Professor Warwick Britton

Bosch Professor of Medicine and Professor of Immunology
Medicine (Immunology & Infectious Diseases), Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9515 5210
Fax +61 2 9351 3968

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Research interests

Professor Britton is the Head of the Discipline of Infectious Diseases & Immunology and the Mycobacterial Research Program in the Centenary Institute of Cancer Medicine & Cell Biology, where he studies the immunological control of tuberculosis and new vaccine strategies to control this major human infection.

Selected grants

2015

  • Discovery of New Tuberculosis Drug Leads Targeting Cell Wall Biosynthesis; Payne R, Britton W, Crick D, West N, Charman S; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • Formulation of novel tuberculosis (TB) subunit vaccines for human delivery; Triccas J, Britton W; Aeras/Research Support.
  • Understanding Cellular Immune Responses to M. tuberculosis Infection; Britton W; Rebecca L Cooper Medical Research Foundation/Research Support.
  • University of Sydney Automated Peptide Synthesis Platform; Payne R, Britton W, Byrne S, Chan H, Clarke R, Hunt N, Jolliffe K, Kassiou M, Lay P, Mackay J, Matthews J, McErlean C, New E, Rasmussen H, Rendina L, Rudrawar S, Rutledge P, Shepherd N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Programming memory T cell responses to recombinant influenza virues; Britton W; DVC Research/Bridging Support Grant.

2013

  • New candidate vaccines to prevent tuberculosis: preclinical assessment of efficacy, safety and mechanism of protection; Triccas J, Britton W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Improving subunit vaccines against tuberculosis for pulmonary delivery; Britton W, West N, Payne R, Chan H; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Tuberculosis control: from discovery to public health practice and policy; Britton W, Marais B, Marks G, Sintchenko V, Graham S, Triccas J, Saunders B, Kerridge I, Bennett B, Gilbert G; National Health and Medical Research Council (NHMRC)/Centres of Research Excellence.
  • Design, development and analysis of new tuberculosis drugs; Payne R, Britton W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • BD Influx 3-L Cell Sorter; Britton W, King N, Grau G, Weninger W, McCaughan G, Slobedman B, Saunders B, West N, Triccas J, Abendroth A, Combes V, Bowen D, Shackel N, Ellis M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Microparticles and Cellular Signalling During Tuberculosis Infection; Saunders B, Britton W, Grau G, Combes V; DVC Research/Bridging Support Grant.
  • Sydney Infectious Diseases and Biosecurity Network (SIBRN); Sorrell T, Bennett B, Booy R, Crawford J, Dwyer D, Gilbert G, Giles F, Holmes A, Hossain L, Iredell J, Jones C, Kesson A, Kerridge I, Marais B, Simpson S, Sintchenko V, Ward M, Werder O, Britton W, Dhand N, Hunter C, Kamradt-Scott A, Mor S, Salkeld G, Shaw T, Smith F, Wood N; DVC Research/Research Network Scheme (SyReNS).

2011

  • Design, development and analysis of new tuberculosis drugs; West N, Britton W, Payne R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Impact of Influenza A infection on T cell-mediated immunity to pulmonary tuberculosis.; Britton W, Triccas J, Florido M, Stambas J; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Inhibition of Siderophore Biosynthesis for Tuberculosis Drug Discovery; Payne R, Britton W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • A new direction for TB control in highly endemic countries: a RCT of active case finding; Marks G, Britton W, Sy D, Nhung N, Wood J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Next-generation high-speed flow cytometric cell sorter; Fazekas B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • 7-laser BD LSR-II and Cellomics Array Scan VTi to Enhance Capability and Throughput for the NSW Advanced Cytometry Facility; King N, Weninger W, Gunning P, Fazekas B, Campbell I, Christopherson R, Black J, Mason R, Richardson D, Halliday G, Grau G, Gandevia S, Kachigian L, Geczy C, Jessup W, Vadas M, Britton W, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • autoMACS Pro Separator; Abendroth A, Britton W, Richardson D, King N, Halliday G, Pollard J, McMinn P, Bishop A, Triccas J, Wang M, Byrne S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Chronic bacterial infection and thye generation of T cell memory: implication for vaccination against tuberculosis; Triccas J, Britton W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Cytokine and macrophage determinants of pulmonary inflammation during tuberculosis; Saunders B, Britton W, Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Immunity Infection Genomics Consortium; Cornall R, Goodnow C, Bell J, Bell J, Lathrop M, Britton W, Vinuesa C; Wellcome Trust (UK)/Research Support.

2008

  • Regulation of pulmonary immune responses to subunit vaccines against tuberculosis; Britton W, Triccas J, West N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • a/ AID EliSpot IFL System, 04IFLb/ AID BacSpotMultiple Plate Reader (Bac02MPR) c/ Glas-Col inhalation exposure system d/ Gelaire ClassII biological safety cabinet; Britton W; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2007

  • High Throughput Sampler (HTS) option for BD LSR-II Flow Cytometer; Britton W; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2006

  • Advanced Bioinformatics Teaching Facility; Arthur J, Triccas J, Jermiin L, Charleston M, Yang J, Britton W; DVC Research/Teaching Equipment Grant (Sesqui).
  • Advanced Imaging Flow Cytometry Facility for NSW; King N, Campbell I, Cook D, Black J, Halliday G, McAvoy J, Gunning P, Pollard J, Murray M, Britton W, Dawes I, Khachigian L, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Identifying determinants of mycobacterial pathogenesis and manipulating host immunity to Mycobacterium tuberculosis with novel vaccines and immunotherapeutic; Britton W; South West Sydney Area Health Service/South West Sydney Area Health Research Grants Program.

2005

  • Role of P2X7 in innate and adaptive immunity to myobacterial infections; Wiley J, Saunders B, Sluyter R, Britton W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Respiratory and Sleep Medicine; Jenkins C, Hensley M, Alison J, Britton W, Irwig L, Rogers N, Rose B, Marks G, Grunstein R, Bye P, Anderson S, King G, Berend N, Gibson P; National Health and Medical Research Council (NHMRC)/Centre of Clinical Research Excellence.
  • Environmental influences on allergic airways disease from birth to 8yrs: long-term outcomes of a randomised trial (CAPS); Marks G, Kemp A, Tovey E, Britton W, Jones G, Leeder S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • High performance liquid chromatography for analysis of mycobacterial and liver proteins and drugs.; Britton W; Ken & Alse Chilton Charitable trus/Project Support.

2004

  • Interactions between HIV and mycobacterial infections of macrophages mediated by changes in gene expression; Cunningham A, Britton W, Slobedman B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Verdi V2 DPSS laser system; Fazekas B, Rasko J, Britton W, Tangye S, Brink R, Basten A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Novel mycobacterial reporter systems for measuring T-Cell responses to tuberculosis and new vaccines; Britton W; DVC Research/Research and Development Scheme: Research and Development (R&D).
  • Molecular approaches to developing subunit vaccines with improved efficacy against tuberculosis; Britton W, Briscoe H, Triccas J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Genetic and environmental risk factors for progression to active tuberculosis in the Liverpool cohort; Britton W; Community Health and Tuberculosis Australia (CHATA)/Harry Windsor Research Grant.

2003

  • Membrane TNF and lymphotoxin control of chemokine induction and inflammation in turberculosis.; Saunders B, Britton W, Briscoe H; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Attenuated and recombinant mycobacterial strains as novel vaccines to control tuberculosis; Britton W, Triccas J; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Cell migration and granuloma formation in the expression of protective immunity against tuberculosis in the lung; Britton W, Saunders B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Improved vaccines against tuberculosis; Britton W, Briscoe H; National Health and Medical Research Council (NHMRC)/Project Grants.
  • A recombinant protein facility at the University of Sydney; Christopherson R, Wake R, Basten A, Britton W; WELLCOME TRUST/Major Equipment Awards for Biomedical Research in Australia.

