Associate Professor Tracy Bryan

Unit Head, Cell Biology Unit, Children's Medical Research Institute
Associate Professor, Sydney Medical School
Sub-dean (postgraduate research), Sydney Medical School
Main email address: tbryan@cmri.org.au

Cancer research network

Telephone +61 2 9687 2800
Fax +61 2 9687 2120

Website Honours in Medical Sciences at Westmead
CMRI lab website

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Biographical details

Associate Professor Tracy Bryan obtained her Bachelor of Science degree from Macquarie University in Sydney. During herPhD studies with Roger Reddel at the Children’s Medical Research Institute (CMRI) in Sydney (1993 – 1997), she discovered a new mechanism for maintenance of the ends of chromosomes (telomeres) in human tumours, called ALT.

Dr. Bryan spent four years conducting postdoctoral research with Tom Cech at the University of Colorado, USA, where she carried out biochemical studies on the enzyme telomerase, which adds DNA to telomeres. She returned to Australia to establish her own research programme at the CMRI in 2001. The research in Dr. Bryan’s laboratory, supported by funding from NHMRC, Viertel Foundation, Wellcome Trust, Cancer Institute NSW and Cancer Council NSW, continues to focus on the role of telomeres in cancer cells and in bone marrow failure syndromes, with an emphasis on understanding the cell biology and biochemistry of telomerase action.

Research interests

Telomerase is the enzyme responsible for lengthening the ends of chromosomes (telomeres), thereby allowing most cancer cells to divide indefinitely. We are determining the mechanisms of telomerase function using biochemical and cell-based approaches, with the aim of developing telomerase inhibitors as cancer therapeutics.

Selected grants

2016

  • G-quadruplex DNA: a molecular target for treatment of cancers using the alternative lengthening of telomeres (ALT) mechanism.; Reddel R, Bryan T; Cancer Council New South Wales/Priority-driven Collaborative Cancer Research Scheme.

2015

  • High content screening (HCS) in-cell imaging system; Robinson P, Chircop (nee Fabbro) M, Reddel R, Bryan T, Cesare A; DVC Research/Equipment Grant.

2014

  • WAVE 20/50 Bioreactor and C5 Cell Disruptor; Chircop (nee Fabbro) M, Kizana E, Robinson P, Diefenbach R, Bryan T, Gottlieb D, Micklethwaite K, Alexander I; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Fluidigm BioMark HD - HX; Alexander I, Jamieson R, Chircop (nee Fabbro) M, Byrne J, Catchpoole D, Reddel R, Tam P, Robinson P, Bryan T, Diefenbach R; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Structure and inhibition of the human telomerase enzyme complex; Bryan T, Cohen S; Cancer Council New South Wales/Research Project Grants.
  • Involvement of helicase DHX36 in human telomere maintenance; Bryan T; Cancer Council New South Wales/Research Project Grants.

2011

  • G-quadruplex stabilisers as cancer therapeutics; Bryan T; Cancer Council New South Wales/Research Project Grants.
  • The BD Influx High Speed Cell Sorter; Cunningham A, George J, Rizos H, Clarke C, Reddel R, Kefford R, North K, Stewart G, Jones C, Tam P, Alexander S, Gottlieb D, Bradstock K, Bryan T, Booth D, Bendall L, Brilot-Turville F, Hebbard L, Cooper S, Wang Y, Wang X; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Recruitment of human telomerase to telomeres; Bryan T, Cohen S; Cancer Council New South Wales/Research Project Grants.
  • The BD Influx High Speed Cell Sorter; Kefford R, Cunningham A, Bendall L, Clarke C, Harris D, Alexander S, Tam P, Sorrell T, Iredell J, Bryan T, Rizos H, Wang Y, Hebbard L; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Westmead Correlative Light and Electron Microscope Suite; North K, Jones C, Christodoulou J, Murray R, O'Neill G, Cantrill L, Cunningham A, Kefford R, Clarke C, Henderson B, Bendall L, Turville S, Reddel R, Tam P, Robinson P, Bryan T, Braithwaite A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Structure, assembly, and inhibition of the human telomerase enzyme complex; Bryan T, Cohen S; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Moye, A., Bryan, T. (2015). Proteins that interact with DNA and RNA G-quadruplexes. In David Monchaud (Eds.), Biological Relevance and Therapeutic Applications of DNA- and RNA-Quadruplexes, (pp. 101-117). London: Future Science Ltd. [More Information]
  • Tomlinson, C., Cohen, S., Bryan, T. (2014). Inhibition of Telomerase: Promise, Progress and Potential Pitfalls. In Stephen Neidle (Eds.), Cancer Drug Design and Discovery, (pp. 491-527). London, United Kingdom: Academic Press.
  • Bryan, T. (2009). Telomeres and the End Replication Problem. In Lynne Cox (Eds.), Molecular Themes in DNA Replication, (pp. 217-268). RSC Publishing.

