Associate Professor Tracy Bryan

Unit Head, Cell Biology Research Unit
Medicine, Children's Medical Research Institute

Telephone +61 2 9687 2800
Fax +61 2 9687 2120

Website Related website

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Research interests

Dr Bryan discovered a new mechanism for cell immortalization called ALT and has since established her own laboratory to continue studies into the role of telomeres in human tumours.

PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

Selected grants

2014

  • WAVE 20/50 Bioreactor and C5 Cell Disruptor; Chircop (nee Fabbro) M, Kizana E, Robinson P, Diefenbach R, Bryan T, Gottlieb D, Micklethwaite K, Alexander I; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Fluidigm BioMark HD - HX; Alexander I, Jamieson R, Chircop (nee Fabbro) M, Byrne J, Catchpoole D, Reddel R, Tam P, Robinson P, Bryan T, Diefenbach R; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Structure and inhibition of the human telomerase enzyme complex; Bryan T, Cohen S; Cancer Council New South Wales/Research Project Grants.
  • Involvement of helicase DHX36 in human telomere maintenance; Bryan T; Cancer Council New South Wales/Research Project Grants.

2011

  • The BD Influx High Speed Cell Sorter; Cunningham A, George J, Rizos H, Clarke C, Reddel R, Kefford R, North K, Stewart G, Jones C, Tam P, Alexander S, Gottlieb D, Bradstock K, Bryan T, Booth D, Bendall L, Brilot-Turville F, Hebbard L, Cooper S, Wang Y, Wang X; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • G-quadruplex stabilisers as cancer therapeutics; Bryan T; Cancer Council New South Wales/Research Project Grants.

2010

  • Westmead Correlative Light and Electron Microscope Suite; North K, Jones C, Christodoulou J, Murray R, O'Neill G, Cantrill L, Cunningham A, Kefford R, Clarke C, Henderson B, Bendall L, Turville S, Reddel R, Tam P, Robinson P, Bryan T, Braithwaite A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The BD Influx High Speed Cell Sorter; Kefford R, Cunningham A, Bendall L, Clarke C, Harris D, Alexander S, Tam P, Sorrell T, Iredell J, Bryan T, Rizos H, Wang Y, Hebbard L; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Recruitment of human telomerase to telomeres; Bryan T, Cohen S; Cancer Council New South Wales/Research Project Grants.

2009

  • Structure, assembly, and inhibition of the human telomerase enzyme complex; Bryan T, Cohen S; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Tomlinson, C., Cohen, S., Bryan, T. (2014). Inhibition of Telemerase: Promise, Progress and Potential Pitfalls. Cancer Drug Design and Discovery 2nd Ed, (pp. 491-528). United Kingdom: Elsevier Inc.
  • Bryan, T. (2009). Telomeres and the End Replication Problem. In Lynne Cox (Eds.), Molecular Themes in DNA Replication, (pp. 217-268). RSC Publishing.

Journals

  • Yatsunyk, L., Bryan, T., Johnson, F. (2012). G-ruption: the third international meeting on G-quadruplex and G-assembly. Biochimie, 94(12), 2475-2483. [More Information]
  • Stern, J., Zyner, K., Pickett, H., Cohen, S., Bryan, T. (2012). Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently. Molecular and Cellular Biology, 32(13), 2384-2395. [More Information]
  • Conomos, D., Stutz, M., Hills, M., Neumann, A., Bryan, T., Reddel, R., Pickett, H. (2012). Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. The Journal of Cell Biology, 199(6), 893-906. [More Information]
  • Bryan, T., Baumann, P. (2011). G-Quadruplexes: From Guanine Gels to Chemotherapeutics. Molecular Biotechnology, 49(2), 198-208. [More Information]
  • Jurczyluk, J., Nouwens, A., Holien, J., Adams, T., Lovrecz, G., Parker, M., Cohen, S., Bryan, T. (2010). Direct involvement of the TEN domain at the active site of human telomerase. Nucleic Acids Research, 39(5), 1774-1788. [More Information]
  • Bryan, T., Baumann, P. (2010). G-quadruplexes: from guanine gels to chemotherapeutics. Methods in Molecular Biology, 608, 1-16. [More Information]
  • Cao, Y., Huschtscha, L., Nouwens, A., Pickett, H., Neumann, A., Chang, A., Toouli, C., Bryan, T., Reddel, R. (2008). Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels. Cancer Research, 68(9), 3115-3123. [More Information]
  • Cao, Y., Bryan, T., Reddel, R. (2008). Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer science, 99(6), 1092-1099. [More Information]
  • Finger, S., Bryan, T. (2008). Multiple DNA-binding sites in Tetrahymena telomerase. Nucleic Acids Research, 36(4), 1260-1272. [More Information]
  • Bryan, T., Stern, J. (2008). Telomerase recruitment to telomeres. Cytogenetic and Genome Research, 122(3-4), 243-254. [More Information]
  • Bryan, T., Jarstfer, M. (2007). Interrogation of G-quadruplex-protein interactions. Methods, 43(4), 332-339. [More Information]
  • Oganesian, L., Bryan, T. (2007). Physiological relevance of telomeric G-quadruplex formation: a potential drug target. BioEssays, 29(2), 155-165. [More Information]
  • Oganesian, L., Graham, M., Robinson, P., Bryan, T. (2007). Telomerase Recognizes G-Quadruplex and Linear DNA as Distinct Substrates. Biochemistry, 46(40), 11279-11290. [More Information]
  • Oganesian, L., Moon, I., Bryan, T., Jarstfer, M. (2006). Extension of G-quadruplex DNA by ciliate telomerase. The EMBO Journal, 25(5), 1148-1159. [More Information]
  • Chen, Y., Fender, J., Legassie, J., Jarstfer, M., Bryan, T., Varani, G. (2006). Structure of stem-loop IV of Tetrahymena telomerase RNA. The EMBO Journal, 25(13), 3156-3166. [More Information]
  • Reddel, R., Bryan, T. (2003). Alternative lengthening of telomeres: dangerous road less travelled. The Lancet, 361(9372), 1840-1841.
  • Bryan, T., Goodrich, K., Cech, T. (2003). Tetrahymena telomerase is active as a monomer. Molecular Biology, 14(12), 4794-4804.
  • Reddel, R., Bryan, T., Colgin, L., Perrem, K., Yeager, T. (2001). Alternative lengthening of telomeres in human cells. Radiation Research, 155(1), 194-200. [More Information]

