Dr Victoria Cogger

Senior Lecturer
Medicine, Concord Clinical School
ANZAC Research Institute

Telephone +61 2 9767 7545
Fax +61 2 9767 5419

Map

Selected grants

2014

  • EVOS FL Auto cell imaging system; Nicholson G, Clark G, Zhou H, Jessup W, Le Couteur D, McMahon A, McLachlan A, Allan C, Handelsman D, Hart D, Walters K, Kritharides L, Kockx M, Kennerson M, Cooper M, Seibel M, Verma N, Silveira P, Fromm P, Simanainen U, Cogger V, Zheng Y; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Insights from ageing and calorie restriction for the prevention and treatment of paracetamol hepatotoxicity; Hilmer S, Kane A, Le Couteur D, Cogger V; Australian Association of Gerontology/RM Gibson Research Grants.
  • IVIS Lumina II in vivo Imaging System; Seibel M, Handelsman D, Le Couteur D, Hart D, Nicholson G, Freedman B, Kritharides L, Jessup W, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, McMahon A, Simanainen U, Kockx M, Speranza T, Zheng Y; DVC Research/Equipment Grant.
  • Automacs Pro Seperator; Hart D, Handelsman D, Le Couteur D, Nicholson G, Kritharides L, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, Simanainen U, Zheng Y, Seibel M; DVC Research/Equipment Grant.

2010

  • The Lunar PIXImus II DEXA Scanner; Zhou H, Seibel M, Handelsman D, Le Couteur D, Nicholson G, Clarke S, Robertson G, van Zandwijk N, Freedman B, Kennerson M, Allan C, Walters K, Cogger V, Blair I, Reid G, Simanainen U; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Effects of aging on Hepatic Drug Clearance and Mechanisms of Drug Induced Liver Disease; Hilmer S, Jones B, Cogger V, De Cabo R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Ageing, Werner syndrome and Pseudocapillarization; Le Couteur D, Cogger V, Lebel M, Quinn R, Hilmer S, McCuskey R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Stereomicroscope-Imaging Workstation; Allan C, Seibel M, Handelsman D, Le Couteur D, Kennerson M, Robertson G, Walters K, Cogger V, Nicholson G, Zhou H, Blair I, Simanainen U, McMahon A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2007

  • Caloric restriction, ageing and the liver sinusoidal endothelium: mechanisms and implications; Le Couteur D, De Cabo R, De Cabo R, Cogger V, Hilmer S, Frazer R; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Mechanisms for ageing changes in the hepatic sinusoid; Le Couteur D, McKinnon K, Fraser R, Muller M, Cogger V, Harris M, Sullivan D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • How is lipoprotein disposition influenced by fenestrae in the hepatic sinusoidal endothelium?; Le Couteur D, McKinnon K, Fraser R, Cogger V, Sullivan D; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Svistounov, D., Zykova, S., Cogger, V., Warren, A., McMahon, A., Fraser, R., Le Couteur, D. (2012). Liver Sinusoidal Endothelial Cells and Regulation of Blood Lipoproteins. In Roya Kelishadi (Eds.), Dyslipidemia - From Prevention to Treatment, (pp. 263-278). Croatia: InTech Publishers.
  • McMahon, A., Hing, A., Cogger, V., Le Couteur, D. (2011). Animal models of early atherosclerosis: How to translate the data into clinical perspectives. In Petru Liuba (Eds.), Silent Vasculopathy in Childhood: Should Clinicians Care, (pp. 39-63). India: Transworld Research Network.
  • Le Couteur, D., Sinclair, D., Cogger, V., McMahon, A., Warren, A., Everitt, A., Lebel, M., De Cabo, R. (2010). The Aging Liver and the Effects of Long Term Caloric Restriction. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 191-216). Dordrecht: Springer.
  • Le Couteur, D., Cogger, V., Hilmer, S., Muller, M., Harris, M., Sullivan, D., McLean, A., Fraser, R. (2006). Aging, atheroscleroisis and the liver sieve. In Clarke, Leon V (Eds.), New research on atherosclerosis, (pp. 19-44). New York: Nova Science Publishers.
  • Le Couteur, D., Naganathan, V., Cogger, V., Cumming, R., McLean, A. (2006). Pharmacotherapy in the elderly: clinical issues and perspectives. In Kohli K, Gupta M, Tejwani S. (Eds.), In Contemporary Perspectives on Clinical Pharmacotherapeutics, (pp. 709-722). New Dehli: Elsevier.

