Associate Professor Wayne Hawthorne

Associate Professor & Principal Research Fellow
Surgery, Westmead Clinical School
Westmead Millennium Institute for Medical Research

Telephone +61 2 9845 7365
Fax +61 2 9893 7440

Map

Selected grants

2014

  • Transplantation of pig islets to treat diabetes; Cowan P, Hawthorne W, Yi S, Nottle M; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Building sustainable collaborations in diabetes and islet transplantation research and practice in Sydney and Shanghai; Hu M, Alexander S, Freckelton L, Hawthorne W, O'Connell P, Wang W, Ning G, Li X, Gu W, Dai J; DVC International/IPDF Grant.
  • New strategies to protect pig-to-human renal xenografts; Hawthorne W; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Small Rodent Airlaw Caging System; George J, O'Connell P, Cunningham A, Hawthorne W, Little D, Djordjevic J, Harris D, Hebbard L, Liddle C, Fletcher J; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2006

  • The Development of a National Centre for Clinical Islet Transplantation; Russ G, Wilson M, Dado M, Kay T, O'Connell P, George J, Hawthorne W; Juvenile Diabetes Research Foundation/Project Support.

2003

  • Non immunological barriers to successful treatment of diabetes by xenotransplantation?; Hawthorne W, Allen R, O'Connell P, Chapman J, Moran C; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Jin, X., Wang, Y., Hawthorne, W., Hu, M., Yi, S., O'Connell, P. (2014). Enhanced Suppression of the Xenogeneic T-Cell Response in Vitro by Xenoantigen Stimulated and Expanded Regulatory T Cells. Transplantation, 97(1), 30-38. [More Information]
  • Wong, M., Tso, A., Ali, M., Hawthorne, W., Manolios, N. (2014). Novel T-cell inhibiting peptides delay the onset of Type 1 diabetes in non-obese diabetic mice. Journal of Diabetes & Metabolism, 40, 229-234. [More Information]
  • Cantley, J., Walters, S., Jung, M., Weinberg, A., Cowley, M., Whitworth, P., Kaplan, W., Hawthorne, W., O'Connell, P., Weir, G., et al (2013). A Preexistent Hypoxic Gene Signature Predicts Impaired Islet Graft Function and Glucose Homeostasis. Cell Transplantation, 22(11), 2147-2159. [More Information]
  • Brady, J., Sutherland, R., Hancock, M., Kitsoulis, S., Lahoud, M., Phillips, P., Hawthorne, W., d'Apice, A., Cowan, P., Harrison, L., O'Connell, P., et al (2013). Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model. Xenotransplantation, 20(2), 100-109. [More Information]
  • Stokes, R., Cheng, K., Deters, N., Lau, S., Hawthorne, W., O'Connell, P., Stolp, J., Grey, S., Loudovaris, T., Kay, T., Gunton, J., et al (2013). Hypoxia-inducible factor-1α (HIF-1α) potentiates β-cell survival after islet transplantation of human and mouse islets. Cell Transplantation, 22(2), 253-266. [More Information]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • O'Connell, P., Holmes-Walker, J., Goodman, D., Hawthorne, W., Loudovaris, T., Gunton, J., Thomas, H., Grey, S., Drogemuller, C., Ward, G., et al (2013). Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes. American Journal of Transplantation, 13(7), 1850-1858. [More Information]
  • Gerace, D., Ren, B., Hawthorne, W., Byrne, M., Phillips, P., O'Brien, B., Nassif, N., Alexander, I., Simpson, A. (2013). Pancreatic Transdifferentiation in Porcine Liver Following Lentiviral Delivery of Human Furin–Cleavable Insulin. Transplantation Proceedings, 45(5), 1869-1874. [More Information]
  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013). Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation, 22(10), 1929-1941. [More Information]
  • Thwaites, S., Lam, V., Yao, J., Kable, K., Jenkins, L., Chen, C., Robertson, P., Hawthorne, W., Ryan, B., Pleass, H., Allen, R. (2013). Surgical Morbidity of Simultaneous Kidney and Pancreas Transplantation: A Single-Centre Experience in the Tacrolimus Era. ISRN Transplantation, 2013, 1-6. [More Information]
  • O'Connell, P., Cowan, P., Hawthorne, W., Yi, S., Lew, A. (2013). Transplantation of Xenogeneic Islets: Are We There Yet? Current Diabetes Reports, 13(5), 687-694. [More Information]
  • Yi, S., Ji, M., Wu, J., Ma, X., Phillips, P., Hawthorne, W., O'Connell, P. (2012). Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes, 61(5), 1180-1191. [More Information]
  • Thwaites, S., Gurung, B., Yao, J., Kable, K., Robertson, P., Ryan, B., Lam, V., Pleass, H., Chapman, J., Hawthorne, W., Allen, R. (2012). Excellent Outcomes of Simultaneous Pancreas Kidney Transplantation in Patients From Rural and Urban Australia: A National Service Experience. Transplantation, 94(12), 1230-1235. [More Information]
