Dr Weiyong Shen

Research Fellow
Clinical Ophthalmology & Eye Health, Central Clinical School
Save Sight Institute

Telephone +61 2 9382 7270
Fax +61 2 9382 7318

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International links

China

(Peking University Eye Center) Prof. Mark Gillies and Dr Weiyong Shen have an ongoing collaborative project to study the role of Muller cell dysfunction in a retinal disease called macular telangiectasis (MacTel) in non-human primates.

United Kingdom

(Institute of Ophthalmology, University College of London) Prof. Mark Gillies and Dr. Weiyong Shen have an ongoing collaborative project with Dr. Marcus Fruttiger to develop a transgenic model for selectively gene targeting Muller cells.

United States

(Prof James Hurley, Department of Biochemistry, University of Washington.) Current collaboration with Prof. Hurley's group is to analyze changes in retinal metabolites and flux through retinas after selective ablation of Muller cells and conditional knockdown of metabolic genes in Muller cells using transgenic models for Muller cell-specific gene targeting.

Selected grants

2013

  • The contribution of aberrant Wnt signalling to neuronal and vascular pathology in retinal disease; Gillies M, Shen W, McAvoy J, Zhu L; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Neuroprotection and anti-angiogenic therapy using a novel transgenic model; Shen W, Zhu L; Ophthalmic Research Institute of Australia (ORIA)/Research Grant.
  • Glial-neuronal-vascular interactions in a novel transgenic model of Muller cell dysfunction; Gillies M, Shen W, Barnett N; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Regulation of bone marrow progenitor cells for diabetic retinopathy; Gillies M, Shen W; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Gilal dysfunction in diabetic retinopathy; Shen W; Ophthalmic Research Institute of Australia (ORIA)/Research Grant.
  • Regulation of bone marrow progenitor cells for treatment of diabetic retinopathy; Shen W, Gillies M; DVC Research/Bridging Support Grant.

