Dr Umaimainthan Palendira

Senior Lecturer - Immunology
Central Clinical School


Map

Selected grants

2018

  • The Role of Tumour-Resident CD8+ T cells in Metastatic Melanoma and Immunotherapy; Palendira U, Wilmott J, Menzies A, Luciani F, Gebhardt T; Cancer Council New South Wales/Research Grant.

2017

  • The Sydney University Immunotherapy Hub: Improving the efficacy of Immunotherapy; Palendira U, Britton W, Scolyer R, Long G, O'Toole S, Hersey P; DVC Research/Sydney Research Excellence Initiative 2020 (SREI).

2015

  • Characterising splenic myeloid responses to CNS pathogens; Mitchell A, Grau G, Fazekas de St Groth B, King N, Palendira U; University of Sydney/Internal Scheme.

2014

  • Mechanisms that control Epstein Barr Virus infection and their dysregulation in X-linked lymphoproliferative disease; Palendira U, Ma C, Rickinson A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms that control oncogenic Epstein Barr Virus infection and their dysregulation in immunodeficiency; Palendira U; Cancer Institute NSW/Career Development Fellowship.

2004

  • Study of CD$+T cell response to Cytomegalovirus in patients following stem cell transplantation; Palendira U; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

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Journals

  • Sheu, A., Chan, Y., Ferguson, A., Bakhtyari, M., Hawke, W., White, C., Chan, Y., Bertolino, P., Woon, H., Palendira, U., Sierro, F., et al (2018). A proinflammatory CD4+ T cell phenotype in gestational diabetes mellitus. Diabetologia, 61(7), 1633-1643. [More Information]
  • Edwards, J., Wilmott, J., Madore, J., Gide, T., Quek, C., Tasker, A., Ferguson, A., Chen, J., Hewavisenti, R., Hersey, P., Weninger, W., Britton, W., Saw, R., Thompson, J., Menzies, A., Long, G., Scolyer, R., Palendira, U., et al (2018). CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naive Melanoma Patients and Expand Significantly During Anti-PD-1 Treatment. Clinical Cancer Research, 24(13), 3036-3045. [More Information]
  • Gebhardt, T., Palendira, U., Tscharke, D., Bedoui, S. (2018). Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance. Immunological Reviews, 283(1), 54-76. [More Information]
  • Abolhassani, H., Edwards, E., Ikinciogullari, A., Jing, H., Borte, S., Buggert, M., Du, L., Matsuda-Lennikov, M., Romano, R., Palendira, U., et al (2017). Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. The Journal of Experimental Medicine, 214(1), 91-106. [More Information]
  • Tangye, S., Palendira, U., Edwards, E. (2017). Human immunity against EBV-lessons from the clinic. The Journal of Experimental Medicine, 214(2), 269-283. [More Information]
  • Woon, H., Braun, A., Li, J., Smith, C., Edwards, J., Sierro, F., Feng, C., Khanna, R., Elliott, M., Bell, A., Britton, W., Palendira, U., et al (2016). Compartmentalization of Total and VirusSpecific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs. PLoS Pathogens, 12(8), 1-19. [More Information]
  • Leong, Y., Chen, Y., Ong, H., Wu, D., Man, K., Deleage, C., Minnich, M., Meckiff, B., Wei, Y., Palendira, U., et al (2016). CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles. Nature Immunology, 17(10), 1187-1196. [More Information]
  • Jurczyluk, J., Munoz, M., Skinner, O., Chai, R., Ali, N., Palendira, U., Quinn, J., Preston, A., Tangye, S., Brown, A., et al (2016). Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases. Immunology and Cell Biology, 94(10), 994-999. [More Information]
  • Gray, P., O'Brien, T., Wagle, M., Tangye, S., Palendira, U., Roscioli, T., Choo, S., Sutton, R., Ziegler, J., Frith, K. (2015). Cerebral Vasculitis in X-linked Lymphoproliferative Disease Cured by Matched Unrelated Cord Blood Transplant. Journal of Clinical Immunology, 35(7), 604-609. [More Information]
  • Palendira, U., Rickinson, A. (2015). Primary immunodeficiencies and the control of Epstein-Barr virus infection. Annals of the New York Academy of Sciences, 1356 (1), 22-44. [More Information]
  • Rickinson, A., Long, H., Palendira, U., Munz, C., Hislop, A. (2014). Cellular immune controls over Epstein-Barr virus infection: New lessons from the clinic and the laboratory. Trends in Immunology, 35(4), 159-169. [More Information]
  • Lucas, C., Kuehn, H., Zhao, F., Niemela, J., Deenick, E., Palendira, U., Avery, D., Moens, L., Cannons, J., Biancalana, M., et al (2014). Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency. Nature Immunology, 15(1), 88-97. [More Information]
  • Koganti, S., Hui-Yuen, J., McAllister, S., Gardner, B., Grasser, F., Palendira, U., Tangye, S., Freeman, A., Baduri-McIntosh, S. (2014). STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation. Proceedings of the National Academy of Sciences of the United States of America, 111(13), 4946-4951. [More Information]
  • Byun, M., Ma, C., Akcay, A., Pedergnana, V., Palendira, U., Myoung, J., Avery, D., Liu, Y., Abhyankar, A., Lorenzo, L., et al (2013). Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. The Journal of Experimental Medicine, 210(9), 1743-1759. [More Information]
  • Ives, M., Ma, C., Palendira, U., Chan, A., Bustamante, J., Boisson-Dupuis, S., Arkwright, P., Engelhard, D., Averbuch, D., Magdorf, K., Adelstein, S., et al (2013). Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function. Journal of Allergy and Clinical Immunology, 132(2), 400-411. [More Information]
  • Hill, E., Koganti, S., Zhi, J., Megyola, C., Freeman, A., Palendira, U., Tangye, S., Farrell, P., Bhaduri-McIntosh, S. (2013). Signal transducer and activator of transcription 3 limits epstein-barr virus lytic activation in B lymphocytes. Journal of Virology, 87(21), 11438-11446. [More Information]
  • Cliffe, S., Bloch, D., Suryani, S., Kamsteeg, E., Avery, D., Palendira, U., Church, J., Wainstein, B., Trizzino, A., et al (2012). Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome. Journal of Allergy and Clinical Immunology, 130(3), 735-742. [More Information]
  • Palendira, U., Low, C., Bell, A., Ma, C., Abbot, R., Phan, T., Riminton, D., Choo, S., Smart, J., Lougaris, V., Adelstein, S., et al (2012). Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus. The Journal of Experimental Medicine, 209(5), 913-924. [More Information]
  • Tangye, S., Deenick, E., Palendira, U., Ma, C. (2012). T cell-B cell interactions in primary immunodeficiencies. Annals of the New York Academy of Sciences, 1250 (1), 1-13. [More Information]
  • Recher, M., Berglund, L., Avery, D., Cowan, M., Gennery, A., Smart, J., Peake, J., Wong, M., Pai, S., Palendira, U., et al (2011). IL-21 is the primary common (upsilon) chain-binding cytokine required for human B-cell differentiation in vivo. Blood, 118(26), 6824-6835. [More Information]
  • Palendira, U., Low, C., Chan, A., Hislop, A., Ho, E., Phan, T., Deenick, E., Cook, M., Riminton, D., Choo, S., et al (2011). Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP. PLoS Biology, 9(11), 1-17. [More Information]
  • Avery, D., Deenick, E., Ma, C., Suryani, S., Simpson, N., Chew, G., Chan, T., Palendira, U., Bustamante, J., Boisson-Dupuis, S., Fulcher, D., et al (2010). B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. The Journal of Experimental Medicine, 207(1), 155-171. [More Information]
  • Palendira, U., Spratt, D., Britton, W., Triccas, J. (2005). Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection. Vaccine, 23(14), 1680-1685. [More Information]
  • Britton, W., Palendira, U. (2003). Improving vaccines against tuberculosis. Immunology and Cell Biology, 81(1), 34-45. [More Information]