2000

  • Does neonatal vaccination with BCG reduce the subsequent incidence of allergic sensitisation?; Marks G, Britton W, Woolcock A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Genetic adaptation of Mycobacterium tuberculosis for intracellular survival; Britton W, Briscoe H; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Edited Books

  • Kaufmann, S., Britton, W. (2008). Handbook of Tuberculosis: Immunology and Cell Biology. Germany: Wiley - V C H Verlag GmbH & Co. KGaA.

Book Chapters

  • Britton, W., Saunders, B. (2010). Pathology and Pathogenesis of Bacterial Infections. In Stefan H. E. Kaufmann, Barry Rouse, David Sacks (Eds.), Immunology of Infectious Diseases, (pp. 260-265). United States of America: ASM Press.
  • O'Garra, A., Britton, W. (2008). Cytokines in Tuberculosis. In S.H.E. Kaufmann; W. J. Britton (Eds.), Handbook of Tuberculosis: Immunology and Cell Biology, (pp. 185-225). Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Britton, W., Triccas, J. (2008). The constituents of the cell envelope and their impact on the host immune system. In Daffe M; Reyrat J-M (Eds.), The Mycobacterial Cell Envelope, (pp. 249-270). Washington DC: ASM Press.
  • Britton, W., Fernando, S., Saunders, B., Sluyter, R., Wiley, J. (2007). The genetic control of susceptibility to Mycobacterium tuberculosis. In Gregory Bock(Organizer) and Jamie Goode (Eds.), Decoding the Genomic Control of Immune Reactions, (pp. 79-92). United Kingdom: John Wiley & Sons. [More Information]

