Dr Trisha Dwight

Research Fellow
Kolling Institute of Medical Research, Northern Clinical School

Telephone +61 2 99264775

Map

Research interests

Genomic alterations - and their functional effects - in endocrine tumours.

International links

United States

(University of Utah Health Sciences Center, Salt Lake City, Utah) collaborating with Professor Dennis Winge, focusing on the impact of genomic alterations and altered metabolic function in adrenal tumours.

Selected grants

2016

  • Hereditary Endocrine Cancer: A Model Based On Phaeochromocytoma-Paraganglioma Syndromes; Clifton-Bligh R, Tothill R, Duncan E, Gill A, Dwight T, Benn D, Tucker K, Trainer A; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Mitochondrial Dysfunction and Hypoxic Responses: Implications for Tumorigenesis; Dwight T, Clifton-Bligh R, Benn D, Robinson B; Pheo Para Alliance/Project grant.
  • The Australasian Succinate Dehydrogenase Consortium; Dwight T, Clifton-Bligh R, Benn D, Robinson B; Pheo Para Alliance/Project grant.
  • Pheo Tumour research; Dwight T; Northern Sydney Local Health District/Research Support.

Selected publications

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Journals

  • Kim, E., Wright, M., Sioson, L., Novos, T., Gill, A., Benn, D., White, C., Dwight, T., Clifton-Bligh, R. (2017). Utility of the succinate: Fumarate ratio for assessing SDH dysfunction in different tumor types. Molecular Genetics and Metabolism Reports, 10, 45-49. [More Information]
  • Cole, A., Dwight, T., Gill, A., Dickson, K., Zhu, Y., Clarkson, A., Gard, G., Maidens, J., Valmadre, S., Clifton-Bligh, R., Marsh, D. (2016). Assessing mutant p53 in primary high-grade serous ovarian cancer using immunohistochemistry and massively parallel sequencing. Scientific Reports, 6, 1-12. [More Information]
  • Harrison, W., Andrici, J., Maclean, F., Madadi-Ghahan, R., Farzin, M., Sioson, L., Toon, C., Clarkson, A., Watson, N., Pickett, J., Anderson, L., Clifton-Bligh, R., Dwight, T., Gill, A., et al (2016). Fumarate hydratase-deficient uterine leiomyomas occur in both the syndromic and sporadic settings. American Journal of Surgical Pathology, 40(5), 599-607. [More Information]
  • Parker, N., Hudson, A., Khong, P., Parkinson, J., Dwight, T., Ikin, R., Zhu, Y., Cheng, Z., Vafaee, F., Chen, J., Wheeler, H., Howell, V. (2016). Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma. Scientific Reports, 6, 1-10. [More Information]
  • Flynn, A., Dwight, T., Harris, J., Benn, D., Zhou, L., Hogg, A., Catchpoole, D., James, P., Duncan, E., Trainer, A., Gill, A., Clifton-Bligh, R., et al (2016). Pheo-Type: A Diagnostic Gene-expression Assay for the Classification of Pheochromocytoma and Paraganglioma. Journal of Clinical Endocrinology and Metabolism, 101(3), 1034-1043. [More Information]
  • Kim, E., Rath, E., Tsang, V., Duff, A., Robinson, B., Church, W., Benn, D., Dwight, T., Clifton-Bligh, R. (2015). Structural and functional consequences of succinate dehydrogenase subunit B mutations. Endocrine-Related Cancer, 22(3), 387-397. [More Information]
  • Tsang, V., Dwight, T., Benn, D., Meyer-Rochow, G., Gill, A., Sywak, M., Sidhu, S., Veivers, D., Sue, C., Robinson, B., Clifton-Bligh, R., Parker, N. (2014). Overexpression of miR-210 is associated with SDH-related pheochromocytomas, paragangliomas, and gastrointestinal stromal tumours. Endocrine-Related Cancer, 21(3), 415-426. [More Information]
  • Gill, A., Toon, C., Clarkson, A., Sioson, L., Chou, A., Winship, I., Robinson, B., Benn, D., Clifton-Bligh, R., Dwight, T. (2014). Succinate dehydrogenase deficiency is rare in pituitary adenomas. American Journal of Surgical Pathology, 38(4), 560-566. [More Information]
  • Dwight, T., Mann, K., Benn, D., Robinson, B., McKelvie, P., Gill, A., Winship, I., Clifton-Bligh, R. (2013). Familial SDHA Mutation Associated With Pituitary Adenoma and Pheochromocytoma/Paraganglioma. Journal of Clinical Endocrinology and Metabolism, 98(6), E1103-E1108. [More Information]
  • Dwight, T., Benn, D., Clarkson, A., Vilain, R., Lipton, L., Robinson, B., Clifton-Bligh, R., Gill, A. (2013). Loss of SDHA Expression Identifies SDHA Mutations in Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumors. The American Journal of Surgical Pathology, 37(2), 226-233. [More Information]
  • Cardinal, J., Bergman, L., Hayward, N., Sweet, A., Warner, J., Marks, L., Learoyd, D., Dwight, T., Robinson, B., Epstein, M., Smith, M., et al (2005). A report of a national mutation testing service for the MEN1 gene: clinical presentations and implications for mutation testing. Journal of Medical Genetics, 42(1), 69-74. [More Information]
  • Dwight, T., Nelson, A., Theodosopoulos, G., Richardson, A., Learoyd, D., Philips, J., Delbridge, L., Zedenius, J., Teh, B., Larsson, C., Marsh, D., Robinson, B. (2002). Independent Genetic Events Associated with the Development of Multiple Parathyroid Tumors in Patients with Primary Hyperparqathyroidism. The American Journal of Pathology, 161(4), 1299-1306.
  • Villablanca, A., Wassif, W., Smith, T., Hoog, A., Vierimaa, O., Kassem, M., Dwight, T., Forsberg, L., Du, Q., Learoyd, D., Robinson, B., et al (2002). Involvement of the MEN1 gene locus in familial isolated hyperparathyroidism. European Journal of Endocrinology, 147(3), 313-322.

