Associate Professor William Phillips

Associate Professor
Physiology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9351 4598
Fax +61 2 9351 2058

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Research interests

Dr Bill Phillips’ group uses techniques of molecular physiology to investigate the mechanisms that underlie the formation and modification of synapses between nerve and muscle throughout life, and how neuromuscular diseases can interfere with these fundamental processes, leading to weakness.

Selected grants

2015

  • Muscle Specific Kinase signalling and its protective effects in neuromuscular diseases; Phillips W; DVC Research/Bridging Support Grant.

2012

  • Upgrade of the Palm Duoflex Combi Laser Microdissection and Optical Tweezers System to a High-resolution and Improved Live-cell Imaging Platform using an Apotome.2 Slider and Associated Software; Cole L, Mason R, Richardson D, Phillips W, Bao B, Buckland M, Morris M, Dos Remedios C; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2010

  • The role of Ten-m3 in patterning ipsilateral retinal projections; Leamey C, Marotte L, Phillips W; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Postsynaptic signalling systems that sustain the nerve-muscle synapse; Phillips W, Reddel S, Noakes P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Multiphoton microscope for Cellular Imaging in Live Animals; Leamey C, Phillips W, Dampney R, Westbrook R, Morley J, Arabzadeh E, Dreher B, Solomon S, Protti D, McGregor I, King N, Hunt N, Keay K, Allen D, Koeppl C, Cullen K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2007

  • Rapsyn controls acetylcholine receptor turnover and packing density in the post-synaptic membrane during development; Phillips W; University of Sydney/Research & Development.

2006

  • Seronegative myasthenia gravis: effects of auto-antibodies against muscle specific kinase (MUSK) on the neuromuscular junction; Phillips W, Reddel S; Muscular Dystrophy Association of New South Wales/Project Support.
  • Anti-Musk antibodies and the mechanisms of seronegative myasthenia gravis; Phillips W; Muscular Dystrophy Association (USA)/Priority Projects.
  • University of Sydney - Bridging Support Grant; Phillips W; University of Sydney/Bridging Support.

2004

  • The role of the acetylcholine receptor-associated protein, rapsyn, in the mature nervous system; Phillips W; Motor Neurone Disease Research Institute of Australia/Research Grant.

2003

  • Protein partners of rapsyn that regulate acetylcholine receptor clustering; Phillips W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Dynamics of Synaptic Protein Aggregation; Phillips W; DVC Research/Research and Development Scheme: Research and Development (R&D).

2002

  • Mechanisms of postsynaptic differentiation; Phillips W; University of Sydney/Medicine Bridging.
  • Identifying protein interactions involved in inhibitory synapse formation; Phillips W; DVC Research/Research and Development Scheme: Research and Development (R&D).

2001

  • Mechanisms of postsynaptic differeniation; Phillips W; DVC Research/Bridging Support Grant.
  • Advanced networked pcr system: multi-block system for the control of polymerase chain reaction work in a multi-user environment; Stone J, Phillips W; Rebecca L Cooper/Medical Research Foundation.

