Dr Tanya Little

NHMRC Career Development Fellow
Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School

Telephone +61 2 9036 3061

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Selected grants

2014

  • Fatty acid sensing receptors in the duodenum of lean and obese humans: role in the regulation of incretin and satiety gut hormone secretion; Little T; Diabetes Australia Research Trust/Awards and Research Grants.

2013

  • Fat sensing in the gut: role in appetite regulation in health and obesity; Little T; National Health and Medical Research Council (NHMRC)/Career Development Fellowship.

2012

  • Gastrointestinal fat sensing mechanisms: role in appetite regulation in health and obesity.; Little T; University of Adelaide - Faculty of Health Sciences/Research Grant.
  • Does Galvus enhance the effects of a protein preload to reduce postprandial glycaemia?; Little T; Novartis Pharmaceuticals Australia Pty Limited/Research Grant.

2011

  • Does DPP-IV inhibition (vildagliptin) potentiate the effects of intraduodenal fat on GLP-1 and GIP, and thereby reduce energy intake and postprandial triglycerides, and increase energy expenditure and fat oxidation?; Little T; Novartis Pharmaceuticals Australia Pty Limited/Research Grant.
  • Defining relationships between oral and intestinal fat sensitivity in the regulation of appetite and eriergy intake in health and obesity.; Little T; Royal Adelaide Hospital, University of Adelaide/Clinical Project Grant.

2008

  • NHMRC Overseas Clinical Research Postdoctoral. Training Fellowship.; Little T; National Health and Medical Research Council Clinical Trials Centre (NHMRC)/Overseas Clinical Research Postdoctoral Training Fellowship.