Journals

  • Killedar, A., Stutz, M., Sobinoff, A., Tomlinson, C., Bryan, T., Beesley, J., Chenevix-Trench, G., Reddel, R., Pickett, H. (2015). A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase. PLoS Genetics, 11(6), 1-23. [More Information]
  • Tong, A., Stern, J., Sfeir, A., Kartawinata, M., De Lange, T., Zhu, X., Bryan, T. (2015). ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Reports, 13(8), 1-14. [More Information]
  • Birrento, M., Bryan, T., Samosorn, S., Beck, J. (2015). ESI-MS Investigation of an Equilibrium between a Bimolecular Quadruplex DNA and a Duplex DNA/RNA Hybrid. Journal of the American Society for Mass Spectrometry, 26(7), 1165-1173. [More Information]
  • Moye, A., Porter, K., Cohen, S., Phan, T., Zyner, K., Sasaki, N., Lovrecz, G., Beck, J., Bryan, T. (2015). Telomeric G-quadruplexes are a substrate and site of localization for human telomerase. Nature Communications, 6, 1-12. [More Information]
  • Tomlinson, C., Moye, A., Holien, J., Parker, M., Cohen, S., Bryan, T. (2015). Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding. The Biochemical Journal, 465(2), 347-357. [More Information]
  • Guo, Y., Kartawinata, M., Li, J., Pickett, H., Teo, J., Kilo, T., Barbaro, P., Keating, B., Chen, Y., Tian, L., Al-Odaib, A., Reddel, R., Christodoulou, J., Bryan, T., et al (2014). Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Blood, 124(18), 2767-2774. [More Information]
  • Yatsunyk, L., Bryan, T., Johnson, F. (2012). G-ruption: the third international meeting on G-quadruplex and G-assembly. Biochimie, 94(12), 2475-2483. [More Information]
  • Stern, J., Zyner, K., Pickett, H., Cohen, S., Bryan, T. (2012). Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently. Molecular and Cellular Biology, 32(13), 2384-2395. [More Information]
  • Conomos, D., Stutz, M., Hills, M., Neumann, A., Bryan, T., Reddel, R., Pickett, H. (2012). Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. The Journal of Cell Biology, 199(6), 893-906. [More Information]
  • Bryan, T., Baumann, P. (2011). G-Quadruplexes: From Guanine Gels to Chemotherapeutics. Molecular Biotechnology, 49(2), 198-208. [More Information]
  • Jurczyluk, J., Nouwens, A., Holien, J., Adams, T., Lovrecz, G., Parker, M., Cohen, S., Bryan, T. (2010). Direct involvement of the TEN domain at the active site of human telomerase. Nucleic Acids Research, 39(5), 1774-1788. [More Information]
  • Bryan, T., Baumann, P. (2010). G-quadruplexes: from guanine gels to chemotherapeutics. Methods in Molecular Biology, 608, 1-16. [More Information]
  • Cao, Y., Huschtscha, L., Nouwens, A., Pickett, H., Neumann, A., Chang, A., Toouli, C., Bryan, T., Reddel, R. (2008). Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels. Cancer Research, 68(9), 3115-3123. [More Information]
  • Cao, Y., Bryan, T., Reddel, R. (2008). Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer science, 99(6), 1092-1099. [More Information]
  • Finger, S., Bryan, T. (2008). Multiple DNA-binding sites in Tetrahymena telomerase. Nucleic Acids Research, 36(4), 1260-1272. [More Information]
  • Bryan, T., Stern, J. (2008). Telomerase recruitment to telomeres. Cytogenetic and Genome Research, 122(3-4), 243-254. [More Information]
  • Bryan, T., Jarstfer, M. (2007). Interrogation of G-quadruplex-protein interactions. Methods, 43(4), 332-339. [More Information]
  • Oganesian, L., Bryan, T. (2007). Physiological relevance of telomeric G-quadruplex formation: a potential drug target. BioEssays, 29(2), 155-165. [More Information]
  • Oganesian, L., Graham, M., Robinson, P., Bryan, T. (2007). Telomerase Recognizes G-Quadruplex and Linear DNA as Distinct Substrates. Biochemistry, 46(40), 11279-11290. [More Information]
  • Oganesian, L., Moon, I., Bryan, T., Jarstfer, M. (2006). Extension of G-quadruplex DNA by ciliate telomerase. The EMBO Journal, 25(5), 1148-1159. [More Information]
  • Chen, Y., Fender, J., Legassie, J., Jarstfer, M., Bryan, T., Varani, G. (2006). Structure of stem-loop IV of Tetrahymena telomerase RNA. The EMBO Journal, 25(13), 3156-3166. [More Information]
  • Reddel, R., Bryan, T. (2003). Alternative lengthening of telomeres: dangerous road less travelled. The Lancet, 361(9372), 1840-1841.
  • Bryan, T., Goodrich, K., Cech, T. (2003). Tetrahymena telomerase is active as a monomer. Molecular Biology, 14(12), 4794-4804.
  • Reddel, R., Bryan, T., Colgin, L., Perrem, K., Yeager, T. (2001). Alternative lengthening of telomeres in human cells. Radiation Research, 155(1), 194-200. [More Information]