2014

  • Tomlinson, C., Cohen, S., Bryan, T. (2014). Inhibition of Telemerase: Promise, Progress and Potential Pitfalls. Cancer Drug Design and Discovery 2nd Ed, (pp. 491-528). United Kingdom: Elsevier Inc.

2012

  • Yatsunyk, L., Bryan, T., Johnson, F. (2012). G-ruption: the third international meeting on G-quadruplex and G-assembly. Biochimie, 94(12), 2475-2483. [More Information]
  • Stern, J., Zyner, K., Pickett, H., Cohen, S., Bryan, T. (2012). Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently. Molecular and Cellular Biology, 32(13), 2384-2395. [More Information]
  • Conomos, D., Stutz, M., Hills, M., Neumann, A., Bryan, T., Reddel, R., Pickett, H. (2012). Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. The Journal of Cell Biology, 199(6), 893-906. [More Information]

2011

  • Bryan, T., Baumann, P. (2011). G-Quadruplexes: From Guanine Gels to Chemotherapeutics. Molecular Biotechnology, 49(2), 198-208. [More Information]

2010

  • Jurczyluk, J., Nouwens, A., Holien, J., Adams, T., Lovrecz, G., Parker, M., Cohen, S., Bryan, T. (2010). Direct involvement of the TEN domain at the active site of human telomerase. Nucleic Acids Research, 39(5), 1774-1788. [More Information]
  • Bryan, T., Baumann, P. (2010). G-quadruplexes: from guanine gels to chemotherapeutics. Methods in Molecular Biology, 608, 1-16. [More Information]

2009

  • Bryan, T. (2009). Telomeres and the End Replication Problem. In Lynne Cox (Eds.), Molecular Themes in DNA Replication, (pp. 217-268). RSC Publishing.

2008

  • Cao, Y., Huschtscha, L., Nouwens, A., Pickett, H., Neumann, A., Chang, A., Toouli, C., Bryan, T., Reddel, R. (2008). Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels. Cancer Research, 68(9), 3115-3123. [More Information]
  • Cao, Y., Bryan, T., Reddel, R. (2008). Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer science, 99(6), 1092-1099. [More Information]
  • Finger, S., Bryan, T. (2008). Multiple DNA-binding sites in Tetrahymena telomerase. Nucleic Acids Research, 36(4), 1260-1272. [More Information]
  • Bryan, T., Stern, J. (2008). Telomerase recruitment to telomeres. Cytogenetic and Genome Research, 122(3-4), 243-254. [More Information]

2007

  • Bryan, T., Jarstfer, M. (2007). Interrogation of G-quadruplex-protein interactions. Methods, 43(4), 332-339. [More Information]
  • Oganesian, L., Bryan, T. (2007). Physiological relevance of telomeric G-quadruplex formation: a potential drug target. BioEssays, 29(2), 155-165. [More Information]
  • Oganesian, L., Graham, M., Robinson, P., Bryan, T. (2007). Telomerase Recognizes G-Quadruplex and Linear DNA as Distinct Substrates. Biochemistry, 46(40), 11279-11290. [More Information]

2006

  • Oganesian, L., Moon, I., Bryan, T., Jarstfer, M. (2006). Extension of G-quadruplex DNA by ciliate telomerase. The EMBO Journal, 25(5), 1148-1159. [More Information]
  • Chen, Y., Fender, J., Legassie, J., Jarstfer, M., Bryan, T., Varani, G. (2006). Structure of stem-loop IV of Tetrahymena telomerase RNA. The EMBO Journal, 25(13), 3156-3166. [More Information]

2003

  • Reddel, R., Bryan, T. (2003). Alternative lengthening of telomeres: dangerous road less travelled. The Lancet, 361(9372), 1840-1841.
  • Bryan, T., Goodrich, K., Cech, T. (2003). Tetrahymena telomerase is active as a monomer. Molecular Biology, 14(12), 4794-4804.

2001

  • Reddel, R., Bryan, T., Colgin, L., Perrem, K., Yeager, T. (2001). Alternative lengthening of telomeres in human cells. Radiation Research, 155(1), 194-200. [More Information]

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