Selected publications

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Journals

  • Seimon, R., Taylor, P., Little, T., Noakes, M., Standfield, S., Clifton, P., Horowitz, M., Feinle-Bisset, C. (2014). Effects of acute and longer-term dietary restriction on upper gut motility, hormone, appetite, and energy-intake responses to duodenal lipid in lean and obese men. The American Journal of Clinical Nutrition, 99(1), 24-34. [More Information]
  • Ryan, A., Luscombe-Marsh, N., Saies, A., Little, T., Standfield, S., Horowitz, M., Feinle-Bisset, C. (2013). Effects of intraduodenal lipid and protein on gut motility and hormone release, glycemia, appetite, and energy intake in lean men. The American Journal of Clinical Nutrition, 98(2), 300-311. [More Information]
  • Seimon, R., Brennan, I., Russo, A., Little, T., Jones, K., Stanfield, S., Wishart, J., Horowitz, M., Feinle-Bisset, C. (2013). Gastric emptying, mouth-to-cecum transit, and glycemic, insulin, incretin, and energy intake responses to a mixed-nutrient liquid in lean, overweight, and obese males. American Journal of Physiology: Endocrinology and Metabolism (online), 304(3), E294-E300. [More Information]
  • Psichas, A., Little, T., Lal, S., McLaughlin, J. (2012). Colestyramine slows gastric emptying of liquids and reduces appetite in healthy subjects. Neurogastroenterology and Motility, 24(12), 1095-1101. [More Information]
  • Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., Young, R., Jones, K., Horowitz, M., Rayner, C. (2012). Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. The American Journal of Clinical Nutrition, 95(1), 78-83. [More Information]
  • Jones, R., McKie, S., Astbury, N., Little, T., Tivey, S., Lassman, D., McLaughlin, J., Luckman, S., Williams, S., Dockray, G., et al (2012). Functional neuroimaging demonstrates that ghrelin inhibits the central nervous system response to ingested lipid. Gut (English Edition): an international journal of gastroenterology and hepatology, 61(11), 1543-1551. [More Information]
  • Little, T., Feinle-Bisset, C. (2011). Effects of dietary fat on appetite and energy intake in health and obesity--oral and gastrointestinal sensory contributions. Physiology and Behavior, 104(4), 613-620. [More Information]
  • Little, T., Gopinath, A., Patel, E., McGlone, A., Lassman, D., D'Amato, M., McLaughlin, J., Thompson, D. (2010). Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCKa?? receptor. Neurogastroenterology and Motility, 22(11), 1183-1190. [More Information]
  • Little, T., Feinle-Bisset, C. (2010). Oral and gastrointestinal sensing of dietary fat and appetite regulation in humans: modification by diet and obesity. Frontiers in Neuroscience, 4(OCT), 178-178. [More Information]
  • Seimon, R., Lange, K., Little, T., Brennan, I., Pilichiewicz, A., Feltrin, K., Smeets, A., Horowitz, M., Feinle-Bisset, C. (2010). Pooled-data analysis identifies pyloric pressures and plasma cholecystokinin concentrations as major determinants of acute energy intake in healthy, lean men. The American Journal of Clinical Nutrition, 92(1), 61-68. [More Information]
  • Brennan, I., Feltrin, K., Nair, N., Hausken, T., Little, T., Gentilcore, D., Wishart, J., Jones, K., Horowitz, M., Feinle-Bisset, C. (2009). Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. American Journal of Physiology: Gastrointestinal and Liver Physiology, 297(3), G602-G610. [More Information]
  • Nair, N., Brennan, I., Little, T., Gentilcore, D., Hausken, T., Jones, K., Wishart, J., Horowitz, M., Feinle-Bisset, C. (2009). Reproducibility of energy intake, gastric emptying, blood glucose, plasma insulin and cholecystokinin responses in healthy young males. British Journal of Nutrition, 101(7), 1094-1102. [More Information]
  • Little, T., Gupta, N., Case, R., Thompson, D., McLaughlin, J. (2009). Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 297(3), R632-R639. [More Information]
  • Seimon, R., Wooster, T., Otto, B., Golding, M., Day, L., Little, T., Horowitz, M., Clifton, P., Feinle-Bisset, C. (2009). The droplet size of intraduodenal fat emulsions influences antropyloroduodenal motility, hormone release, and appetite in healthy males. The American Journal of Clinical Nutrition, 89(6), 1729-1736. [More Information]
  • Little, T., Feltrin, K., Horowitz, M., Meyer, J., Wishart, J., Chapman, I., Feinle-Bisset, C. (2008). A high-fat diet raises fasting plasma CCK but does not affect upper gut motility, PYY, and ghrelin, or energy intake during CCK-8 infusion in lean men. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (Print), 294(1), R45-R51. [More Information]
  • Feltrin, K., Little, T., Meyer, J., Horowitz, M., Rades, T., Wishart, J., Feinle-Bisset, C. (2008). Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men. The American Journal of Clinical Nutrition, 87(5), 1181-1187. [More Information]
  • Brennan, I., Little, T., Feltrin, K., Smout, A., Wishart, J., Horowitz, M., Feinle-Bisset, C. (2008). Dose-dependent effects of cholecystokinin-8 on antropyloroduodenal motility, gastrointestinal hormones, appetite, and energy intake in healthy men. American Journal of Physiology: Endocrinology and Metabolism (online), 295(6), E1487-E1494. [More Information]
  • Feltrin, K., Little, T., Meyer, J., Horowitz, M., Rades, T., Wishart, J., Feinle-Bisset, C. (2007). Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans. The Journal of Physiology, 581(Pt 2), 767-777. [More Information]
  • Little, T., Russo, A., Meyer, J., Horowitz, M., Smyth, D., Bellon, M., Wishart, J., Jones, K., Feinle-Bisset, C. (2007). Free fatty acids have more potent effects on gastric emptying, gut hormones, and appetite than triacylglycerides. Gastroenterology, 133(4), 1124-1131. [More Information]
  • Pilichiewicz, A., Papadopoulos, P., Brennan, I., Little, T., Meyer, J., Wishart, J., Horowitz, M., Feinle-Bisset, C. (2007). Load-dependent effects of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (Print), 293(6), R2170-R2178. [More Information]
  • Little, T., Horowitz, M., Feinle-Bisset, C. (2007). Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity. American Journal of Clinical Nutrition, 86(3), 531-541. [More Information]
  • Gentilcore, D., Little, T., Feinle-Bisset, C., Samsom, M., Smout, A., Horowitz, M., Jones, K. (2007). Role of 5-hydroxytryptamine mechanisms in mediating the effects of small intestinal glucose on blood pressure and antropyloroduodenal motility in older subjects. American Journal of Physiology: Gastrointestinal and Liver Physiology, 293(4), G692-G698. [More Information]
  • Little, T., Horowitz, M., Feinle-Bisset, C. (2005). Role of cholecystokinin in appetite control and body weight regulation. Obesity Reviews, 6(4), 297-306. [More Information]

