cells in the retina: normal development and pathophysiology; Chan-Ling T; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • Mechanisms of retinal vascularisation and remodelling: relevance to retinopathy of prematurity; Chan-Ling T; Ronald Geoffrey Arnott Foundation/Project Support.
  • Characterisation, expansion and transplantation of type-1 astrocyte precursor cells from rat retina; Chan-Ling T; Clive & Vera Ramaciotti Foundation/Research Grants.
  • Mechanisms of retinal vascularisation and remodelling: relevance to retinopathy of prematurity; Chan-Ling T; Baxter Charitable Foundation/Research Grant.
  • Control of hypoxia in retinopathy of prematurity: a basis for intervention; Chan-Ling T, Stone J; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.
  • Developmental biology of retinal astroccytes; Stone J, Chan-Ling T, Tout S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms of retinal vascularisation & remodelling: relevance to retinopathy of prematurity; Chan-Ling T; National Health and Medical Research Council (NHMRC)/Project Grants.

1999

  • Travel to Huntsman Cancer Institute, University of Utah - 23.11.99 to 14.12.99; Chan-Ling T; Clive & Vera Ramaciotti Foundation/TRAVEL AWARD.

Selected publications

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Book Chapters

  • Chan-Ling, T. (2010). Development of the Retinal Vasculature. In Darlene A Dartt, Joseph C Besharse, Reza Dana (Eds.), Encyclopedia of the Eye, (pp. 22-34). United Kingdom: Elsevier Ltd.
  • Chan-Ling, T. (2008). Vasculogenesis and angiogenesis in formation of the human retinal vasculature: cell-cell interactions and molecular cues. In John Penn (Eds.), Retinal and Choroidal Angiogenesis, (pp. 119-138). Netherlands: Springer.
  • Chan-Ling, T. (2006). The Blood Retinal Interface: Similarities and Contrasts with the Blood-Brain Interface. In Dermietzel, R., Spray, D. C., Nedergaard, M (Eds.), Blood-Brain Barriers - From Ontogeny to Artificial Interfaces, (pp. 97-115). Weinheim: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Ransom, B., Chan-Ling, T. (2004). Astrocytes. In H. Richard Winn, Julian R. Youmans (Eds.), Youmans Neurological Surgery, (pp. 97-115). Philadelphia: Elsevier - Health Sciences Division.