2018

  • Sheu, A., Chan, Y., Ferguson, A., Bakhtyari, M., Hawke, W., White, C., Chan, Y., Bertolino, P., Woon, H., Palendira, U., Sierro, F., et al (2018). A proinflammatory CD4+ T cell phenotype in gestational diabetes mellitus. Diabetologia, 61(7), 1633-1643. [More Information]
  • Edwards, J., Wilmott, J., Madore, J., Gide, T., Quek, C., Tasker, A., Ferguson, A., Chen, J., Hewavisenti, R., Hersey, P., Weninger, W., Britton, W., Saw, R., Thompson, J., Menzies, A., Long, G., Scolyer, R., Palendira, U., et al (2018). CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naive Melanoma Patients and Expand Significantly During Anti-PD-1 Treatment. Clinical Cancer Research, 24(13), 3036-3045. [More Information]
  • Gebhardt, T., Palendira, U., Tscharke, D., Bedoui, S. (2018). Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance. Immunological Reviews, 283(1), 54-76. [More Information]

2017

  • Abolhassani, H., Edwards, E., Ikinciogullari, A., Jing, H., Borte, S., Buggert, M., Du, L., Matsuda-Lennikov, M., Romano, R., Palendira, U., et al (2017). Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. The Journal of Experimental Medicine, 214(1), 91-106. [More Information]
  • Tangye, S., Palendira, U., Edwards, E. (2017). Human immunity against EBV-lessons from the clinic. The Journal of Experimental Medicine, 214(2), 269-283. [More Information]

