Dr Vincent Lee

Clinical Senior Lecturer
Medicine, Westmead Clinical School

Telephone +61 2 9845 6962
Fax +61 2 9633 9351

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Biographical details

Dr Lee is a nephrologist at Westmead and Blacktown Hospitals in Sydney. He is Sub-Dean
(Medicine) of the Western Clinical School of the University of Sydney, and Medical Director of
Dialysis at Norwest Private Hospital, Sydney.

Research interests

Progression of chronic kidney disease, immunology, glomerulonephritis, vascular calcification, acute kidney injury, preeclampsia and other obstetric outcomes associated with kidney disease.

Teaching and supervision

Broad field of teaching interests encompassing clinical and basic science of renal medicine.

Selected grants

2011

  • The Role of Macrophages in Uraemic Vascular Clacification; Lee V; Royal Australasian College of Physicians/Jacquot Research Establishment Award.

Selected publications

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Book Chapters

  • Lee, V., Cao, Q., Wang, Y., Harris, D. (2011). Role of Macrophages in Renal Injury,Repair and Regeneration. In Michael S. Goligorsky (Eds.), Regenerative Nephrology, (pp. 125-139). USA: Elsevier.
  • Lee, V. (2008). Acute Renal Failure and Rhabdomyolysis. In David Harris (Eds.), Clinical Cases in Kidney Disease. Australia: McGraw Hill.
  • Lee, V. (2008). Oedema and Nephrotic Syndrome. In David Harris (Eds.), Clinical Cases in Kidney Disease, (pp. 438-450). Australia: McGraw Hill.
  • Lee, V., Harris, D., Anderson, R., Schrier, R. (2007). Acute Renal Failure. In Robert W. Schrier (Eds.), Diseases of the Kidney and Urinary Tract, (pp. 986-1034). Philadelphia: Lippincott Williams & Wilkins.

Journals

  • Alahakoon, T., Zhang, W., Trudinger, B., Lee, V. (2014). Discordant clinical presentations of preeclampsia and intrauterine fetal growth restriction with similar pro- and anti-angiogenic profiles. The Journal of Maternal - Fetal & Neonatal Medicine, 27(18), 1854-1859. [More Information]
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, C., Wang, X., Lee, V., Wang, Y., Wang, Y., Zheng, G., Tan, T., Harris, D., et al (2014). Failed renoprotection by alternatively activated macrophages from bone marrow due to proliferation-dependent phenotype switch in vivo. Kidney International, 85(4), 794-806. [More Information]
  • Tian, X., Zhang, J., Tan, T., Lyons, G., Zhao, H., Niu, B., Lee, S., Tsatralis, T., Zhao, Y., Wang, Y., Cao, Q., Wang, C., Wang, Y., Lee, V., Zheng, G., Harris, D., et al (2013). Association of beta catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF- beta1. Journal of Cell Science, 126(1), 67-76. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Harris, D., Alexander, S., Durkan, A. (2013). Cx3cr1-dec205 dc-targeted dna Vaccine Induces Specific Antibodies and Limits Atherosclerosis and Macrophage Infiltration in the apo-e Knockout Mouse Model of Atherosclerosis. Nephrology, 18(Supp. 1), 16-16.
  • Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V., Zheng, G., Tan, T., Wang, X., Harris, D., Wang, Y., et al (2013). Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney International, 84(4), 745-755. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Lee, S., Zhang, J., Zhao, Y., Tian, X., Wang, Y., Wang, Y., Cao, Q., Wang, Y., Lee, V., Wang, C., Zheng, D., Alexander, S., Harris, D., et al (2013). Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage. Laboratory Investigation, 93(4), 434-449. [More Information]
  • Lee, V., Wang, Y., Harris, D. (2013). The Role of the Immune System in the Pathogenesis of Hypertension. Current Hypertension Reviews, 9(1), 76-84. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Phoon, R., Zhang, G., Wang, Y., Tan, T., Hu, M., Wang, D., Saito, M., Harris, D., Durkan, A., et al (2012). DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. International Journal of Clinical and Experimental Medicine, 5(1), 24-33. [More Information]
  • Zheng, D., Cao, Q., Lee, V., Wang, Y., Zheng, G., Wang, Y., Tan, T., Wang, C., Alexander, S., Harris, D., Wang, Y. (2012). Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney International, 81(9), 892-902. [More Information]
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Harris, D., Alexander, S., et al (2012). Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology, 42(9), 2441-2451. [More Information]
  • Lee, V., Harris, D. (2011). Adriamycin nephropathy: A model of focal segmental glomerulosclerosis. Nephrology, 16(1), 30-38. [More Information]
  • Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011). IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology, 22(7), 1229-1239. [More Information]
  • Zheng, D., Wang, Y., Cao, Q., Lee, V., Zheng, G., Sun, Y., Tan, T., Wang, Y., Alexander, S., Harris, D. (2011). Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus. Nephron Experimental Nephrology, 118(4), e87-e99. [More Information]
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010). IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology, 21(6), 933-942. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Wang, Y., Lee, V., Tian, X., Wang, Y., Cao, Q., Wang, Y., Harris, D. (2010). Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells. The American Journal of Pathology: cellular and molecular biology of disease, 176(3), 1256-1270. [More Information]
  • Lee, V., Qin, X., Wang, Y., Zheng, G., Wang, Y., Wang, Y., Ince, J., Tan, T., Kairaitis, L., Alexander, S., Harris, D. (2010). The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrology, Dialysis, Transplantation, 25(3), 717-730. [More Information]
  • Wang, Y., Wang, Y., Cai, Q., Zheng, G., Lee, V., Zheng, D., Li, X., Tan, T., Harris, D. (2008). By Homing to the Kidney, Activated Macrophages Potently Exacerbate Renal Injury. The American Journal of Pathology: cellular and molecular biology of disease, 172(6), 1491-1499. [More Information]
  • Lee, V., Wang, Y., Wang, Y., Zheng, D., Polhill, T., Cao, Q., Wu, H., Alexander, I., Alexander, S., Harris, D. (2008). Regulatory immune cells in kidney disease. American Journal of Physiology: Renal Physiology (Print), 295(2), F335-F342. [More Information]
  • Wang, Y., Hu, M., Wang, Y., Polhill, T., Zhang, G., Wang, Y., Lee, V., Harris, D., Alexander, S. (2008). Regulatory T Cells in Renal Disease. International Journal of Clinical and Experimental Medicine, 1(4), 294-304. [More Information]
  • Wang, Y., Wang, Y., Zheng, G., Lee, V., Ouyang, L., Chang, D., Mahajan, D., Coombs, J., Wang, Y., Alexander, S., Harris, D. (2007). Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney International, 72(3), 290-299. [More Information]
  • Qin, X., Lee, V., Wang, Y., Zheng, G., Wang, Y., Alexander, S., Harris, D. (2006). A protective role for programmed death 1 in progression of murine adriamycin nephropathy. Kidney International, 70, 1244-1250. [More Information]
  • Lee, V., Wang, Y., Qin, X., Wang, Y., Zheng, G., Mahajan, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrology, Dialysis, Transplantation. [More Information]
  • Lee, V., Chapman, J. (2005). Sirolimus: its role in nephrology. Nephrology, 10(6), 606-14. [More Information]