Journals

  • Braidy, N., Poljak, A., Grant, R., Jayasena, T., Mansour, H., Chan-Ling, T., Guillemin, G., Smythe, G., Sachdev, P. (2014). Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology, 15, 177-198. [More Information]
  • Braidy, N., Poljak, A., Grant, R., Jayasena, T., Mansour, H., Chan-Ling, T., Guillemin, G., Smythe, G., Sachdev, P. (2014). Mapping NAD+ metabolism in the brain of ageing Wistar rats: Potential targets for influencing brain senescence. Biogerontology, 15(2), 177-198. [More Information]
  • Eamegdool, S., Weible, M., Pham, T., Hawkett, B., Grieve, S., Chan-Ling, T. (2014). Ultrasmall superparamagnetic iron oxide nanoparticle prelabelling of human neural precursor cells. Biomaterials, 35(21), 5549-5564. [More Information]
  • Hu, P., Thinschmidt, J., Yan, Y., Hazra, S., Bhatwadekar, A., Caballero, S., Salazar, T., Miyan, J., Li, W., Derbenev, A., Chan-Ling, T., et al (2013). CNS Inflammation and Bone Marrow Neuropathy in Type 1 Diabetes. The American Journal of Pathology: cellular and molecular biology of disease, 183(5), 1608-1620. [More Information]
  • Mansour, H., McColm, J., Cole, L., Weible, M., Korlimbinis, A., Chan-Ling, T. (2013). Connexin 30 expression and frequency of connexin heterogeneity in astrocyte gap junction plaques increase with age in the rat retina. PLoS One, 8(3), 1-14. [More Information]
  • Kur, J., Newman, E., Chan-Ling, T. (2012). Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Progress in Retinal and Eye Research, 31(5), 377-406. [More Information]
  • Jarajapu, Y., Cai, J., Yan, Y., Calzi, S., Kielczewski, J., Hu, P., Shaw, L., Firth, S., Chan-Ling, T., Boulton, M., Baxter, R., et al (2012). Protection of Blood Retinal Barrier and Systemic Vasculature by Insulin-Like Growth Factor Binding Protein-3. PLoS One, 7(7), 1-16. [More Information]
  • Combes, V., Guillemin, G., Chan-Ling, T., Hunt, N., Grau, G. (2012). The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes. Trends in Parasitology, 28(8), 311-319. [More Information]
  • Hunt, G., van Nieuwenhuijzen, P., Chan-Ling, T., McGregor, I. (2011). 'When an old rat smells a cat': a decline in defense-related, but not accessory olfactory, Fos expression in aged rats. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 32(4), 737-749. [More Information]
  • Braidy, N., Guillemin, G., Mansour, H., Chan-Ling, T., Poljak, A., Grant, R. (2011). Age related changes in NAD+ metabolism oxidative stress and sirt1 activity in wistar rats. PLoS One, 6(4), e19194 - 1-e19194 - 18. [More Information]
  • Braidy, N., Guillemin, G., Mansour, H., Chan-Ling, T., Grant, R. (2011). Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. The FEBS Journal, 278(22), 4425-4434. [More Information]
  • Chan-Ling, T., Dahlstrom, J., Koina, M., McColm, J., Sterling, R., Bean, E., Adamson, S., Hughes, S., Baxter, L. (2011). Evidence of hematopoietic differentiation, vasculogenesis and angiogenesis in the formation of human choroidal blood vessels. Experimental Eye Research, 92(5), 361-376. [More Information]
  • Kielczewski, J., Calzi, S., Shaw, L., Cai, J., Qi, X., Ruan, Q., Wu, L., Liu, L., Hu, P., Chan-Ling, T., Firth, S., Baxter, R., et al (2011). Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase). Investigative Ophthalmology and Visual Science, 52(11), 8278-8286. [More Information]
  • Kielczewski, J., Hu, P., Shaw, L., Calzi, S., Mames, R., Gardiner, T., McFarland, E., Chan-Ling, T., Grant, M. (2011). Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury. The American Journal of Pathology: cellular and molecular biology of disease, 178(4), 1517-1528. [More Information]
  • Ampawong, S., Combes, V., Hunt, N., Radford, J., Chan-Ling, T., Pongponratn, E., Grau, G. (2011). Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. International Journal of Clinical and Experimental Pathology, 4(6), 566-574. [More Information]
  • Chan-Ling, T., Koina, M., McColm, J., Dahlstrom, J., Bean, E., Adamson, S., Yun, S., Baxter, L. (2011). Role of CD44+ Stem Cells in Mural Cell Formation in the Human Choroid: Evidence of Vascular Instability Due to Limited Pericyte Ensheathment. Investigative Ophthalmology and Visual Science, 52(1), 399-410. [More Information]
  • Howitt, J., Putz, U., Lackovic, J., Doan, A., Dorstyn, L., Cheng, H., Yang, B., Chan-Ling, T., Silke, J., Kumar, S., et al (2009). Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 106(36), 15489-15494. [More Information]
  • Chan-Ling, T., Chu, Y., Baxter, L., Weible, M., Hughes, S. (2009). In Vivo Characterization of Astrocyte Precursor Cells (APCs) and Astrocytes in Developing Rat Retinae: Differentiation, Proliferation, and Apoptosis. Glia, 57(1), 39-53. [More Information]
  • Kielczewski, J., Jarajapu, Y., McFarland, E., Cai, J., Afzal, A., Calzi, S., Chang, K., Lydic, T., Shaw, L., Busik, J., Chan-Ling, T., et al (2009). Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair by Enhancing Nitric Oxide Generation. Circulation Research, 105(9), 897-905. [More Information]
  • Mansour, H., Chamberlain, C., Weible, M., Hughes, S., Chu, Y., Chan-Ling, T. (2008). Aging-related changes in astrocytes in the rat retina: Imbalance between cell proliferation and cell death reduces astrocyte availability. Aging Cell, 7(4), 526-540. [More Information]
  • Kuo, I., Chan-Ling, T., Wojcikiewicz, R., Hill, C. (2008). Limited Intravascular Coupling in the Rodent Brainstem and Retina Supports a Role for Glia in Regional Blood Flow. The Journal of Comparative Neurology, 511(5), 773-787. [More Information]
