student profile: Mr Vincent Caillet


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Thesis work

Thesis title: Advanced Calypso Image Guided Radiotherapy for Lung Cancer SBRT.

Supervisors: Jeremy BOOTH, Paul KEALL

Thesis abstract:

BIBLIOGRAPHY
Vincent Caillet is currently a PhD student at the University of Sydney currently working under the supervision of Prof Paul Keall and Dr Jeremy Booth. In addition to his current studies, he is also employed as a hospital scientist at Royal North Shore Hospital in Sydney, Australia. Before joining the Radiation Physics Laboratory, he briefly worked in nuclear medicine in the IRSN (France), on the Monte Carlo simulation of patient injected with microsphere of yttrium-90 in the liver.
His main research has been focusing on the clinical implementation of multi-leaf collimator (MLC) tracking for patient diagnosed with lung cancer. Other subject of interests are the evaluation of dosimetric errors during MLC tracking, comparison of tracking algorithms and the occasional KIM gating treatment. When he is not working, the highest chance of meeting him is at the beach, most probably swimming from one beach to the other.



PURPOSE OF MY WORK
Clinically implement this new technology in a clinical trial entitled LIGHT SABR (Clinical trial ID NCT02514512)

1. Treat 20 patients with adaptive real-time tumour tracking.

2. Provide thorough analysis to compare real-time tumour tracking against the current standard of care.

3. Finish all of the above before the end of my Ph.D in October 2018.

LAY EXPLANATION OF PHD
Occasionally, we swallow, cough, twitch and without admitting it publicly, we are subjected to inconvenient gas passing. Some more than others. In a way, we are constantly moving, whether we are aware or it or not, such as our hear beating or lungs inflating during respiration.

Despite radiotherapy’s key role in cancer treatment, clinicians are still facing with a major problem: patient movement and internal motion are currently ignored during patient's radiotherapy.

The current work undertaken as part of my Ph.D. is to provide a clinical solution that accounts for tumour motion during cancer radiotherapy for patient diagnosed with lung cancer (non-small cell lung carcinoma). This technique, called "MLC Tracking", has been clinically implemented as part of the first-in-world MLC tracking treatment for prostate (finalized in 2014 by Dr. Emma Colvill as part of her Ph.D.) and lung cancer (currently ongoing, my Ph.D.).
This work is under the supervision of

- Prof Paul Keall from the Radiation Physics Laboratory at the University of Sydney
- Dr Jeremy Booth, Head of Physics at Northern Sydney Cancer Centre (See link for Dr. Booth talking about the clinical trial to Channel 7 News : Channel 7News report on LIGHT SABR).
- Ricky O'Brien, the C# guru developer of the clinical MLC tracking interface available for LIGHTSABR.


ADAPTIVE MLC TRACKING FOR PATIENT DIAGNOSED WITH LUNG CANCER OPERATES IN THREE STEPS :

1. Tumour movement is detected. The tracking system currently feeding the position of the tumour is called Varian Calypso positioning monitoring system.

2. The software reads the tumour position, and optimize the position of the MLC accordingly. The new MLC aperture position is then sent to the MLC controller.