Conferences

  • Tsang, V., Parker, N., Cassano, J., Dwight, T., Sue, C., Veivers, D., Robinson, B., Benn, D., Clifton-Bligh, R. (2012). Interaction between hypoxia and mutations in the SDH subunit genes associated with phaeochromocytoma/paragangliomas. 2012 Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology, Gold Coast, Queensland, Australia.

2017

  • Kim, E., Wright, M., Sioson, L., Novos, T., Gill, A., Benn, D., White, C., Dwight, T., Clifton-Bligh, R. (2017). Utility of the succinate: Fumarate ratio for assessing SDH dysfunction in different tumor types. Molecular Genetics and Metabolism Reports, 10, 45-49. [More Information]

2016

  • Cole, A., Dwight, T., Gill, A., Dickson, K., Zhu, Y., Clarkson, A., Gard, G., Maidens, J., Valmadre, S., Clifton-Bligh, R., Marsh, D. (2016). Assessing mutant p53 in primary high-grade serous ovarian cancer using immunohistochemistry and massively parallel sequencing. Scientific Reports, 6, 1-12. [More Information]
  • Harrison, W., Andrici, J., Maclean, F., Madadi-Ghahan, R., Farzin, M., Sioson, L., Toon, C., Clarkson, A., Watson, N., Pickett, J., Anderson, L., Clifton-Bligh, R., Dwight, T., Gill, A., et al (2016). Fumarate hydratase-deficient uterine leiomyomas occur in both the syndromic and sporadic settings. American Journal of Surgical Pathology, 40(5), 599-607. [More Information]
  • Parker, N., Hudson, A., Khong, P., Parkinson, J., Dwight, T., Ikin, R., Zhu, Y., Cheng, Z., Vafaee, F., Chen, J., Wheeler, H., Howell, V. (2016). Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma. Scientific Reports, 6, 1-10. [More Information]
  • Flynn, A., Dwight, T., Harris, J., Benn, D., Zhou, L., Hogg, A., Catchpoole, D., James, P., Duncan, E., Trainer, A., Gill, A., Clifton-Bligh, R., et al (2016). Pheo-Type: A Diagnostic Gene-expression Assay for the Classification of Pheochromocytoma and Paraganglioma. Journal of Clinical Endocrinology and Metabolism, 101(3), 1034-1043. [More Information]