2000

  • Characterisation of a novel human neuromuscular disease associated with deficiency of the syntrophins and dystrobrevin; North K, Phillips W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The localization of acetylcholine receptors in the postsynaptic membrane of skeletal muscle; Phillips W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Syncytial integration of autonomic transmission; Bennett M, Phillips W, Gibson W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Role of rapsyn in postsynaptic receptor clustering; Phillips W, Noakes P; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Reddel, S., Morsch, M., Phillips, W. (2014). Clinical and scientific aspects of muscle-specific tyrosine kinase-related myasthenia gravis. Current Opinion In Neurology, 27(5), 558-565. [More Information]
  • Ghazanfari, N., Morsch, M., Tse, N., Reddel, S., Phillips, W. (2014). Effects of the Beta2-Adrenoceptor Agonist, Albuterol, in a Mouse Model of Anti-MuSK myasthenia Gravis. PloS One, 9(2), 1-11. [More Information]
  • Ghazanfari, N., Morsch, M., Reddel, S., Liang, S., Phillips, W. (2014). Muscle Specific Kinase autoantibodies suppress the MuSK pathway and ACh receptor retention at the mouse neuromuscular junction. The Journal of Physiology, 592(pt 13), 2881-2897. [More Information]
  • Liang, S., Phillips, W. (2013). Migration of Resident Cardiac Stem Cells in Myocardial Infarction. Anatomical Record - Advances in Integrative Anatomy and Evolutionary Biology, 296(2), 184-191. [More Information]
  • Morsch, M., Reddel, S., Ghazanfari, N., Toyka, K., Phillips, W. (2013). Pyridostigmine but not 3,4-diaminopyridine exacerbates ACh receptor loss and myasthenia induced in mice by muscle specific kinase autoantibody. The Journal of Physiology, 591(10), 2747-2762. [More Information]
  • Cheng, A., Morsch, M., Murata, Y., Ghazanfari, N., Reddel, S., Phillips, W. (2013). Sequence of Age-Associated Changes to the Mouse Neuromuscular Junction and the Protective Effects of Voluntary Exercise. PloS One, 8(7), 1-8. [More Information]
  • Morsch, M., Reddel, S., Ghazanfari, N., Toyka, K., Phillips, W. (2012). Muscle specific kinase autoantibodies cause synaptic failure through progressive wastage of postsynaptic acetylcholine receptors. Experimental Neurology, 237(2), 286-295. [More Information]
  • Ngo, S., Cole, R., Sunn, N., Phillips, W., Noakes, P. (2012). Neuregulin-1 Potentiates Agrin-Induced Acetylcholine Receptor Clustering via Muscle Specific Kinase Phosphorylation. Journal of Cell Science, 125(6), 1531-1543. [More Information]
  • Gervasio, O., Phillips, W., Cole, L., Allen, D. (2011). Caveolae respond to cell stretch and contribute to stretch-induced signaling. Journal of Cell Science, 124(21), 3581-3590. [More Information]
  • Ghazanfari, N., Fernandez, K., Murata, Y., Morsch, M., Ngo, S., Reddel, S., Noakes, P., Phillips, W. (2011). Muscle Specific Kinase: Organiser of synaptic membrane domains. The International Journal of Biochemistry and Cell Biology, 43(3), 295-298. [More Information]
  • Cole, R., Ghazanfari, N., Ngo, S., Gervasio, O., Reddel, S., Phillips, W. (2010). Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice. The Journal of Physiology, 588(17), 3217-3229. [More Information]
  • Cole, R., Reddel, S., Gervasio, O., Phillips, W. (2008). Anti-MuSK Patient Antibodies Disrupt the Mouse Neuromuscular Junction. Annals of Neurology, 63(6), 782-789. [More Information]
  • Brockhausen, J., Cole, R., Gervasio, O., Ngo, S., Noakes, P., Phillips, W. (2008). Neural agrin increases postsynaptic ACh receptor packing by elevating rapsyn protein at the mouse neuromuscular synapse. Developmental Neurobiology, 68(9), 1153-1169. [More Information]
  • Gervasio, O., Whitehead, N., Yeung, E., Phillips, W., Allen, D. (2008). TRPC1 binds to caveolin-3 and is regulated by Src kinase – role in Duchenne muscular dystrophy. Journal of Cell Science, 121(13), 2246-2255. [More Information]
  • Gervasio, O., Armson, P., Phillips, W. (2007). Developmental increase in the amount of rapsyn per acetylcholine receptor promotes postsynaptic receptor packing and stability. Developmental Biology, 305(1), 262-275. [More Information]
  • Ngo, S., Noakes, P., Phillips, W. (2007). Neural agrin: a synaptic stabiliser. The International Journal of Biochemistry and Cell Biology, 39(5), 863-867. [More Information]
  • Gervasio, O., Phillips, W. (2005). Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse. The Journal of Physiology, 562(3), 673-685.
  • Ngo, S., Balke, C., Phillips, W., Noakes, P. (2004). Neuregulin potentiates agrin-induced acetylcholine receptor clustering in myotubes. NeuroReport, 15(16), 2501-2505. [More Information]
  • Knight, D., D'Arbe, M., Liang, S., Phillips, W., Lavidis, N. (2003). Regional differences in sympathetic purinergic transmission along the length of the mouse vas deferens. Synapse (New York), 47, 225-235. [More Information]
  • Phillips, W., Froehner, S. (2002). GABARAP and GABAa receptor clustering. Neuron, 33(1), 1-2.
  • Jiang, L., Tsubakihara, M., Heinke, M., Phillips, W., Dos Remedios, C., Nosworthy, N., Yao, M. (2001). Heart failure and apoptosis: Electrophoretic methods support data from micro- and macro-arrays. A critical review of genomics and proteomics. Proteomics, 1 (12), 1481-1488.
  • Liang, S., Phillips, W., Moussa, C., Motin, L., Lavidis,, N. (2001). Spatial Distribution and developmental appearance of Postjunctional P2X1 Receptors on smooth muscle cells of the mouse vas deferencs. Synapse (New York), 42, 1-11.
  • Liang, S., Phillips, W., Jenkins, N., Gilbert, D., Copeland, N. (2001). Structure and chromosome location of the mouse P2X1 purinoceptor gene (P2rx1). Cytogenetics and Cell Genetics, 92, 333-336.

