Dr Valery Combes

Senior Research Fellow
Pathology, School of Medical Sciences

Telephone +61 2 9036 63236
Fax +61 2 9036 63286

Map

Selected grants

2014

  • Characterizing plasma microparticle content in multiple sclerosis patients; Wheway J, Zinger A, Hawke S, Grau G, Combes V; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2013

  • Deciphering the role of microparticles from discrete origins in the pathogenesis of cerebral malaria using a novel in vitro system to replace animal models.; Grau G, Combes V; Medical Advances Without Animals/Research Grants.
  • Cryptococcal meningoencephalitis - fungal determinants of invasion of the CNS; Sorrell T, Djordjevic J, Combes V; National Health and Medical Research Council (NHMRC)/Project Grants.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Microparticles and Cellular Signalling During Tuberculosis Infection; Saunders B, Britton W, Grau G, Combes V; DVC Research/Bridging Support Grant.
  • In vivo characterisation and role of microparticles during neuroinfection; Combes V; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • BD Influx 3-L Cell Sorter; Britton W, King N, Grau G, Weninger W, McCaughan G, Slobedman B, Saunders B, West N, Triccas J, Abendroth A, Combes V, Bowen D, Shackel N, Ellis M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Microparticles are pathogenic elements in the pathophysiology of cerebral malaria; Combes V, Grau G, Wheway J; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Microparticles and Selective Trait Dominance in Multidrug Resistant Cancers; Bebawy M, Grau G, Combes V; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Microparticles and Selective Trait Dominance in Multidrug Resistant Cancers; Bebawy M, Grau G, Combes V; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The involvement of the kynurenine pathway in blood brain barrier disruption and its relevance for neuroinflammatory diseases; Guillemin G, Combes V, Grau G, Brew B; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Pathophysiological consequences of phagocytic microparticles; Combes V; DVC Research/Bridging Support Grant.
  • Next-generation high-speed flow cytometric cell sorter; Fazekas B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Pathophysiological alterations of brain microvascular endothelial cells in cerebral malaria; Grau G, Sanchez-Perez A, Combes V; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Microparticle Mediated Transfer of P-glycoprotein in Conferring Multidrug Resistance in Cancer; Bebawy M, Grau G, Combes V; Cancer Council New South Wales/Research Project Grants.

2007

  • Faculty of Medicine Strategic Research Grants; Combes V; Faculty of Medicine/Strategic Research Grant.

Selected publications

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Book Chapters

  • Combes, V., El-Assaad, F., Grau, G. (2011). Immunopathology and pathophysiology of cerebral malaria. In Mauro Bendinelli, Herman Friedman and Andreas Seyfang (Eds.), Infectious Agents and Pathogenesis. tba: Springer Publishing Company (Mannheim Trust, New York - Health care publishing).
  • Combes, V., Lou, J., Grau, G. (2007). The endothelium in cerebral malaria - Both a target cell and a major player. In William Aird (Eds.), Endothelial Biomedicine, (pp. 1303-1310). United States: Cambridge University Press.
  • Combes, V., Grau, G. (2006). Cytokines in defence and pathology of the central nervous system. In Richard M. Ransohoff, Etty N. Benveniste (Eds.), Cytokines and the CNS - 2nd Edition, (pp. 243-268). United States: CRC Press.