Journals

  • Chan, J., Duke, C., Ong, H., Chan, J., Tyne, A., Chan, H., Britton, W., Young, P., Traini, D. (2014). A Novel Inhalable Form of Rifapentine. Journal of Pharmaceutical Sciences, 103(5), 1141-1421. [More Information]
  • Chan, J., Tyne, A., Pang, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2014). A Rifapentine-Containing Inhaled Triple Antibiotic Formulation for Rapid Treatment of Tubercular Infection. Pharmaceutical Research, 31(5), 1239-1253. [More Information]
  • Majumdar, S., Marais, B., Denholm, J., Britton, W. (2014). Drug-resistant tuberculosis: collaborative regional leadership required. Medical Journal of Australia, 200(5), 241-242. [More Information]
  • Gunaratnam, P., Britton, W., Hofmeyr, A. (2013). Bug breakfast in the bulletin: Leprosy. NSW Public Health Bulletin, 24(1), 50-50.
  • Fox, G., Barry, S., Britton, W., Marks, G. (2013). Contact investigation for tuberculosis: a systematic review and meta-analysis. The European Respiratory Journal, 41(1), 140-156. [More Information]
  • Burke, C., Liu, M., Britton, W., Triccas, J., Thomas, T., Smith, A., Allen, S., Salomon, R., Harry, E. (2013). Harnessing single cell sorting to identify cell division genes and regulators in bacteria. PLoS One, 8(4), 1-13. [More Information]
  • Pinto, R., Leotta, L., Shanahan, E., West, N., Leyh, T., Britton, W., Triccas, J. (2013). Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. The Journal of Infectious Diseases, 207(5), 778-785. [More Information]
  • Fox, G., Nhung, N., Sy, D., Britton, W., Marks, G. (2013). Household contact investigation for tuberculosis in Vietnam: study protocol for a cluster randomized controlled trial. Trials, 14(1), 1-7. [More Information]
  • Florido, M., Grima, M., Gillis, C., Xia, Y., Turner, S., Triccas, J., Stambas, J., Britton, W. (2013). Influenza A Virus Infection Impairs Mycobacteria-Specific T Cell Responses and Mycobacterial Clearance in the Lung during Pulmonary Coinfection. Journal of Immunology, 191(1), 302-311. [More Information]
  • Tran, A., Wen, D., West, N., Baker, E., Britton, W., Payne, R. (2013). Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry, 11(46), 8113-8126. [More Information]
  • Walters, S., Kieckbusch, J., Nagalingam, G., Swain, A., Latham, S., Grau, G., Britton, W., Combes, V., Saunders, B. (2013). Microparticles from Mycobacteria-Infected Macrophages Promote Inflammation and Cellular Migration. Journal of Immunology, 190(2), 669-677. [More Information]
  • Ritz, N., Casalaz, D., Hanekom, W., Britton, W., Dutta, B., Donath, S., Connell, T., Tebruegge, M., Robins-Browne, R., Curtis, N. (2013). Reply: Bacille calmette-guérin vaccine: Innate immunity and nonspecific effects. American Journal of Respiratory and Critical Care Medicine, 187(7), 779-780. [More Information]
  • Tyne, A., Chan, J., Shanahan, E., Atmosukarto, I., Chan, H., Britton, W., West, N. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31(40), 4322-4329. [More Information]
  • Giltrap, A., Cergol, K., Pang, A., Britton, W., Payne, R. (2013). Total Synthesis of Fellutamide B and Deoxy-Fellutamides B, C, and D. Marine Drugs, 11(7), 2382-2397. [More Information]
  • Ritz, N., Strach, M., Yau, C., Dutta, B., Tebruegge, M., Connell, T., Hanekom, W., Britton, W., Robins-Browne, R., Curtis, N. (2012). A comparative analysis of polyfunctional T cells and secreted cytokines induced by Bacille Calmette-Guerin immunisation in children and adults. PLoS One, 7(7), 1-12. [More Information]
  • Fox, G., Nhung, N., Sy, D., Lien, L., Cuong, N., Britton, W., Marks, G. (2012). Contact investigation in households of patients with tuberculosis in hanoi, Vietnam: a prospective cohort study. PLoS One, 7(11), 1-7. [More Information]
  • Tran, A., West, N., Britton, W., Payne, R. (2012). Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy. ChemMedChem: chemistry enabling drug discovery, 7(6), 1031-1043. [More Information]
  • Blumenthal, A., Nagalingam, G., Huch, J., Walker, L., Guillemin, G., Smythe, G., Ehrt, S., Britton, W., Saunders, B. (2012). M. tuberculosis Induces Potent Activation of IDO-1, but This Is Not Essential for the Immunological Control of Infection. PLoS One, 7(5), 1-11. [More Information]
  • Nambiar, J., Pinto, R., Aguilo, J., Takatsu, K., Martin, C., Britton, W., Triccas, J. (2012). Protective immunity afforded by attenuated, PhoP-deficient Mycobacterium tuberculosis is associated with sustained generation of CD4+ T-cell memory. European Journal of Immunology, 42(2), 385-392. [More Information]
  • Gracey, D., Garsia, R., Britton, W., McKenzie, P. (2012). Rapid recovery of renal function after pulse steroid therapy in a human immunodeficiency virus-infected patient with glomerulonephritis. Internal Medicine Journal, 42(12), 1363-1365. [More Information]
  • Manos-Turvey, A., Cergol, K., Salam, N., Bulloch, E., Chi, G., Pang, A., Britton, W., West, N., Baker, E., Lott, J., Payne, R. (2012). Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Organic and Biomolecular Chemistry, 10(46), 9223-9236. [More Information]
  • Ritz, N., Dutta, B., Donath, S., Casalaz, D., Connell, T., Tebruegge, M., Robins-Browne, R., Hanekom, W., Britton, W., Curtis, N. (2012). The Influence of Bacille Calmette-Guerin Vaccine Strain on the Immune Response against Tuberculosis: A Randomized Trial. American Journal of Respiratory and Critical Care Medicine, 185(2), 213-222. [More Information]
  • Kao, F., Mahmuda, S., Pinto, R., Triccas, J., West, N., Britton, W. (2012). The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice. PLoS One, 7(5), 1-12. [More Information]
  • West, N., Thomson, S., Triccas, J., Medveczky, C., Ramshaw, I., Britton, W. (2011). Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis. Vaccine, 29(44), 7759-7765. [More Information]
  • West, N., Cergol, K., Xue, M., Randall, E., Britton, W., Payne, R. (2011). Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chemical Communications, 47(18), 5166-5168. [More Information]
  • Fox, G., Britton, W. (2011). Learning from the genetics of enteric tuberculosis. Journal of Gastroenterology and Hepatology, 26(7), 1086-1088. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and Evaluation of Potent Ene-yne inhibitors of type II Dehydroquinases as Tuberculosis Drug Leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]
  • Shanahan, E., Pinto (Pinto-Nadanachandran), R., Triccas, J., Britton, W., West, N. (2010). Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine. Vaccine, 28(5), 1341-1346. [More Information]
  • Spratt, J., Britton, W., Triccas, J. (2010). In vivo persistence and protective efficacy of the bacille Calmette Guerin vaccine overexpressing the HspX latency antigen. Bioengineered Bugs, 1(1), 61-65. [More Information]
  • Musicki, K., Briscoe, H., Britton, W., Saunders, B. (2010). LIGHT contributes to early but not late control of Mycobacterium tuberculosis infection. International Immunology, 22(5), 353-358. [More Information]
  • Nambiar, J., Ryan, A., Kong, C., Britton, W., Triccas, J. (2010). Modulation of pulmonary DC function by vaccine-encoded GM-CSF enhances protective immunity against Mycobacterium tuberculosis infection. European Journal of Immunology, 40(1), 153-161. [More Information]
  • Wozniak, T., Saunders, B., Ryan, A., Britton, W. (2010). Mycobacterium bovis BCG-Specific Th17 Cells Confer Partial Protection against Mycobacterium tuberculosis Infection in the Absence of Gamma Interferon. Infection and Immunity, 78(10), 4187-4194. [More Information]
  • Tran, A., Cergol, K., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2010). Rapid assembly of potent type II dehydroquinase inhibitors via "click" chemistry. MedChemComm (Medicinal Chemistry Communications), 1(4), 271-275.
  • Crellin, P., Vivian, J., Scoble, J., Chow, F., West, N., Brammananth, R., Proellocks, N., Shahine, A., Le Nours, J., Wilce, M., Britton, W., et al (2010). Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability. Journal of Biological Chemistry, 285(39), 30050-30060. [More Information]
  • Ryan, A., Nambiar, J., Wozniak, T., Roediger, B., Shklovskaya, E., Britton, W., Fazekas, B., Triccas, J. (2009). Antigen load governs the differential priming of CD8 T cells in response to the bacille Calmette Guerin vaccine or Mycobacterium tuberculosis infection. Journal of Immunology, 182(11), 7172-7177. [More Information]
  • West, N., Chow, F., Randall, E., Wu, J., Chen, J., Ribeiro, J., Britton, W. (2009). Cutinase-like proteins of Mycobacterium tuberculosis: characterization of their variable enzymatic functions and active site identification. The F A S E B Journal, 23(6), 1-11. [More Information]
  • Maddocks, S., Scandurra, G., Nourse, C., Bye, C., Williams, R., Slobedman, B., Cunningham, A., Britton, W. (2009). Gene expression in HIV-1/Mycobacterium tuberculosis co-infected macrophages is dominated by M. tuberculosis. Tuberculosis, 89(4), 285-293. [More Information]
  • Hagge, D., Saunders, B., Ebenezer, G., Ray, N., Marks, V., Britton, W., Krahenbuhl, J., Adams, L. (2009). Lymphotoxin-alpha and TNF have essential but independent roles in the evolution of the granulomatous response in experimental leprosy. The American Journal of Pathology: cellular and molecular biology of disease, 174(4), 1379-1389. [More Information]
  • Weir, R., Fine, P., Floyd, S., Stenson, S., Carolynne, S., Branson, K., Britton, W., Huygen, K., Singh, M., Black, G., et al (2008). Comparison of IFN-gamma responses to mycobacterial antigens as markers of response to BCG vaccination. Tuberculosis, 88(1), 31-38. [More Information]
  • West, N., Wozniak, T., Valenzuela, J., Feng, C., Sher, A., Ribeiro, J., Britton, W. (2008). Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis. Vaccine, 26(31), 3853-3859. [More Information]
  • Scandurra, G., Britton, W., Triccas, J. (2008). Inactivation of the Mycobacterium tuberculosis fadB4 gene results in increased virulence in host cell and mice. Microbes and Infection, 10, 38-44. [More Information]
  • Ritz, N., Hanekom, W., Robins-Browne, R., Britton, W., Curtis, N. (2008). Influence of BCG vaccine strain on the immune response and protection against tuberculosis. FEMS Microbiology Reviews, 32(5), 821-841. [More Information]
  • Almqvist, C., Li, Q., Britton, W., Kemp, A., Xuan, W., Tovey, E., Marks, G. (2007). Early predictors for developing allergic disease and asthma - separate steps in the 'allergic march'. Allergy, 62(Suppl. 83), 65.
  • Almqvist, C., Li, Q., Britton, W., Kemp, A., Xuan, W., Tovey, E., Marks, G. (2007). Early predictors for developing allergic disease and asthma: examining separate steps in the 'allergic march'. Clinical and Experimental Allergy, 37(9), 1296-1302. [More Information]
  • Triccas, J., Shklovskaya, E., Spratt, J., Ryan, A., Palindera, U., Fazekas, B., Britton, W. (2007). Effects of DNA- and Mycobacterium bovis BCG-based delivery of Flt3 ligand on protective immunity to Mycobacterium tuberculosis. Infection and Immunity, 75(11), 5368-5375. [More Information]
  • Weber-Chrysochoou, C., Crisafulli, D., Almqvist, C., Li, Q., Kemp, A., Britton, W., Marks, G. (2007). IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life. Journal of Allergy and Clinical Immunology, 120(2), 286-292. [More Information]
  • Ryan, A., Wozniak, T., Shklovskaya, E., O’Donnell, M., Fazekas, B., Britton, W., Triccas, J. (2007). Improved protection against disseminated tuberculosis by Mycobacterium bovis bacillus Calmette-Guerin secreting murine GM-CSF Is associated with expansion and activation of APCs. Journal of Immunology, 179(12), 8418-8424. [More Information]
  • Saunders, B., Britton, W. (2007). Life and death in the granuloma: immunopathology of tuberculosis. Immunology and Cell Biology, 85, 103-111. [More Information]
  • Saunders, B., Britton, W. (2007). Review: Life and death in the granuloma: immunopathology of tuberculosis. Immunology and Cell Biology, 85(2), 103-111. [More Information]