  • Campbell, P., Weinberg, A., Chee, J., Mariana, L., Ayala, R., Hawthorne, W., O'Connell, P., Loudovaris, T., Cowley, M., Kay, T., et al (2012). Expression of Pro- and Anti-apoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation. Cell Transplantation, 21(1), 49-60. [More Information]
  • Cowley, M., Weinberg, A., Zammit, N., Walters, S., Hawthorne, W., Loudovaris, T., Thomas, H., Kay, T., Gunton, J., Alexander, S., O'Connell, P., et al (2012). Human islets express a marked proinflammatory molecular signature prior to transplantation. Cell Transplantation, 21(9), 2063-2078. [More Information]
  • Tran, H., Saliba, L., Chandratnam, E., Turingan, I., Hawthorne, W. (2012). Strategies to Minimize Adhesions to Intraperitoneally Placed Mesh in Laparoscopic Ventral Hernia Repair. Journal of the Society of Laparoendoscopic Surgeons, 16(1), 89-94. [More Information]
  • Lucewicz, A., Wong, G., Lam, V., Hawthorne, W., Allen, R., Craig, J., Pleass, H. (2011). Management of Primary Symptomatic Lymphocele After Kidney Transplantation: A Systematic Review. Transplantation, 92(6), 663-673. [More Information]
  • Chew, M., Hawthorne, W., Bendall, J., Whereat, S., Huang, S., Ting, I., Simond, D., McLean, A. (2011). No beneficial effects of levosimendan in acute porcine endotoxaemia. Acta Anaesthesiologica Scandinavica: an international journal of anaesthesiology and intensive care, pain and emergency medicine, 55(7), 851-861. [More Information]
  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011). Pre-clinical model of composite foetal pig pancreas fragment/renal xenotransplantation to treat renal failure and diabetes. Xenotransplantation, 18(6), 390-399. [More Information]
  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011). Subcapsular Fetal Pig Pancreas Fragment Transplantation Provides Normal Blood Glucose Control in a Preclinical Model of Diabetes. Transplantation, 91(5), 515-521. [More Information]
  • Ji, M., Yi, S., Smith-Hurst, H., Phillips, P., Wu, J., Hawthorne, W., O'Connell, P. (2011). The Importance of Tissue Factor Expression by Porcine NICC in Triggering IBMIR in the Xenograft Setting. Transplantation, 91(8), 841-846. [More Information]
  • Lam, V., Pleass, H., Hawthorne, W., Allen, R. (2010). Evolution of pancreas transplant surgery. ANZ Journal of Surgery, 80(6), 411-418. [More Information]
  • Wong, M., Hawthorne, W., Manolios, N. (2010). Gene Therapy in Diabetes. Self Nonself, 1(3), 165-175. [More Information]
  • Wang, T., Liu, S., Zheng, W., Gao, F., Hawthorne, W., Yi, S. (2010). Hepatic artery vs. portal vein infusion of microbeads: a large animal pre-clinical model evaluating the intrahepatic capacity for cell infusion and imaging. Xenotransplantation, 17(3), 207-214. [More Information]
  • Cheng, K., Ho, K., Stokes, R., Scott, C., Lau, S., Hawthorne, W., O'Connell, P., Loudovaris, T., Kay, T., Kulkarni, R., Biankin, A., Kench, J., Gunton, J., et al (2010). Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. Journal of Clinical Investigation, 120(6), 2171-2183. [More Information]
  • Lam, V., Laurence, J., Robertson, P., Hawthorne, W., Ryan, B., Lau, H., Allen, R., Pleass, H. (2009). En bloc paediatric kidney transplant: is this the best use of a scarce resource? ANZ Journal of Surgery, 79(1-2), 27-32. [More Information]
  • Hawthorne, W., Xing, X., Yi, S., Simond, D., Dong, Q., Ye, B., Tong, Q., Ye, Z., Wang, W. (2009). Investigation of porcine endogenous retrovirus in the conservation population of ningxiang pig. Transplantation Proceedings, 41(10), 4389-4393. [More Information]
  • Londrigan, S., Brady, J., Sutherland, R., Cowan, P., d'Apice, A., Hawthorne, W., O'Connell, P., Lew, A. (2009). Optimizing transduction of pig islet cell clusters for xenotransplantation. Xenotransplantation, 16(1), 45-46. [More Information]
  • Akima, S., Hawthorne, W., Favaloro, E., Patel, A., Blyth, K., Mudaliar, M., Chapman, J., O'Connell, P. (2009). Tirofiban and Activated Protein C Synergistically Inhibit the Instant Blood Mediated Inflammatory Reaction (IBMIR) from Allogeneic Islet Cells Exposure to Human Blood. American Journal Of Transplantation, 9, 1533-1540. [More Information]
  • Feller, J., Simpson, A., Nelson, M., O'Connell, P., Swan, M., Hawthorne, W., Tao, C., O'Brien, B. (2008). Growth Promoting Effect of Rh(D) Antibody on Human Pancreatic Islet Cells. Journal of Clinical Endocrinology and Metabolism, 93(9), 3560-3567. [More Information]