  • Chamberlain, C., Chan-Ling, T., Huang, W., Sarafian, R. (2008). MHC class II expression by beta2 integrin (CD18)-positive microglia, macrophages and macrophage-like cells in rabbit retina. Neuron Glia Biology, 4(4), 285-294. [More Information]
  • Hughes, S., Gardiner, T., Baxter, L., Chan-Ling, T. (2007). Changes in pericytes and smooth muscle cells in the kitten model of retinopathy of prematurity: implications for plus disease. Investigative Ophthalmology and Visual Science, 48(3), 1368. [More Information]
  • Low, R., Jones, A., Houang, M., Newland, L., Morey, A., Chan-Ling, T. (2007). Endometriosis of the inguinal region: magnetic resonance imaging (MRI) findings. Journal of Medical Imaging and Radiation Oncology, 51, B272-5. [More Information]
  • Chang, K., Chan-Ling, T., McFarland, E., Afzal, A., Pan, H., Baxter, L., Shaw, L., Caballero, S., Sengupta, N., Calzi, S., Sullivan, S., et al (2007). IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 104(25), 10595-10600.
  • Chan-Ling, T., Hughes, S., Baxter, L., Rosinova, E., McGregor, I., Morcos, Y., van Nieuwenhuijzen, P., Hu, P. (2007). Inflammation and breakdown of the blood-retinal barrier during "physiological aging" in the rat retina: A model for CNS aging. Microcirculation, 14(1), 63-76. [More Information]
  • Weible, M., Chan-Ling, T. (2007). Phenotypic characterization of neural stem cells from human fetal spinal cord: Synergistic effect of LIF and BMP4 to generate astrocytes. Glia, 55(11), 1156-1168. [More Information]
  • Potter, S., Chan-Ling, T., Rosinova, E., Ball, H., Mitchell, A., Hunt, N. (2006). A critical role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. Journal of Neuroimmunology, 173(1-2), 96-107. [More Information]
  • Hughes, S., Gardiner, T., Hu, P., Baxter, L., Rosinova, E., Chan-Ling, T. (2006). Altered pericyte-endothelial relationship during physiological aging: Implications for vessel stability. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 27(12), 1838-1847. [More Information]
  • Chan-Ling, T., Baxter, L., Afzal, A., Sengupta, N., Caballero, S., Rosinova, E., Grant, M. (2006). Hematopoietic stem cells provide repair functions after laser-induced Bruch's membrane rupture model of choroidal neovascularization. The American Journal of Pathology: cellular and molecular biology of disease, 168(3), 1031-1044. [More Information]
  • Hunt, N., Golenser, J., Chan-Ling, T., Parekh, S., Rae, C., Potter, S., Medana, I., Miu, J., Ball, H. (2006). Immunopathogenesis of cerebral malaria. International Journal for Parasitology, 36(5), 569-582. [More Information]
  • Potter, S., Chan-Ling, T., Ball, H., Mansour, H., Mitchell, A., Maluish, L., Hunt, N. (2006). Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. International Journal for Parasitology, 36(4), 485-496. [More Information]
  • Lutty, G., Chan-Ling, T., Phelps, D., Adamis, A., Bernstein, K., Berns, K., Chan, C., et, A. (2006). Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Molecular Vision, 12, 532-580. [More Information]
  • Flynn, J., Chan-Ling, T. (2006). Retinopathy of prematurity: Two distinct mechanisms that underlie zone 1 and zone 2 disease. American Journal of Ophthalmology, 142(1), 46-59. [More Information]
  • Chan-Ling, T., Hughes, S. (2005). NG2 can be used to identify arteries versus veins enabling the characterization of the different functional roles of arterioles and venules during microvascular network growth and remodeling. Microcirculation, 12(7), 539-40; author reply 540-1. [More Information]
  • Chan-Ling, T., McLeod, D., Hughes, S., Baxter, L., Chu, Y., Hasegawa, T., Lutty, G. (2004). Astrocyte-Endothelial Cell Relationships During Human Retinal Vascular Development. Investigative Ophthalmology and Visual Science, 45(6), 2020-2032.
  • Hughes, S., Chan-Ling, T. (2004). Characterization Of Smooth Muscle Cell And Pericyte Differentiation In The Rat Retina In Vivo. Investigative Ophthalmology and Visual Science, 45(8), 2795-2806.
  • Chan-Ling, T., Page, M., Gardiner, T., Baxter, L., Rosenfeld, E., Hughes, S. (2004). Desmin Ensheathment ratio as an indicator of vessel stability: Evidence in normal development and in Retinopathy of prematurity. The American Journal of Pathology: cellular and molecular biology of disease, 165(4), 1301-1313.
  • Chan-Ling, T., Gerritsen, M., Hill,, C., Kubes,, P., Perry, M. (2002). Microcirculation down under. Trends In Pharmacological Sciences, , 106-108.
  • Chu, Y., Hughes, S., Chan-Ling, T. (2001). Differentiation and migration of astrocyte precursor cells (APCs) and astrocytes in human fetal retina: relevance to optic nerve coloboma. The F A S E B Journal.
  • Chu, Y., Hughes, S., Chan-Ling, T. (2001). Differentiation and migration of astrocyte precursor cells and astrocytes in human fetal retina: relevance to optic nerve coloboma. The F A S E B Journal, 10, 1-16.
  • Morcos, Y., Hosie, M., Chan-Ling, T., Bauer, H. (2001). Immunolocalisation of occludin and claudin-1 to tight junctions in intact CNS vessels of mammalian retina. Brain Cell Biology, 30 (2), 107-123.
  • Medana, I., Chaudhri, G., Chan-Ling, T., Hunt, N. (2001). The central nervous system in cerebral malaria: "innocent bystander" or active participant in the induction of pathology? Immunology and Cell Biology, 79, 101-120.