Journals

  • El-Assaad, F., Combes, V., Grau, G., Jambou, R. (2014). Potential Efficacy of Citicoline as Adjunct Therapy in Treatment of Cerebral Malaria. Antimicrobial Agents and Chemotherapy, 58(1), 602-605. [More Information]
  • Latham, S., Chaponnier, C., Dugina, V., Couraud, P., Grau, G., Combes, V. (2013). Cooperation between beta- and gamma-cytoplasmic actins in the mechanical regulation of endothelial microparticle formation. The FASEB Journal, 27(2), 672-683. [More Information]
  • Razakandrainibe, R., Combes, V., Grau, G., Jambou, R. (2013). Crossing the wall: The opening of endothelial cell junctions during infectious diseases. The International Journal of Biochemistry and Cell Biology, 45(7), 1165-1173. [More Information]
  • El-Assaad, F., Wheway, J., Mitchell, A., Lou, J., Hunt, N., Combes, V., Grau, G. (2013). Cytoadherence of Plasmodium berghei-infected red blood cells to murine brain and lung microvascular endothelial cells in vitro. Infection and Immunity, 81(11), 3984-3991. [More Information]
  • Dietmann, A., Millonig, A., Combes, V., Couraud, P., Kachlany, S., Grau, G. (2013). Effects of aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells. Microbial Pathogenesis, 61 - 62, 43-50. [More Information]
  • Khaw, L., Ball, H., Golenser, J., Combes, V., Grau, G., Wheway, J., Mitchell, A., Hunt, N. (2013). Endothelial Cells Potentiate Interferon-γ Production in a Novel Tripartite Culture Model of Human Cerebral Malaria. PLoS One, 8(7), 1-13. [More Information]
  • Li, C., Eaton, S., Young, P., Lee, M., Shuttleworth, R., Humphreys, D., Grau, G., Combes, V., Bebawy, M., Gong, J., Buckland, M., et al (2013). Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells. RNA Biology, 10(8), 1333-1344. [More Information]
  • Walters, S., Kieckbusch, J., Nagalingam, G., Swain, A., Latham, S., Grau, G., Britton, W., Combes, V., Saunders, B. (2013). Microparticles from Mycobacteria-Infected Macrophages Promote Inflammation and Cellular Migration. Journal of Immunology, 190(2), 669-677. [More Information]
  • Wheway, J., Obeid, S., Couraud, P., Combes, V., Grau, G. (2013). The brain microvascular endothelium supports t cell proliferation and has potential for alloantigen presentation. PLoS One, 8(1), 1-8. [More Information]
  • Faille, D., El Assaad, F., Mitchell, A., Alessi, M., Chimini, G., Fusai, T., Grau, G., Combes, V. (2012). Endocytosis and intracellular processing of platelet microparticles by brain endothelial cells. Journal of Cellular and Molecular Medicine, 16(8), 1731-1738. [More Information]
  • Jaiswal, R., Gong, J., Sambasivam, S., Combes, V., Mathys, J., Davey, R., Grau, G., Bebawy, M. (2012). Microparticle-associated nucleic acids mediate trait dominance in cancer. The FASEB Journal, 26(1), 420-429. [More Information]
  • Gong, J., Jaiswal, R., Mathys, J., Combes, V., Grau, G., Bebawy, M. (2012). Microparticles and their emerging role in cancer multidrug resistance. Cancer Treatment Reviews, 38(3), 226-234. [More Information]
  • Combes, V., Guillemin, G., Chan-Ling, T., Hunt, N., Grau, G. (2012). The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes. Trends in Parasitology, 28(8), 311-319. [More Information]
  • Nantakomol, D., Dondorp, A., Krudsood, S., Udomsangpetch, R., Pattanapanyasat, K., Combes, V., Grau, G., White, N., Viriyavejakul, P., Day, N., et al (2011). Circulating red cell-derived microparticles in human malaria. The Journal of Infectious Diseases, 203(5), 700-706. [More Information]
  • Hempel, C., Combes, V., Hunt, N., Kurtzhals, J., Grau, G. (2011). CNS Hypoxia Is More Pronounced in Murine Cerebral than Noncerebral Malaria and is Reversed by Erythropoietin. The American Journal of Pathology: cellular and molecular biology of disease, 179(4), 1939-1950. [More Information]
  • McQuillan, J., Mitchell, A., Ho, Y., Combes, V., Ball, H., Golenser, J., Grau, G., Hunt, N. (2011). Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria. International Journal for Parasitology, 41(2), 155-163. [More Information]
  • El Assaad, F., Hempel, C., Combes, V., Mitchell, A., Ball, H., Kurtzhals, J., Hunt, N., Mathys, J., Grau, G. (2011). Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria. Infection and Immunity, 79(6), 2379-2384. [More Information]