  • Wu, J., Yi, S., Ouyang, L., Jimenez, E., Simond, D., Wang, W., Wang, Y., Hawthorne, W., O'Connell, P. (2008). In Vitro Expanded Human CD4+CD25+ Regulatory T Cells are Potent Suppressors of T-Cell-Mediated Xenogeneic Responses. Transplantation, 85(12), 1841-1848. [More Information]
  • Fu, Y., Yi, S., Wu, J., Jimenez-Vera, E., Simond, D., Hawthorne, W., O'Connell, P. (2008). In vitro suppression of xenoimmune-mediated macrophage activation by human CD4+CD25+ regulatory T cells. Transplantation, 86(6), 865-874. [More Information]
  • Jung, K., Simond, D., Moran, C., Hawthorne, W., Jeon, J., Jin, D., Lee, J. (2008). Investigation of Deletion Variation and Methylation Patterns in the 5' LTR of Porcine Endogenous Retroviruses. Asian - Australasian Journal of Animal Sciences, 21(11), 1572-1575.
  • Fu, Y., Lu, X., Yi, S., O'Hara, J., Hawthorne, W., Hucker, K., O'Connell, P. (2008). Selective rejection of porcine islet xenografts by macrophages. Xenotransplantation, 15(5), 307-312. [More Information]
  • Horton, P., Hawthorne, W., Walters, S., Patel, T., Stewart, G., Allen, R., Chapman, J. (2008). Tolerance Induction in a Large-Animal Model Using Total Lymphoid Irradiation and Intrathymic Bone Marrow. Transplantation, 86(12), 1830-1836. [More Information]
  • Chandra, A., Ouyang, L., Wong, J., Ha, H., Walters, S., Patel, A., Hawthorne, W., Yi, S. (2007). Association between islet xenograft rejection mediated by activated macrophages and upregulated chemokines. Zhongnan Daxue Xuebao (Yixue Ban), 32(1), 26-35. [More Information]
  • Chandra, A., Ouyang, L., Yi, S., Wong, J., Ha, H., Walters, S., Patel, A., Stokes, R., Jardine, M., Hawthorne, W., O'Connell, P. (2007). Chemokine and toll-like receptor signaling in macrophage mediated islet xenograft rejection. Xenotransplantation, 14(1), 48-59. [More Information]
  • Londrigan, S., Brady, J., Sutherland, R., Hawthorne, W., Thomas, H., Jhala, G., Cowan, P., Kay, T., O'Connell, P., Lew, A. (2007). Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets. Xenotransplantation, 14(2), 119-125. [More Information]
  • Yi, S., Wang, Y., Chandra, A., O'Hara, J., Wu, J., Ouyang, L., Burgess, J., Hawthorne, W., Wu, H., Chadban, S., O'Connell, P. (2007). Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transfer. Transplantation, 83(5), 615-623. [More Information]
  • O'Connell, P., Hawthorne, W., Holmes-Walker, D., Nankivell (Nankievell), B., Gunton, J., Patel, A., Walters, S., Pleass, H., Allen, R., Chapman, J. (2006). Clinical islet transplantation in type 1 diabetes mellitus: results of Australia's first trial. Medical Journal of Australia, 184(5), 221-225. [More Information]
  • Akima, S., Hawthorne, W., Koutts, J., Patel, A., Burgess, J., O'Hara, J., Mudaliar, Y., Favaloro, E., O'Connell, P. (2006). Differences in the efficacy of recombinant human activated protein C against allogeneic and xenogeneic IBMIR. 84(3), A16-A16.
  • O'Connell, P., Lew, A., Cowan, P., Londrigan, S., Hawthorne, W., Nottle, M., d'Apice, A. (2006). Islet xenotransplantation: progress towards a clinical therapy. Current Opinion in Organ Transplantation, 11(2), 174-179.
  • Lam, V., Wong, K., Hawthorne, W., Ryan, B., Lau, H., Robertson, P., Allen, R., Pleass, H. (2006). The linear cutting stapler for enteric anastomosis: a new technique in pancreas transplantation. Transplant International, 19(11), 915-918. [More Information]
  • Harvey (Holyoake), P., Stevenson, J., Moran, C., Stokes, R., Kirk, E., Sugo, E., Hawthorne, W. (2006). The occurrence of congenital heart defects in an inbred herd of pigs in Australia. Australian Veterinary Journal, 84(4), 129-133. [More Information]
  • Varcoe, R., Mikhail, M., Guiffre, A., Pennings, G., Vicaretti, M., Hawthorne, W., Fletcher, J., Medbury, H. (2006). The role of the fibrocyte in intimal hyperplasia. Journal of Thrombosis and Haemostasis, 4(5), 1125-1133. [More Information]
  • Wong, K., Kable, K., Hawthorne, W., Robertson, P., Chan, K., Nankivell (Nankievell), B., O'Connell, P., Chapman, J., Lau, H., Pleass, H., Allen, R. (2005). A comparison of 2 surgical techniques in pancreas transplantation. Immunology and Cell Biology, 83(4), A23-A24.
  • Lee, J., Simond, D., Hawthorne, W., Walters, S., Patel, A., Smith, D., O'Connell, P., Moran, C. (2005). Characterization of the swine major histocompatibility complex alleles at eight loci in Westran pigs. Xenotransplantation, 12(4), 303-307. [More Information]