Conferences

  • Webster, A., Lee, V., Powell, J., Chapman, J., Craig, J. (2004). (O78) Tor-Inhibitors (sirolimus and everolimus) for primary immunosuppression of renal transplant recipients: A meta-analysis randomized trials. IPNA meeting, 13th Congress.

2014

  • Alahakoon, T., Zhang, W., Trudinger, B., Lee, V. (2014). Discordant clinical presentations of preeclampsia and intrauterine fetal growth restriction with similar pro- and anti-angiogenic profiles. The Journal of Maternal - Fetal & Neonatal Medicine, 27(18), 1854-1859. [More Information]
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, C., Wang, X., Lee, V., Wang, Y., Wang, Y., Zheng, G., Tan, T., Harris, D., et al (2014). Failed renoprotection by alternatively activated macrophages from bone marrow due to proliferation-dependent phenotype switch in vivo. Kidney International, 85(4), 794-806. [More Information]

2013

  • Tian, X., Zhang, J., Tan, T., Lyons, G., Zhao, H., Niu, B., Lee, S., Tsatralis, T., Zhao, Y., Wang, Y., Cao, Q., Wang, C., Wang, Y., Lee, V., Zheng, G., Harris, D., et al (2013). Association of beta catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF- beta1. Journal of Cell Science, 126(1), 67-76. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Harris, D., Alexander, S., Durkan, A. (2013). Cx3cr1-dec205 dc-targeted dna Vaccine Induces Specific Antibodies and Limits Atherosclerosis and Macrophage Infiltration in the apo-e Knockout Mouse Model of Atherosclerosis. Nephrology, 18(Supp. 1), 16-16.
  • Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V., Zheng, G., Tan, T., Wang, X., Harris, D., Wang, Y., et al (2013). Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney International, 84(4), 745-755. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Lee, S., Zhang, J., Zhao, Y., Tian, X., Wang, Y., Wang, Y., Cao, Q., Wang, Y., Lee, V., Wang, C., Zheng, D., Alexander, S., Harris, D., et al (2013). Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage. Laboratory Investigation, 93(4), 434-449. [More Information]
  • Lee, V., Wang, Y., Harris, D. (2013). The Role of the Immune System in the Pathogenesis of Hypertension. Current Hypertension Reviews, 9(1), 76-84. [More Information]

