Dr Tara Speranza

Research Fellow
Physiology, School of Medical Sciences

Telephone +61 2 9351 4099
Fax +61 2 9351 2510

Map

Selected grants

2015

  • Is the Insulin Receptor-Related Receptor required for osteocalcin signalling; Speranza T; Clive and Vera Ramaciotti Foundations/Awards for Biomedical Research: Establishment Gifts.

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • IVIS Lumina II in vivo Imaging System; Seibel M, Handelsman D, Le Couteur D, Hart D, Nicholson G, Freedman B, Kritharides L, Jessup W, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, McMahon A, Simanainen U, Kockx M, Speranza T, Zheng Y; DVC Research/Equipment Grant.

2011

  • The influence of cortisone on the synthesis and signaling of osteoblastic-derived mediators of metabolic dysfunction.; Speranza T; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Journals

  • Henneicke, H., Gasparini, S., Speranza, T., Zhou, H., Seibel, M. (2014). Glucocorticoids and bone: local effects and systemic implications. Trends in Endocrinology and Metabolism, 25(4), 197-211. [More Information]
  • Maimoun, L., Brennan-Speranza, T., Rizzoli, R., Ammann, P. (2012). Effects of ovariectomy on the changes in microarchitecture and material level properties in response to hind leg disuse in female rats. Bone, 51(3), 586-591. [More Information]
  • Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11), 4172-4189. [More Information]
  • Dubois-Ferriere, V., Speranza, T., Dayer, R., Rizzoli, T., Ammann, P. (2011). Calcitropic hormones and IGF-I are influenced by dietary protein. Endocrinology, 152(5), 1839-1847. [More Information]
  • Henneicke, H., Herrmann, M., Kalak, R., Speranza, T., Bertollo, N., Day, R., Huscher, D., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2011). Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism. Bone, 49(4), 733-742. [More Information]
  • Speranza, T., Rizzoli, R., Kream, B., Rosen, C., Ammann, P. (2011). Selective osteoblast overexpression of IGF-I in mice prevents low protein-induced deterioration of bone strength and material level properties. Bone, 49(5), 1073-1079. [More Information]
  • Ammann, P., Speranza, T., Mekraldi, S., Aubert, M., Rizzoli, R. (2010). Administration of growth hormone in selectively protein-deprived rats decreases BMD and bone strength. Bone, 46(6), 1574-1581. [More Information]
  • Simanainen, U., Lampinen, A., Henneicke, H., Speranza, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2010). Long-Term Corticosterone Treatment Induced Lobe-Specific Pathology in Mouse Prostate. The Prostate, 71(3), 289-297. [More Information]
  • Dayer, R., Speranza, T., Rizzoli, T., Ammann, P. (2010). PTH improves titanium implant fixation more than pamidronate or renutrition in osteopenic rats chronically fed a low protein diet. Osteoporosis International, 21(6), 957-967. [More Information]
  • Maimoun, L., Speranza, T., Badoud, I., Dubios-Ferriere, V., Rizzoli, R., Ammann, P. (2010). Strontium ranelate improves implant osseointegration. Bone, 46(5), 1436-1441. [More Information]
  • Huang, H., Speranza, T., Muir, M., Mason, R. (2009). Functional α1- and β2-adrenergic receptors in human osteoblasts. Journal of Cellular Physiology, 220(1), 267-275. [More Information]
  • Speranza, T., Rybchyn, M., Green, W., Atwa, S., Conigrave, A., Mason, R. (2009). Osteoblasts play key roles in the mechanisms of action of strontium ranelate. British Journal of Pharmacology, 157, 1291-1300. [More Information]
  • Brennan-Speranza, T., Rizzoli, R., Ammann, P. (2009). Selective Modification of Bone Quality by PTH, Pamidronate or Raloxifene. Journal of Bone and Mineral Research, 24(5), 800-809. [More Information]
  • Speranza, T., Mason, R. (2008). Le ranelate de strontium stimule la replication des osteoblastes et reduit leur capacite osteoclastogenique en modulant !'expression de l'osteoprotegerine et du RANK ligand. [Strontium ranelate stimulates the replication of osteoblasts and reduces their osteoclastogenic capacity by modulating! Expression of osteoprotegerin and RANK ligand]. Joint Bone Spine, 73(10), 1175.
  • Sivagurunathan, S., Muir, M., Speranza, T., Seale, J., Mason, R. (2005). Influence of glucocorticoids on human osteoclast generation and activity. Journal of Bone and Mineral Research, 20(3), 390-398. [More Information]