3. The MLC controller re-shapes the MLC aperture and re-aligns the radiation with the tumour.

Selected publications

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Journals

  • Alnaghy, S., Kyme, A., Caillet, V., Nguyen, D., O'Brien, R., Booth, J., Keall, P. (2019). A six-degree-of-freedom robotic motion system for quality assurance of real-time image-guided radiotherapy. Physics in Medicine and Biology. [More Information]
  • Steiner, E., Shieh, C., Caillet, V., Booth, J., Hardcastle, N., Briggs, A., Jayamanne, D., Haddad, C., Eade, T., Keall, P. (2018). 4-Dimensional Cone Beam Computed Tomography´┐ŻMeasured Target Motion Underrepresents Actual Motion. International Journal of Radiation Oncology Biology Physics, 102(4), 932-940. [More Information]
  • Montanaro, T., Nguyen, D., Keall, P., Booth, J., Eade, T., Haddad, C., Caillet, V., Shieh, C. (2018). A comparison of gantry-mounted x-ray-based real-Time target tracking methods. Medical Physics, 45(3), 1222-1232. [More Information]
  • Nguyen, D., Booth, J., Caillet, V., Hardcastle, N., Briggs, A., Haddad, C., Eade, T., O'Brien, R., Keall, P. (2018). An augmented correlation framework for the estimation of tumour translational and rotational motion during external beam radiotherapy treatments using intermittent monoscopic X-ray imaging and an external respiratory signal. Physics in Medicine and Biology, 63(20), 1-17. [More Information]
  • Keall, P., Colvill, E., O'Brien, R., Caillet, V., Eade, T., Kneebone, A., Hruby, G., Poulsen, P., Zwan, B., Greer, P., Booth, J. (2018). Electromagnetic-Guided MLC Tracking Radiation Therapy for Prostate Cancer Patients: Prospective Clinical Trial Results. International Journal of Radiation Oncology Biology Physics, 101(2), 387-395. [More Information]
  • Lydiard, S., Caillet, V., Ipsen, S., O'Brien, R., Blanck, O., Poulsen, P., Booth, J., Keall, P. (2018). Investigating multi-leaf collimator tracking in stereotactic arrhythmic radioablation (STAR) treatments for atrial fibrillation. Physics in Medicine and Biology, 63(19), 1-13. [More Information]
  • Kim, J., Nguyen, D., Booth, J., Huang, C., Fuangrod, T., Poulsen, P., O'Brien, R., Caillet, V., Eade, T., Kneebone, A., Keall, P. (2018). The accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom prostate motion measurements during patient treatments. Radiotherapy and Oncology, 126(2), 236-243. [More Information]
  • Keall, P., Nguyen, D., O'Brien, R., Caillet, V., Hewson, E., Poulsen, P., Bromley, R., Bell, L., Eade, T., Kneebone, A., Booth, J., et al (2018). The first clinical implementation of real-time image-guided adaptive radiotherapy using a standard linear accelerator. Radiotherapy and Oncology, 127(1), 6-11. [More Information]
  • Shieh, C., Caillet, V., Dunbar, M., Keall, P., Booth, J., Hardcastle, N., Haddad, C., Eade, T., Feain, I. (2017). A Bayesian approach for three-dimensional markerless tumor tracking using kV imaging during lung radiotherapy. Physics in Medicine and Biology, 62(8), 3065-3080. [More Information]
  • Caillet, V., Booth, J., Keall, P. (2017). IGRT and motion management during lung SBRT delivery. Physica Medica, 44, 113-122. [More Information]
  • Caillet, V., Keall, P., Colvill, E., Hardcastle, N., O'Brien, R., Szymura, K., Booth, J. (2017). MLC tracking for lung SABR reduces planning target volumes and dose to organs at risk. Radiotherapy and Oncology, 124(1), 18-24. [More Information]
  • Kim, J., Nguyen, D., Huang, C., Fuangrod, T., Caillet, V., O'Brien, R., Poulsen, P., Booth, J., Keall, P. (2017). Quantifying the accuracy and precision of a novel real-time 6 degree-of-freedom kilovoltage intrafraction monitoring (KIM) target tracking system. Physics in Medicine and Biology, 62(14), 5744-5759. [More Information]
  • Juneja, P., Caillet, V., Shaw, T., Martland, J., Booth, J. (2016). Kilovoltage intrafraction monitoring for real-time image guided adaptive radiotherapy reduces total dose for lung SABR. Radiotherapy and Oncology, 121(1), 15-18. [More Information]
  • Keall, P., Ng, J., Juneja, P., O'Brien, R., Huang, C., Colvill, E., Caillet, V., Simpson, E., Poulsen, P., Kneebone, A., Eade, T., Booth, J. (2016). Real-Time 3D Image Guidance Using a Standard LINAC: Measured Motion, Accuracy, and Precision of the First Prospective Clinical Trial of Kilovoltage Intrafraction Monitoringe-Guided Gating for Prostate Cancer Radiation Therapy. International Journal of Radiation Oncology Biology Physics, 94(5), 1015-1021. [More Information]
  • Booth, J., Caillet, V., Hardcastle, N., O'Brien, R., Szymura, K., Crasta, C., Harris, B., Haddad, C., Eade, T., Keall, P. (2016). The first patient treatment of electromagnetic-guided real time adaptive radiotherapy using MLC tracking for lung SABR. Radiotherapy and Oncology, 121(1), 19-25. [More Information]

2019

  • Alnaghy, S., Kyme, A., Caillet, V., Nguyen, D., O'Brien, R., Booth, J., Keall, P. (2019). A six-degree-of-freedom robotic motion system for quality assurance of real-time image-guided radiotherapy. Physics in Medicine and Biology. [More Information]

