Dr Tegan Cheng

BE(Mechanical(Biomedical))/BMedSc '11 PhD '16
Conjoint Lecturer, Discipline of Child and Adolescent Health, Sydney Medical School
Adjunct Lecturer, School of Biomedical Engineering


Website Sydney Medical School

School of Aerospace, Mechanical and Mechatronic Engineering

Kids Research Institute

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Biographical details

Dr Tegan Cheng is a biomedical engineer and scientist principally based in Kids Research at the Children's Hospital at Westmead. She works closely with clinicians to develop novel solutions to address unmet needs in paediatrics. Her main research areas are the development and commercialisation of implantable and wearable medical devices for children's musculoskeletal conditions and the application of 3D printing to improve health outcomes for children.

Research interests

The treatment of musculoskeletal disorders in children’s growing skeletons comes with unique challenges, including the need to consider their small size, fast growth and high levels of activity. Dr Tegan Cheng leverages her academic backgrounds in biomedical engineering and medical sciences to create solutions facing our health care system. Her current research program involves working with clinicians to develop medical devices for children. Although historically overlooked by large medical device companies, it is her vision to drive commercial interest in paediatric medical devices by effectively crossing the “Valley of Death” that lies between conception and commercialization.

Dr Tegan Cheng has been at the University of Sydney since 2007, when she started her undergraduate degrees in Biomedical Engineering and Medical Science. She now has conjoint appointments with the Sydney Medical School and the Faculty of Engineering and Information Technologies.

Current research students

Project title Research student
Printhotics Predict: Machine Learning to Understand Orthoses Production Joyce WANG
Personalised orthotic therapy using 3D printing technologies Elizabeth WOJCIECHOWSKI