Conferences

  • Chan-Ling, T., Hughes, S. (2006). Cell-cell interactions in the formation of the human retinal vasculature. Proceedings of the Third International Symposium on Retinopathy of Prematurity: An update on ROP from the lab to the nursery, Anaheim, California: Molecular Vision.
  • Gardiner, T., Hughes, S., Baxter, L., Chan-Ling, T. (2006). Smooth muscle cell and pericyte changes underlie pathogenesis of Plus Disease in Retinopathy of Prematurity. Nature Biotech Winter symposium on Angiogenesis.
  • Lutty, G., Chan-Ling, T., Phelps, D., Adamis, A., Berns, K., Chan, C., Cole, C., D'Amore, P., Das, A., Deng, W., Hughes, S., et al (2003). Review of - Proceedings of the Third International Symposium on Retinopathy of Prematurity: An update on ROP from the lab to the nursery. Proceedings of the Third International Symposium on Retinopathy of Prematurity: An update on ROP from the lab to the nursery, Anaheim, California: Molecular Vision.

2014

  • Braidy, N., Poljak, A., Grant, R., Jayasena, T., Mansour, H., Chan-Ling, T., Guillemin, G., Smythe, G., Sachdev, P. (2014). Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology, 15, 177-198. [More Information]
  • Braidy, N., Poljak, A., Grant, R., Jayasena, T., Mansour, H., Chan-Ling, T., Guillemin, G., Smythe, G., Sachdev, P. (2014). Mapping NAD+ metabolism in the brain of ageing Wistar rats: Potential targets for influencing brain senescence. Biogerontology, 15(2), 177-198. [More Information]
  • Eamegdool, S., Weible, M., Pham, T., Hawkett, B., Grieve, S., Chan-Ling, T. (2014). Ultrasmall superparamagnetic iron oxide nanoparticle prelabelling of human neural precursor cells. Biomaterials, 35(21), 5549-5564. [More Information]

2013

  • Hu, P., Thinschmidt, J., Yan, Y., Hazra, S., Bhatwadekar, A., Caballero, S., Salazar, T., Miyan, J., Li, W., Derbenev, A., Chan-Ling, T., et al (2013). CNS Inflammation and Bone Marrow Neuropathy in Type 1 Diabetes. The American Journal of Pathology: cellular and molecular biology of disease, 183(5), 1608-1620. [More Information]
  • Mansour, H., McColm, J., Cole, L., Weible, M., Korlimbinis, A., Chan-Ling, T. (2013). Connexin 30 expression and frequency of connexin heterogeneity in astrocyte gap junction plaques increase with age in the rat retina. PLoS One, 8(3), 1-14. [More Information]