2015

  • Killedar, A., Stutz, M., Sobinoff, A., Tomlinson, C., Bryan, T., Beesley, J., Chenevix-Trench, G., Reddel, R., Pickett, H. (2015). A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase. PLoS Genetics, 11(6), 1-23. [More Information]
  • Tong, A., Stern, J., Sfeir, A., Kartawinata, M., De Lange, T., Zhu, X., Bryan, T. (2015). ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Reports, 13(8), 1-14. [More Information]
  • Birrento, M., Bryan, T., Samosorn, S., Beck, J. (2015). ESI-MS Investigation of an Equilibrium between a Bimolecular Quadruplex DNA and a Duplex DNA/RNA Hybrid. Journal of the American Society for Mass Spectrometry, 26(7), 1165-1173. [More Information]
  • Moye, A., Bryan, T. (2015). Proteins that interact with DNA and RNA G-quadruplexes. In David Monchaud (Eds.), Biological Relevance and Therapeutic Applications of DNA- and RNA-Quadruplexes, (pp. 101-117). London: Future Science Ltd. [More Information]
  • Moye, A., Porter, K., Cohen, S., Phan, T., Zyner, K., Sasaki, N., Lovrecz, G., Beck, J., Bryan, T. (2015). Telomeric G-quadruplexes are a substrate and site of localization for human telomerase. Nature Communications, 6, 1-12. [More Information]
  • Tomlinson, C., Moye, A., Holien, J., Parker, M., Cohen, S., Bryan, T. (2015). Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding. The Biochemical Journal, 465(2), 347-357. [More Information]

2014

  • Guo, Y., Kartawinata, M., Li, J., Pickett, H., Teo, J., Kilo, T., Barbaro, P., Keating, B., Chen, Y., Tian, L., Al-Odaib, A., Reddel, R., Christodoulou, J., Bryan, T., et al (2014). Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Blood, 124(18), 2767-2774. [More Information]
  • Tomlinson, C., Cohen, S., Bryan, T. (2014). Inhibition of Telomerase: Promise, Progress and Potential Pitfalls. In Stephen Neidle (Eds.), Cancer Drug Design and Discovery, (pp. 491-527). London, United Kingdom: Academic Press.