  • Fernando, S., Saunders, B., Sluyter, R., Skarratt, K., Goldburg, H., Marks, G., Wiley, J., Britton, W. (2006). A Polymorphism in the P2X7 Gene Increases Susceptibility to Extrapulmonary Tuberculosis. American Journal of Respiratory and Critical Care Medicine, 175(4), 360-366. [More Information]
  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2006). A Thr(357) to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X(7) function and impairs ATP-induced mycobacterial killing by macrophages. Journal of Biological Chemistry, 281(4), 2079-2086. [More Information]
  • Scandurra, G., Ryan, A., Pinto (Pinto-Nadanachandran), R., Britton, W., Triccas, J. (2006). Contribution of L-Alanine Dehydrogenase to In Vivo Persistence and Protective Efficacy of the BCG Vaccine. Microbiology and immunology, 50(10), 805-810. [More Information]
  • Musicki, K., Briscoe, H., Tran, S., Britton, W., Saunders, B. (2006). Differential requirements for soluble and transmembrane tumor necrosis factor in the immunological control of primary and secondary Listeria monocytogenes infection. Infection and Immunity, 74(6), 3180-3189. [More Information]
  • Scandurra, G., Williams, R., Triccas, J., Pinto (Pinto-Nadanachandran), R., Gicquel, B., Slobedman, B., Cunningham, A., Britton, W. (2006). Effect of phthiocerol dimycocerosate deficiency on the transcriptional response of human macrophages to Mycobacterium tuberculosis. Microbes and Infection, 9(1), 87-95. [More Information]
  • Fernando, S., Britton, W. (2006). Genetic susceptibility to mycobacterial disease in humans. Immunology and Cell Biology, 84(2), 125-137. [More Information]
  • Wozniak, T., Ryan, A., Britton, W. (2006). Interleukin-23 Restores Immunity to Mycobacterium tuberculosis Infection in IL-12p40-Deficient Mice and Is Not Required for the Development of IL-17-Secreting T Cell Responses. Journal of Immunology, 177(12), 8684-8692. [More Information]
  • Wozniak, T., Ryan, A., Triccas, J., Britton, W. (2006). Plasmid interleukin-23 (IL-23), but not plasmid IL-27, enhances the protective efficacy of a DNA vaccine against Mycobacterium tuberculosis infection. Infection and Immunity, 74(1), 557-565. [More Information]
  • Ryan, A., Spratt, J., Britton, W., Triccas, J. (2006). Secretion of functional Monocyte Chemotactic Protein-3 by recombinant Mycobacterium bovis BCG attenuates vaccine virulence and maintains protective efficacy against M. tuberculosis infection. Infection and Immunity, 75(1), 523-526. [More Information]
  • Spratt, J., Ryan, A., Britton, W., Triccas, J. (2005). Epitope-tagging vectors for the expression and detection of recombinant proteins in mycobacteria. Plasmid, 53(3), 269-273. [More Information]
  • Palendira, U., Spratt, D., Britton, W., Triccas, J. (2005). Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection. Vaccine, 23(14), 1680-1685. [More Information]
  • Fernando, S., Saunders, B., Sluyter, R., Skarratt, K., Wiley, J., Britton, W. (2005). Gene Dosage Determines the Negative Effects of Polymorphic Alleles of the P2X7 Receptor on Adenosine Triphosphate–Mediated Killing of Mycobacteria by Human Macrophages. The Journal of Infectious Diseases, 192(1), 149-155. [More Information]
  • Roach, D., Briscoe, H., Saunders, B., Britton, W. (2005). Independent protective effects for tumor necrosis factor and lymphotoxin alpha in the host response to Listeria monocytogenes infection. Infection and Immunity, 73(8), 4787-4792. [More Information]
  • Britton, W., Gilbert, G., Wheatley, J., Leslie, D., Rothel, J., Jones, S., Bradley, P. (2005). Sensitivity of human gamma interferon assay and tuberculin skin testing for detecting infection with Mycobacterium tuberculosis in patients with culture positive tuberculosis. Tuberculosis, 85(3), 137-145. [More Information]
  • Demangel, C., Zhou, J., Choo, A., Shoebridge, G., Halliday, G., Britton, W. (2005). Single chain antibody fragments for the selective targeting of antigens to dendritic cells. Molecular Immunology, 42(8), 979-985. [More Information]
  • Saunders, B., Tran, S., Ruuls, S., Sedgwick, J., Briscoe, H., Britton, W. (2005). Transmembrane TNF is sufficient to initiate cell migration and granuloma formation and provide acute, but not long-term, control of Mycobacterium tuberculosis infection. Journal of Immunology, 174(8), 4852-4859. [More Information]
  • Britton, W., Lockwood, D. (2004). Leprosy. The Lancet, 363(9416), 1209-1219.
  • Pinto (Pinto-Nadanachandran), R., Saunders, B., Britton, W., Camacho, L., Gicquel, B., Triccas, J. (2004). Mycobacterium Tuberculosis Defective In Phthiocerol Dimycocerosate Translocation Provides Greater Protective Immunity Against Tuberculosis Than The Existing Bacille Calmette-Gu?Rin Vaccine. The Journal of Infectious Diseases, 189(1), 105-112.
  • Briscoe, H., Britton, W., Saunders, B. (2004). T Cell-Derived Tumour Necrosis Factor Is Essential, But Not Sufficient, For Protection Against Mycobacterium Tuberculosis Infection. Clinical and Experimental Immunology, 137(2), 279-287.
  • van Broekhoven, C., Parish, C., Demangel, C., Britton, W., Altin, J. (2004). Targeting Dendritic Cells With Antigen-Containing Liposomes: A Highly Effective Procedure For Induction Of Antitumor Immunity And For Tumor Immunotherapy. Cancer Research, 64(12), 4357-4365.
  • Pinto (Pinto-Nadanachandran), R., Tang, Q., Britton, W., Leyh, T., Triccas, J. (2004). The Mycobacterium Tuberculosis Cysd And Cysnc Genes Form A Stress-Induced Operon That Encodes A Tri-Functional Sulfate-Activating Complex. Microbiology, 150(6), 1681-1686.
  • Saunders, B., Fernando, S., Sluyter, R., Britton, W., Wiley, J. (2003). A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of Mycobacteria. Journal of Immunology, 171(10), 5442-5446.
  • Mihrshahi, S., Peat, J., Marks, G., Mellis, C., Tovey, E., Webb, K., Britton, W., Leeder, S. (2003). Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the Childhood Asthma Prevention Study (CAPS). Journal of Allergy and Clinical Immunology, 111(1), 162-168. [More Information]
  • Black, G., Weir, R., Chaguluka, S., Warndorff, D., Crampin, A., Mwaungulu, L., Sichali, L., Floyd, S., Bliss, L., Jarman, E., Britton, W., et al (2003). Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis BCG-Vaccinated Malawian young adults. Clinical and Diagnostic Laboratory Immunology, 10(4), 602-611.
  • Spratt, J., Britton, W., Triccas, J. (2003). Identification of strong promoter elements of Mycobacterium smegmatis and their utility for foreign gene expression in mycobacteria. FEMS Microbiology Letters, 224(1), 139-142.
  • Britton, W., Palendira, U. (2003). Improving vaccines against tuberculosis. Immunology and Cell Biology, 81(1), 34-45.
  • Pinto, R., Saunders, B., Camacho, L., Britton, W., Gicquel, B., Triccas, J. (2003). Mycobacterium tuberculosis defective in phthiocerol dimycocerosate translocation provides greater protective immunity against tuberculosis than existing Bacille Calmette-Guerin Vaccine. The Journal of Infectious Diseases, 11, 105-112.
  • Martin, E., Kamath, A., Briscoe, H., Britton, W. (2003). The combination of plasmid interleukin-12 with a single DNA vaccine is more effective than Myobacterium bovis (bacille Calmette-Guerin) in protecting against systemic Mycobacterim avium infection. Immunology, 109(2), 308-314.
  • Marks, G., Ng, K., Zhou, J., Toelle, B., Xuan, W., Belousova, E., Britton, W. (2003). The effect of neonatal BCG vaccination on atopy and asthma at age 7 to 14 years: A historical cohort study in a community with a very low prevalence of tuberculosis infection and a high prevalence of atopic disease. Journal of Allergy and Clinical Immunology, 111(3), 541-549.
  • Demangel, C., Bertolino, P., Britton, W. (2002). Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. European Journal of Immunology, 32(4), 994-1002.
  • Saunders, B., Dane, A., Briscoe, H., Britton, W. (2002). Characterization of immune responses during infection with Mycobacterium avium strains 100, 101 and the recently sequenced 104. Immunology and Cell Biology, 80(6), 544-549.
  • Umaimainthan, P., Kamath, A., Feng, C., Martin, E., Chaplin, P., Triccas, J., Britton, W. (2002). Coexpression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis. Infection and Immunity, 70(4), 1949-1956.
  • Triccas, J., Sun, L., Umaimainthan, P., Britton, W. (2002). Comparative affects of plasmid-encoded interleukin 12 and interleukin 18 on the protective efficacy of DNA vaccination againt Mycobacterium tuberculosis. Immunology and Cell Biology, 80(1), 346-350.
  • Marks, G., Zhou, J., Yang, H., Joshi, P., Bishop, A., Britton, W., The Caps Investigators, (. (2002). Cord blood mononuclear cell cytokine responses in relation to maternal house dust mite allergen exposure. Clinical and Experimental Allergy, 32(3), 355-360.
  • Pinto (Pinto-Nadanachandran), R., Britton, W., Triccas, J. (2002). Destabilized green fluorescent protein for monitoring transient changes in mycobacterial gene expression. Research in Microbiology, 153(6), 379-383.
  • Karihaloo, C., Tovey, E., Mitakakis, T., Britton, W., Duffy, D. (2002). Evidence for the genetic control of immunoglobulin E reactivity to the allergens of Alternaria alternata. Clinical and Experimental Allergy, 32, 1316-1322.
  • Umaimainthan, P., Bean, A., Feng, C., Britton, W. (2002). Lymphocyte recruitment and protective efficacy against pulmonary mycobacterial infection are independent of the route of prior Mycobacterium bovis BCG immunization. Infection and Immunity, 70(3), 1410-1416.
  • Roach, D., Bean, A., Demangel, C., France, M., Briscoe, H., Britton, W. (2002). TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection. Journal of Immunology, 168(9), 4620-4627.
  • Britton, W., Martin, E., Triccas, J., Kamath, A., Winter, N. (2001). Comparative protective effects of recombinant DNA and Mycobacterium bovis bacille Calmette-Guerin vaccines againts M. avium infection. Clinical and Experimental Immunology, 126, 482-487.
  • Feng, C., Britton, W., Demangel, C., Kamath, A., Macdonald, M. (2001). Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8+ T cells with specificity for a novel mycobacterial epitope. International Immunology, 13, 451-458.
  • Britton, W., Roche, P., Triccas, J., Martin, E. (2001). DNA encoding a single mycobacterial antigen protects against leprosy infection. Vaccine, 19, 1391-1396.
  • Roach, D., Martin, E., Briscoe, H., Britton, W., Bean, A., Rennick, D. (2001). Endogenous inhibition of antimycobacterial immunity by IL-10 varies between mycobacterial species. Scandinavian Journal of Immunology, 54, 163-170.
  • Feng, C., Britton, W., Blanchard,, T., Smith, G., Hill, A. (2001). Induction of CD8+ T-lymphocyte responses to a secreted antigen of Mycobacterium tuberculosis by an attenuated vaccine virus. Immunology and Cell Biology, 79, 569-575.
  • Britton, W., Triccas, J., Gicquel,, B. (2001). Isolation of strong expression signals of Mycobacterium tuberculosis. Microbiology, 147, 1253-1258.
  • Feng, C., Umaimainthan, P., Britton, W., Demangel, C., Spratt, J., Malin, A. (2001). Priming by DNA immunization augments protective efficacy of Mycobacterium bovis bacille Calmette-Guerin against tuberculosis. Infection and Immunity, 69, 4174-4176.
  • Roach, D., Briscoe, H., Saunders, B., France, M., Riminton, S., Britton, W. (2001). Secreted lymphotoxin-alpha is essential for the control of an intracellular bacterial infection. The Journal of Experimental Medicine, 193, 239-246.
  • Umaimainthan, P., Feng, C., Britton, W., Demangel, C., Heath, A., Bean, A. (2001). Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection. Infection and Immunity, 69, 2456-2461.
  • Britton, W., Roche, P., Neupane,, K., Failbus, S., Kamath, A. (2001). Vaccination with DNA of the Mycobaterium tuberculosis 85B antigen protects mouse foot pad against infection with M. leprae. International Journal of Leprosy and Other Mycobacterial Diseases, 69, 93-98.