2012

  • Kur, J., Newman, E., Chan-Ling, T. (2012). Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Progress in Retinal and Eye Research, 31(5), 377-406. [More Information]
  • Jarajapu, Y., Cai, J., Yan, Y., Calzi, S., Kielczewski, J., Hu, P., Shaw, L., Firth, S., Chan-Ling, T., Boulton, M., Baxter, R., et al (2012). Protection of Blood Retinal Barrier and Systemic Vasculature by Insulin-Like Growth Factor Binding Protein-3. PLoS One, 7(7), 1-16. [More Information]
  • Combes, V., Guillemin, G., Chan-Ling, T., Hunt, N., Grau, G. (2012). The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes. Trends in Parasitology, 28(8), 311-319. [More Information]

2011

  • Hunt, G., van Nieuwenhuijzen, P., Chan-Ling, T., McGregor, I. (2011). 'When an old rat smells a cat': a decline in defense-related, but not accessory olfactory, Fos expression in aged rats. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 32(4), 737-749. [More Information]
  • Braidy, N., Guillemin, G., Mansour, H., Chan-Ling, T., Poljak, A., Grant, R. (2011). Age related changes in NAD+ metabolism oxidative stress and sirt1 activity in wistar rats. PLoS One, 6(4), e19194 - 1-e19194 - 18. [More Information]
  • Braidy, N., Guillemin, G., Mansour, H., Chan-Ling, T., Grant, R. (2011). Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. The FEBS Journal, 278(22), 4425-4434. [More Information]
  • Chan-Ling, T., Dahlstrom, J., Koina, M., McColm, J., Sterling, R., Bean, E., Adamson, S., Hughes, S., Baxter, L. (2011). Evidence of hematopoietic differentiation, vasculogenesis and angiogenesis in the formation of human choroidal blood vessels. Experimental Eye Research, 92(5), 361-376. [More Information]
  • Kielczewski, J., Calzi, S., Shaw, L., Cai, J., Qi, X., Ruan, Q., Wu, L., Liu, L., Hu, P., Chan-Ling, T., Firth, S., Baxter, R., et al (2011). Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase). Investigative Ophthalmology and Visual Science, 52(11), 8278-8286. [More Information]
  • Kielczewski, J., Hu, P., Shaw, L., Calzi, S., Mames, R., Gardiner, T., McFarland, E., Chan-Ling, T., Grant, M. (2011). Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury. The American Journal of Pathology: cellular and molecular biology of disease, 178(4), 1517-1528. [More Information]
  • Ampawong, S., Combes, V., Hunt, N., Radford, J., Chan-Ling, T., Pongponratn, E., Grau, G. (2011). Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. International Journal of Clinical and Experimental Pathology, 4(6), 566-574. [More Information]
  • Chan-Ling, T., Koina, M., McColm, J., Dahlstrom, J., Bean, E., Adamson, S., Yun, S., Baxter, L. (2011). Role of CD44+ Stem Cells in Mural Cell Formation in the Human Choroid: Evidence of Vascular Instability Due to Limited Pericyte Ensheathment. Investigative Ophthalmology and Visual Science, 52(1), 399-410. [More Information]

2010

  • Chan-Ling, T. (2010). Development of the Retinal Vasculature. In Darlene A Dartt, Joseph C Besharse, Reza Dana (Eds.), Encyclopedia of the Eye, (pp. 22-34). United Kingdom: Elsevier Ltd.

2009

  • Howitt, J., Putz, U., Lackovic, J., Doan, A., Dorstyn, L., Cheng, H., Yang, B., Chan-Ling, T., Silke, J., Kumar, S., et al (2009). Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 106(36), 15489-15494. [More Information]
  • Chan-Ling, T., Chu, Y., Baxter, L., Weible, M., Hughes, S. (2009). In Vivo Characterization of Astrocyte Precursor Cells (APCs) and Astrocytes in Developing Rat Retinae: Differentiation, Proliferation, and Apoptosis. Glia, 57(1), 39-53. [More Information]
  • Kielczewski, J., Jarajapu, Y., McFarland, E., Cai, J., Afzal, A., Calzi, S., Chang, K., Lydic, T., Shaw, L., Busik, J., Chan-Ling, T., et al (2009). Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair by Enhancing Nitric Oxide Generation. Circulation Research, 105(9), 897-905. [More Information]