2018

  • Steiner, E., Shieh, C., Caillet, V., Booth, J., Hardcastle, N., Briggs, A., Jayamanne, D., Haddad, C., Eade, T., Keall, P. (2018). 4-Dimensional Cone Beam Computed Tomography´┐ŻMeasured Target Motion Underrepresents Actual Motion. International Journal of Radiation Oncology Biology Physics, 102(4), 932-940. [More Information]
  • Montanaro, T., Nguyen, D., Keall, P., Booth, J., Eade, T., Haddad, C., Caillet, V., Shieh, C. (2018). A comparison of gantry-mounted x-ray-based real-Time target tracking methods. Medical Physics, 45(3), 1222-1232. [More Information]
  • Nguyen, D., Booth, J., Caillet, V., Hardcastle, N., Briggs, A., Haddad, C., Eade, T., O'Brien, R., Keall, P. (2018). An augmented correlation framework for the estimation of tumour translational and rotational motion during external beam radiotherapy treatments using intermittent monoscopic X-ray imaging and an external respiratory signal. Physics in Medicine and Biology, 63(20), 1-17. [More Information]
  • Keall, P., Colvill, E., O'Brien, R., Caillet, V., Eade, T., Kneebone, A., Hruby, G., Poulsen, P., Zwan, B., Greer, P., Booth, J. (2018). Electromagnetic-Guided MLC Tracking Radiation Therapy for Prostate Cancer Patients: Prospective Clinical Trial Results. International Journal of Radiation Oncology Biology Physics, 101(2), 387-395. [More Information]
  • Lydiard, S., Caillet, V., Ipsen, S., O'Brien, R., Blanck, O., Poulsen, P., Booth, J., Keall, P. (2018). Investigating multi-leaf collimator tracking in stereotactic arrhythmic radioablation (STAR) treatments for atrial fibrillation. Physics in Medicine and Biology, 63(19), 1-13. [More Information]
  • Kim, J., Nguyen, D., Booth, J., Huang, C., Fuangrod, T., Poulsen, P., O'Brien, R., Caillet, V., Eade, T., Kneebone, A., Keall, P. (2018). The accuracy and precision of Kilovoltage Intrafraction Monitoring (KIM) six degree-of-freedom prostate motion measurements during patient treatments. Radiotherapy and Oncology, 126(2), 236-243. [More Information]
  • Keall, P., Nguyen, D., O'Brien, R., Caillet, V., Hewson, E., Poulsen, P., Bromley, R., Bell, L., Eade, T., Kneebone, A., Booth, J., et al (2018). The first clinical implementation of real-time image-guided adaptive radiotherapy using a standard linear accelerator. Radiotherapy and Oncology, 127(1), 6-11. [More Information]

2017

  • Shieh, C., Caillet, V., Dunbar, M., Keall, P., Booth, J., Hardcastle, N., Haddad, C., Eade, T., Feain, I. (2017). A Bayesian approach for three-dimensional markerless tumor tracking using kV imaging during lung radiotherapy. Physics in Medicine and Biology, 62(8), 3065-3080. [More Information]
  • Caillet, V., Booth, J., Keall, P. (2017). IGRT and motion management during lung SBRT delivery. Physica Medica, 44, 113-122. [More Information]
  • Caillet, V., Keall, P., Colvill, E., Hardcastle, N., O'Brien, R., Szymura, K., Booth, J. (2017). MLC tracking for lung SABR reduces planning target volumes and dose to organs at risk. Radiotherapy and Oncology, 124(1), 18-24. [More Information]
  • Kim, J., Nguyen, D., Huang, C., Fuangrod, T., Caillet, V., O'Brien, R., Poulsen, P., Booth, J., Keall, P. (2017). Quantifying the accuracy and precision of a novel real-time 6 degree-of-freedom kilovoltage intrafraction monitoring (KIM) target tracking system. Physics in Medicine and Biology, 62(14), 5744-5759. [More Information]

2016

  • Juneja, P., Caillet, V., Shaw, T., Martland, J., Booth, J. (2016). Kilovoltage intrafraction monitoring for real-time image guided adaptive radiotherapy reduces total dose for lung SABR. Radiotherapy and Oncology, 121(1), 15-18. [More Information]
  • Keall, P., Ng, J., Juneja, P., O'Brien, R., Huang, C., Colvill, E., Caillet, V., Simpson, E., Poulsen, P., Kneebone, A., Eade, T., Booth, J. (2016). Real-Time 3D Image Guidance Using a Standard LINAC: Measured Motion, Accuracy, and Precision of the First Prospective Clinical Trial of Kilovoltage Intrafraction Monitoringe-Guided Gating for Prostate Cancer Radiation Therapy. International Journal of Radiation Oncology Biology Physics, 94(5), 1015-1021. [More Information]
  • Booth, J., Caillet, V., Hardcastle, N., O'Brien, R., Szymura, K., Crasta, C., Harris, B., Haddad, C., Eade, T., Keall, P. (2016). The first patient treatment of electromagnetic-guided real time adaptive radiotherapy using MLC tracking for lung SABR. Radiotherapy and Oncology, 121(1), 19-25. [More Information]

Note: This profile is for a student at the University of Sydney. Views presented here are not necessarily those of the University.