Dr Ulla Simanainen

Research Fellow
Medicine, Concord Clinical School
ANZAC Research Institute

Telephone +61 2 9767 9116
Fax +61 2 9767 9101

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Selected grants

2014

  • EVOS FL Auto cell imaging system; Nicholson G, Clark G, Zhou H, Jessup W, Le Couteur D, McMahon A, McLachlan A, Allan C, Handelsman D, Hart D, Walters K, Kritharides L, Kockx M, Kennerson M, Cooper M, Seibel M, Verma N, Silveira P, Fromm P, Simanainen U, Cogger V, Zheng Y; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Androgens and breast cancer; Simanainen U; DVC Research/Bridging Support Grant.
  • Automacs Pro Seperator; Hart D, Handelsman D, Le Couteur D, Nicholson G, Kritharides L, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, Simanainen U, Zheng Y, Seibel M; DVC Research/Equipment Grant.
  • IVIS Lumina II in vivo Imaging System; Seibel M, Handelsman D, Le Couteur D, Hart D, Nicholson G, Freedman B, Kritharides L, Jessup W, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, McMahon A, Simanainen U, Kockx M, Speranza T, Zheng Y; DVC Research/Equipment Grant.

2011

  • Intraprostatic androgen signalling as a target in prostate cancer; Simanainen U, Handelsman D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • MOLECULAR IMAGER CHEMIDoc XRS SYSTEM & MINI P ROTEAN GEL/TRANSBLOT Cell SYSTEM (BIO-RAD. AUSTRALIA; Allan C, Handelsman D, Zhou H, Seibel M, Kennerson M, Nicholson G, Blair I, Le Couteur D, McMahon A, Hart D, Clark G, Simanainen U; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Steroid signalling pathways as targets in experimental prostate cancer; Simanainen U; DVC Research/Bridging Support Grant.
  • The Lunar PIXImus II DEXA Scanner; Zhou H, Seibel M, Handelsman D, Le Couteur D, Nicholson G, Clarke S, Robertson G, van Zandwijk N, Freedman B, Kennerson M, Allan C, Walters K, Cogger V, Blair I, Reid G, Simanainen U; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • The role of intraprostatic glucocorticoid action in prostate physiology and pathology; Simanainen U; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.
  • Stereomicroscope-Imaging Workstation; Allan C, Seibel M, Handelsman D, Le Couteur D, Kennerson M, Robertson G, Walters K, Cogger V, Nicholson G, Zhou H, Blair I, Simanainen U, McMahon A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2007

  • The role of androgens in prostate physiology and pathology; Simanainen U, Handelsman D; University of Sydney/Cancer Research Fund.

2006

  • The role of androgens in prostate physiology and pathology; Simanainen U; Cure Cancer Australia Foundation/Research Support.