2008

  • Mansour, H., Chamberlain, C., Weible, M., Hughes, S., Chu, Y., Chan-Ling, T. (2008). Aging-related changes in astrocytes in the rat retina: Imbalance between cell proliferation and cell death reduces astrocyte availability. Aging Cell, 7(4), 526-540. [More Information]
  • Kuo, I., Chan-Ling, T., Wojcikiewicz, R., Hill, C. (2008). Limited Intravascular Coupling in the Rodent Brainstem and Retina Supports a Role for Glia in Regional Blood Flow. The Journal of Comparative Neurology, 511(5), 773-787. [More Information]
  • Chamberlain, C., Chan-Ling, T., Huang, W., Sarafian, R. (2008). MHC class II expression by beta2 integrin (CD18)-positive microglia, macrophages and macrophage-like cells in rabbit retina. Neuron Glia Biology, 4(4), 285-294. [More Information]
  • Chan-Ling, T. (2008). Vasculogenesis and angiogenesis in formation of the human retinal vasculature: cell-cell interactions and molecular cues. In John Penn (Eds.), Retinal and Choroidal Angiogenesis, (pp. 119-138). Netherlands: Springer.

2007

  • Hughes, S., Gardiner, T., Baxter, L., Chan-Ling, T. (2007). Changes in pericytes and smooth muscle cells in the kitten model of retinopathy of prematurity: implications for plus disease. Investigative Ophthalmology and Visual Science, 48(3), 1368. [More Information]
  • Low, R., Jones, A., Houang, M., Newland, L., Morey, A., Chan-Ling, T. (2007). Endometriosis of the inguinal region: magnetic resonance imaging (MRI) findings. Journal of Medical Imaging and Radiation Oncology, 51, B272-5. [More Information]
  • Chang, K., Chan-Ling, T., McFarland, E., Afzal, A., Pan, H., Baxter, L., Shaw, L., Caballero, S., Sengupta, N., Calzi, S., Sullivan, S., et al (2007). IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 104(25), 10595-10600.
  • Chan-Ling, T., Hughes, S., Baxter, L., Rosinova, E., McGregor, I., Morcos, Y., van Nieuwenhuijzen, P., Hu, P. (2007). Inflammation and breakdown of the blood-retinal barrier during "physiological aging" in the rat retina: A model for CNS aging. Microcirculation, 14(1), 63-76. [More Information]
  • Weible, M., Chan-Ling, T. (2007). Phenotypic characterization of neural stem cells from human fetal spinal cord: Synergistic effect of LIF and BMP4 to generate astrocytes. Glia, 55(11), 1156-1168. [More Information]

2006

  • Potter, S., Chan-Ling, T., Rosinova, E., Ball, H., Mitchell, A., Hunt, N. (2006). A critical role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. Journal of Neuroimmunology, 173(1-2), 96-107. [More Information]
  • Hughes, S., Gardiner, T., Hu, P., Baxter, L., Rosinova, E., Chan-Ling, T. (2006). Altered pericyte-endothelial relationship during physiological aging: Implications for vessel stability. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 27(12), 1838-1847. [More Information]
  • Chan-Ling, T., Hughes, S. (2006). Cell-cell interactions in the formation of the human retinal vasculature. Proceedings of the Third International Symposium on Retinopathy of Prematurity: An update on ROP from the lab to the nursery, Anaheim, California: Molecular Vision.
  • Chan-Ling, T., Baxter, L., Afzal, A., Sengupta, N., Caballero, S., Rosinova, E., Grant, M. (2006). Hematopoietic stem cells provide repair functions after laser-induced Bruch's membrane rupture model of choroidal neovascularization. The American Journal of Pathology: cellular and molecular biology of disease, 168(3), 1031-1044. [More Information]
  • Hunt, N., Golenser, J., Chan-Ling, T., Parekh, S., Rae, C., Potter, S., Medana, I., Miu, J., Ball, H. (2006). Immunopathogenesis of cerebral malaria. International Journal for Parasitology, 36(5), 569-582. [More Information]
  • Potter, S., Chan-Ling, T., Ball, H., Mansour, H., Mitchell, A., Maluish, L., Hunt, N. (2006). Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. International Journal for Parasitology, 36(4), 485-496. [More Information]
  • Lutty, G., Chan-Ling, T., Phelps, D., Adamis, A., Bernstein, K., Berns, K., Chan, C., et, A. (2006). Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Molecular Vision, 12, 532-580. [More Information]
  • Flynn, J., Chan-Ling, T. (2006). Retinopathy of prematurity: Two distinct mechanisms that underlie zone 1 and zone 2 disease. American Journal of Ophthalmology, 142(1), 46-59. [More Information]
  • Gardiner, T., Hughes, S., Baxter, L., Chan-Ling, T. (2006). Smooth muscle cell and pericyte changes underlie pathogenesis of Plus Disease in Retinopathy of Prematurity. Nature Biotech Winter symposium on Angiogenesis.
  • Chan-Ling, T. (2006). The Blood Retinal Interface: Similarities and Contrasts with the Blood-Brain Interface. In Dermietzel, R., Spray, D. C., Nedergaard, M (Eds.), Blood-Brain Barriers - From Ontogeny to Artificial Interfaces, (pp. 97-115). Weinheim: Wiley - V C H Verlag GmbH & Co. KGaA.