Selected publications

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Journals

  • Barthelmes, D., Zhu, L., Shen, W., Gillies, M., Irhimeh, M. (2014). Differential gene expression in Lin-/VEGF-R2+ bone marrow-derived endothelial progenitor cells isolated from diabetic mice. Cardiovascular Diabetology, 13(1), 1-10. [More Information]
  • Shen, W., Lee, S., Araujo, J., Chung, S., Zhu, L., Gillies, M. (2014). Effect of glucocorticoids on neuronal and vascular pathology in a transgenic model of selective Muller cell ablation. Glia, 62(7), 1110-1124. [More Information]
  • Zhu, L., Shen, W., Zhu, M., Coorey, N., Nguyen, A., Barthelmes, D., Gillies, M. (2013). Anti-Retinal Antibodies in Patients With Macular Telangiectasia Type 2. Investigative Ophthalmology and Visual Science, 54(8), 5675-5683. [More Information]
  • Barthelmes, D., Irhimeh, M., Gillies, M., Karimipour, M., Zhou, M., Zhu, L., Shen, W. (2013). Diabetes impairs mobilization of mouse bone marrow-derived Lin−/VEGF-R2+ progenitor cells. Blood Cells, Molecules and Diseases, 51(3), 163-173. [More Information]
  • Chung, S., Shen, W., Jayawardana, K., Wang, P., Yang, J., Shackel, N., Gillies, M. (2013). Differential gene expression profiling after conditional müller-cell ablation in a novel transgenic model. Investigative Ophthalmology and Visual Science, 54(3), 2142-2152. [More Information]
  • Shen, W., Zhu, L., Lee, S., Chung, S., Gillies, M. (2013). Involvement of NT3 and P75NTR in photoreceptor degeneration following selective Muller cell ablation. Journal of Neuroinflammation, 10(137), 1-13. [More Information]
  • Barthelmes, D., Irhimeh, M., Gillies, M., Zhu, L., Shen, W. (2013). Isolation and characterization of mouse bone marrow-derived Lin−/VEGF-R2+ progenitor cells. Annals of Hematology, 92(11), 1461-1472. [More Information]
  • Chung, S., Shen, W., Gillies, M. (2013). Laser Capture Microdissection-Directed Profiling of Glycolytic and mTOR Pathways in Areas of Selectively Ablated Muller Cells in the Murine Retina. Investigative Ophthalmology and Visual Science, 54(10), 6578-6584. [More Information]
  • Shen, W., Fruttiger, M., Zhu, L., Chung, S., Barnett, N., Kirk, J., Lee, S., Coorey, N., Killingsworth, M., Sherman, L., Gillies, M. (2012). Conditional Muller Cell Ablation Causes Independent Neuronal and Vascular Pathologies in a Novel Transgenic Model. The Journal of Neuroscience, 32(45), 15715-15727. [More Information]
  • Coorey, N., Shen, W., Chung, S., Zhu, L., Gillies, M. (2012). The role of glia in retinal vascular disease. Clinical & Experimental Optometry, 95(3), 266-281. [More Information]
  • Irhimeh, M., Shen, W., Chung, S., Zhu, L., Barthelmes, D., Gillies, M. (2011). Erythropoetin treatment recruits pECFCs from the marrow into the blood and stabilizes retinal vasculature. Experimental Hematology, 39(8), S77-S78.
  • Shen, W., Zhang, J., Chung, S., Hu, Y., Ma, Z., Gillies, M. (2011). Submacular DL-alpha-Aminoadipic Acid Eradicates Primate Photoreceptors but Does Not Affect Luteal Pigment or the Retinal Vasculature. Investigative Ophthalmology and Visual Science, 52(1), 119-127. [More Information]
  • Shen, W., Li, S., Chung, S., Zhu, L., Stayt, J., Su, T., Couraud, P., Romero, I., Weksler, B., Gillies, M. (2011). Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium. European Journal of Cell Biology, 90(4), 323-332. [More Information]
  • Shen, W., Li, S., Chung, S., Gillies, M. (2010). Retinal vascular changes after glial disruption in rats. Journal of Neuroscience Research, 88(7), 1485-1499. [More Information]
  • van Eeden, P., Tee, L., Shen, W., Lukehurst, S., Lai, C., Rakoczy, P., Beazley, L., Dunlop, S. (2006). Characterisation of a Model for Retinal Neovascularisation: VEGF model characterisation. Advances in Experimental Medicine and Biology, 572(Retinal Degenerative Diseases), 163-168. [More Information]
  • Graham, C., Binz, N., Shen, W., Constable, I., Rakoczy, P. (2006). Laser Photocoagulation: Ocular Research and Therapy in Diabetic Retinopathy. Advances in Experimental Medicine and Biology, 572(Retinal Degenerative Diseases), 195-200. [More Information]