Selected publications

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Journals

  • Simanainen, U., Ryan, T., Li, D., Garces Suarez, F., Gao, Y., Watson, G., Wang, Y., Handelsman, D. (2015). Androgen Receptor Actions Modify Skin Structure and Chemical Carcinogen-induced Skin Cancer Susceptibility in Mice. Hormones and Cancer, 6(1), 45-53. [More Information]
  • Solon-Biet, S., Walters, K., Simanainen, U., McMahon, A., Ruohonen, K., Ballard, J., Raubenheimer, D., Handelsman, D., Le Couteur, D., Simpson, S. (2015). Macronutrient balance, reproductive function, and lifespan in aging mice. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 112(11), 3481-3486. [More Information]
  • Niittynen, M., Simanainen, U., Pohjanvirta, R., Sankari, S., Tuomisto, J. (2014). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Increases Bilirubin Formation but Hampers Quantitative Hepatic Conversion of Biliverdin to Bilirubin in Rats with Wild-Type AH Receptor. Basic and Clinical Pharmacology and Toxicology, 114(6), 497-509. [More Information]
  • Gao, Y., Walters, K., Desai, R., Zhou, H., Handelsman, D., Simanainen, U. (2014). Androgen receptor inactivation resulted in acceleration in pubertal mammary gland growth, upregulation of ERα expression, and Wnt/β-catenin signaling in female mice. Endocrinology, 155(12), 4951-4963. [More Information]
  • Zhao, B., Choi, J., Jaehne, M., Gao, Y., Desai, R., Tuckermann, J., Zhou, H., Handelsman, D., Simanainen, U. (2014). Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate. The Prostate, 74(10), 1068-1078. [More Information]
  • Vignarajan, S., Xie, C., Yao, M., Sun, Y., Simanainen, U., Sved, P., Liu, T., Dong, Q. (2014). Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A₂α via AKT in prostate cancer cells. Oncotarget, 5(15), 6289-6299.
  • Choi, J., Psarommatis, B., Gao, Y., Zheng, Y., Handelsman, D., Simanainen, U. (2014). The role of androgens in experimental rodent mammary carcinogenesis. Breast Cancer Research, 16(6), 1-12. [More Information]
  • Simanainen, U., Gao, Y., Desai, R., Jimenez, M., Spaliviero, J., Keast, J., Handelsman, D. (2013). Evidence for increased tissue androgen sensitivity in neurturin knockout mice. The Journal of Endocrinology, 218(2), 151-163. [More Information]
  • McNamara, K., Nakamura, Y., Sasano, H., Handelsman, D., Simanainen, U. (2013). Prostate Epithelial AR Inactivation Leads to Increased Intraprostatic Androgen Synthesis. The Prostate, 73(3), 316-327. [More Information]
  • Simanainen, U., Gao, Y., Walters, K., Watson, G., Desai, R., Jimenez, M., Handelsman, D. (2012). Androgen Resistance in Female Mice Increases Susceptibility to DMBA-Induced Mammary Tumors. Hormones and Cancer, 3(3), 113-124. [More Information]
  • Walters, K., Middleton, L., Joseph, S., Hazra, R., Jimenez, M., Simanainen, U., Allan, C., Handelsman, D. (2012). Targeted Loss of Androgen Receptor Signaling in Murine Granulosa Cells of Preantral and Antral Follicles Causes Female Subfertility. Biology of Reproduction, 87(6), 1-11. [More Information]
  • McNamara, K., Handelsman, D., Simanainen, U. (2012). The mouse as a model to investigate sex steroid metabolism in the normal and pathological prostate. Journal of Steroid Biochemistry and Molecular Biology, 131(3-5), 107-121. [More Information]
  • Simanainen, U., McNamara, K., Gao, Y., McPherson, S., Desai, R., Jimenez, M., Handelsman, D. (2011). Anterior prostate epithelial AR inactivation modifies estrogen receptor expression and increases estrogen sensitivity. American Journal of Physiology: Endocrinology and Metabolism, 301(4), E727-E735. [More Information]
  • Allan, C., Walters, K., Simanainen, U., Handelsman, D. (2011). Genetic models for hormonal regulation of reproduction. Australian Biochemist, 42(1), 4-7.
  • Simanainen, U., Brogley, M., Gao, Y., Jimenez, M., Harwood, D., Handelsman, D., Robins, D. (2011). Length of the human androgen receptor glutamine tract determines androgen sensitivity in vivo. Molecular And Cellular Endocrinology, 342(1-2), 81-86. [More Information]
  • Finnila, M., Zioupos, P., Herlin, M., Miettinen, H., Simanainen, U., Hakansson, H., Tuukkanen, J., Viluksela, M., Jamsa, T. (2010). Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin Exposure on Bone Material Properties. Journal of Biomechanics, 43(6), 1097-1103. [More Information]
  • Allan, C., Couse, J., Simanainen, U., Spaliviero, J., Jimenez, M., Rodriguez, K., Korach, K., Handelsman, D. (2010). Estradiol Induction of Spermatogenesis Is Mediated via an Estrogen Receptor-{alpha} Mechanism Involving Neuroendocrine Activation of Follicle-Stimulating Hormone Secretion. Endocrinology, 151(6), 2800-2810. [More Information]
  • Simanainen, U., Lampinen, A., Henneicke, H., Speranza, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2010). Long-Term Corticosterone Treatment Induced Lobe-Specific Pathology in Mouse Prostate. The Prostate, 71(3), 289-297. [More Information]
  • McNamara, K., Harwood, D., Simanainen, U., Walters, K., Jimenez, M., Handelsman, D. (2010). Measurement of sex steroids in murine blood and reproductive tissues by liquid chromatography-tandem mass spectrometry. Journal of Steroid Biochemistry and Molecular Biology, 121(3-May), 611-618. [More Information]
  • Walters, K., Simanainen, U., Handelsman, D. (2010). Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models. Human Reproduction Update, 16(5), 543-558. [More Information]
  • Simanainen, U., McNamara, K., Gao, Y., Handelsman, D. (2009). Androgen sensitivity of prostate epithelium is enhanced by postnatal androgen receptor inactivation. American Journal of Physiology: Endocrinology and Metabolism, 296(6), E1335-E1343. [More Information]
  • Simanainen, U., McNamara, K., Davey, R., Zajac, J., Handelsman, D. (2008). Severe subfertility in mice with AR inactivation in sex accessory organs but not in testis. Endocrinology, 149(7), 3330-3338. [More Information]
  • Simanainen, U., Allan, C., Lim, P., McPherson, S., Jimenez, M., Zajac, J., Davey, R., Handelsman, D. (2007). Disruption of prostate epithelial androgen receptor impedes lobe-specific growth and function. Endocrinology, 148(5), 2264-2272. [More Information]