Themes

Biomedical engineering and technology

Selected publications

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Journals

  • Bateman, J., Sampurno, L., Maurizi, A., Lamande, S., Sims, N., Cheng, T., Schindeler, A., Little, D. (2019). Effect of rapamycin on bone mass and strength in the α2(I)-G610C mouse model of osteogenesis imperfecta. Journal of Cellular and Molecular Medicine, 23(3), 1735-1745. [More Information]
  • Wojciechowski, E., Chang, A., Balassone, D., Ford, J., Cheng, T., Little, D., Menezes, M., Hogan, S., Burns, J. (2019). Feasibility of designing, manufacturing and delivering 3D printed ankle-foot orthoses: a systematic review. Journal of Foot and Ankle Research, 12(1). [More Information]
  • Franks, D., Shatrov, J., Symes, M., Little, D., Cheng, T. (2018). Cannulated screw versus kirschner-wire fixation for milch II lateral condyle fractures in a paediatric sawbone model: A biomechanical comparison. Journal of Children's Orthopaedics, 12(1), 29-35. [More Information]
  • Mills, R., Cheng, T., Mikulec, K., Peacock, L., Isaacs, D., Genberg, C., Savage, P., Little, D., Schindeler, A. (2018). CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model. Clinical Orthopaedics and Related Research, 476(6), 1311-1323. [More Information]
  • Morse, A., Cheng, T., Schindeler, A., McDonald, M., Mohanty, S., Kneissel, M., Kramer, I., Little, D. (2018). Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume. Calcified Tissue International, 103(3), 298-310. [More Information]
  • McDonald, M., Morse, A., Schindeler, A., Mikulec, K., Peacock, L., Cheng, T., Bobyn, J., Lee, L., Baldock, P., Croucher, P., Tam, P., Little, D. (2018). Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation. Calcified Tissue International, 102(1), 105-116. [More Information]
  • Deo, N., Cheng, T., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). Improved union and bone strength in a mouse model of NF1 pseudarthrosis treated with recombinant human bone morphogenetic protein-2 and zoledronic acid. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 36(3), 930-936. [More Information]
  • Leblanc, E., Bellemore, J., Cheng, T., Little, D., Birke, O. (2017). Biomechanical considerations in slipped capital femoral epiphysis and insights into prophylactic fixation. Journal of Children's Orthopaedics, 11(2), 120-127. [More Information]
  • Little, D., Peacock, L., Mikulec, K., Kneissel, M., Kramer, I., Cheng, T., Schindeler, A., Munns, C. (2017). Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta. Bone, 101, 96-103. [More Information]
  • Manavi Tehrani, I., Fathi, A., Wang, Y., Maitz, P., Mirmohseni, F., Cheng, T., Peacock, L., Little, D., Schindeler, A., Dehghani, F. (2017). Fabrication of a Biodegradable Implant with Tunable Characteristics for Bone Implant Applications. Biomacromolecules, 18(6), 1736-1746. [More Information]
  • McDonald, M., Reagan, M., Youlten, S., Mohanty, S., Seckinger, A., Terry, R., Pettitt, J., Simic, M., Cheng, T., Morse, A., Little, D., et al (2017). Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood, 129(26), 3452-3464. [More Information]
  • Morse, A., McDonald, M., Schindeler, A., Peacock, L., Mikulec, K., Cheng, T., Liu, M., Ke, H., Little, D. (2017). Sclerostin Antibody Increases Callus Size and Strength but does not Improve Fracture Union in a Challenged Open Rat Fracture Model. Calcified Tissue International, 101(2), 217-228. [More Information]
  • Cheng, T., Schindeler, A., Little, D. (2016). BMP-2 delivered via sucrose acetate isobutyrate (SAIB) improves bone repair in a rat open fracture model. Journal of Orthopaedic Research, 34(7), 1168-1176. [More Information]
  • Morse, A., Cheng, T., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2016). RAP-011 augments callus formation in closed fractures in rats. Journal of Orthopaedic Research, 34(2), 320-330. [More Information]
  • Cheng, T., Murphy, C., Ravarian, R., Dehghani, F., Little, D., Schindeler, A. (2015). Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering. Journal of Tissue Engineering, 6, 1-9. [More Information]
  • Schindeler, A., Yu, N., Cheng, T., Sullivan, K., Mikulec, K., Peacock, L., Matthews, R., Little, D. (2015). Local delivery of the cationic steroid antibiotic CSA-90 enables osseous union in a rat open fracture model of Staphylococcus aureus infection. Journal of Bone and Joint Surgery: American Volume, 97(4), 302-309. [More Information]
  • Shen, K., Murphy, C., Chan, B., Kolind, M., Cheng, T., Cheng, T., Mikulec, K., Peacock, L., Xue, M., Park, S., Little, D., Jackson, C., Schindeler, A. (2014). Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism. Journal of Orthopaedic Research, 32(12), 1549-1556. [More Information]
  • Cheng, T., Murphy, C., Cantrill, L., Mikulec, K., Carpenter, C., Schindeler, A., Little, D. (2014). Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. International Orthopaedics, 38(7), 1527-1533. [More Information]
  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]

2019

  • Bateman, J., Sampurno, L., Maurizi, A., Lamande, S., Sims, N., Cheng, T., Schindeler, A., Little, D. (2019). Effect of rapamycin on bone mass and strength in the α2(I)-G610C mouse model of osteogenesis imperfecta. Journal of Cellular and Molecular Medicine, 23(3), 1735-1745. [More Information]
  • Wojciechowski, E., Chang, A., Balassone, D., Ford, J., Cheng, T., Little, D., Menezes, M., Hogan, S., Burns, J. (2019). Feasibility of designing, manufacturing and delivering 3D printed ankle-foot orthoses: a systematic review. Journal of Foot and Ankle Research, 12(1). [More Information]