2015

  • Kim, E., Rath, E., Tsang, V., Duff, A., Robinson, B., Church, W., Benn, D., Dwight, T., Clifton-Bligh, R. (2015). Structural and functional consequences of succinate dehydrogenase subunit B mutations. Endocrine-Related Cancer, 22(3), 387-397. [More Information]

2014

  • Tsang, V., Dwight, T., Benn, D., Meyer-Rochow, G., Gill, A., Sywak, M., Sidhu, S., Veivers, D., Sue, C., Robinson, B., Clifton-Bligh, R., Parker, N. (2014). Overexpression of miR-210 is associated with SDH-related pheochromocytomas, paragangliomas, and gastrointestinal stromal tumours. Endocrine-Related Cancer, 21(3), 415-426. [More Information]
  • Gill, A., Toon, C., Clarkson, A., Sioson, L., Chou, A., Winship, I., Robinson, B., Benn, D., Clifton-Bligh, R., Dwight, T. (2014). Succinate dehydrogenase deficiency is rare in pituitary adenomas. American Journal of Surgical Pathology, 38(4), 560-566. [More Information]

2013

  • Dwight, T., Mann, K., Benn, D., Robinson, B., McKelvie, P., Gill, A., Winship, I., Clifton-Bligh, R. (2013). Familial SDHA Mutation Associated With Pituitary Adenoma and Pheochromocytoma/Paraganglioma. Journal of Clinical Endocrinology and Metabolism, 98(6), E1103-E1108. [More Information]
  • Dwight, T., Benn, D., Clarkson, A., Vilain, R., Lipton, L., Robinson, B., Clifton-Bligh, R., Gill, A. (2013). Loss of SDHA Expression Identifies SDHA Mutations in Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumors. The American Journal of Surgical Pathology, 37(2), 226-233. [More Information]

2012

  • Tsang, V., Parker, N., Cassano, J., Dwight, T., Sue, C., Veivers, D., Robinson, B., Benn, D., Clifton-Bligh, R. (2012). Interaction between hypoxia and mutations in the SDH subunit genes associated with phaeochromocytoma/paragangliomas. 2012 Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology, Gold Coast, Queensland, Australia.

2005

  • Cardinal, J., Bergman, L., Hayward, N., Sweet, A., Warner, J., Marks, L., Learoyd, D., Dwight, T., Robinson, B., Epstein, M., Smith, M., et al (2005). A report of a national mutation testing service for the MEN1 gene: clinical presentations and implications for mutation testing. Journal of Medical Genetics, 42(1), 69-74. [More Information]

2002

  • Dwight, T., Nelson, A., Theodosopoulos, G., Richardson, A., Learoyd, D., Philips, J., Delbridge, L., Zedenius, J., Teh, B., Larsson, C., Marsh, D., Robinson, B. (2002). Independent Genetic Events Associated with the Development of Multiple Parathyroid Tumors in Patients with Primary Hyperparqathyroidism. The American Journal of Pathology, 161(4), 1299-1306.
  • Villablanca, A., Wassif, W., Smith, T., Hoog, A., Vierimaa, O., Kassem, M., Dwight, T., Forsberg, L., Du, Q., Learoyd, D., Robinson, B., et al (2002). Involvement of the MEN1 gene locus in familial isolated hyperparathyroidism. European Journal of Endocrinology, 147(3), 313-322.

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