  • Jambou, R., El Assaad, F., Combes, V., Grau, G. (2011). In vitro culture of Plasmodium berghei-ANKA maintains infectivity of mouse erythrocytes inducing cerebral malaria. Malaria Journal, 10(1), Article 346 - 1-Article 346 - 5. [More Information]
  • Ling, Z., Combes, V., Grau, G., King, N. (2011). Microparticles as immune regulators in infectious disease - an opinion. Frontiers in Immunology, 2(67), 1-8. [More Information]
  • Ampawong, S., Combes, V., Hunt, N., Radford, J., Chan-Ling, T., Pongponratn, E., Grau, G. (2011). Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. International Journal of Clinical and Experimental Pathology, 4(6), 566-574. [More Information]
  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Combes, V., Grau, G., Amvam Zollo, P. (2010). Biochemical markers of nutritional status and childhood malaria severity in Cameroon. British Journal of Nutrition, 104(6), 886-892. [More Information]
  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Amvam Zollo, P., Grau, G., Combes, V. (2010). Elevated Cell-Specific Microparticles Are a Biological Marker for Cerebral Dysfunctions in Human Severe Malaria. PLoS One, 5(10), e13415 - 1-e13415 - 9. [More Information]
  • Carpintero, R., Gruaz, L., Brandt, K., Scanu, A., Faille, D., Combes, V., Grau, G., Burger, D. (2010). HDL Interfere with the Binding of T Cell Microparticles to Human Monocytes to Inhibit Pro-Inflammatory Cytokine Production. PLoS One, 5(7), e11869-1-e11869-8. [More Information]
  • Couper, K., Barnes, T., Hafalla, J., Combes, V., Ryffel, B., Secher, T., Grau, G., Riley, E., De Souza, J. (2010). Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation. PLoS Pathogens, 6(1), e1000744-1-e1000744-13. [More Information]
  • Jambou, R., Combes, V., Mege-Jambou, M., Weksler, B., Couraud, P., Grau, G. (2010). Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions. PLoS Pathogens, 6(7), 1-13. [More Information]
  • Bridges, D., Bunn, J., Van Mourik, J., Grau, G., Preston, R., Molyneux, M., Combes, V., O'Donnell, J., De Laat, B., Craig, A. (2010). Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings. Blood, 115(7), 1472-1474. [More Information]
  • El-Assaad, F., Combes, V., Grau, G. (2009). Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases. The International Journal of Biochemistry and Cell Biology, 41(7), 1467-1470. [More Information]
  • Bebawy, M., Combes, V., Lee, E., Jaiswal, R., Gong, J., Bonhoure, A., Grau, G. (2009). Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells. Leukemia, 23(9), 1643-1649. [More Information]
  • Gouado, I., Pankoui Mfonkeu, J., Fotso, H., Zambou, O., Nguele, S., Combes, V., Grau, G., Amvam Zollo, P. (2009). Physiopathologic factors resulting in poor outcome in childhood severe malaria in Cameroon. The Pediatric Infectious Disease Journal, 28(12), 1081-1084. [More Information]
  • Faille, D., Combes, V., Mitchell, A., Fontaine, A., Juhan-Vague, I., Alessi, M., Chimini, G., Fusai, T., Grau, G. (2009). Platelet microparticles: a new player in malaria parasite cytoadherence to human brain endothelium. The F A S E B Journal, 23(10), 3449-3458. [More Information]
  • Faille, D., El Assaad, F., Alessi, M., Fusai, T., Combes, V., Grau, G. (2009). Platelet-endothelial cell interactions in cerebral malaria: The end of a cordial understanding. Thrombosis and Haemostasis, 102(6), 1093-1102. [More Information]
  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Grau, G., Combes, V., Amvam Zollo, P. (2008). Clinical presentation, haematological indices and management of children with severe and uncomplicated malaria in Douala, Cameroon. Pakistan Journal of Biological Sciences, 11(20), 2401-2406.
  • Hunt, N., Mitchell, A., Hee, L., Xu, Y., Ho, Y., McQuillan, J., Sanchez-Perez, A., Miu, J., Weiser, S., Austin, C., Grau, G., Combes, V., Jambou, R., Ball, H. (2008). Early interactions between malaria-infected erythrocytes and the innate immune system determine the course of immune and immunopathological outcomes. International Journal for Parasitology, 38(Suppl 1), S23-S24. [More Information]