Conferences

  • Little, T., Ott, R., Young, R., Isaacs, N., Rayner, C., Horowitz, M., Feinle-Bisset, C. (2012). Altered expression of fatty acid receptors in the duodenum of lean and obese humans. XIIth Little Brain Big Brain Meeting.
  • Little, T. (2012). Altered expression of fatty acid receptors in the duodenum of obese humans. 2012 Enteric Nervous System Workshop.
  • Little, T. (2011). Gastrointestinal factors involved in appetite regulation. 2011 Australian and New Zealand Obesity Society Annual Scientific Meeting.
  • Little, T. (2010). Effects of fat on gut function and appetite and energy intake in humans - Implications for Obesity. 18th Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB).
  • Little, T. (2009). The role of endogenous CCK in the human glucose-induced brain activation matrix. XIth Little Brain Big Brain Meeting.

2014

  • Seimon, R., Taylor, P., Little, T., Noakes, M., Standfield, S., Clifton, P., Horowitz, M., Feinle-Bisset, C. (2014). Effects of acute and longer-term dietary restriction on upper gut motility, hormone, appetite, and energy-intake responses to duodenal lipid in lean and obese men. The American Journal of Clinical Nutrition, 99(1), 24-34. [More Information]

2013

  • Ryan, A., Luscombe-Marsh, N., Saies, A., Little, T., Standfield, S., Horowitz, M., Feinle-Bisset, C. (2013). Effects of intraduodenal lipid and protein on gut motility and hormone release, glycemia, appetite, and energy intake in lean men. The American Journal of Clinical Nutrition, 98(2), 300-311. [More Information]
  • Seimon, R., Brennan, I., Russo, A., Little, T., Jones, K., Stanfield, S., Wishart, J., Horowitz, M., Feinle-Bisset, C. (2013). Gastric emptying, mouth-to-cecum transit, and glycemic, insulin, incretin, and energy intake responses to a mixed-nutrient liquid in lean, overweight, and obese males. American Journal of Physiology: Endocrinology and Metabolism (online), 304(3), E294-E300. [More Information]

2012

  • Little, T., Ott, R., Young, R., Isaacs, N., Rayner, C., Horowitz, M., Feinle-Bisset, C. (2012). Altered expression of fatty acid receptors in the duodenum of lean and obese humans. XIIth Little Brain Big Brain Meeting.
  • Little, T. (2012). Altered expression of fatty acid receptors in the duodenum of obese humans. 2012 Enteric Nervous System Workshop.
  • Psichas, A., Little, T., Lal, S., McLaughlin, J. (2012). Colestyramine slows gastric emptying of liquids and reduces appetite in healthy subjects. Neurogastroenterology and Motility, 24(12), 1095-1101. [More Information]
  • Wu, T., Zhao, B., Bound, M., Checklin, H., Bellon, M., Little, T., Young, R., Jones, K., Horowitz, M., Rayner, C. (2012). Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. The American Journal of Clinical Nutrition, 95(1), 78-83. [More Information]
  • Jones, R., McKie, S., Astbury, N., Little, T., Tivey, S., Lassman, D., McLaughlin, J., Luckman, S., Williams, S., Dockray, G., et al (2012). Functional neuroimaging demonstrates that ghrelin inhibits the central nervous system response to ingested lipid. Gut (English Edition): an international journal of gastroenterology and hepatology, 61(11), 1543-1551. [More Information]

2011

  • Little, T., Feinle-Bisset, C. (2011). Effects of dietary fat on appetite and energy intake in health and obesity--oral and gastrointestinal sensory contributions. Physiology and Behavior, 104(4), 613-620. [More Information]
  • Little, T. (2011). Gastrointestinal factors involved in appetite regulation. 2011 Australian and New Zealand Obesity Society Annual Scientific Meeting.

2010

  • Little, T. (2010). Effects of fat on gut function and appetite and energy intake in humans - Implications for Obesity. 18th Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB).
  • Little, T., Gopinath, A., Patel, E., McGlone, A., Lassman, D., D'Amato, M., McLaughlin, J., Thompson, D. (2010). Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCKa?? receptor. Neurogastroenterology and Motility, 22(11), 1183-1190. [More Information]
  • Little, T., Feinle-Bisset, C. (2010). Oral and gastrointestinal sensing of dietary fat and appetite regulation in humans: modification by diet and obesity. Frontiers in Neuroscience, 4(OCT), 178-178. [More Information]
  • Seimon, R., Lange, K., Little, T., Brennan, I., Pilichiewicz, A., Feltrin, K., Smeets, A., Horowitz, M., Feinle-Bisset, C. (2010). Pooled-data analysis identifies pyloric pressures and plasma cholecystokinin concentrations as major determinants of acute energy intake in healthy, lean men. The American Journal of Clinical Nutrition, 92(1), 61-68. [More Information]