  • Binz, N., Graham, C., Simpson, K., Lai, Y., Shen, W., Lai, C., Speed, T., Rakoczy, P. (2006). Long-term effect of therapeutic laser photocoagulation on gene expression in the eye. The F A S E B Journal, 20(2), 383-385. [More Information]
  • Shen, W., Lai, C., Graham, C., Binz, N., Lai, Y., Eade, J., Guidolin, D., Ribatti, D., Dunlop, S., Rakoczy, P. (2006). Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model. Diabetologia: clinical and experimental diabetes and metabolism, 49(7), 1690-1701. [More Information]
  • Shen, W., Lai, Y., Lai, C., Binz, N., Beazley, L., Dunlop, S., Rakoczy, P. (2006). Pathological Heterogeneity of Vasoproliferative Retinopathy in Transgenic Mice Overexpressing Vascular Endothelial Growth Factor in Photoreceptors. Advances in Experimental Medicine and Biology. [More Information]
  • Sutanto, E., Zhang, D., Lai, Y., Shen, W., Rakoczy, P. (2006). Potential Use of Cellular Promoter(s) to Target RPE in AAV-Mediated Delivery: Cellular promoters and RPE-targeting. Advances in Experimental Medicine and Biology, 572(Retinal Degenerative Diseases), 267-273. [More Information]
  • Kicic, A., Hall, C., Shen, W., Rakoczy, P. (2005). Are stem cell characteristics altered by disease state? Stem Cells and Development, 14(1), 15-28. [More Information]
  • Sutanto, E., Zhang, D., Lai, Y., Shen, W., Rakoczy, P. (2005). Development and Evaluation of the Specificity of a Cathepsin D Proximal Promoter in the Eye. Current Eye Research, 30(1), 53-61. [More Information]
  • Constable, I., Shen, W., Rakoczy, E. (2005). Emerging biological therapies for age-related macula degeneration. Expert opinion on biological therapy, 5(10), 1373-1385. [More Information]
  • Rodger, J., Symonds, A., Springbett, J., Shen, W., Bartlett, C., Rakoczy, P., Beazley, L., Dunlop, S. (2005). Eph/ephrin expression in the adult rat visual system following localized retinal lesions: localized and transneuronal up-regulation in the retina and superior colliculus. European Journal of Neuroscience, 22(8), 1840-1852. [More Information]
  • Lai, C., Dunlop, S., May, L., Gorbatov, M., Brankov, M., Shen, W., Binz, N., Lai, Y., Graham, C., Barry, C., Constable, I., Beazley, L., et al (2005). Generation of transgenic mice with mild and severe retinal neovascularisation. The British Journal of Ophthalmology, 89(7), 911-916. [More Information]
  • Lai, C., Shen, W., Brankov, M., Lai, Y., Barnett, N., Lee, S., Yeo, I., Mathur, R., Ho, J., Pineda, P., et al (2005). Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys. Molecular Therapy, 12(4), 659-668. [More Information]
  • Shen, W., Lai, Y., Lai, C., Rakoczy, P. (2004). Impurity of recombinant adeno-associated virus type 2 affects the transduction characteristics following subretinal injection in the rat. Vision Research, 44(4), 339-348. [More Information]
  • Shen, W., Lee, S., Yeo, I., Lai, C., Mathur, R., Tan, D., Constable, I., Rakoczy, P. (2004). Predilection of the macular region to high incidence of choroidal neovascularization after intense laser photocoagulation in the monkey. Archives of Ophthalmology, 122(3), 353-360. [More Information]
  • Wilson, A., Hobbs, B., Shen, W., Speed, T., Schmidt, U., Begley, C., Rakoczy, P. (2003). Argon Laser Photocoagulation-Induced Modification of Gene Expression in the Retina. Investigative Ophthalmology and Visual Science, 44(4), 1426-1434. [More Information]
  • Kicic, A., Shen, W., Wilson, A., Constable, I., Robertson, T., Rakoczy, P. (2003). Differentiation of Marrow Stromal Cells into Photoreceptors in the Rat Eye. The Journal of Neuroscience, 23(21), 7742-7749. [More Information]
  • Shen, W., Lai, C., Lai, Y., Zhang, D., Zaknich, T., Sutanto, E., Constable, I., Rakoczy, P. (2003). Practical considerations of recombinant adeno-associated virus-mediated gene transfer for treatment of retinal degenerations. Journal of Gene Medicine, 5(7), 576-587. [More Information]
  • Daniels, D., Shen, W., Constable, I., Rakoczy, P. (2003). Quantitative model demonstrating that recombinant adeno-associated virus and green fluorescent protein are non-toxic to the rat retina. Clinical and Experimental Ophthalmology, 31. [More Information]