Conferences

  • Chan, J., Tyne, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2013). A novel inhaled antibiotic powder to shorten treatment time for latent tuberculosis. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Britton, W., Ritz, N., Robins-Browne, R., Curtis, N. (2007). Does BCG strain matter?
  • Saunders, B., Fernando, S., Marks, G., Sluyter, R., Wiley, S., Britton, W. (2005). A single nucleotide polymorphism in the P2X7 gene lends susceptibility to extrapulmonary tuberculosis. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2005). A Thr(357) to ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.

2014

  • Chan, J., Duke, C., Ong, H., Chan, J., Tyne, A., Chan, H., Britton, W., Young, P., Traini, D. (2014). A Novel Inhalable Form of Rifapentine. Journal of Pharmaceutical Sciences, 103(5), 1141-1421. [More Information]
  • Chan, J., Tyne, A., Pang, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2014). A Rifapentine-Containing Inhaled Triple Antibiotic Formulation for Rapid Treatment of Tubercular Infection. Pharmaceutical Research, 31(5), 1239-1253. [More Information]
  • Majumdar, S., Marais, B., Denholm, J., Britton, W. (2014). Drug-resistant tuberculosis: collaborative regional leadership required. Medical Journal of Australia, 200(5), 241-242. [More Information]

2013

  • Chan, J., Tyne, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2013). A novel inhaled antibiotic powder to shorten treatment time for latent tuberculosis. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Gunaratnam, P., Britton, W., Hofmeyr, A. (2013). Bug breakfast in the bulletin: Leprosy. NSW Public Health Bulletin, 24(1), 50-50.
  • Fox, G., Barry, S., Britton, W., Marks, G. (2013). Contact investigation for tuberculosis: a systematic review and meta-analysis. The European Respiratory Journal, 41(1), 140-156. [More Information]
  • Burke, C., Liu, M., Britton, W., Triccas, J., Thomas, T., Smith, A., Allen, S., Salomon, R., Harry, E. (2013). Harnessing single cell sorting to identify cell division genes and regulators in bacteria. PLoS One, 8(4), 1-13. [More Information]
  • Pinto, R., Leotta, L., Shanahan, E., West, N., Leyh, T., Britton, W., Triccas, J. (2013). Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. The Journal of Infectious Diseases, 207(5), 778-785. [More Information]
  • Fox, G., Nhung, N., Sy, D., Britton, W., Marks, G. (2013). Household contact investigation for tuberculosis in Vietnam: study protocol for a cluster randomized controlled trial. Trials, 14(1), 1-7. [More Information]
  • Florido, M., Grima, M., Gillis, C., Xia, Y., Turner, S., Triccas, J., Stambas, J., Britton, W. (2013). Influenza A Virus Infection Impairs Mycobacteria-Specific T Cell Responses and Mycobacterial Clearance in the Lung during Pulmonary Coinfection. Journal of Immunology, 191(1), 302-311. [More Information]
  • Tran, A., Wen, D., West, N., Baker, E., Britton, W., Payne, R. (2013). Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry, 11(46), 8113-8126. [More Information]
  • Walters, S., Kieckbusch, J., Nagalingam, G., Swain, A., Latham, S., Grau, G., Britton, W., Combes, V., Saunders, B. (2013). Microparticles from Mycobacteria-Infected Macrophages Promote Inflammation and Cellular Migration. Journal of Immunology, 190(2), 669-677. [More Information]
  • Ritz, N., Casalaz, D., Hanekom, W., Britton, W., Dutta, B., Donath, S., Connell, T., Tebruegge, M., Robins-Browne, R., Curtis, N. (2013). Reply: Bacille calmette-guérin vaccine: Innate immunity and nonspecific effects. American Journal of Respiratory and Critical Care Medicine, 187(7), 779-780. [More Information]
  • Tyne, A., Chan, J., Shanahan, E., Atmosukarto, I., Chan, H., Britton, W., West, N. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31(40), 4322-4329. [More Information]
  • Giltrap, A., Cergol, K., Pang, A., Britton, W., Payne, R. (2013). Total Synthesis of Fellutamide B and Deoxy-Fellutamides B, C, and D. Marine Drugs, 11(7), 2382-2397. [More Information]