2012

  • Yatsunyk, L., Bryan, T., Johnson, F. (2012). G-ruption: the third international meeting on G-quadruplex and G-assembly. Biochimie, 94(12), 2475-2483. [More Information]
  • Stern, J., Zyner, K., Pickett, H., Cohen, S., Bryan, T. (2012). Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently. Molecular and Cellular Biology, 32(13), 2384-2395. [More Information]
  • Conomos, D., Stutz, M., Hills, M., Neumann, A., Bryan, T., Reddel, R., Pickett, H. (2012). Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. The Journal of Cell Biology, 199(6), 893-906. [More Information]

2011

  • Bryan, T., Baumann, P. (2011). G-Quadruplexes: From Guanine Gels to Chemotherapeutics. Molecular Biotechnology, 49(2), 198-208. [More Information]

2010

  • Jurczyluk, J., Nouwens, A., Holien, J., Adams, T., Lovrecz, G., Parker, M., Cohen, S., Bryan, T. (2010). Direct involvement of the TEN domain at the active site of human telomerase. Nucleic Acids Research, 39(5), 1774-1788. [More Information]
  • Bryan, T., Baumann, P. (2010). G-quadruplexes: from guanine gels to chemotherapeutics. Methods in Molecular Biology, 608, 1-16. [More Information]

2009

  • Bryan, T. (2009). Telomeres and the End Replication Problem. In Lynne Cox (Eds.), Molecular Themes in DNA Replication, (pp. 217-268). RSC Publishing.

2008

  • Cao, Y., Huschtscha, L., Nouwens, A., Pickett, H., Neumann, A., Chang, A., Toouli, C., Bryan, T., Reddel, R. (2008). Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels. Cancer Research, 68(9), 3115-3123. [More Information]
  • Cao, Y., Bryan, T., Reddel, R. (2008). Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer science, 99(6), 1092-1099. [More Information]
  • Finger, S., Bryan, T. (2008). Multiple DNA-binding sites in Tetrahymena telomerase. Nucleic Acids Research, 36(4), 1260-1272. [More Information]
  • Bryan, T., Stern, J. (2008). Telomerase recruitment to telomeres. Cytogenetic and Genome Research, 122(3-4), 243-254. [More Information]

2007

  • Bryan, T., Jarstfer, M. (2007). Interrogation of G-quadruplex-protein interactions. Methods, 43(4), 332-339. [More Information]
  • Oganesian, L., Bryan, T. (2007). Physiological relevance of telomeric G-quadruplex formation: a potential drug target. BioEssays, 29(2), 155-165. [More Information]
  • Oganesian, L., Graham, M., Robinson, P., Bryan, T. (2007). Telomerase Recognizes G-Quadruplex and Linear DNA as Distinct Substrates. Biochemistry, 46(40), 11279-11290. [More Information]

2006

  • Oganesian, L., Moon, I., Bryan, T., Jarstfer, M. (2006). Extension of G-quadruplex DNA by ciliate telomerase. The EMBO Journal, 25(5), 1148-1159. [More Information]
  • Chen, Y., Fender, J., Legassie, J., Jarstfer, M., Bryan, T., Varani, G. (2006). Structure of stem-loop IV of Tetrahymena telomerase RNA. The EMBO Journal, 25(13), 3156-3166. [More Information]

2003

  • Reddel, R., Bryan, T. (2003). Alternative lengthening of telomeres: dangerous road less travelled. The Lancet, 361(9372), 1840-1841.
  • Bryan, T., Goodrich, K., Cech, T. (2003). Tetrahymena telomerase is active as a monomer. Molecular Biology, 14(12), 4794-4804.

2001

  • Reddel, R., Bryan, T., Colgin, L., Perrem, K., Yeager, T. (2001). Alternative lengthening of telomeres in human cells. Radiation Research, 155(1), 194-200. [More Information]

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