2014

  • Barthelmes, D., Zhu, L., Shen, W., Gillies, M., Irhimeh, M. (2014). Differential gene expression in Lin-/VEGF-R2+ bone marrow-derived endothelial progenitor cells isolated from diabetic mice. Cardiovascular Diabetology, 13(1), 1-10. [More Information]
  • Shen, W., Lee, S., Araujo, J., Chung, S., Zhu, L., Gillies, M. (2014). Effect of glucocorticoids on neuronal and vascular pathology in a transgenic model of selective Muller cell ablation. Glia, 62(7), 1110-1124. [More Information]

2013

  • Zhu, L., Shen, W., Zhu, M., Coorey, N., Nguyen, A., Barthelmes, D., Gillies, M. (2013). Anti-Retinal Antibodies in Patients With Macular Telangiectasia Type 2. Investigative Ophthalmology and Visual Science, 54(8), 5675-5683. [More Information]
  • Barthelmes, D., Irhimeh, M., Gillies, M., Karimipour, M., Zhou, M., Zhu, L., Shen, W. (2013). Diabetes impairs mobilization of mouse bone marrow-derived Lin−/VEGF-R2+ progenitor cells. Blood Cells, Molecules and Diseases, 51(3), 163-173. [More Information]
  • Chung, S., Shen, W., Jayawardana, K., Wang, P., Yang, J., Shackel, N., Gillies, M. (2013). Differential gene expression profiling after conditional müller-cell ablation in a novel transgenic model. Investigative Ophthalmology and Visual Science, 54(3), 2142-2152. [More Information]
  • Shen, W., Zhu, L., Lee, S., Chung, S., Gillies, M. (2013). Involvement of NT3 and P75NTR in photoreceptor degeneration following selective Muller cell ablation. Journal of Neuroinflammation, 10(137), 1-13. [More Information]
  • Barthelmes, D., Irhimeh, M., Gillies, M., Zhu, L., Shen, W. (2013). Isolation and characterization of mouse bone marrow-derived Lin−/VEGF-R2+ progenitor cells. Annals of Hematology, 92(11), 1461-1472. [More Information]
  • Chung, S., Shen, W., Gillies, M. (2013). Laser Capture Microdissection-Directed Profiling of Glycolytic and mTOR Pathways in Areas of Selectively Ablated Muller Cells in the Murine Retina. Investigative Ophthalmology and Visual Science, 54(10), 6578-6584. [More Information]

2012

  • Shen, W., Fruttiger, M., Zhu, L., Chung, S., Barnett, N., Kirk, J., Lee, S., Coorey, N., Killingsworth, M., Sherman, L., Gillies, M. (2012). Conditional Muller Cell Ablation Causes Independent Neuronal and Vascular Pathologies in a Novel Transgenic Model. The Journal of Neuroscience, 32(45), 15715-15727. [More Information]
  • Coorey, N., Shen, W., Chung, S., Zhu, L., Gillies, M. (2012). The role of glia in retinal vascular disease. Clinical & Experimental Optometry, 95(3), 266-281. [More Information]

2011

  • Irhimeh, M., Shen, W., Chung, S., Zhu, L., Barthelmes, D., Gillies, M. (2011). Erythropoetin treatment recruits pECFCs from the marrow into the blood and stabilizes retinal vasculature. Experimental Hematology, 39(8), S77-S78.
  • Shen, W., Zhang, J., Chung, S., Hu, Y., Ma, Z., Gillies, M. (2011). Submacular DL-alpha-Aminoadipic Acid Eradicates Primate Photoreceptors but Does Not Affect Luteal Pigment or the Retinal Vasculature. Investigative Ophthalmology and Visual Science, 52(1), 119-127. [More Information]
  • Shen, W., Li, S., Chung, S., Zhu, L., Stayt, J., Su, T., Couraud, P., Romero, I., Weksler, B., Gillies, M. (2011). Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium. European Journal of Cell Biology, 90(4), 323-332. [More Information]

2010

  • Shen, W., Li, S., Chung, S., Gillies, M. (2010). Retinal vascular changes after glial disruption in rats. Journal of Neuroscience Research, 88(7), 1485-1499. [More Information]

2006

  • van Eeden, P., Tee, L., Shen, W., Lukehurst, S., Lai, C., Rakoczy, P., Beazley, L., Dunlop, S. (2006). Characterisation of a Model for Retinal Neovascularisation: VEGF model characterisation. Advances in Experimental Medicine and Biology, 572(Retinal Degenerative Diseases), 163-168. [More Information]
  • Graham, C., Binz, N., Shen, W., Constable, I., Rakoczy, P. (2006). Laser Photocoagulation: Ocular Research and Therapy in Diabetic Retinopathy. Advances in Experimental Medicine and Biology, 572(Retinal Degenerative Diseases), 195-200. [More Information]
  • Binz, N., Graham, C., Simpson, K., Lai, Y., Shen, W., Lai, C., Speed, T., Rakoczy, P. (2006). Long-term effect of therapeutic laser photocoagulation on gene expression in the eye. The F A S E B Journal, 20(2), 383-385. [More Information]
  • Shen, W., Lai, C., Graham, C., Binz, N., Lai, Y., Eade, J., Guidolin, D., Ribatti, D., Dunlop, S., Rakoczy, P. (2006). Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model. Diabetologia: clinical and experimental diabetes and metabolism, 49(7), 1690-1701. [More Information]
  • Shen, W., Lai, Y., Lai, C., Binz, N., Beazley, L., Dunlop, S., Rakoczy, P. (2006). Pathological Heterogeneity of Vasoproliferative Retinopathy in Transgenic Mice Overexpressing Vascular Endothelial Growth Factor in Photoreceptors. Advances in Experimental Medicine and Biology. [More Information]
  • Sutanto, E., Zhang, D., Lai, Y., Shen, W., Rakoczy, P. (2006). Potential Use of Cellular Promoter(s) to Target RPE in AAV-Mediated Delivery: Cellular promoters and RPE-targeting. Advances in Experimental Medicine and Biology, 572(Retinal Degenerative Diseases), 267-273. [More Information]