  • Benseler, V., Bishop, A., Chng, K., Watson, J., Wang, C., Dahlke, M., Koutalistras, N., Watts, A., Hawthorne, W., McKenzie, P., Hennessy, A., Pleass, H., Chadban, S., Schlitt, H., McCaughan, G., et al (2005). Development of a primate model to evaluate strategies to achieve long term renal allograft acceptance. Immunology and Cell Biology, 83(4 Suppl.), A26-A26.
  • O'Connell, P., Hawthorne, W., Simond, D., Chapman, J., Chen, Y., Patel, A., Walters, S., Burgess, J., Weston, L., Stokes, R., Moran, C., Allen, R. (2005). Genetic and Functional evaluation of the level of inbreeding of the Westran pig: a herd with potential for use in xenotransplantation. Xenotransplantation, 12(4), 308-315. [More Information]
  • Yi, S., Ouyang, L., Ha, H., O'Hara, J., Chandra, A., Akima, S., Hawthorne, W., Patel, A., Stokes, R., O'Connell, P. (2005). Involvement of CCR5 Signaling in Macrophage Recruitment to Porcine Islet Xenografts. Transplantation, 80(10), 1468-1475. [More Information]
  • Gunton, J., Kulkarni, R., Yim, S., Okada, T., Hawthorne, W., Tseng, Y., Roberson, R., Ricordi, C., O'Connell, P., Gonzalez, F., et al (2005). Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell, 122(3), 337-349. [More Information]
  • Fletcher, J., Ao, P., Hawthorne, W. (2004). Antiproliferative Effects Of Low Molecular Weight Heparin. ANZ Journal of Surgery, 74(9), 793-796.
  • Huang, P., Hawthorne, W., Fletcher, J. (2004). Time Course Of Cellular Proliferation, Neointima Formation, Apoptosis And Its Fas Pathway Following Dacron Patch Graft Implantation In Sheep Carotid Artery. Cardiovascular Pathology, 13(3 Supplement 1), S118.
  • Yi, S., Hawthorne, W., Lehnert, A., Ha, H., Wong, J., Rooijen, N., Davey, K., Patel, A., Walters, S., Chandra, A., O'Connell, P. (2003). T Cell-Activated Macrophages Are Capable of Both Recognition and Rejection of Pancreatic Islet Xenografts. Journal of Immunology, 170(5), 2750-2758.
  • Yi, S., Feng, X., Hawthorne, W., Patel, A., Walters, S., O'Connel, P. (2002). CD4+ T Cells initiate Pancreatic Islet Xenograft rejection via an interferon-y-Dependent recruitment of macrophages and natural killer cells. Transplantation, 73(3), 437-446.
  • Tso, C., Skinner, M., Hawthorne, W., Fletcher, J. (2002). Matrigel-coated stents reduce intimal thickening in a large animal vascular stent Model. International Angiology, 21(3), 244-249.
  • Hawthorne, W., Pye, A., Vicaretti, M., Fletcher, J. (2002). New Methodology for Assessment of Intimal Hyperplasia of Vascular Prostheses. ANZ Journal of Surgery, 72(9), 623-627.
  • Huang, P., Hawthorne, W., Ao, P., Angeli, G., Medbury, H., Fletcher, J. (2002). Perigraft adventitia and intima remodeling after synthetic patch implantation in sheep carotid artery: Role of apoptosis and proliferation. Journal Of Vascular Surgery, 36(2), 371-378.
  • Hawthorne, W., Ao, P., Fletcher, J. (2002). Vascular closure staples reducae intimal hyperplasia in prosthesis implantation. ANZ Journal of Surgery, 72(12), 862-866.
  • Lehnert, A., Hawthorne, W., O'Connell, P., Mottram, P., Han, W., Walters, S., Patel, A., Cowan, P., d'Apice, A. (2001). Blockage of the cd28 and cd40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice. Transplant Immunology, 9, 51-56.
  • Huang, P., Hawthorne, W., Ao, P., Fletcher, J., Angeli, G., Medbury,, H. (2001). Calcium channel antagonist verapamil inhibits neoinitimal formation and enhances apoptosis in a vas. The American Journal Of Surgery, 181(6), 492-498.
  • Ao, P., Hawthorne, W., Fletcher, J., Bobryshev,, Y., Inder,, S., Cherian, S., Lord,, R. (2001). Colonisation of prosthetic grafts by immunocompetent cells in a sheep model. Vascular, 9(2), 166-176.
  • Allen, R., Nankivell (Nankievell), B., Hawthorne, W., O'Connell, P., Chapman, J. (2001). Pancreas and islet transplantation: an unfinished journey. Transplantation Proceedings, 33, 3485-3488.
  • Hawthorne, W., Cachia, A., Walters, S., Patel, A., Clarke, J., O'Connell, P., Chapman, J., Allen, R. (2000). A large-animal model to evaluate the clinical potential of fetal pig pancreas fragment transplantation. Cell Transplantation, 9, 867-875.
  • Ao, P., Hawthorne, W., Vicaretti, M., Fletcher, J. (2000). Development of Intimal Hyperplasia in six different Vascular Prostheses. European Journal of Vascular and Endovascular Surgery, 20, 241-249.
  • Horton, P., Hawthorne, W., Walters, S., Patel, A., O'Connell, P., Chapman, J., Allen, R. (2000). Induction of allogenic islet tolerance in a large-animal model. Cell Transplantation, 9, 877-887.
  • Ao, P., Hawthorne, W., Vicaretti, M., Fletcher, J. (2000). Verapamil reduces intimal hyperplasia in a sheep carotid artery patch graft model. ANZ Journal of Surgery, 70(1), 64-67.