  • Nantakomol, D., Chimma, P., Day, N., Dondorp, A., Combes, V., Krudsood, S., Looareesuwan, S., White, N., Pattanapanyasat, K., Chotivanich, K. (2008). Quantitation of cell-derived microparticles in plasma using flow rate based calibration. Southeast Asian Journal of Tropical Medicine and Public Health, 39(1), 146-153. [More Information]
  • Ramaswamy, Y., Wu, C., Van Hummel, A., Combes, V., Grau, G., Zreiqat, H. (2008). The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials, 29(33), 4392-4402. [More Information]
  • van der Heyde, H., Nolan, J., Combes, V., Gramaglia, I., Grau, G. (2006). A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction. Trends in Parasitology, 22(11), 503-508. [More Information]
  • Coltel, N., Combes, V., Grau, G., Wassmer, S., Chimini, G. (2006). Cell vesiculation and immunopathology: implications in cerebral malaria. Microbes and Infection, 8(8), 2305-2316. [More Information]
  • Combes, V., Coltel, N., Faille, D., Wassmer, S., Grau, G. (2006). Cerebral malaria: role of microparticles and platelets in alterations of the blood-brain barrier. International Journal for Parasitology, 36(5), 541-546. [More Information]
  • Wassmer, S., Cianciolo, G., Combes, V., Grau, G. (2006). LMP-420, a new therapeutic approach for cerebral malaria? Medecine Sciences, 22(4), 343-345.
  • Wassmer, S., Combes, V., Candal, F., Juhan-Vague, I., Grau, G. (2006). Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum. Infection and Immunity, 74(1), 645-653. [More Information]
  • Combes, V., Coltel, N., Alibert, M., van Eck, M., Raymond, C., Juhan-Vague, I., Grau, G., Chimini, G. (2005). ABCA1 Gene Deletion Protects against Cerebral Malaria: Potential Pathogenic Role of Microparticles in Neuropathology. The American Journal of Pathology: cellular and molecular biology of disease, 166(1), 295-302. [More Information]
  • Combes, V., De Souza, J., Rénia, L., Hunt, N., Grau, G. (2005). Cerebral malaria: Which parasite? Which model? Drug Discovery Today: Disease Models, 2(2), 141-147. [More Information]
  • Wassmer, S., Cianciolo, G., Combes, V., Grau, G. (2005). Inhibition of Endothelial Activation: A New Way to Treat Cerebral Malaria? PLoS Medicine, 2(9), 885-890. [More Information]
  • Layez, C., Nogueira, P., Combes, V., Costa, F., Juhan-Vague, I., Pereira Da Silva, L., Gysin, J. (2005). Plasmodium falciparum rhoptry protein RSP2 triggers destruction of the erythroid lineage. Blood, 106(10), 3632-3638. [More Information]
  • Coltel, N., Combes, V., Hunt, N., Grau, G. (2004). Cerebral Malaria - A Neurovascular Pathology with Many Riddles Still to be Solved. Current Neurovascular Research, 1(2), 91-110.
  • Combes, V., Taylor, T., Juhan-Vague, I., Mege, J., Mwenechanya, J., Tembo, M., Grau, G., Molyneux, M. (2004). Circulating Endothelial Microparticles in Malawian Children With Severe Falciparum Malaria Complicated With Coma. JAMA: The Journal of the American Medical Association, 291(21), 2542-2544.
  • Dignat-George, F., Camoin-Jau, L., Sabatier, F., Arnoux, D., Anfosso, F., Bardin, N., Veit, V., Combes, V., Gentile, S., Moal, V., et al (2004). Endothelial microparticles: a potential contribution to the thrombotic complications of the antiphospholipid syndrome. Thrombosis and Haemostasis, 91(4), 667-673.
  • Combes, V., Rosenkranz, A., Redard, M., Pizzolato, G., Lepidi, H., Vestweber, D., Mayadas, T., Grau, G. (2004). Pathogenic Role of P-Selectin in Experimental Cerebral Malaria. The American Journal of Pathology: cellular and molecular biology of disease, 164(3), 781-786.
  • Bretelle, F., Sabatier, F., Desprez, D., Camoin, L., Grunebaum, L., Combes, V., D'Ercole, C., Dignat-George, F. (2003). Circulating microparticles: a marker of procoagulant state in normal pregnancy and pregnancy complicated by preeclampsia or intrauterine growth restriction. Thrombosis and Haemostasis, 89(3), 486-492.
  • Wassmer, S., Coltel, N., Combes, V., Grau, G. (2003). Pathogenesis of cerebral malaria: facts and hypotheses. Medecine Tropicale, 63(3), 254-257.
  • Wassmer, S., Combes, V., Grau, G. (2003). Pathophysiology of Cerebral Malaria: Role of host cells in the modulation of cytoadhesion. New York Academy of Sciences. Annals, 992, 30-38.