Conferences

  • Blankenstein, K., Speranza, T., Lyon, K., Dunstan, C., Zhou, H., Seibel, M. (2011). The negative effects of glucocorticoids on bone are primarily mediated by genes involved in osteoblast differentiation and bone remodeling (poster). 2011 Annual Scientific Meeting of the Australian and New Zealand Bone and Mineral Society, Gold Coast, Queensland, Australia.
  • Speranza, T., Blankenstein, K., Gundberg, C., Dunstan, C., Zhou, H., Seibel, M. (2011). The Role of Osteocalcin in Glucocorticoid-Induced Metabolic Dysfunction. 2011 Annual Scientific Meeting of the Australian and New Zealand Bone and Mineral Society, Gold Coast, Queensland, Australia.
  • Speranza, T., Blangenstein, K., Zhou, H., Seibel, M. (2010). The Role of Osteocalcin in Glucocorticoid-Induced Metabolic Dysfunction. Concord Hospital Clinical Week Research Symposium.
  • Ammann, P., Rizzoli, R., Brennan-Speranza, T. (2009). Osteoblast in Vivo IGF-I Production Regulates Tissue Level Properties in Mice. ASBMR 31st Annual Meeting/ American Society of Bone and Mineral Research Congress, Denver, Colorado, USA.
  • Brennan-Speranza, T., Rizzoli, R., Ammann, P. (2009). Osteoblastic IGF-I overexpression inreases the beneficial effect of PTH in aged mice. ASBMR 31st Annual Meeting/ American Society of Bone and Mineral Research Congress, Denver, Colorado, USA.
  • Speranza, T., Rizzoli, R., Ammann, P. (2009). Strontium Renelate Stimulates the Production of IGF-I and Decreases Signals For Osteoclastogenesis In Vivo. 15th Annual Swiss Bone and Mineral Society & SVGO/ASCO Meeting, Bern, Switzerland.
  • Speranza, T., Rizzoli, R., Ammann, P. (2009). The mode of action of strontium ranelate involves the stimulation of IGF-I production and a decrease in signals for osteoclastogenesis in vivo. 36th European Symposium on Calcified Tissues, Vienna, Austria.
  • Speranza, T., Rizzoli, R., Ammann, P. (2008). Bone Tissue Quality is Differently Altered by PTH, Bisphosphonates and SERMs. 2008 Annual Meeting/American Society of Bone and Mineral Research Congress, Montreal, Canada.
  • Speranza, T., Rybchyn, M., Conigrave, A., Mason, R. (2008). Le ranelate de strontium diminue l'osteoclastogenese induite par les osteoblastes par I'intermediaire du recepteur sensible au calcium. French Society of Rheumatology Annual Meeting, Paris, France.
  • Speranza, T., Rybchyn, M., Conigrave, A., Mason, R. (2008). Strontium ranelate decreases osteoblast-induced osteoclastogenesis through the involvement of the calcium-sensing receptor. 2008 Annual Meeting/American Society of Bone and Mineral Research Congress, Montreal, Canada.
  • Speranza, T., Rybchyn, M., Halbout, P., Conigrave, A., Mason, R. (2007). Strontium ranelate effects in human osteoblasts support its uncoupling effect on bone formation and bone resorption. 29th Annual Meeting American Society for Bone and Mineral Research (ASBMR), Washington DC, USA: American Society for Bone and Mineral Research.
  • Huang, H., Speranza, T., Muir, M., Mason, R. (2006). Alpha1 adrenergic agents modify RANKL/OPG expression and cell proliferation in osteoblastic cells. 16th Annual Scientific Meeting of the Australian & New Zealand Bone & Mineral Society.
  • Speranza, T., Muir, M., Conigrave, A., Mason, R. (2005). Is strontium anabolic?: Mechanisms of action in human osteoblasts. 15th Annual Scientific Meeting of the Australian and New Zealand Bone and Mineral Society 2005.
  • Speranza, T., Muir, M., Conigrave, A., Mason, R. (2004). Functional responses of bone cells to stimulation by strontium. Australian and New Zealand Bone and Mineral Society, 14th Annual Scientific Meeting.