2016

  • Woon, H., Braun, A., Li, J., Smith, C., Edwards, J., Sierro, F., Feng, C., Khanna, R., Elliott, M., Bell, A., Britton, W., Palendira, U., et al (2016). Compartmentalization of Total and VirusSpecific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs. PLoS Pathogens, 12(8), 1-19. [More Information]
  • Leong, Y., Chen, Y., Ong, H., Wu, D., Man, K., Deleage, C., Minnich, M., Meckiff, B., Wei, Y., Palendira, U., et al (2016). CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles. Nature Immunology, 17(10), 1187-1196. [More Information]
  • Jurczyluk, J., Munoz, M., Skinner, O., Chai, R., Ali, N., Palendira, U., Quinn, J., Preston, A., Tangye, S., Brown, A., et al (2016). Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases. Immunology and Cell Biology, 94(10), 994-999. [More Information]

2015

  • Gray, P., O'Brien, T., Wagle, M., Tangye, S., Palendira, U., Roscioli, T., Choo, S., Sutton, R., Ziegler, J., Frith, K. (2015). Cerebral Vasculitis in X-linked Lymphoproliferative Disease Cured by Matched Unrelated Cord Blood Transplant. Journal of Clinical Immunology, 35(7), 604-609. [More Information]
  • Palendira, U., Rickinson, A. (2015). Primary immunodeficiencies and the control of Epstein-Barr virus infection. Annals of the New York Academy of Sciences, 1356 (1), 22-44. [More Information]

2014

  • Rickinson, A., Long, H., Palendira, U., Munz, C., Hislop, A. (2014). Cellular immune controls over Epstein-Barr virus infection: New lessons from the clinic and the laboratory. Trends in Immunology, 35(4), 159-169. [More Information]
  • Lucas, C., Kuehn, H., Zhao, F., Niemela, J., Deenick, E., Palendira, U., Avery, D., Moens, L., Cannons, J., Biancalana, M., et al (2014). Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency. Nature Immunology, 15(1), 88-97. [More Information]
  • Koganti, S., Hui-Yuen, J., McAllister, S., Gardner, B., Grasser, F., Palendira, U., Tangye, S., Freeman, A., Baduri-McIntosh, S. (2014). STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation. Proceedings of the National Academy of Sciences of the United States of America, 111(13), 4946-4951. [More Information]

2013

  • Byun, M., Ma, C., Akcay, A., Pedergnana, V., Palendira, U., Myoung, J., Avery, D., Liu, Y., Abhyankar, A., Lorenzo, L., et al (2013). Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. The Journal of Experimental Medicine, 210(9), 1743-1759. [More Information]
  • Ives, M., Ma, C., Palendira, U., Chan, A., Bustamante, J., Boisson-Dupuis, S., Arkwright, P., Engelhard, D., Averbuch, D., Magdorf, K., Adelstein, S., et al (2013). Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function. Journal of Allergy and Clinical Immunology, 132(2), 400-411. [More Information]
  • Hill, E., Koganti, S., Zhi, J., Megyola, C., Freeman, A., Palendira, U., Tangye, S., Farrell, P., Bhaduri-McIntosh, S. (2013). Signal transducer and activator of transcription 3 limits epstein-barr virus lytic activation in B lymphocytes. Journal of Virology, 87(21), 11438-11446. [More Information]

2012

  • Cliffe, S., Bloch, D., Suryani, S., Kamsteeg, E., Avery, D., Palendira, U., Church, J., Wainstein, B., Trizzino, A., et al (2012). Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome. Journal of Allergy and Clinical Immunology, 130(3), 735-742. [More Information]
  • Palendira, U., Low, C., Bell, A., Ma, C., Abbot, R., Phan, T., Riminton, D., Choo, S., Smart, J., Lougaris, V., Adelstein, S., et al (2012). Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus. The Journal of Experimental Medicine, 209(5), 913-924. [More Information]
  • Tangye, S., Deenick, E., Palendira, U., Ma, C. (2012). T cell-B cell interactions in primary immunodeficiencies. Annals of the New York Academy of Sciences, 1250 (1), 1-13. [More Information]

2011

  • Recher, M., Berglund, L., Avery, D., Cowan, M., Gennery, A., Smart, J., Peake, J., Wong, M., Pai, S., Palendira, U., et al (2011). IL-21 is the primary common (upsilon) chain-binding cytokine required for human B-cell differentiation in vivo. Blood, 118(26), 6824-6835. [More Information]
  • Palendira, U., Low, C., Chan, A., Hislop, A., Ho, E., Phan, T., Deenick, E., Cook, M., Riminton, D., Choo, S., et al (2011). Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP. PLoS Biology, 9(11), 1-17. [More Information]

2010

  • Avery, D., Deenick, E., Ma, C., Suryani, S., Simpson, N., Chew, G., Chan, T., Palendira, U., Bustamante, J., Boisson-Dupuis, S., Fulcher, D., et al (2010). B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. The Journal of Experimental Medicine, 207(1), 155-171. [More Information]

2005

  • Palendira, U., Spratt, D., Britton, W., Triccas, J. (2005). Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection. Vaccine, 23(14), 1680-1685. [More Information]

2003

  • Britton, W., Palendira, U. (2003). Improving vaccines against tuberculosis. Immunology and Cell Biology, 81(1), 34-45. [More Information]

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