Conferences

  • Lee, J., Carter, E., Grau, G., Combes, V., Bonhoure, B., Lay, P. (2009). The investigation of monocyte cell signalling by FT-IR spectroscopy. International Conference on Advanced Vibrational Spectroscopy, N/A: N/A.

2014

  • El-Assaad, F., Combes, V., Grau, G., Jambou, R. (2014). Potential Efficacy of Citicoline as Adjunct Therapy in Treatment of Cerebral Malaria. Antimicrobial Agents and Chemotherapy, 58(1), 602-605. [More Information]

2013

  • Latham, S., Chaponnier, C., Dugina, V., Couraud, P., Grau, G., Combes, V. (2013). Cooperation between beta- and gamma-cytoplasmic actins in the mechanical regulation of endothelial microparticle formation. The FASEB Journal, 27(2), 672-683. [More Information]
  • Razakandrainibe, R., Combes, V., Grau, G., Jambou, R. (2013). Crossing the wall: The opening of endothelial cell junctions during infectious diseases. The International Journal of Biochemistry and Cell Biology, 45(7), 1165-1173. [More Information]
  • El-Assaad, F., Wheway, J., Mitchell, A., Lou, J., Hunt, N., Combes, V., Grau, G. (2013). Cytoadherence of Plasmodium berghei-infected red blood cells to murine brain and lung microvascular endothelial cells in vitro. Infection and Immunity, 81(11), 3984-3991. [More Information]
  • Dietmann, A., Millonig, A., Combes, V., Couraud, P., Kachlany, S., Grau, G. (2013). Effects of aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells. Microbial Pathogenesis, 61 - 62, 43-50. [More Information]
  • Khaw, L., Ball, H., Golenser, J., Combes, V., Grau, G., Wheway, J., Mitchell, A., Hunt, N. (2013). Endothelial Cells Potentiate Interferon-γ Production in a Novel Tripartite Culture Model of Human Cerebral Malaria. PLoS One, 8(7), 1-13. [More Information]
  • Li, C., Eaton, S., Young, P., Lee, M., Shuttleworth, R., Humphreys, D., Grau, G., Combes, V., Bebawy, M., Gong, J., Buckland, M., et al (2013). Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells. RNA Biology, 10(8), 1333-1344. [More Information]
  • Walters, S., Kieckbusch, J., Nagalingam, G., Swain, A., Latham, S., Grau, G., Britton, W., Combes, V., Saunders, B. (2013). Microparticles from Mycobacteria-Infected Macrophages Promote Inflammation and Cellular Migration. Journal of Immunology, 190(2), 669-677. [More Information]
  • Wheway, J., Obeid, S., Couraud, P., Combes, V., Grau, G. (2013). The brain microvascular endothelium supports t cell proliferation and has potential for alloantigen presentation. PLoS One, 8(1), 1-8. [More Information]