Conferences

  • Hawthorne, W., Patel, A., O'Hara, J., Akima, S., Salvaris, E., Nottle, M., d'Aspice, A., Cowan, P., O'Connell, P. (2006). Elimination of the alpha Gal antigen on NICC reduces ibmir following exposure of pig NICC to human blood. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Chandra, A., Wong, J., Yi, S., Ha, H., Patel, A., O'Connell, P., Hawthorne, W. (2006). Lack of IL-15 reduces recruitment of xenoreactive leukocytes into discordant islet xenografts but does not prolong graft survival. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Simond, D., Moran, C., Garkavenko, O., O'Connell, P., Hawthorne, W. (2006). Real-time PCR detection of porcine endogenous retroviruses. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Harvey (Holyoake), P., Stevenson, J., Moran, C., Stokes, R., Kirk, E., Sugo, E., Hawthorne, W. (2006). The first reported case of congenital heart defects in pigs in Australia. 19th International Pig Veterinary Society Congress IPVS 2006, Denmark: International Pig Veterinary Society.
  • Hawthorne, W., Stokes, R., Patel, A., Burgess, J., Walters, S., Simond, D., O'Connell, P. (2006). Westran fetal pig pancreas fragment transplants provide long-term normoglycaemia in adult pi. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.

2014

  • Jin, X., Wang, Y., Hawthorne, W., Hu, M., Yi, S., O'Connell, P. (2014). Enhanced Suppression of the Xenogeneic T-Cell Response in Vitro by Xenoantigen Stimulated and Expanded Regulatory T Cells. Transplantation, 97(1), 30-38. [More Information]
  • Wong, M., Tso, A., Ali, M., Hawthorne, W., Manolios, N. (2014). Novel T-cell inhibiting peptides delay the onset of Type 1 diabetes in non-obese diabetic mice. Journal of Diabetes & Metabolism, 40, 229-234. [More Information]

2013

  • Cantley, J., Walters, S., Jung, M., Weinberg, A., Cowley, M., Whitworth, P., Kaplan, W., Hawthorne, W., O'Connell, P., Weir, G., et al (2013). A Preexistent Hypoxic Gene Signature Predicts Impaired Islet Graft Function and Glucose Homeostasis. Cell Transplantation, 22(11), 2147-2159. [More Information]
  • Brady, J., Sutherland, R., Hancock, M., Kitsoulis, S., Lahoud, M., Phillips, P., Hawthorne, W., d'Apice, A., Cowan, P., Harrison, L., O'Connell, P., et al (2013). Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model. Xenotransplantation, 20(2), 100-109. [More Information]
  • Stokes, R., Cheng, K., Deters, N., Lau, S., Hawthorne, W., O'Connell, P., Stolp, J., Grey, S., Loudovaris, T., Kay, T., Gunton, J., et al (2013). Hypoxia-inducible factor-1α (HIF-1α) potentiates β-cell survival after islet transplantation of human and mouse islets. Cell Transplantation, 22(2), 253-266. [More Information]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • O'Connell, P., Holmes-Walker, J., Goodman, D., Hawthorne, W., Loudovaris, T., Gunton, J., Thomas, H., Grey, S., Drogemuller, C., Ward, G., et al (2013). Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes. American Journal of Transplantation, 13(7), 1850-1858. [More Information]
  • Gerace, D., Ren, B., Hawthorne, W., Byrne, M., Phillips, P., O'Brien, B., Nassif, N., Alexander, I., Simpson, A. (2013). Pancreatic Transdifferentiation in Porcine Liver Following Lentiviral Delivery of Human Furin–Cleavable Insulin. Transplantation Proceedings, 45(5), 1869-1874. [More Information]
  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013). Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation, 22(10), 1929-1941. [More Information]
  • Thwaites, S., Lam, V., Yao, J., Kable, K., Jenkins, L., Chen, C., Robertson, P., Hawthorne, W., Ryan, B., Pleass, H., Allen, R. (2013). Surgical Morbidity of Simultaneous Kidney and Pancreas Transplantation: A Single-Centre Experience in the Tacrolimus Era. ISRN Transplantation, 2013, 1-6. [More Information]
  • O'Connell, P., Cowan, P., Hawthorne, W., Yi, S., Lew, A. (2013). Transplantation of Xenogeneic Islets: Are We There Yet? Current Diabetes Reports, 13(5), 687-694. [More Information]

2012

  • Yi, S., Ji, M., Wu, J., Ma, X., Phillips, P., Hawthorne, W., O'Connell, P. (2012). Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes, 61(5), 1180-1191. [More Information]
  • Thwaites, S., Gurung, B., Yao, J., Kable, K., Robertson, P., Ryan, B., Lam, V., Pleass, H., Chapman, J., Hawthorne, W., Allen, R. (2012). Excellent Outcomes of Simultaneous Pancreas Kidney Transplantation in Patients From Rural and Urban Australia: A National Service Experience. Transplantation, 94(12), 1230-1235. [More Information]
  • Campbell, P., Weinberg, A., Chee, J., Mariana, L., Ayala, R., Hawthorne, W., O'Connell, P., Loudovaris, T., Cowley, M., Kay, T., et al (2012). Expression of Pro- and Anti-apoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation. Cell Transplantation, 21(1), 49-60. [More Information]
  • Cowley, M., Weinberg, A., Zammit, N., Walters, S., Hawthorne, W., Loudovaris, T., Thomas, H., Kay, T., Gunton, J., Alexander, S., O'Connell, P., et al (2012). Human islets express a marked proinflammatory molecular signature prior to transplantation. Cell Transplantation, 21(9), 2063-2078. [More Information]
  • Tran, H., Saliba, L., Chandratnam, E., Turingan, I., Hawthorne, W. (2012). Strategies to Minimize Adhesions to Intraperitoneally Placed Mesh in Laparoscopic Ventral Hernia Repair. Journal of the Society of Laparoendoscopic Surgeons, 16(1), 89-94. [More Information]