2012

  • Ritz, N., Strach, M., Yau, C., Dutta, B., Tebruegge, M., Connell, T., Hanekom, W., Britton, W., Robins-Browne, R., Curtis, N. (2012). A comparative analysis of polyfunctional T cells and secreted cytokines induced by Bacille Calmette-Guerin immunisation in children and adults. PLoS One, 7(7), 1-12. [More Information]
  • Fox, G., Nhung, N., Sy, D., Lien, L., Cuong, N., Britton, W., Marks, G. (2012). Contact investigation in households of patients with tuberculosis in hanoi, Vietnam: a prospective cohort study. PLoS One, 7(11), 1-7. [More Information]
  • Tran, A., West, N., Britton, W., Payne, R. (2012). Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy. ChemMedChem: chemistry enabling drug discovery, 7(6), 1031-1043. [More Information]
  • Blumenthal, A., Nagalingam, G., Huch, J., Walker, L., Guillemin, G., Smythe, G., Ehrt, S., Britton, W., Saunders, B. (2012). M. tuberculosis Induces Potent Activation of IDO-1, but This Is Not Essential for the Immunological Control of Infection. PLoS One, 7(5), 1-11. [More Information]
  • Nambiar, J., Pinto, R., Aguilo, J., Takatsu, K., Martin, C., Britton, W., Triccas, J. (2012). Protective immunity afforded by attenuated, PhoP-deficient Mycobacterium tuberculosis is associated with sustained generation of CD4+ T-cell memory. European Journal of Immunology, 42(2), 385-392. [More Information]
  • Gracey, D., Garsia, R., Britton, W., McKenzie, P. (2012). Rapid recovery of renal function after pulse steroid therapy in a human immunodeficiency virus-infected patient with glomerulonephritis. Internal Medicine Journal, 42(12), 1363-1365. [More Information]
  • Manos-Turvey, A., Cergol, K., Salam, N., Bulloch, E., Chi, G., Pang, A., Britton, W., West, N., Baker, E., Lott, J., Payne, R. (2012). Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Organic and Biomolecular Chemistry, 10(46), 9223-9236. [More Information]
  • Ritz, N., Dutta, B., Donath, S., Casalaz, D., Connell, T., Tebruegge, M., Robins-Browne, R., Hanekom, W., Britton, W., Curtis, N. (2012). The Influence of Bacille Calmette-Guerin Vaccine Strain on the Immune Response against Tuberculosis: A Randomized Trial. American Journal of Respiratory and Critical Care Medicine, 185(2), 213-222. [More Information]
  • Kao, F., Mahmuda, S., Pinto, R., Triccas, J., West, N., Britton, W. (2012). The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice. PLoS One, 7(5), 1-12. [More Information]

2011

  • West, N., Thomson, S., Triccas, J., Medveczky, C., Ramshaw, I., Britton, W. (2011). Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis. Vaccine, 29(44), 7759-7765. [More Information]
  • West, N., Cergol, K., Xue, M., Randall, E., Britton, W., Payne, R. (2011). Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chemical Communications, 47(18), 5166-5168. [More Information]
  • Fox, G., Britton, W. (2011). Learning from the genetics of enteric tuberculosis. Journal of Gastroenterology and Hepatology, 26(7), 1086-1088. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and Evaluation of Potent Ene-yne inhibitors of type II Dehydroquinases as Tuberculosis Drug Leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]

2010

  • Shanahan, E., Pinto (Pinto-Nadanachandran), R., Triccas, J., Britton, W., West, N. (2010). Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine. Vaccine, 28(5), 1341-1346. [More Information]
  • Spratt, J., Britton, W., Triccas, J. (2010). In vivo persistence and protective efficacy of the bacille Calmette Guerin vaccine overexpressing the HspX latency antigen. Bioengineered Bugs, 1(1), 61-65. [More Information]
  • Musicki, K., Briscoe, H., Britton, W., Saunders, B. (2010). LIGHT contributes to early but not late control of Mycobacterium tuberculosis infection. International Immunology, 22(5), 353-358. [More Information]
  • Nambiar, J., Ryan, A., Kong, C., Britton, W., Triccas, J. (2010). Modulation of pulmonary DC function by vaccine-encoded GM-CSF enhances protective immunity against Mycobacterium tuberculosis infection. European Journal of Immunology, 40(1), 153-161. [More Information]
  • Wozniak, T., Saunders, B., Ryan, A., Britton, W. (2010). Mycobacterium bovis BCG-Specific Th17 Cells Confer Partial Protection against Mycobacterium tuberculosis Infection in the Absence of Gamma Interferon. Infection and Immunity, 78(10), 4187-4194. [More Information]
  • Britton, W., Saunders, B. (2010). Pathology and Pathogenesis of Bacterial Infections. In Stefan H. E. Kaufmann, Barry Rouse, David Sacks (Eds.), Immunology of Infectious Diseases, (pp. 260-265). United States of America: ASM Press.
  • Tran, A., Cergol, K., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2010). Rapid assembly of potent type II dehydroquinase inhibitors via "click" chemistry. MedChemComm (Medicinal Chemistry Communications), 1(4), 271-275.
  • Crellin, P., Vivian, J., Scoble, J., Chow, F., West, N., Brammananth, R., Proellocks, N., Shahine, A., Le Nours, J., Wilce, M., Britton, W., et al (2010). Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability. Journal of Biological Chemistry, 285(39), 30050-30060. [More Information]

2009

  • Ryan, A., Nambiar, J., Wozniak, T., Roediger, B., Shklovskaya, E., Britton, W., Fazekas, B., Triccas, J. (2009). Antigen load governs the differential priming of CD8 T cells in response to the bacille Calmette Guerin vaccine or Mycobacterium tuberculosis infection. Journal of Immunology, 182(11), 7172-7177. [More Information]
  • West, N., Chow, F., Randall, E., Wu, J., Chen, J., Ribeiro, J., Britton, W. (2009). Cutinase-like proteins of Mycobacterium tuberculosis: characterization of their variable enzymatic functions and active site identification. The F A S E B Journal, 23(6), 1-11. [More Information]
  • Maddocks, S., Scandurra, G., Nourse, C., Bye, C., Williams, R., Slobedman, B., Cunningham, A., Britton, W. (2009). Gene expression in HIV-1/Mycobacterium tuberculosis co-infected macrophages is dominated by M. tuberculosis. Tuberculosis, 89(4), 285-293. [More Information]
  • Hagge, D., Saunders, B., Ebenezer, G., Ray, N., Marks, V., Britton, W., Krahenbuhl, J., Adams, L. (2009). Lymphotoxin-alpha and TNF have essential but independent roles in the evolution of the granulomatous response in experimental leprosy. The American Journal of Pathology: cellular and molecular biology of disease, 174(4), 1379-1389. [More Information]

2008

  • Weir, R., Fine, P., Floyd, S., Stenson, S., Carolynne, S., Branson, K., Britton, W., Huygen, K., Singh, M., Black, G., et al (2008). Comparison of IFN-gamma responses to mycobacterial antigens as markers of response to BCG vaccination. Tuberculosis, 88(1), 31-38. [More Information]
  • O'Garra, A., Britton, W. (2008). Cytokines in Tuberculosis. In S.H.E. Kaufmann; W. J. Britton (Eds.), Handbook of Tuberculosis: Immunology and Cell Biology, (pp. 185-225). Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Kaufmann, S., Britton, W. (2008). Handbook of Tuberculosis: Immunology and Cell Biology. Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • West, N., Wozniak, T., Valenzuela, J., Feng, C., Sher, A., Ribeiro, J., Britton, W. (2008). Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis. Vaccine, 26(31), 3853-3859. [More Information]
  • Scandurra, G., Britton, W., Triccas, J. (2008). Inactivation of the Mycobacterium tuberculosis fadB4 gene results in increased virulence in host cell and mice. Microbes and Infection, 10, 38-44. [More Information]
  • Ritz, N., Hanekom, W., Robins-Browne, R., Britton, W., Curtis, N. (2008). Influence of BCG vaccine strain on the immune response and protection against tuberculosis. FEMS Microbiology Reviews, 32(5), 821-841. [More Information]
  • Britton, W., Triccas, J. (2008). The constituents of the cell envelope and their impact on the host immune system. In Daffe M; Reyrat J-M (Eds.), The Mycobacterial Cell Envelope, (pp. 249-270). Washington DC: ASM Press.