2012

  • Faille, D., El Assaad, F., Mitchell, A., Alessi, M., Chimini, G., Fusai, T., Grau, G., Combes, V. (2012). Endocytosis and intracellular processing of platelet microparticles by brain endothelial cells. Journal of Cellular and Molecular Medicine, 16(8), 1731-1738. [More Information]
  • Jaiswal, R., Gong, J., Sambasivam, S., Combes, V., Mathys, J., Davey, R., Grau, G., Bebawy, M. (2012). Microparticle-associated nucleic acids mediate trait dominance in cancer. The FASEB Journal, 26(1), 420-429. [More Information]
  • Gong, J., Jaiswal, R., Mathys, J., Combes, V., Grau, G., Bebawy, M. (2012). Microparticles and their emerging role in cancer multidrug resistance. Cancer Treatment Reviews, 38(3), 226-234. [More Information]
  • Combes, V., Guillemin, G., Chan-Ling, T., Hunt, N., Grau, G. (2012). The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes. Trends in Parasitology, 28(8), 311-319. [More Information]

2011

  • Nantakomol, D., Dondorp, A., Krudsood, S., Udomsangpetch, R., Pattanapanyasat, K., Combes, V., Grau, G., White, N., Viriyavejakul, P., Day, N., et al (2011). Circulating red cell-derived microparticles in human malaria. The Journal of Infectious Diseases, 203(5), 700-706. [More Information]
  • Hempel, C., Combes, V., Hunt, N., Kurtzhals, J., Grau, G. (2011). CNS Hypoxia Is More Pronounced in Murine Cerebral than Noncerebral Malaria and is Reversed by Erythropoietin. The American Journal of Pathology: cellular and molecular biology of disease, 179(4), 1939-1950. [More Information]
  • McQuillan, J., Mitchell, A., Ho, Y., Combes, V., Ball, H., Golenser, J., Grau, G., Hunt, N. (2011). Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria. International Journal for Parasitology, 41(2), 155-163. [More Information]
  • El Assaad, F., Hempel, C., Combes, V., Mitchell, A., Ball, H., Kurtzhals, J., Hunt, N., Mathys, J., Grau, G. (2011). Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria. Infection and Immunity, 79(6), 2379-2384. [More Information]
  • Combes, V., El-Assaad, F., Grau, G. (2011). Immunopathology and pathophysiology of cerebral malaria. In Mauro Bendinelli, Herman Friedman and Andreas Seyfang (Eds.), Infectious Agents and Pathogenesis. tba: Springer Publishing Company (Mannheim Trust, New York - Health care publishing).
  • Jambou, R., El Assaad, F., Combes, V., Grau, G. (2011). In vitro culture of Plasmodium berghei-ANKA maintains infectivity of mouse erythrocytes inducing cerebral malaria. Malaria Journal, 10(1), Article 346 - 1-Article 346 - 5. [More Information]
  • Ling, Z., Combes, V., Grau, G., King, N. (2011). Microparticles as immune regulators in infectious disease - an opinion. Frontiers in Immunology, 2(67), 1-8. [More Information]
  • Ampawong, S., Combes, V., Hunt, N., Radford, J., Chan-Ling, T., Pongponratn, E., Grau, G. (2011). Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. International Journal of Clinical and Experimental Pathology, 4(6), 566-574. [More Information]

2010

  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Combes, V., Grau, G., Amvam Zollo, P. (2010). Biochemical markers of nutritional status and childhood malaria severity in Cameroon. British Journal of Nutrition, 104(6), 886-892. [More Information]
  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Amvam Zollo, P., Grau, G., Combes, V. (2010). Elevated Cell-Specific Microparticles Are a Biological Marker for Cerebral Dysfunctions in Human Severe Malaria. PLoS One, 5(10), e13415 - 1-e13415 - 9. [More Information]
  • Carpintero, R., Gruaz, L., Brandt, K., Scanu, A., Faille, D., Combes, V., Grau, G., Burger, D. (2010). HDL Interfere with the Binding of T Cell Microparticles to Human Monocytes to Inhibit Pro-Inflammatory Cytokine Production. PLoS One, 5(7), e11869-1-e11869-8. [More Information]
  • Couper, K., Barnes, T., Hafalla, J., Combes, V., Ryffel, B., Secher, T., Grau, G., Riley, E., De Souza, J. (2010). Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation. PLoS Pathogens, 6(1), e1000744-1-e1000744-13. [More Information]
  • Jambou, R., Combes, V., Mege-Jambou, M., Weksler, B., Couraud, P., Grau, G. (2010). Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions. PLoS Pathogens, 6(7), 1-13. [More Information]
  • Bridges, D., Bunn, J., Van Mourik, J., Grau, G., Preston, R., Molyneux, M., Combes, V., O'Donnell, J., De Laat, B., Craig, A. (2010). Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings. Blood, 115(7), 1472-1474. [More Information]