2011

  • Lucewicz, A., Wong, G., Lam, V., Hawthorne, W., Allen, R., Craig, J., Pleass, H. (2011). Management of Primary Symptomatic Lymphocele After Kidney Transplantation: A Systematic Review. Transplantation, 92(6), 663-673. [More Information]
  • Chew, M., Hawthorne, W., Bendall, J., Whereat, S., Huang, S., Ting, I., Simond, D., McLean, A. (2011). No beneficial effects of levosimendan in acute porcine endotoxaemia. Acta Anaesthesiologica Scandinavica: an international journal of anaesthesiology and intensive care, pain and emergency medicine, 55(7), 851-861. [More Information]
  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011). Pre-clinical model of composite foetal pig pancreas fragment/renal xenotransplantation to treat renal failure and diabetes. Xenotransplantation, 18(6), 390-399. [More Information]
  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011). Subcapsular Fetal Pig Pancreas Fragment Transplantation Provides Normal Blood Glucose Control in a Preclinical Model of Diabetes. Transplantation, 91(5), 515-521. [More Information]
  • Ji, M., Yi, S., Smith-Hurst, H., Phillips, P., Wu, J., Hawthorne, W., O'Connell, P. (2011). The Importance of Tissue Factor Expression by Porcine NICC in Triggering IBMIR in the Xenograft Setting. Transplantation, 91(8), 841-846. [More Information]

2010

  • Lam, V., Pleass, H., Hawthorne, W., Allen, R. (2010). Evolution of pancreas transplant surgery. ANZ Journal of Surgery, 80(6), 411-418. [More Information]
  • Wong, M., Hawthorne, W., Manolios, N. (2010). Gene Therapy in Diabetes. Self Nonself, 1(3), 165-175. [More Information]
  • Wang, T., Liu, S., Zheng, W., Gao, F., Hawthorne, W., Yi, S. (2010). Hepatic artery vs. portal vein infusion of microbeads: a large animal pre-clinical model evaluating the intrahepatic capacity for cell infusion and imaging. Xenotransplantation, 17(3), 207-214. [More Information]
  • Cheng, K., Ho, K., Stokes, R., Scott, C., Lau, S., Hawthorne, W., O'Connell, P., Loudovaris, T., Kay, T., Kulkarni, R., Biankin, A., Kench, J., Gunton, J., et al (2010). Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. Journal of Clinical Investigation, 120(6), 2171-2183. [More Information]

2009

  • Lam, V., Laurence, J., Robertson, P., Hawthorne, W., Ryan, B., Lau, H., Allen, R., Pleass, H. (2009). En bloc paediatric kidney transplant: is this the best use of a scarce resource? ANZ Journal of Surgery, 79(1-2), 27-32. [More Information]
  • Hawthorne, W., Xing, X., Yi, S., Simond, D., Dong, Q., Ye, B., Tong, Q., Ye, Z., Wang, W. (2009). Investigation of porcine endogenous retrovirus in the conservation population of ningxiang pig. Transplantation Proceedings, 41(10), 4389-4393. [More Information]
  • Londrigan, S., Brady, J., Sutherland, R., Cowan, P., d'Apice, A., Hawthorne, W., O'Connell, P., Lew, A. (2009). Optimizing transduction of pig islet cell clusters for xenotransplantation. Xenotransplantation, 16(1), 45-46. [More Information]
  • Akima, S., Hawthorne, W., Favaloro, E., Patel, A., Blyth, K., Mudaliar, M., Chapman, J., O'Connell, P. (2009). Tirofiban and Activated Protein C Synergistically Inhibit the Instant Blood Mediated Inflammatory Reaction (IBMIR) from Allogeneic Islet Cells Exposure to Human Blood. American Journal Of Transplantation, 9, 1533-1540. [More Information]

2008

  • Feller, J., Simpson, A., Nelson, M., O'Connell, P., Swan, M., Hawthorne, W., Tao, C., O'Brien, B. (2008). Growth Promoting Effect of Rh(D) Antibody on Human Pancreatic Islet Cells. Journal of Clinical Endocrinology and Metabolism, 93(9), 3560-3567. [More Information]
  • Wu, J., Yi, S., Ouyang, L., Jimenez, E., Simond, D., Wang, W., Wang, Y., Hawthorne, W., O'Connell, P. (2008). In Vitro Expanded Human CD4+CD25+ Regulatory T Cells are Potent Suppressors of T-Cell-Mediated Xenogeneic Responses. Transplantation, 85(12), 1841-1848. [More Information]
  • Fu, Y., Yi, S., Wu, J., Jimenez-Vera, E., Simond, D., Hawthorne, W., O'Connell, P. (2008). In vitro suppression of xenoimmune-mediated macrophage activation by human CD4+CD25+ regulatory T cells. Transplantation, 86(6), 865-874. [More Information]
  • Jung, K., Simond, D., Moran, C., Hawthorne, W., Jeon, J., Jin, D., Lee, J. (2008). Investigation of Deletion Variation and Methylation Patterns in the 5' LTR of Porcine Endogenous Retroviruses. Asian - Australasian Journal of Animal Sciences, 21(11), 1572-1575.
  • Fu, Y., Lu, X., Yi, S., O'Hara, J., Hawthorne, W., Hucker, K., O'Connell, P. (2008). Selective rejection of porcine islet xenografts by macrophages. Xenotransplantation, 15(5), 307-312. [More Information]
  • Horton, P., Hawthorne, W., Walters, S., Patel, T., Stewart, G., Allen, R., Chapman, J. (2008). Tolerance Induction in a Large-Animal Model Using Total Lymphoid Irradiation and Intrathymic Bone Marrow. Transplantation, 86(12), 1830-1836. [More Information]