2009

  • Brennan, I., Feltrin, K., Nair, N., Hausken, T., Little, T., Gentilcore, D., Wishart, J., Jones, K., Horowitz, M., Feinle-Bisset, C. (2009). Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. American Journal of Physiology: Gastrointestinal and Liver Physiology, 297(3), G602-G610. [More Information]
  • Nair, N., Brennan, I., Little, T., Gentilcore, D., Hausken, T., Jones, K., Wishart, J., Horowitz, M., Feinle-Bisset, C. (2009). Reproducibility of energy intake, gastric emptying, blood glucose, plasma insulin and cholecystokinin responses in healthy young males. British Journal of Nutrition, 101(7), 1094-1102. [More Information]
  • Little, T., Gupta, N., Case, R., Thompson, D., McLaughlin, J. (2009). Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 297(3), R632-R639. [More Information]
  • Seimon, R., Wooster, T., Otto, B., Golding, M., Day, L., Little, T., Horowitz, M., Clifton, P., Feinle-Bisset, C. (2009). The droplet size of intraduodenal fat emulsions influences antropyloroduodenal motility, hormone release, and appetite in healthy males. The American Journal of Clinical Nutrition, 89(6), 1729-1736. [More Information]
  • Little, T. (2009). The role of endogenous CCK in the human glucose-induced brain activation matrix. XIth Little Brain Big Brain Meeting.

2008

  • Little, T., Feltrin, K., Horowitz, M., Meyer, J., Wishart, J., Chapman, I., Feinle-Bisset, C. (2008). A high-fat diet raises fasting plasma CCK but does not affect upper gut motility, PYY, and ghrelin, or energy intake during CCK-8 infusion in lean men. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (Print), 294(1), R45-R51. [More Information]
  • Feltrin, K., Little, T., Meyer, J., Horowitz, M., Rades, T., Wishart, J., Feinle-Bisset, C. (2008). Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men. The American Journal of Clinical Nutrition, 87(5), 1181-1187. [More Information]
  • Brennan, I., Little, T., Feltrin, K., Smout, A., Wishart, J., Horowitz, M., Feinle-Bisset, C. (2008). Dose-dependent effects of cholecystokinin-8 on antropyloroduodenal motility, gastrointestinal hormones, appetite, and energy intake in healthy men. American Journal of Physiology: Endocrinology and Metabolism (online), 295(6), E1487-E1494. [More Information]

2007

  • Feltrin, K., Little, T., Meyer, J., Horowitz, M., Rades, T., Wishart, J., Feinle-Bisset, C. (2007). Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans. The Journal of Physiology, 581(Pt 2), 767-777. [More Information]
  • Little, T., Russo, A., Meyer, J., Horowitz, M., Smyth, D., Bellon, M., Wishart, J., Jones, K., Feinle-Bisset, C. (2007). Free fatty acids have more potent effects on gastric emptying, gut hormones, and appetite than triacylglycerides. Gastroenterology, 133(4), 1124-1131. [More Information]
  • Pilichiewicz, A., Papadopoulos, P., Brennan, I., Little, T., Meyer, J., Wishart, J., Horowitz, M., Feinle-Bisset, C. (2007). Load-dependent effects of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (Print), 293(6), R2170-R2178. [More Information]
  • Little, T., Horowitz, M., Feinle-Bisset, C. (2007). Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity. American Journal of Clinical Nutrition, 86(3), 531-541. [More Information]
  • Gentilcore, D., Little, T., Feinle-Bisset, C., Samsom, M., Smout, A., Horowitz, M., Jones, K. (2007). Role of 5-hydroxytryptamine mechanisms in mediating the effects of small intestinal glucose on blood pressure and antropyloroduodenal motility in older subjects. American Journal of Physiology: Gastrointestinal and Liver Physiology, 293(4), G692-G698. [More Information]

2005

  • Little, T., Horowitz, M., Feinle-Bisset, C. (2005). Role of cholecystokinin in appetite control and body weight regulation. Obesity Reviews, 6(4), 297-306. [More Information]

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