2007

  • Britton, W., Ritz, N., Robins-Browne, R., Curtis, N. (2007). Does BCG strain matter?
  • Almqvist, C., Li, Q., Britton, W., Kemp, A., Xuan, W., Tovey, E., Marks, G. (2007). Early predictors for developing allergic disease and asthma - separate steps in the 'allergic march'. Allergy, 62(Suppl. 83), 65.
  • Almqvist, C., Li, Q., Britton, W., Kemp, A., Xuan, W., Tovey, E., Marks, G. (2007). Early predictors for developing allergic disease and asthma: examining separate steps in the 'allergic march'. Clinical and Experimental Allergy, 37(9), 1296-1302. [More Information]
  • Triccas, J., Shklovskaya, E., Spratt, J., Ryan, A., Palindera, U., Fazekas, B., Britton, W. (2007). Effects of DNA- and Mycobacterium bovis BCG-based delivery of Flt3 ligand on protective immunity to Mycobacterium tuberculosis. Infection and Immunity, 75(11), 5368-5375. [More Information]
  • Weber-Chrysochoou, C., Crisafulli, D., Almqvist, C., Li, Q., Kemp, A., Britton, W., Marks, G. (2007). IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life. Journal of Allergy and Clinical Immunology, 120(2), 286-292. [More Information]
  • Ryan, A., Wozniak, T., Shklovskaya, E., O’Donnell, M., Fazekas, B., Britton, W., Triccas, J. (2007). Improved protection against disseminated tuberculosis by Mycobacterium bovis bacillus Calmette-Guerin secreting murine GM-CSF Is associated with expansion and activation of APCs. Journal of Immunology, 179(12), 8418-8424. [More Information]
  • Saunders, B., Britton, W. (2007). Life and death in the granuloma: immunopathology of tuberculosis. Immunology and Cell Biology, 85, 103-111. [More Information]
  • Saunders, B., Britton, W. (2007). Review: Life and death in the granuloma: immunopathology of tuberculosis. Immunology and Cell Biology, 85(2), 103-111. [More Information]
  • Britton, W., Fernando, S., Saunders, B., Sluyter, R., Wiley, J. (2007). The genetic control of susceptibility to Mycobacterium tuberculosis. In Gregory Bock(Organizer) and Jamie Goode (Eds.), Decoding the Genomic Control of Immune Reactions, (pp. 79-92). United Kingdom: John Wiley & Sons. [More Information]

2006

  • Fernando, S., Saunders, B., Sluyter, R., Skarratt, K., Goldburg, H., Marks, G., Wiley, J., Britton, W. (2006). A Polymorphism in the P2X7 Gene Increases Susceptibility to Extrapulmonary Tuberculosis. American Journal of Respiratory and Critical Care Medicine, 175(4), 360-366. [More Information]
  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2006). A Thr(357) to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X(7) function and impairs ATP-induced mycobacterial killing by macrophages. Journal of Biological Chemistry, 281(4), 2079-2086. [More Information]
  • Scandurra, G., Ryan, A., Pinto (Pinto-Nadanachandran), R., Britton, W., Triccas, J. (2006). Contribution of L-Alanine Dehydrogenase to In Vivo Persistence and Protective Efficacy of the BCG Vaccine. Microbiology and immunology, 50(10), 805-810. [More Information]
  • Musicki, K., Briscoe, H., Tran, S., Britton, W., Saunders, B. (2006). Differential requirements for soluble and transmembrane tumor necrosis factor in the immunological control of primary and secondary Listeria monocytogenes infection. Infection and Immunity, 74(6), 3180-3189. [More Information]
  • Scandurra, G., Williams, R., Triccas, J., Pinto (Pinto-Nadanachandran), R., Gicquel, B., Slobedman, B., Cunningham, A., Britton, W. (2006). Effect of phthiocerol dimycocerosate deficiency on the transcriptional response of human macrophages to Mycobacterium tuberculosis. Microbes and Infection, 9(1), 87-95. [More Information]
  • Fernando, S., Britton, W. (2006). Genetic susceptibility to mycobacterial disease in humans. Immunology and Cell Biology, 84(2), 125-137. [More Information]
  • Wozniak, T., Ryan, A., Britton, W. (2006). Interleukin-23 Restores Immunity to Mycobacterium tuberculosis Infection in IL-12p40-Deficient Mice and Is Not Required for the Development of IL-17-Secreting T Cell Responses. Journal of Immunology, 177(12), 8684-8692. [More Information]
  • Wozniak, T., Ryan, A., Triccas, J., Britton, W. (2006). Plasmid interleukin-23 (IL-23), but not plasmid IL-27, enhances the protective efficacy of a DNA vaccine against Mycobacterium tuberculosis infection. Infection and Immunity, 74(1), 557-565. [More Information]
  • Ryan, A., Spratt, J., Britton, W., Triccas, J. (2006). Secretion of functional Monocyte Chemotactic Protein-3 by recombinant Mycobacterium bovis BCG attenuates vaccine virulence and maintains protective efficacy against M. tuberculosis infection. Infection and Immunity, 75(1), 523-526. [More Information]

2005

  • Saunders, B., Fernando, S., Marks, G., Sluyter, R., Wiley, S., Britton, W. (2005). A single nucleotide polymorphism in the P2X7 gene lends susceptibility to extrapulmonary tuberculosis. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2005). A Thr(357) to ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Spratt, J., Ryan, A., Britton, W., Triccas, J. (2005). Epitope-tagging vectors for the expression and detection of recombinant proteins in mycobacteria. Plasmid, 53(3), 269-273. [More Information]
  • Palendira, U., Spratt, D., Britton, W., Triccas, J. (2005). Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection. Vaccine, 23(14), 1680-1685. [More Information]
  • Fernando, S., Saunders, B., Sluyter, R., Skarratt, K., Wiley, J., Britton, W. (2005). Gene Dosage Determines the Negative Effects of Polymorphic Alleles of the P2X7 Receptor on Adenosine Triphosphate–Mediated Killing of Mycobacteria by Human Macrophages. The Journal of Infectious Diseases, 192(1), 149-155. [More Information]
  • Roach, D., Briscoe, H., Saunders, B., Britton, W. (2005). Independent protective effects for tumor necrosis factor and lymphotoxin alpha in the host response to Listeria monocytogenes infection. Infection and Immunity, 73(8), 4787-4792. [More Information]
  • Britton, W., Gilbert, G., Wheatley, J., Leslie, D., Rothel, J., Jones, S., Bradley, P. (2005). Sensitivity of human gamma interferon assay and tuberculin skin testing for detecting infection with Mycobacterium tuberculosis in patients with culture positive tuberculosis. Tuberculosis, 85(3), 137-145. [More Information]
  • Demangel, C., Zhou, J., Choo, A., Shoebridge, G., Halliday, G., Britton, W. (2005). Single chain antibody fragments for the selective targeting of antigens to dendritic cells. Molecular Immunology, 42(8), 979-985. [More Information]
  • Saunders, B., Tran, S., Ruuls, S., Sedgwick, J., Briscoe, H., Britton, W. (2005). Transmembrane TNF is sufficient to initiate cell migration and granuloma formation and provide acute, but not long-term, control of Mycobacterium tuberculosis infection. Journal of Immunology, 174(8), 4852-4859. [More Information]

2004

  • Britton, W., Lockwood, D. (2004). Leprosy. The Lancet, 363(9416), 1209-1219.
  • Pinto (Pinto-Nadanachandran), R., Saunders, B., Britton, W., Camacho, L., Gicquel, B., Triccas, J. (2004). Mycobacterium Tuberculosis Defective In Phthiocerol Dimycocerosate Translocation Provides Greater Protective Immunity Against Tuberculosis Than The Existing Bacille Calmette-Gu?Rin Vaccine. The Journal of Infectious Diseases, 189(1), 105-112.
  • Briscoe, H., Britton, W., Saunders, B. (2004). T Cell-Derived Tumour Necrosis Factor Is Essential, But Not Sufficient, For Protection Against Mycobacterium Tuberculosis Infection. Clinical and Experimental Immunology, 137(2), 279-287.
  • van Broekhoven, C., Parish, C., Demangel, C., Britton, W., Altin, J. (2004). Targeting Dendritic Cells With Antigen-Containing Liposomes: A Highly Effective Procedure For Induction Of Antitumor Immunity And For Tumor Immunotherapy. Cancer Research, 64(12), 4357-4365.
  • Pinto (Pinto-Nadanachandran), R., Tang, Q., Britton, W., Leyh, T., Triccas, J. (2004). The Mycobacterium Tuberculosis Cysd And Cysnc Genes Form A Stress-Induced Operon That Encodes A Tri-Functional Sulfate-Activating Complex. Microbiology, 150(6), 1681-1686.