2018

  • Franks, D., Shatrov, J., Symes, M., Little, D., Cheng, T. (2018). Cannulated screw versus kirschner-wire fixation for milch II lateral condyle fractures in a paediatric sawbone model: A biomechanical comparison. Journal of Children's Orthopaedics, 12(1), 29-35. [More Information]
  • Mills, R., Cheng, T., Mikulec, K., Peacock, L., Isaacs, D., Genberg, C., Savage, P., Little, D., Schindeler, A. (2018). CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model. Clinical Orthopaedics and Related Research, 476(6), 1311-1323. [More Information]
  • Morse, A., Cheng, T., Schindeler, A., McDonald, M., Mohanty, S., Kneissel, M., Kramer, I., Little, D. (2018). Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume. Calcified Tissue International, 103(3), 298-310. [More Information]
  • McDonald, M., Morse, A., Schindeler, A., Mikulec, K., Peacock, L., Cheng, T., Bobyn, J., Lee, L., Baldock, P., Croucher, P., Tam, P., Little, D. (2018). Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation. Calcified Tissue International, 102(1), 105-116. [More Information]
  • Deo, N., Cheng, T., Mikulec, K., Peacock, L., Little, D., Schindeler, A. (2018). Improved union and bone strength in a mouse model of NF1 pseudarthrosis treated with recombinant human bone morphogenetic protein-2 and zoledronic acid. Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 36(3), 930-936. [More Information]

2017

  • Leblanc, E., Bellemore, J., Cheng, T., Little, D., Birke, O. (2017). Biomechanical considerations in slipped capital femoral epiphysis and insights into prophylactic fixation. Journal of Children's Orthopaedics, 11(2), 120-127. [More Information]
  • Little, D., Peacock, L., Mikulec, K., Kneissel, M., Kramer, I., Cheng, T., Schindeler, A., Munns, C. (2017). Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta. Bone, 101, 96-103. [More Information]
  • Manavi Tehrani, I., Fathi, A., Wang, Y., Maitz, P., Mirmohseni, F., Cheng, T., Peacock, L., Little, D., Schindeler, A., Dehghani, F. (2017). Fabrication of a Biodegradable Implant with Tunable Characteristics for Bone Implant Applications. Biomacromolecules, 18(6), 1736-1746. [More Information]
  • McDonald, M., Reagan, M., Youlten, S., Mohanty, S., Seckinger, A., Terry, R., Pettitt, J., Simic, M., Cheng, T., Morse, A., Little, D., et al (2017). Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood, 129(26), 3452-3464. [More Information]
  • Morse, A., McDonald, M., Schindeler, A., Peacock, L., Mikulec, K., Cheng, T., Liu, M., Ke, H., Little, D. (2017). Sclerostin Antibody Increases Callus Size and Strength but does not Improve Fracture Union in a Challenged Open Rat Fracture Model. Calcified Tissue International, 101(2), 217-228. [More Information]

2016

  • Cheng, T., Schindeler, A., Little, D. (2016). BMP-2 delivered via sucrose acetate isobutyrate (SAIB) improves bone repair in a rat open fracture model. Journal of Orthopaedic Research, 34(7), 1168-1176. [More Information]
  • Morse, A., Cheng, T., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2016). RAP-011 augments callus formation in closed fractures in rats. Journal of Orthopaedic Research, 34(2), 320-330. [More Information]

2015

  • Cheng, T., Murphy, C., Ravarian, R., Dehghani, F., Little, D., Schindeler, A. (2015). Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering. Journal of Tissue Engineering, 6, 1-9. [More Information]
  • Schindeler, A., Yu, N., Cheng, T., Sullivan, K., Mikulec, K., Peacock, L., Matthews, R., Little, D. (2015). Local delivery of the cationic steroid antibiotic CSA-90 enables osseous union in a rat open fracture model of Staphylococcus aureus infection. Journal of Bone and Joint Surgery: American Volume, 97(4), 302-309. [More Information]

2014

  • Shen, K., Murphy, C., Chan, B., Kolind, M., Cheng, T., Cheng, T., Mikulec, K., Peacock, L., Xue, M., Park, S., Little, D., Jackson, C., Schindeler, A. (2014). Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism. Journal of Orthopaedic Research, 32(12), 1549-1556. [More Information]
  • Cheng, T., Murphy, C., Cantrill, L., Mikulec, K., Carpenter, C., Schindeler, A., Little, D. (2014). Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs. International Orthopaedics, 38(7), 1527-1533. [More Information]

2013

  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013). A sugar-based phase-transitioning delivery system for bone tissue-engineering. European Cells and Materials, 26, 208-221. [More Information]

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