2014

  • Henneicke, H., Gasparini, S., Speranza, T., Zhou, H., Seibel, M. (2014). Glucocorticoids and bone: local effects and systemic implications. Trends in Endocrinology and Metabolism, 25(4), 197-211. [More Information]

2012

  • Maimoun, L., Brennan-Speranza, T., Rizzoli, R., Ammann, P. (2012). Effects of ovariectomy on the changes in microarchitecture and material level properties in response to hind leg disuse in female rats. Bone, 51(3), 586-591. [More Information]
  • Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11), 4172-4189. [More Information]

2011

  • Dubois-Ferriere, V., Speranza, T., Dayer, R., Rizzoli, T., Ammann, P. (2011). Calcitropic hormones and IGF-I are influenced by dietary protein. Endocrinology, 152(5), 1839-1847. [More Information]
  • Henneicke, H., Herrmann, M., Kalak, R., Speranza, T., Bertollo, N., Day, R., Huscher, D., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2011). Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism. Bone, 49(4), 733-742. [More Information]
  • Speranza, T., Rizzoli, R., Kream, B., Rosen, C., Ammann, P. (2011). Selective osteoblast overexpression of IGF-I in mice prevents low protein-induced deterioration of bone strength and material level properties. Bone, 49(5), 1073-1079. [More Information]
  • Blankenstein, K., Speranza, T., Lyon, K., Dunstan, C., Zhou, H., Seibel, M. (2011). The negative effects of glucocorticoids on bone are primarily mediated by genes involved in osteoblast differentiation and bone remodeling (poster). 2011 Annual Scientific Meeting of the Australian and New Zealand Bone and Mineral Society, Gold Coast, Queensland, Australia.
  • Speranza, T., Blankenstein, K., Gundberg, C., Dunstan, C., Zhou, H., Seibel, M. (2011). The Role of Osteocalcin in Glucocorticoid-Induced Metabolic Dysfunction. 2011 Annual Scientific Meeting of the Australian and New Zealand Bone and Mineral Society, Gold Coast, Queensland, Australia.

2010

  • Ammann, P., Speranza, T., Mekraldi, S., Aubert, M., Rizzoli, R. (2010). Administration of growth hormone in selectively protein-deprived rats decreases BMD and bone strength. Bone, 46(6), 1574-1581. [More Information]
  • Simanainen, U., Lampinen, A., Henneicke, H., Speranza, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2010). Long-Term Corticosterone Treatment Induced Lobe-Specific Pathology in Mouse Prostate. The Prostate, 71(3), 289-297. [More Information]
  • Dayer, R., Speranza, T., Rizzoli, T., Ammann, P. (2010). PTH improves titanium implant fixation more than pamidronate or renutrition in osteopenic rats chronically fed a low protein diet. Osteoporosis International, 21(6), 957-967. [More Information]
  • Maimoun, L., Speranza, T., Badoud, I., Dubios-Ferriere, V., Rizzoli, R., Ammann, P. (2010). Strontium ranelate improves implant osseointegration. Bone, 46(5), 1436-1441. [More Information]
  • Speranza, T., Blangenstein, K., Zhou, H., Seibel, M. (2010). The Role of Osteocalcin in Glucocorticoid-Induced Metabolic Dysfunction. Concord Hospital Clinical Week Research Symposium.