2003

  • Saunders, B., Fernando, S., Sluyter, R., Britton, W., Wiley, J. (2003). A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of Mycobacteria. Journal of Immunology, 171(10), 5442-5446.
  • Mihrshahi, S., Peat, J., Marks, G., Mellis, C., Tovey, E., Webb, K., Britton, W., Leeder, S. (2003). Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the Childhood Asthma Prevention Study (CAPS). Journal of Allergy and Clinical Immunology, 111(1), 162-168. [More Information]
  • Black, G., Weir, R., Chaguluka, S., Warndorff, D., Crampin, A., Mwaungulu, L., Sichali, L., Floyd, S., Bliss, L., Jarman, E., Britton, W., et al (2003). Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis BCG-Vaccinated Malawian young adults. Clinical and Diagnostic Laboratory Immunology, 10(4), 602-611.
  • Spratt, J., Britton, W., Triccas, J. (2003). Identification of strong promoter elements of Mycobacterium smegmatis and their utility for foreign gene expression in mycobacteria. FEMS Microbiology Letters, 224(1), 139-142.
  • Britton, W., Palendira, U. (2003). Improving vaccines against tuberculosis. Immunology and Cell Biology, 81(1), 34-45.
  • Pinto, R., Saunders, B., Camacho, L., Britton, W., Gicquel, B., Triccas, J. (2003). Mycobacterium tuberculosis defective in phthiocerol dimycocerosate translocation provides greater protective immunity against tuberculosis than existing Bacille Calmette-Guerin Vaccine. The Journal of Infectious Diseases, 11, 105-112.
  • Martin, E., Kamath, A., Briscoe, H., Britton, W. (2003). The combination of plasmid interleukin-12 with a single DNA vaccine is more effective than Myobacterium bovis (bacille Calmette-Guerin) in protecting against systemic Mycobacterim avium infection. Immunology, 109(2), 308-314.
  • Marks, G., Ng, K., Zhou, J., Toelle, B., Xuan, W., Belousova, E., Britton, W. (2003). The effect of neonatal BCG vaccination on atopy and asthma at age 7 to 14 years: A historical cohort study in a community with a very low prevalence of tuberculosis infection and a high prevalence of atopic disease. Journal of Allergy and Clinical Immunology, 111(3), 541-549.

2002

  • Demangel, C., Bertolino, P., Britton, W. (2002). Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. European Journal of Immunology, 32(4), 994-1002.
  • Saunders, B., Dane, A., Briscoe, H., Britton, W. (2002). Characterization of immune responses during infection with Mycobacterium avium strains 100, 101 and the recently sequenced 104. Immunology and Cell Biology, 80(6), 544-549.
  • Umaimainthan, P., Kamath, A., Feng, C., Martin, E., Chaplin, P., Triccas, J., Britton, W. (2002). Coexpression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis. Infection and Immunity, 70(4), 1949-1956.
  • Triccas, J., Sun, L., Umaimainthan, P., Britton, W. (2002). Comparative affects of plasmid-encoded interleukin 12 and interleukin 18 on the protective efficacy of DNA vaccination againt Mycobacterium tuberculosis. Immunology and Cell Biology, 80(1), 346-350.
  • Marks, G., Zhou, J., Yang, H., Joshi, P., Bishop, A., Britton, W., The Caps Investigators, (. (2002). Cord blood mononuclear cell cytokine responses in relation to maternal house dust mite allergen exposure. Clinical and Experimental Allergy, 32(3), 355-360.
  • Pinto (Pinto-Nadanachandran), R., Britton, W., Triccas, J. (2002). Destabilized green fluorescent protein for monitoring transient changes in mycobacterial gene expression. Research in Microbiology, 153(6), 379-383.
  • Karihaloo, C., Tovey, E., Mitakakis, T., Britton, W., Duffy, D. (2002). Evidence for the genetic control of immunoglobulin E reactivity to the allergens of Alternaria alternata. Clinical and Experimental Allergy, 32, 1316-1322.
  • Umaimainthan, P., Bean, A., Feng, C., Britton, W. (2002). Lymphocyte recruitment and protective efficacy against pulmonary mycobacterial infection are independent of the route of prior Mycobacterium bovis BCG immunization. Infection and Immunity, 70(3), 1410-1416.
  • Roach, D., Bean, A., Demangel, C., France, M., Briscoe, H., Britton, W. (2002). TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection. Journal of Immunology, 168(9), 4620-4627.

2001

  • Britton, W., Martin, E., Triccas, J., Kamath, A., Winter, N. (2001). Comparative protective effects of recombinant DNA and Mycobacterium bovis bacille Calmette-Guerin vaccines againts M. avium infection. Clinical and Experimental Immunology, 126, 482-487.
  • Feng, C., Britton, W., Demangel, C., Kamath, A., Macdonald, M. (2001). Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8+ T cells with specificity for a novel mycobacterial epitope. International Immunology, 13, 451-458.
  • Britton, W., Roche, P., Triccas, J., Martin, E. (2001). DNA encoding a single mycobacterial antigen protects against leprosy infection. Vaccine, 19, 1391-1396.
  • Roach, D., Martin, E., Briscoe, H., Britton, W., Bean, A., Rennick, D. (2001). Endogenous inhibition of antimycobacterial immunity by IL-10 varies between mycobacterial species. Scandinavian Journal of Immunology, 54, 163-170.
  • Feng, C., Britton, W., Blanchard,, T., Smith, G., Hill, A. (2001). Induction of CD8+ T-lymphocyte responses to a secreted antigen of Mycobacterium tuberculosis by an attenuated vaccine virus. Immunology and Cell Biology, 79, 569-575.
  • Britton, W., Triccas, J., Gicquel,, B. (2001). Isolation of strong expression signals of Mycobacterium tuberculosis. Microbiology, 147, 1253-1258.
  • Feng, C., Umaimainthan, P., Britton, W., Demangel, C., Spratt, J., Malin, A. (2001). Priming by DNA immunization augments protective efficacy of Mycobacterium bovis bacille Calmette-Guerin against tuberculosis. Infection and Immunity, 69, 4174-4176.
  • Roach, D., Briscoe, H., Saunders, B., France, M., Riminton, S., Britton, W. (2001). Secreted lymphotoxin-alpha is essential for the control of an intracellular bacterial infection. The Journal of Experimental Medicine, 193, 239-246.
  • Umaimainthan, P., Feng, C., Britton, W., Demangel, C., Heath, A., Bean, A. (2001). Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection. Infection and Immunity, 69, 2456-2461.
  • Britton, W., Roche, P., Neupane,, K., Failbus, S., Kamath, A. (2001). Vaccination with DNA of the Mycobaterium tuberculosis 85B antigen protects mouse foot pad against infection with M. leprae. International Journal of Leprosy and Other Mycobacterial Diseases, 69, 93-98.

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