2012

  • Zhou, J., Wang, Y., Lee, V., Phoon, R., Zhang, G., Wang, Y., Tan, T., Hu, M., Wang, D., Saito, M., Harris, D., Durkan, A., et al (2012). DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. International Journal of Clinical and Experimental Medicine, 5(1), 24-33. [More Information]
  • Zheng, D., Cao, Q., Lee, V., Wang, Y., Zheng, G., Wang, Y., Tan, T., Wang, C., Alexander, S., Harris, D., Wang, Y. (2012). Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney International, 81(9), 892-902. [More Information]
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Harris, D., Alexander, S., et al (2012). Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology, 42(9), 2441-2451. [More Information]

2011

  • Lee, V., Harris, D. (2011). Adriamycin nephropathy: A model of focal segmental glomerulosclerosis. Nephrology, 16(1), 30-38. [More Information]
  • Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011). IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology, 22(7), 1229-1239. [More Information]
  • Lee, V., Cao, Q., Wang, Y., Harris, D. (2011). Role of Macrophages in Renal Injury,Repair and Regeneration. In Michael S. Goligorsky (Eds.), Regenerative Nephrology, (pp. 125-139). USA: Elsevier.
  • Zheng, D., Wang, Y., Cao, Q., Lee, V., Zheng, G., Sun, Y., Tan, T., Wang, Y., Alexander, S., Harris, D. (2011). Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus. Nephron Experimental Nephrology, 118(4), e87-e99. [More Information]

2010

  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010). IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology, 21(6), 933-942. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Wang, Y., Lee, V., Tian, X., Wang, Y., Cao, Q., Wang, Y., Harris, D. (2010). Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells. The American Journal of Pathology: cellular and molecular biology of disease, 176(3), 1256-1270. [More Information]
  • Lee, V., Qin, X., Wang, Y., Zheng, G., Wang, Y., Wang, Y., Ince, J., Tan, T., Kairaitis, L., Alexander, S., Harris, D. (2010). The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrology, Dialysis, Transplantation, 25(3), 717-730. [More Information]

2008

  • Lee, V. (2008). Acute Renal Failure and Rhabdomyolysis. In David Harris (Eds.), Clinical Cases in Kidney Disease. Australia: McGraw Hill.
  • Wang, Y., Wang, Y., Cai, Q., Zheng, G., Lee, V., Zheng, D., Li, X., Tan, T., Harris, D. (2008). By Homing to the Kidney, Activated Macrophages Potently Exacerbate Renal Injury. The American Journal of Pathology: cellular and molecular biology of disease, 172(6), 1491-1499. [More Information]
  • Lee, V. (2008). Oedema and Nephrotic Syndrome. In David Harris (Eds.), Clinical Cases in Kidney Disease, (pp. 438-450). Australia: McGraw Hill.
  • Lee, V., Wang, Y., Wang, Y., Zheng, D., Polhill, T., Cao, Q., Wu, H., Alexander, I., Alexander, S., Harris, D. (2008). Regulatory immune cells in kidney disease. American Journal of Physiology: Renal Physiology (Print), 295(2), F335-F342. [More Information]
  • Wang, Y., Hu, M., Wang, Y., Polhill, T., Zhang, G., Wang, Y., Lee, V., Harris, D., Alexander, S. (2008). Regulatory T Cells in Renal Disease. International Journal of Clinical and Experimental Medicine, 1(4), 294-304. [More Information]

2007

  • Lee, V., Harris, D., Anderson, R., Schrier, R. (2007). Acute Renal Failure. In Robert W. Schrier (Eds.), Diseases of the Kidney and Urinary Tract, (pp. 986-1034). Philadelphia: Lippincott Williams & Wilkins.
  • Wang, Y., Wang, Y., Zheng, G., Lee, V., Ouyang, L., Chang, D., Mahajan, D., Coombs, J., Wang, Y., Alexander, S., Harris, D. (2007). Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney International, 72(3), 290-299. [More Information]

2006

  • Qin, X., Lee, V., Wang, Y., Zheng, G., Wang, Y., Alexander, S., Harris, D. (2006). A protective role for programmed death 1 in progression of murine adriamycin nephropathy. Kidney International, 70, 1244-1250. [More Information]
  • Lee, V., Wang, Y., Qin, X., Wang, Y., Zheng, G., Mahajan, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrology, Dialysis, Transplantation. [More Information]

2005

  • Lee, V., Chapman, J. (2005). Sirolimus: its role in nephrology. Nephrology, 10(6), 606-14. [More Information]

2004

  • Webster, A., Lee, V., Powell, J., Chapman, J., Craig, J. (2004). (O78) Tor-Inhibitors (sirolimus and everolimus) for primary immunosuppression of renal transplant recipients: A meta-analysis randomized trials. IPNA meeting, 13th Congress.

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