2009

  • Huang, H., Speranza, T., Muir, M., Mason, R. (2009). Functional α1- and β2-adrenergic receptors in human osteoblasts. Journal of Cellular Physiology, 220(1), 267-275. [More Information]
  • Ammann, P., Rizzoli, R., Brennan-Speranza, T. (2009). Osteoblast in Vivo IGF-I Production Regulates Tissue Level Properties in Mice. ASBMR 31st Annual Meeting/ American Society of Bone and Mineral Research Congress, Denver, Colorado, USA.
  • Brennan-Speranza, T., Rizzoli, R., Ammann, P. (2009). Osteoblastic IGF-I overexpression inreases the beneficial effect of PTH in aged mice. ASBMR 31st Annual Meeting/ American Society of Bone and Mineral Research Congress, Denver, Colorado, USA.
  • Speranza, T., Rybchyn, M., Green, W., Atwa, S., Conigrave, A., Mason, R. (2009). Osteoblasts play key roles in the mechanisms of action of strontium ranelate. British Journal of Pharmacology, 157, 1291-1300. [More Information]
  • Brennan-Speranza, T., Rizzoli, R., Ammann, P. (2009). Selective Modification of Bone Quality by PTH, Pamidronate or Raloxifene. Journal of Bone and Mineral Research, 24(5), 800-809. [More Information]
  • Speranza, T., Rizzoli, R., Ammann, P. (2009). Strontium Renelate Stimulates the Production of IGF-I and Decreases Signals For Osteoclastogenesis In Vivo. 15th Annual Swiss Bone and Mineral Society & SVGO/ASCO Meeting, Bern, Switzerland.
  • Speranza, T., Rizzoli, R., Ammann, P. (2009). The mode of action of strontium ranelate involves the stimulation of IGF-I production and a decrease in signals for osteoclastogenesis in vivo. 36th European Symposium on Calcified Tissues, Vienna, Austria.

2008

  • Speranza, T., Rizzoli, R., Ammann, P. (2008). Bone Tissue Quality is Differently Altered by PTH, Bisphosphonates and SERMs. 2008 Annual Meeting/American Society of Bone and Mineral Research Congress, Montreal, Canada.
  • Speranza, T., Rybchyn, M., Conigrave, A., Mason, R. (2008). Le ranelate de strontium diminue l'osteoclastogenese induite par les osteoblastes par I'intermediaire du recepteur sensible au calcium. French Society of Rheumatology Annual Meeting, Paris, France.
  • Speranza, T., Mason, R. (2008). Le ranelate de strontium stimule la replication des osteoblastes et reduit leur capacite osteoclastogenique en modulant !'expression de l'osteoprotegerine et du RANK ligand. [Strontium ranelate stimulates the replication of osteoblasts and reduces their osteoclastogenic capacity by modulating! Expression of osteoprotegerin and RANK ligand]. Joint Bone Spine, 73(10), 1175.
  • Speranza, T., Rybchyn, M., Conigrave, A., Mason, R. (2008). Strontium ranelate decreases osteoblast-induced osteoclastogenesis through the involvement of the calcium-sensing receptor. 2008 Annual Meeting/American Society of Bone and Mineral Research Congress, Montreal, Canada.

2007

  • Speranza, T., Rybchyn, M., Halbout, P., Conigrave, A., Mason, R. (2007). Strontium ranelate effects in human osteoblasts support its uncoupling effect on bone formation and bone resorption. 29th Annual Meeting American Society for Bone and Mineral Research (ASBMR), Washington DC, USA: American Society for Bone and Mineral Research.

2006

  • Huang, H., Speranza, T., Muir, M., Mason, R. (2006). Alpha1 adrenergic agents modify RANKL/OPG expression and cell proliferation in osteoblastic cells. 16th Annual Scientific Meeting of the Australian & New Zealand Bone & Mineral Society.

2005

  • Sivagurunathan, S., Muir, M., Speranza, T., Seale, J., Mason, R. (2005). Influence of glucocorticoids on human osteoclast generation and activity. Journal of Bone and Mineral Research, 20(3), 390-398. [More Information]
  • Speranza, T., Muir, M., Conigrave, A., Mason, R. (2005). Is strontium anabolic?: Mechanisms of action in human osteoblasts. 15th Annual Scientific Meeting of the Australian and New Zealand Bone and Mineral Society 2005.

2004

  • Speranza, T., Muir, M., Conigrave, A., Mason, R. (2004). Functional responses of bone cells to stimulation by strontium. Australian and New Zealand Bone and Mineral Society, 14th Annual Scientific Meeting.

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