2005

  • Kicic, A., Hall, C., Shen, W., Rakoczy, P. (2005). Are stem cell characteristics altered by disease state? Stem Cells and Development, 14(1), 15-28. [More Information]
  • Sutanto, E., Zhang, D., Lai, Y., Shen, W., Rakoczy, P. (2005). Development and Evaluation of the Specificity of a Cathepsin D Proximal Promoter in the Eye. Current Eye Research, 30(1), 53-61. [More Information]
  • Constable, I., Shen, W., Rakoczy, E. (2005). Emerging biological therapies for age-related macula degeneration. Expert opinion on biological therapy, 5(10), 1373-1385. [More Information]
  • Rodger, J., Symonds, A., Springbett, J., Shen, W., Bartlett, C., Rakoczy, P., Beazley, L., Dunlop, S. (2005). Eph/ephrin expression in the adult rat visual system following localized retinal lesions: localized and transneuronal up-regulation in the retina and superior colliculus. European Journal of Neuroscience, 22(8), 1840-1852. [More Information]
  • Lai, C., Dunlop, S., May, L., Gorbatov, M., Brankov, M., Shen, W., Binz, N., Lai, Y., Graham, C., Barry, C., Constable, I., Beazley, L., et al (2005). Generation of transgenic mice with mild and severe retinal neovascularisation. The British Journal of Ophthalmology, 89(7), 911-916. [More Information]
  • Lai, C., Shen, W., Brankov, M., Lai, Y., Barnett, N., Lee, S., Yeo, I., Mathur, R., Ho, J., Pineda, P., et al (2005). Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys. Molecular Therapy, 12(4), 659-668. [More Information]

2004

  • Shen, W., Lai, Y., Lai, C., Rakoczy, P. (2004). Impurity of recombinant adeno-associated virus type 2 affects the transduction characteristics following subretinal injection in the rat. Vision Research, 44(4), 339-348. [More Information]
  • Shen, W., Lee, S., Yeo, I., Lai, C., Mathur, R., Tan, D., Constable, I., Rakoczy, P. (2004). Predilection of the macular region to high incidence of choroidal neovascularization after intense laser photocoagulation in the monkey. Archives of Ophthalmology, 122(3), 353-360. [More Information]

2003

  • Wilson, A., Hobbs, B., Shen, W., Speed, T., Schmidt, U., Begley, C., Rakoczy, P. (2003). Argon Laser Photocoagulation-Induced Modification of Gene Expression in the Retina. Investigative Ophthalmology and Visual Science, 44(4), 1426-1434. [More Information]
  • Kicic, A., Shen, W., Wilson, A., Constable, I., Robertson, T., Rakoczy, P. (2003). Differentiation of Marrow Stromal Cells into Photoreceptors in the Rat Eye. The Journal of Neuroscience, 23(21), 7742-7749. [More Information]
  • Shen, W., Lai, C., Lai, Y., Zhang, D., Zaknich, T., Sutanto, E., Constable, I., Rakoczy, P. (2003). Practical considerations of recombinant adeno-associated virus-mediated gene transfer for treatment of retinal degenerations. Journal of Gene Medicine, 5(7), 576-587. [More Information]
  • Daniels, D., Shen, W., Constable, I., Rakoczy, P. (2003). Quantitative model demonstrating that recombinant adeno-associated virus and green fluorescent protein are non-toxic to the rat retina. Clinical and Experimental Ophthalmology, 31. [More Information]

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