Journals

  • Cogger, V., Mitchell, S., Warren, A., De Cabo, R., Le Couteur, D. (2014). Age-Related Loss of Responsiveness to 2,5-Dimethoxy-4-Iodoamphetamine in Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(5), 514-518. [More Information]
  • Cogger, V., Svistounov, D., Warren, A., Zykova, S., Melvin, R., Solon-Biet, S., O'Reilly, J., McMahon, A., Ballard, J., De Cabo, R., Le Couteur, D., et al (2014). Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(9), 1076-1086. [More Information]
  • Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2014). The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(4), 387-397. [More Information]
  • Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Gokam, R., Khalil, M., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]
  • Cogger, V., Roessner, U., Warren, A., Fraser, R., Le Couteur, D. (2013). A Sieve-Raft Hypothesis for the regulation of endothelial fenestrations. Computational and Structural Biotechnology Journal, 8(11), 1-9. [More Information]
  • Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11), 4172-4189. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]
  • Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
  • Svistounov, D., Warren, A., McNerney, G., Owen, D., Zencak, D., Zykova, S., Crane, H., Huser, T., Quinn, R., Smedsrod, B., Le Couteur, D., Cogger, V. (2012). The Relationship between Fenestrations, Sieve Plates and Rafts in Liver Sinusoidal Endothelial Cells. PLoS One, 7(9), 1-9. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
  • Le Couteur, D., Cogger, V., Dobbs, B., Fraser, R. (2011). Fenestrations and lipoproteins. Cardiovascular pathology, 20(3), 191-193. [More Information]
  • Cogger, V., Hilmer, S., Svistounov, D. (2011). Mechanisms and implications of age-related changes in the liver. Current Gerontology and Geriatrics Research, 2011, 150364-150364. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]
  • Labbé, A., Garand, C., Cogger, V., Paquet, E., Desbiens, M., Le Couteur, D., Lebel, M. (2011). Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(312492), 264-278. [More Information]
  • Warren, A., Cogger, V., Fraser, R., DeLeve, L., McCuskey, R., Le Couteur, D. (2011). The Effects of Old Age on Hepatic Stellate Cells. Current Gerontology and Geriatrics Research, 2011 (Article ID 439835), 1-7. [More Information]
  • Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]
  • Warren, A., Cogger, V., Arias, I., McCuskey, R., Le Couteur, D. (2010). Liver sinusoidal endothelial fenestrations in caveolin-1 knockout mice. Microcirculation, 17(1), 32-38. [More Information]
  • Pallardo, F., Lloret, A., Lebel, M., d’Ischia, M., Cogger, V., Le Couteur, D., Gadaleta, M., Castello, G., Pagano, G. (2010). Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome. Biogerontology, 11(4), 401-419. [More Information]
  • O'Reilly, J., Cogger, V., Fraser, R., Le Couteur, D. (2010). The effect of feeding and fasting on fenestrations in the liver sinusoidal endothelial cell. Pathology, 42(3), 255-258. [More Information]
  • Cogger, V., McNerney, G., Nyunt, T., DeLeve, L., McCourt, P., Smedsrod, B., Le Couteur, D., Huser, T. (2010). Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. Journal of Structural Biology, 171(3), 382-388. [More Information]
  • Massip, L., Garand, C., Paquet, E., Cogger, V., O'Reilly, J., Tworek, L., Hatherall, A., Taylor, C., Thorin, E., Zahradka, P., Le Couteur, D., et al (2010). Vitamin C restores healthy aging in a mouse model for Werner syndrome. The F A S E B Journal, 24(1), 158-172. [More Information]
  • O'Reilly, J., Cogger, V., Le Couteur, D. (2009). Old age is associated with ultrastructural changes in isolated rat liver sinusoidal endothelial cells. Journal of Electron Microscopy, 59(1), 65-69. [More Information]
  • Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