2005

  • Chan-Ling, T., Hughes, S. (2005). NG2 can be used to identify arteries versus veins enabling the characterization of the different functional roles of arterioles and venules during microvascular network growth and remodeling. Microcirculation, 12(7), 539-40; author reply 540-1. [More Information]

2004

  • Chan-Ling, T., McLeod, D., Hughes, S., Baxter, L., Chu, Y., Hasegawa, T., Lutty, G. (2004). Astrocyte-Endothelial Cell Relationships During Human Retinal Vascular Development. Investigative Ophthalmology and Visual Science, 45(6), 2020-2032.
  • Ransom, B., Chan-Ling, T. (2004). Astrocytes. In H. Richard Winn, Julian R. Youmans (Eds.), Youmans Neurological Surgery, (pp. 97-115). Philadelphia: Elsevier - Health Sciences Division.
  • Hughes, S., Chan-Ling, T. (2004). Characterization Of Smooth Muscle Cell And Pericyte Differentiation In The Rat Retina In Vivo. Investigative Ophthalmology and Visual Science, 45(8), 2795-2806.
  • Chan-Ling, T., Page, M., Gardiner, T., Baxter, L., Rosenfeld, E., Hughes, S. (2004). Desmin Ensheathment ratio as an indicator of vessel stability: Evidence in normal development and in Retinopathy of prematurity. The American Journal of Pathology: cellular and molecular biology of disease, 165(4), 1301-1313.

2003

  • Lutty, G., Chan-Ling, T., Phelps, D., Adamis, A., Berns, K., Chan, C., Cole, C., D'Amore, P., Das, A., Deng, W., Hughes, S., et al (2003). Review of - Proceedings of the Third International Symposium on Retinopathy of Prematurity: An update on ROP from the lab to the nursery. Proceedings of the Third International Symposium on Retinopathy of Prematurity: An update on ROP from the lab to the nursery, Anaheim, California: Molecular Vision.

2002

  • Chan-Ling, T., Gerritsen, M., Hill,, C., Kubes,, P., Perry, M. (2002). Microcirculation down under. Trends In Pharmacological Sciences, , 106-108.

2001

  • Chu, Y., Hughes, S., Chan-Ling, T. (2001). Differentiation and migration of astrocyte precursor cells (APCs) and astrocytes in human fetal retina: relevance to optic nerve coloboma. The F A S E B Journal.
  • Chu, Y., Hughes, S., Chan-Ling, T. (2001). Differentiation and migration of astrocyte precursor cells and astrocytes in human fetal retina: relevance to optic nerve coloboma. The F A S E B Journal, 10, 1-16.
  • Morcos, Y., Hosie, M., Chan-Ling, T., Bauer, H. (2001). Immunolocalisation of occludin and claudin-1 to tight junctions in intact CNS vessels of mammalian retina. Brain Cell Biology, 30 (2), 107-123.
  • Medana, I., Chaudhri, G., Chan-Ling, T., Hunt, N. (2001). The central nervous system in cerebral malaria: "innocent bystander" or active participant in the induction of pathology? Immunology and Cell Biology, 79, 101-120.

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