2009

  • El-Assaad, F., Combes, V., Grau, G. (2009). Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases. The International Journal of Biochemistry and Cell Biology, 41(7), 1467-1470. [More Information]
  • Bebawy, M., Combes, V., Lee, E., Jaiswal, R., Gong, J., Bonhoure, A., Grau, G. (2009). Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells. Leukemia, 23(9), 1643-1649. [More Information]
  • Gouado, I., Pankoui Mfonkeu, J., Fotso, H., Zambou, O., Nguele, S., Combes, V., Grau, G., Amvam Zollo, P. (2009). Physiopathologic factors resulting in poor outcome in childhood severe malaria in Cameroon. The Pediatric Infectious Disease Journal, 28(12), 1081-1084. [More Information]
  • Faille, D., Combes, V., Mitchell, A., Fontaine, A., Juhan-Vague, I., Alessi, M., Chimini, G., Fusai, T., Grau, G. (2009). Platelet microparticles: a new player in malaria parasite cytoadherence to human brain endothelium. The F A S E B Journal, 23(10), 3449-3458. [More Information]
  • Faille, D., El Assaad, F., Alessi, M., Fusai, T., Combes, V., Grau, G. (2009). Platelet-endothelial cell interactions in cerebral malaria: The end of a cordial understanding. Thrombosis and Haemostasis, 102(6), 1093-1102. [More Information]
  • Lee, J., Carter, E., Grau, G., Combes, V., Bonhoure, B., Lay, P. (2009). The investigation of monocyte cell signalling by FT-IR spectroscopy. International Conference on Advanced Vibrational Spectroscopy, N/A: N/A.

2008

  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Grau, G., Combes, V., Amvam Zollo, P. (2008). Clinical presentation, haematological indices and management of children with severe and uncomplicated malaria in Douala, Cameroon. Pakistan Journal of Biological Sciences, 11(20), 2401-2406.
  • Hunt, N., Mitchell, A., Hee, L., Xu, Y., Ho, Y., McQuillan, J., Sanchez-Perez, A., Miu, J., Weiser, S., Austin, C., Grau, G., Combes, V., Jambou, R., Ball, H. (2008). Early interactions between malaria-infected erythrocytes and the innate immune system determine the course of immune and immunopathological outcomes. International Journal for Parasitology, 38(Suppl 1), S23-S24. [More Information]
  • Nantakomol, D., Chimma, P., Day, N., Dondorp, A., Combes, V., Krudsood, S., Looareesuwan, S., White, N., Pattanapanyasat, K., Chotivanich, K. (2008). Quantitation of cell-derived microparticles in plasma using flow rate based calibration. Southeast Asian Journal of Tropical Medicine and Public Health, 39(1), 146-153. [More Information]
  • Ramaswamy, Y., Wu, C., Van Hummel, A., Combes, V., Grau, G., Zreiqat, H. (2008). The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials, 29(33), 4392-4402. [More Information]

2007

  • Combes, V., Lou, J., Grau, G. (2007). The endothelium in cerebral malaria - Both a target cell and a major player. In William Aird (Eds.), Endothelial Biomedicine, (pp. 1303-1310). United States: Cambridge University Press.