  • Cheluvappa, R., Cogger, V., Kwun, S., O'Reilly, J., Le Couteur, D., Hilmer, S. (2008). Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin. International Journal of Experimental Pathology: mechanisms and models of disease, 89(6), 410-418. [More Information]
  • Le Couteur, D., Warren, A., Cogger, V., Smedsrod, B., Sorensen, K., De Cabo, R., Fraser, R., McCuskey, R. (2008). Old age and the hepatic sinusoid. Anatomical Record - Advances in Integrative Anatomy and Evolutionary Biology, 291(6), 672-683. [More Information]
  • Cogger, V., Arias, I., Warren, A., McMahon, A., Kiss, D., Avery, V., Le Couteur, D. (2008). The response of fenestrations, actin and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells (a liver endothelial cell line). American Journal of Physiology: Gastrointestinal and Liver Physiology, 295(1), G137-G145. [More Information]
  • Le Couteur, D., Cogger, V., McCuskey, R., De Cabo, R., Smedsrod, B., Sorensen, K., Warren, A., Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. New York Academy of Sciences. Annals, 1114, 79-87. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia: clinical and experimental diabetes and metabolism, 50(9), 1969-1976. [More Information]
  • Hilmer, S., Cogger, V., Le Couteur, D. (2007). Basal activity of Kupffer cells increases with old age. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62(9), 973-978. [More Information]
  • Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Cogger, V., Le Couteur, D. (2007). Effects of old age on hepatocyte oxygenation. New York Academy of Sciences. Annals, 1114, 88-92. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Jamieson, H., O'Reilly, J., Muller, M., Cogger, V., Le Couteur, D. (2007). The effect of old age on liver oxygenation and the hepatic expression of VEGF and VEGFR2. Experimental Gerontology, 42(10), 1012-1019. [More Information]
  • Cogger, V., Hilmer, S., Sullivan, D., Muller, M., Fraser, R., Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281. [More Information]
  • Hilmer, S., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42(6), 1349-1354. [More Information]
  • Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]
  • Cogger, V., Warren, A., Fraser, R., Ngu, M., McLean, A., Le Couteur, D. (2004). Preliminary Analysis Of The Sinusoidal Endothelium And Space Of Disse In Ageing Papio Hamadrayas. Comparative Hepatology, 3(Suppl 1), S26-S27.
  • Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57.
  • Cogger, V., Muller, M., Fraser, R., McLean, A., Khan, J., Le Couteur, D. (2004). The Effects Of Oxidative Stress On The Liver Sieve. Journal of Hepatology, 41(3), 370-376.
  • Hilmer, S., Cogger, V., Muller, M., Le Couteur, D. (2004). The Hepatic Pharmacokinetics Of Doxorubicin And Liposomal Doxorubicin. Drug Metabolism and Disposition, 32(8), 794-799.
  • McLean, A., Cogger, V., Chong, G., Warren, A., Markus, A., Dahlstrom, J., Le Couteur, D. (2003). Age-related pseudocapillarization of the human liver. Journal of Pathology, 200(1), 112-117. [More Information]
  • Cogger, V., Warren, A., Fraser, R., Ngu, M., Le Couteur, D., McLean, A. (2003). Hepatic sinusoidal pseudocappilarization with aging in the non-human primate. Experimental Gerontology, 38(10), 1101-1107. [More Information]
  • Le Couteur, D., Fraser, R., Cogger, V., McLean, A. (2002). Hepatic pseudocapillarisation and atherosclerosis in ageing. The Lancet, 359(9317), 1612-1615.
  • Cogger, V., Markus, A., Harvey, P., Ansselin, A., McLean, A., Le Couteur, D., Yin,, Z. (2001). Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology, 33, 537-543.
  • Cogger, V., Ansselin, A., Le Couteur, D., McLean, A., Mross, P., Hosie, M. (2001). The effect of acute oxidative stress on the ultrastructure of the perfused rat liver. Pharmacology and Toxicology, 89, 306-311.