Conferences

  • Liu, P., Kalak, R., Lue, Y., Erkkilla, K., Simanainen, U., Zhou, H., Hikim, A., Handelsman, D., Seibel, M., Wang, C., Dunstan, C., et al (2007). XXY Mice have an Osteoporotic Phenotype. 29th Annual Meeting American Society for Bone and Mineral Research (ASBMR), Washington DC, USA: American Society for Bone and Mineral Research.

2015

  • Simanainen, U., Ryan, T., Li, D., Garces Suarez, F., Gao, Y., Watson, G., Wang, Y., Handelsman, D. (2015). Androgen Receptor Actions Modify Skin Structure and Chemical Carcinogen-induced Skin Cancer Susceptibility in Mice. Hormones and Cancer, 6(1), 45-53. [More Information]
  • Solon-Biet, S., Walters, K., Simanainen, U., McMahon, A., Ruohonen, K., Ballard, J., Raubenheimer, D., Handelsman, D., Le Couteur, D., Simpson, S. (2015). Macronutrient balance, reproductive function, and lifespan in aging mice. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 112(11), 3481-3486. [More Information]

2014

  • Niittynen, M., Simanainen, U., Pohjanvirta, R., Sankari, S., Tuomisto, J. (2014). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Increases Bilirubin Formation but Hampers Quantitative Hepatic Conversion of Biliverdin to Bilirubin in Rats with Wild-Type AH Receptor. Basic and Clinical Pharmacology and Toxicology, 114(6), 497-509. [More Information]
  • Gao, Y., Walters, K., Desai, R., Zhou, H., Handelsman, D., Simanainen, U. (2014). Androgen receptor inactivation resulted in acceleration in pubertal mammary gland growth, upregulation of ERα expression, and Wnt/β-catenin signaling in female mice. Endocrinology, 155(12), 4951-4963. [More Information]
  • Zhao, B., Choi, J., Jaehne, M., Gao, Y., Desai, R., Tuckermann, J., Zhou, H., Handelsman, D., Simanainen, U. (2014). Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate. The Prostate, 74(10), 1068-1078. [More Information]
  • Vignarajan, S., Xie, C., Yao, M., Sun, Y., Simanainen, U., Sved, P., Liu, T., Dong, Q. (2014). Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A₂α via AKT in prostate cancer cells. Oncotarget, 5(15), 6289-6299.
  • Choi, J., Psarommatis, B., Gao, Y., Zheng, Y., Handelsman, D., Simanainen, U. (2014). The role of androgens in experimental rodent mammary carcinogenesis. Breast Cancer Research, 16(6), 1-12. [More Information]

2013

  • Simanainen, U., Gao, Y., Desai, R., Jimenez, M., Spaliviero, J., Keast, J., Handelsman, D. (2013). Evidence for increased tissue androgen sensitivity in neurturin knockout mice. The Journal of Endocrinology, 218(2), 151-163. [More Information]
  • McNamara, K., Nakamura, Y., Sasano, H., Handelsman, D., Simanainen, U. (2013). Prostate Epithelial AR Inactivation Leads to Increased Intraprostatic Androgen Synthesis. The Prostate, 73(3), 316-327. [More Information]