2007

  • Chandra, A., Ouyang, L., Wong, J., Ha, H., Walters, S., Patel, A., Hawthorne, W., Yi, S. (2007). Association between islet xenograft rejection mediated by activated macrophages and upregulated chemokines. Zhongnan Daxue Xuebao (Yixue Ban), 32(1), 26-35. [More Information]
  • Chandra, A., Ouyang, L., Yi, S., Wong, J., Ha, H., Walters, S., Patel, A., Stokes, R., Jardine, M., Hawthorne, W., O'Connell, P. (2007). Chemokine and toll-like receptor signaling in macrophage mediated islet xenograft rejection. Xenotransplantation, 14(1), 48-59. [More Information]
  • Londrigan, S., Brady, J., Sutherland, R., Hawthorne, W., Thomas, H., Jhala, G., Cowan, P., Kay, T., O'Connell, P., Lew, A. (2007). Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets. Xenotransplantation, 14(2), 119-125. [More Information]
  • Yi, S., Wang, Y., Chandra, A., O'Hara, J., Wu, J., Ouyang, L., Burgess, J., Hawthorne, W., Wu, H., Chadban, S., O'Connell, P. (2007). Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transfer. Transplantation, 83(5), 615-623. [More Information]

2006

  • O'Connell, P., Hawthorne, W., Holmes-Walker, D., Nankivell (Nankievell), B., Gunton, J., Patel, A., Walters, S., Pleass, H., Allen, R., Chapman, J. (2006). Clinical islet transplantation in type 1 diabetes mellitus: results of Australia's first trial. Medical Journal of Australia, 184(5), 221-225. [More Information]
  • Akima, S., Hawthorne, W., Koutts, J., Patel, A., Burgess, J., O'Hara, J., Mudaliar, Y., Favaloro, E., O'Connell, P. (2006). Differences in the efficacy of recombinant human activated protein C against allogeneic and xenogeneic IBMIR. 84(3), A16-A16.
  • Hawthorne, W., Patel, A., O'Hara, J., Akima, S., Salvaris, E., Nottle, M., d'Aspice, A., Cowan, P., O'Connell, P. (2006). Elimination of the alpha Gal antigen on NICC reduces ibmir following exposure of pig NICC to human blood. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • O'Connell, P., Lew, A., Cowan, P., Londrigan, S., Hawthorne, W., Nottle, M., d'Apice, A. (2006). Islet xenotransplantation: progress towards a clinical therapy. Current Opinion in Organ Transplantation, 11(2), 174-179.
  • Chandra, A., Wong, J., Yi, S., Ha, H., Patel, A., O'Connell, P., Hawthorne, W. (2006). Lack of IL-15 reduces recruitment of xenoreactive leukocytes into discordant islet xenografts but does not prolong graft survival. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Simond, D., Moran, C., Garkavenko, O., O'Connell, P., Hawthorne, W. (2006). Real-time PCR detection of porcine endogenous retroviruses. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Harvey (Holyoake), P., Stevenson, J., Moran, C., Stokes, R., Kirk, E., Sugo, E., Hawthorne, W. (2006). The first reported case of congenital heart defects in pigs in Australia. 19th International Pig Veterinary Society Congress IPVS 2006, Denmark: International Pig Veterinary Society.
  • Lam, V., Wong, K., Hawthorne, W., Ryan, B., Lau, H., Robertson, P., Allen, R., Pleass, H. (2006). The linear cutting stapler for enteric anastomosis: a new technique in pancreas transplantation. Transplant International, 19(11), 915-918. [More Information]
  • Harvey (Holyoake), P., Stevenson, J., Moran, C., Stokes, R., Kirk, E., Sugo, E., Hawthorne, W. (2006). The occurrence of congenital heart defects in an inbred herd of pigs in Australia. Australian Veterinary Journal, 84(4), 129-133. [More Information]
  • Varcoe, R., Mikhail, M., Guiffre, A., Pennings, G., Vicaretti, M., Hawthorne, W., Fletcher, J., Medbury, H. (2006). The role of the fibrocyte in intimal hyperplasia. Journal of Thrombosis and Haemostasis, 4(5), 1125-1133. [More Information]
  • Hawthorne, W., Stokes, R., Patel, A., Burgess, J., Walters, S., Simond, D., O'Connell, P. (2006). Westran fetal pig pancreas fragment transplants provide long-term normoglycaemia in adult pi. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.