2006

  • van der Heyde, H., Nolan, J., Combes, V., Gramaglia, I., Grau, G. (2006). A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction. Trends in Parasitology, 22(11), 503-508. [More Information]
  • Coltel, N., Combes, V., Grau, G., Wassmer, S., Chimini, G. (2006). Cell vesiculation and immunopathology: implications in cerebral malaria. Microbes and Infection, 8(8), 2305-2316. [More Information]
  • Combes, V., Coltel, N., Faille, D., Wassmer, S., Grau, G. (2006). Cerebral malaria: role of microparticles and platelets in alterations of the blood-brain barrier. International Journal for Parasitology, 36(5), 541-546. [More Information]
  • Combes, V., Grau, G. (2006). Cytokines in defence and pathology of the central nervous system. In Richard M. Ransohoff, Etty N. Benveniste (Eds.), Cytokines and the CNS - 2nd Edition, (pp. 243-268). United States: CRC Press.
  • Wassmer, S., Cianciolo, G., Combes, V., Grau, G. (2006). LMP-420, a new therapeutic approach for cerebral malaria? Medecine Sciences, 22(4), 343-345.
  • Wassmer, S., Combes, V., Candal, F., Juhan-Vague, I., Grau, G. (2006). Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum. Infection and Immunity, 74(1), 645-653. [More Information]

2005

  • Combes, V., Coltel, N., Alibert, M., van Eck, M., Raymond, C., Juhan-Vague, I., Grau, G., Chimini, G. (2005). ABCA1 Gene Deletion Protects against Cerebral Malaria: Potential Pathogenic Role of Microparticles in Neuropathology. The American Journal of Pathology: cellular and molecular biology of disease, 166(1), 295-302. [More Information]
  • Combes, V., De Souza, J., Rénia, L., Hunt, N., Grau, G. (2005). Cerebral malaria: Which parasite? Which model? Drug Discovery Today: Disease Models, 2(2), 141-147. [More Information]
  • Wassmer, S., Cianciolo, G., Combes, V., Grau, G. (2005). Inhibition of Endothelial Activation: A New Way to Treat Cerebral Malaria? PLoS Medicine, 2(9), 885-890. [More Information]
  • Layez, C., Nogueira, P., Combes, V., Costa, F., Juhan-Vague, I., Pereira Da Silva, L., Gysin, J. (2005). Plasmodium falciparum rhoptry protein RSP2 triggers destruction of the erythroid lineage. Blood, 106(10), 3632-3638. [More Information]

2004

  • Coltel, N., Combes, V., Hunt, N., Grau, G. (2004). Cerebral Malaria - A Neurovascular Pathology with Many Riddles Still to be Solved. Current Neurovascular Research, 1(2), 91-110.
  • Combes, V., Taylor, T., Juhan-Vague, I., Mege, J., Mwenechanya, J., Tembo, M., Grau, G., Molyneux, M. (2004). Circulating Endothelial Microparticles in Malawian Children With Severe Falciparum Malaria Complicated With Coma. JAMA: The Journal of the American Medical Association, 291(21), 2542-2544.
  • Dignat-George, F., Camoin-Jau, L., Sabatier, F., Arnoux, D., Anfosso, F., Bardin, N., Veit, V., Combes, V., Gentile, S., Moal, V., et al (2004). Endothelial microparticles: a potential contribution to the thrombotic complications of the antiphospholipid syndrome. Thrombosis and Haemostasis, 91(4), 667-673.
  • Combes, V., Rosenkranz, A., Redard, M., Pizzolato, G., Lepidi, H., Vestweber, D., Mayadas, T., Grau, G. (2004). Pathogenic Role of P-Selectin in Experimental Cerebral Malaria. The American Journal of Pathology: cellular and molecular biology of disease, 164(3), 781-786.

2003

  • Bretelle, F., Sabatier, F., Desprez, D., Camoin, L., Grunebaum, L., Combes, V., D'Ercole, C., Dignat-George, F. (2003). Circulating microparticles: a marker of procoagulant state in normal pregnancy and pregnancy complicated by preeclampsia or intrauterine growth restriction. Thrombosis and Haemostasis, 89(3), 486-492.
  • Wassmer, S., Coltel, N., Combes, V., Grau, G. (2003). Pathogenesis of cerebral malaria: facts and hypotheses. Medecine Tropicale, 63(3), 254-257.
  • Wassmer, S., Combes, V., Grau, G. (2003). Pathophysiology of Cerebral Malaria: Role of host cells in the modulation of cytoadhesion. New York Academy of Sciences. Annals, 992, 30-38.

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