2014

  • Cogger, V., Mitchell, S., Warren, A., De Cabo, R., Le Couteur, D. (2014). Age-Related Loss of Responsiveness to 2,5-Dimethoxy-4-Iodoamphetamine in Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(5), 514-518. [More Information]
  • Cogger, V., Svistounov, D., Warren, A., Zykova, S., Melvin, R., Solon-Biet, S., O'Reilly, J., McMahon, A., Ballard, J., De Cabo, R., Le Couteur, D., et al (2014). Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(9), 1076-1086. [More Information]
  • Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2014). The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(4), 387-397. [More Information]
  • Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Gokam, R., Khalil, M., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]

2013

  • Cogger, V., Roessner, U., Warren, A., Fraser, R., Le Couteur, D. (2013). A Sieve-Raft Hypothesis for the regulation of endothelial fenestrations. Computational and Structural Biotechnology Journal, 8(11), 1-9. [More Information]

2012

  • Svistounov, D., Zykova, S., Cogger, V., Warren, A., McMahon, A., Fraser, R., Le Couteur, D. (2012). Liver Sinusoidal Endothelial Cells and Regulation of Blood Lipoproteins. In Roya Kelishadi (Eds.), Dyslipidemia - From Prevention to Treatment, (pp. 263-278). Croatia: InTech Publishers.
  • Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11), 4172-4189. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]
  • Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
  • Svistounov, D., Warren, A., McNerney, G., Owen, D., Zencak, D., Zykova, S., Crane, H., Huser, T., Quinn, R., Smedsrod, B., Le Couteur, D., Cogger, V. (2012). The Relationship between Fenestrations, Sieve Plates and Rafts in Liver Sinusoidal Endothelial Cells. PLoS One, 7(9), 1-9. [More Information]

2011

  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
  • McMahon, A., Hing, A., Cogger, V., Le Couteur, D. (2011). Animal models of early atherosclerosis: How to translate the data into clinical perspectives. In Petru Liuba (Eds.), Silent Vasculopathy in Childhood: Should Clinicians Care, (pp. 39-63). India: Transworld Research Network.
  • Le Couteur, D., Cogger, V., Dobbs, B., Fraser, R. (2011). Fenestrations and lipoproteins. Cardiovascular pathology, 20(3), 191-193. [More Information]
  • Cogger, V., Hilmer, S., Svistounov, D. (2011). Mechanisms and implications of age-related changes in the liver. Current Gerontology and Geriatrics Research, 2011, 150364-150364. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]
  • Labbé, A., Garand, C., Cogger, V., Paquet, E., Desbiens, M., Le Couteur, D., Lebel, M. (2011). Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(312492), 264-278. [More Information]
  • Warren, A., Cogger, V., Fraser, R., DeLeve, L., McCuskey, R., Le Couteur, D. (2011). The Effects of Old Age on Hepatic Stellate Cells. Current Gerontology and Geriatrics Research, 2011 (Article ID 439835), 1-7. [More Information]
  • Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]

2010

  • Warren, A., Cogger, V., Arias, I., McCuskey, R., Le Couteur, D. (2010). Liver sinusoidal endothelial fenestrations in caveolin-1 knockout mice. Microcirculation, 17(1), 32-38. [More Information]
  • Pallardo, F., Lloret, A., Lebel, M., d’Ischia, M., Cogger, V., Le Couteur, D., Gadaleta, M., Castello, G., Pagano, G. (2010). Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome. Biogerontology, 11(4), 401-419. [More Information]
  • Le Couteur, D., Sinclair, D., Cogger, V., McMahon, A., Warren, A., Everitt, A., Lebel, M., De Cabo, R. (2010). The Aging Liver and the Effects of Long Term Caloric Restriction. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 191-216). Dordrecht: Springer.
  • O'Reilly, J., Cogger, V., Fraser, R., Le Couteur, D. (2010). The effect of feeding and fasting on fenestrations in the liver sinusoidal endothelial cell. Pathology, 42(3), 255-258. [More Information]
  • Cogger, V., McNerney, G., Nyunt, T., DeLeve, L., McCourt, P., Smedsrod, B., Le Couteur, D., Huser, T. (2010). Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. Journal of Structural Biology, 171(3), 382-388. [More Information]
  • Massip, L., Garand, C., Paquet, E., Cogger, V., O'Reilly, J., Tworek, L., Hatherall, A., Taylor, C., Thorin, E., Zahradka, P., Le Couteur, D., et al (2010). Vitamin C restores healthy aging in a mouse model for Werner syndrome. The F A S E B Journal, 24(1), 158-172. [More Information]

2009

  • O'Reilly, J., Cogger, V., Le Couteur, D. (2009). Old age is associated with ultrastructural changes in isolated rat liver sinusoidal endothelial cells. Journal of Electron Microscopy, 59(1), 65-69. [More Information]