2005

  • Wong, K., Kable, K., Hawthorne, W., Robertson, P., Chan, K., Nankivell (Nankievell), B., O'Connell, P., Chapman, J., Lau, H., Pleass, H., Allen, R. (2005). A comparison of 2 surgical techniques in pancreas transplantation. Immunology and Cell Biology, 83(4), A23-A24.
  • Lee, J., Simond, D., Hawthorne, W., Walters, S., Patel, A., Smith, D., O'Connell, P., Moran, C. (2005). Characterization of the swine major histocompatibility complex alleles at eight loci in Westran pigs. Xenotransplantation, 12(4), 303-307. [More Information]
  • Benseler, V., Bishop, A., Chng, K., Watson, J., Wang, C., Dahlke, M., Koutalistras, N., Watts, A., Hawthorne, W., McKenzie, P., Hennessy, A., Pleass, H., Chadban, S., Schlitt, H., McCaughan, G., et al (2005). Development of a primate model to evaluate strategies to achieve long term renal allograft acceptance. Immunology and Cell Biology, 83(4 Suppl.), A26-A26.
  • O'Connell, P., Hawthorne, W., Simond, D., Chapman, J., Chen, Y., Patel, A., Walters, S., Burgess, J., Weston, L., Stokes, R., Moran, C., Allen, R. (2005). Genetic and Functional evaluation of the level of inbreeding of the Westran pig: a herd with potential for use in xenotransplantation. Xenotransplantation, 12(4), 308-315. [More Information]
  • Yi, S., Ouyang, L., Ha, H., O'Hara, J., Chandra, A., Akima, S., Hawthorne, W., Patel, A., Stokes, R., O'Connell, P. (2005). Involvement of CCR5 Signaling in Macrophage Recruitment to Porcine Islet Xenografts. Transplantation, 80(10), 1468-1475. [More Information]
  • Gunton, J., Kulkarni, R., Yim, S., Okada, T., Hawthorne, W., Tseng, Y., Roberson, R., Ricordi, C., O'Connell, P., Gonzalez, F., et al (2005). Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell, 122(3), 337-349. [More Information]

2004

  • Fletcher, J., Ao, P., Hawthorne, W. (2004). Antiproliferative Effects Of Low Molecular Weight Heparin. ANZ Journal of Surgery, 74(9), 793-796.
  • Huang, P., Hawthorne, W., Fletcher, J. (2004). Time Course Of Cellular Proliferation, Neointima Formation, Apoptosis And Its Fas Pathway Following Dacron Patch Graft Implantation In Sheep Carotid Artery. Cardiovascular Pathology, 13(3 Supplement 1), S118.

2003

  • Yi, S., Hawthorne, W., Lehnert, A., Ha, H., Wong, J., Rooijen, N., Davey, K., Patel, A., Walters, S., Chandra, A., O'Connell, P. (2003). T Cell-Activated Macrophages Are Capable of Both Recognition and Rejection of Pancreatic Islet Xenografts. Journal of Immunology, 170(5), 2750-2758.

2002

  • Yi, S., Feng, X., Hawthorne, W., Patel, A., Walters, S., O'Connel, P. (2002). CD4+ T Cells initiate Pancreatic Islet Xenograft rejection via an interferon-y-Dependent recruitment of macrophages and natural killer cells. Transplantation, 73(3), 437-446.
  • Tso, C., Skinner, M., Hawthorne, W., Fletcher, J. (2002). Matrigel-coated stents reduce intimal thickening in a large animal vascular stent Model. International Angiology, 21(3), 244-249.
  • Hawthorne, W., Pye, A., Vicaretti, M., Fletcher, J. (2002). New Methodology for Assessment of Intimal Hyperplasia of Vascular Prostheses. ANZ Journal of Surgery, 72(9), 623-627.
  • Huang, P., Hawthorne, W., Ao, P., Angeli, G., Medbury, H., Fletcher, J. (2002). Perigraft adventitia and intima remodeling after synthetic patch implantation in sheep carotid artery: Role of apoptosis and proliferation. Journal Of Vascular Surgery, 36(2), 371-378.
  • Hawthorne, W., Ao, P., Fletcher, J. (2002). Vascular closure staples reducae intimal hyperplasia in prosthesis implantation. ANZ Journal of Surgery, 72(12), 862-866.

2001

  • Lehnert, A., Hawthorne, W., O'Connell, P., Mottram, P., Han, W., Walters, S., Patel, A., Cowan, P., d'Apice, A. (2001). Blockage of the cd28 and cd40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice. Transplant Immunology, 9, 51-56.
  • Huang, P., Hawthorne, W., Ao, P., Fletcher, J., Angeli, G., Medbury,, H. (2001). Calcium channel antagonist verapamil inhibits neoinitimal formation and enhances apoptosis in a vas. The American Journal Of Surgery, 181(6), 492-498.
  • Ao, P., Hawthorne, W., Fletcher, J., Bobryshev,, Y., Inder,, S., Cherian, S., Lord,, R. (2001). Colonisation of prosthetic grafts by immunocompetent cells in a sheep model. Vascular, 9(2), 166-176.
  • Allen, R., Nankivell (Nankievell), B., Hawthorne, W., O'Connell, P., Chapman, J. (2001). Pancreas and islet transplantation: an unfinished journey. Transplantation Proceedings, 33, 3485-3488.

2000

  • Hawthorne, W., Cachia, A., Walters, S., Patel, A., Clarke, J., O'Connell, P., Chapman, J., Allen, R. (2000). A large-animal model to evaluate the clinical potential of fetal pig pancreas fragment transplantation. Cell Transplantation, 9, 867-875.
  • Ao, P., Hawthorne, W., Vicaretti, M., Fletcher, J. (2000). Development of Intimal Hyperplasia in six different Vascular Prostheses. European Journal of Vascular and Endovascular Surgery, 20, 241-249.
  • Horton, P., Hawthorne, W., Walters, S., Patel, A., O'Connell, P., Chapman, J., Allen, R. (2000). Induction of allogenic islet tolerance in a large-animal model. Cell Transplantation, 9, 877-887.
  • Ao, P., Hawthorne, W., Vicaretti, M., Fletcher, J. (2000). Verapamil reduces intimal hyperplasia in a sheep carotid artery patch graft model. ANZ Journal of Surgery, 70(1), 64-67.

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