2012

  • Simanainen, U., Gao, Y., Walters, K., Watson, G., Desai, R., Jimenez, M., Handelsman, D. (2012). Androgen Resistance in Female Mice Increases Susceptibility to DMBA-Induced Mammary Tumors. Hormones and Cancer, 3(3), 113-124. [More Information]
  • Walters, K., Middleton, L., Joseph, S., Hazra, R., Jimenez, M., Simanainen, U., Allan, C., Handelsman, D. (2012). Targeted Loss of Androgen Receptor Signaling in Murine Granulosa Cells of Preantral and Antral Follicles Causes Female Subfertility. Biology of Reproduction, 87(6), 1-11. [More Information]
  • McNamara, K., Handelsman, D., Simanainen, U. (2012). The mouse as a model to investigate sex steroid metabolism in the normal and pathological prostate. Journal of Steroid Biochemistry and Molecular Biology, 131(3-5), 107-121. [More Information]

2011

  • Simanainen, U., McNamara, K., Gao, Y., McPherson, S., Desai, R., Jimenez, M., Handelsman, D. (2011). Anterior prostate epithelial AR inactivation modifies estrogen receptor expression and increases estrogen sensitivity. American Journal of Physiology: Endocrinology and Metabolism, 301(4), E727-E735. [More Information]
  • Allan, C., Walters, K., Simanainen, U., Handelsman, D. (2011). Genetic models for hormonal regulation of reproduction. Australian Biochemist, 42(1), 4-7.
  • Simanainen, U., Brogley, M., Gao, Y., Jimenez, M., Harwood, D., Handelsman, D., Robins, D. (2011). Length of the human androgen receptor glutamine tract determines androgen sensitivity in vivo. Molecular And Cellular Endocrinology, 342(1-2), 81-86. [More Information]

2010

  • Finnila, M., Zioupos, P., Herlin, M., Miettinen, H., Simanainen, U., Hakansson, H., Tuukkanen, J., Viluksela, M., Jamsa, T. (2010). Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin Exposure on Bone Material Properties. Journal of Biomechanics, 43(6), 1097-1103. [More Information]
  • Allan, C., Couse, J., Simanainen, U., Spaliviero, J., Jimenez, M., Rodriguez, K., Korach, K., Handelsman, D. (2010). Estradiol Induction of Spermatogenesis Is Mediated via an Estrogen Receptor-{alpha} Mechanism Involving Neuroendocrine Activation of Follicle-Stimulating Hormone Secretion. Endocrinology, 151(6), 2800-2810. [More Information]
  • Simanainen, U., Lampinen, A., Henneicke, H., Speranza, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2010). Long-Term Corticosterone Treatment Induced Lobe-Specific Pathology in Mouse Prostate. The Prostate, 71(3), 289-297. [More Information]
  • McNamara, K., Harwood, D., Simanainen, U., Walters, K., Jimenez, M., Handelsman, D. (2010). Measurement of sex steroids in murine blood and reproductive tissues by liquid chromatography-tandem mass spectrometry. Journal of Steroid Biochemistry and Molecular Biology, 121(3-May), 611-618. [More Information]
  • Walters, K., Simanainen, U., Handelsman, D. (2010). Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models. Human Reproduction Update, 16(5), 543-558. [More Information]

2009

  • Simanainen, U., McNamara, K., Gao, Y., Handelsman, D. (2009). Androgen sensitivity of prostate epithelium is enhanced by postnatal androgen receptor inactivation. American Journal of Physiology: Endocrinology and Metabolism, 296(6), E1335-E1343. [More Information]

2008

  • Simanainen, U., McNamara, K., Davey, R., Zajac, J., Handelsman, D. (2008). Severe subfertility in mice with AR inactivation in sex accessory organs but not in testis. Endocrinology, 149(7), 3330-3338. [More Information]

2007

  • Simanainen, U., Allan, C., Lim, P., McPherson, S., Jimenez, M., Zajac, J., Davey, R., Handelsman, D. (2007). Disruption of prostate epithelial androgen receptor impedes lobe-specific growth and function. Endocrinology, 148(5), 2264-2272. [More Information]
  • Liu, P., Kalak, R., Lue, Y., Erkkilla, K., Simanainen, U., Zhou, H., Hikim, A., Handelsman, D., Seibel, M., Wang, C., Dunstan, C., et al (2007). XXY Mice have an Osteoporotic Phenotype. 29th Annual Meeting American Society for Bone and Mineral Research (ASBMR), Washington DC, USA: American Society for Bone and Mineral Research.

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