2008

  • Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
  • Cheluvappa, R., Cogger, V., Kwun, S., O'Reilly, J., Le Couteur, D., Hilmer, S. (2008). Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin. International Journal of Experimental Pathology: mechanisms and models of disease, 89(6), 410-418. [More Information]
  • Le Couteur, D., Warren, A., Cogger, V., Smedsrod, B., Sorensen, K., De Cabo, R., Fraser, R., McCuskey, R. (2008). Old age and the hepatic sinusoid. Anatomical Record - Advances in Integrative Anatomy and Evolutionary Biology, 291(6), 672-683. [More Information]
  • Cogger, V., Arias, I., Warren, A., McMahon, A., Kiss, D., Avery, V., Le Couteur, D. (2008). The response of fenestrations, actin and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells (a liver endothelial cell line). American Journal of Physiology: Gastrointestinal and Liver Physiology, 295(1), G137-G145. [More Information]

2007

  • Le Couteur, D., Cogger, V., McCuskey, R., De Cabo, R., Smedsrod, B., Sorensen, K., Warren, A., Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. New York Academy of Sciences. Annals, 1114, 79-87. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia: clinical and experimental diabetes and metabolism, 50(9), 1969-1976. [More Information]
  • Hilmer, S., Cogger, V., Le Couteur, D. (2007). Basal activity of Kupffer cells increases with old age. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62(9), 973-978. [More Information]
  • Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Cogger, V., Le Couteur, D. (2007). Effects of old age on hepatocyte oxygenation. New York Academy of Sciences. Annals, 1114, 88-92. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Jamieson, H., O'Reilly, J., Muller, M., Cogger, V., Le Couteur, D. (2007). The effect of old age on liver oxygenation and the hepatic expression of VEGF and VEGFR2. Experimental Gerontology, 42(10), 1012-1019. [More Information]

2006

  • Le Couteur, D., Cogger, V., Hilmer, S., Muller, M., Harris, M., Sullivan, D., McLean, A., Fraser, R. (2006). Aging, atheroscleroisis and the liver sieve. In Clarke, Leon V (Eds.), New research on atherosclerosis, (pp. 19-44). New York: Nova Science Publishers.
  • Cogger, V., Hilmer, S., Sullivan, D., Muller, M., Fraser, R., Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281. [More Information]
  • Le Couteur, D., Naganathan, V., Cogger, V., Cumming, R., McLean, A. (2006). Pharmacotherapy in the elderly: clinical issues and perspectives. In Kohli K, Gupta M, Tejwani S. (Eds.), In Contemporary Perspectives on Clinical Pharmacotherapeutics, (pp. 709-722). New Dehli: Elsevier.

2005

  • Hilmer, S., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42(6), 1349-1354. [More Information]
  • Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]

2004

  • Cogger, V., Warren, A., Fraser, R., Ngu, M., McLean, A., Le Couteur, D. (2004). Preliminary Analysis Of The Sinusoidal Endothelium And Space Of Disse In Ageing Papio Hamadrayas. Comparative Hepatology, 3(Suppl 1), S26-S27.
  • Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57.
  • Cogger, V., Muller, M., Fraser, R., McLean, A., Khan, J., Le Couteur, D. (2004). The Effects Of Oxidative Stress On The Liver Sieve. Journal of Hepatology, 41(3), 370-376.
  • Hilmer, S., Cogger, V., Muller, M., Le Couteur, D. (2004). The Hepatic Pharmacokinetics Of Doxorubicin And Liposomal Doxorubicin. Drug Metabolism and Disposition, 32(8), 794-799.

2003

  • McLean, A., Cogger, V., Chong, G., Warren, A., Markus, A., Dahlstrom, J., Le Couteur, D. (2003). Age-related pseudocapillarization of the human liver. Journal of Pathology, 200(1), 112-117. [More Information]
  • Cogger, V., Warren, A., Fraser, R., Ngu, M., Le Couteur, D., McLean, A. (2003). Hepatic sinusoidal pseudocappilarization with aging in the non-human primate. Experimental Gerontology, 38(10), 1101-1107. [More Information]

2002

  • Le Couteur, D., Fraser, R., Cogger, V., McLean, A. (2002). Hepatic pseudocapillarisation and atherosclerosis in ageing. The Lancet, 359(9317), 1612-1615.

2001

  • Cogger, V., Markus, A., Harvey, P., Ansselin, A., McLean, A., Le Couteur, D., Yin,, Z. (2001). Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology, 33, 537-543.
  • Cogger, V., Ansselin, A., Le Couteur, D., McLean, A., Mross, P., Hosie, M. (2001). The effect of acute oxidative stress on the ultrastructure of the perfused rat liver. Pharmacology and Toxicology, 89, 306-311.

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