2014

  • Reddel, S., Morsch, M., Phillips, W. (2014). Clinical and scientific aspects of muscle-specific tyrosine kinase-related myasthenia gravis. Current Opinion In Neurology, 27(5), 558-565. [More Information]
  • Ghazanfari, N., Morsch, M., Tse, N., Reddel, S., Phillips, W. (2014). Effects of the Beta2-Adrenoceptor Agonist, Albuterol, in a Mouse Model of Anti-MuSK myasthenia Gravis. PloS One, 9(2), 1-11. [More Information]
  • Ghazanfari, N., Morsch, M., Reddel, S., Liang, S., Phillips, W. (2014). Muscle Specific Kinase autoantibodies suppress the MuSK pathway and ACh receptor retention at the mouse neuromuscular junction. The Journal of Physiology, 592(pt 13), 2881-2897. [More Information]

2013

  • Liang, S., Phillips, W. (2013). Migration of Resident Cardiac Stem Cells in Myocardial Infarction. Anatomical Record - Advances in Integrative Anatomy and Evolutionary Biology, 296(2), 184-191. [More Information]
  • Morsch, M., Reddel, S., Ghazanfari, N., Toyka, K., Phillips, W. (2013). Pyridostigmine but not 3,4-diaminopyridine exacerbates ACh receptor loss and myasthenia induced in mice by muscle specific kinase autoantibody. The Journal of Physiology, 591(10), 2747-2762. [More Information]
  • Cheng, A., Morsch, M., Murata, Y., Ghazanfari, N., Reddel, S., Phillips, W. (2013). Sequence of Age-Associated Changes to the Mouse Neuromuscular Junction and the Protective Effects of Voluntary Exercise. PloS One, 8(7), 1-8. [More Information]

2012

  • Morsch, M., Reddel, S., Ghazanfari, N., Toyka, K., Phillips, W. (2012). Muscle specific kinase autoantibodies cause synaptic failure through progressive wastage of postsynaptic acetylcholine receptors. Experimental Neurology, 237(2), 286-295. [More Information]
  • Ngo, S., Cole, R., Sunn, N., Phillips, W., Noakes, P. (2012). Neuregulin-1 Potentiates Agrin-Induced Acetylcholine Receptor Clustering via Muscle Specific Kinase Phosphorylation. Journal of Cell Science, 125(6), 1531-1543. [More Information]

2011

  • Gervasio, O., Phillips, W., Cole, L., Allen, D. (2011). Caveolae respond to cell stretch and contribute to stretch-induced signaling. Journal of Cell Science, 124(21), 3581-3590. [More Information]
  • Ghazanfari, N., Fernandez, K., Murata, Y., Morsch, M., Ngo, S., Reddel, S., Noakes, P., Phillips, W. (2011). Muscle Specific Kinase: Organiser of synaptic membrane domains. The International Journal of Biochemistry and Cell Biology, 43(3), 295-298. [More Information]

2010

  • Cole, R., Ghazanfari, N., Ngo, S., Gervasio, O., Reddel, S., Phillips, W. (2010). Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice. The Journal of Physiology, 588(17), 3217-3229. [More Information]

2008

  • Cole, R., Reddel, S., Gervasio, O., Phillips, W. (2008). Anti-MuSK Patient Antibodies Disrupt the Mouse Neuromuscular Junction. Annals of Neurology, 63(6), 782-789. [More Information]
  • Brockhausen, J., Cole, R., Gervasio, O., Ngo, S., Noakes, P., Phillips, W. (2008). Neural agrin increases postsynaptic ACh receptor packing by elevating rapsyn protein at the mouse neuromuscular synapse. Developmental Neurobiology, 68(9), 1153-1169. [More Information]
  • Gervasio, O., Whitehead, N., Yeung, E., Phillips, W., Allen, D. (2008). TRPC1 binds to caveolin-3 and is regulated by Src kinase – role in Duchenne muscular dystrophy. Journal of Cell Science, 121(13), 2246-2255. [More Information]

2007

  • Gervasio, O., Armson, P., Phillips, W. (2007). Developmental increase in the amount of rapsyn per acetylcholine receptor promotes postsynaptic receptor packing and stability. Developmental Biology, 305(1), 262-275. [More Information]
  • Ngo, S., Noakes, P., Phillips, W. (2007). Neural agrin: a synaptic stabiliser. The International Journal of Biochemistry and Cell Biology, 39(5), 863-867. [More Information]

2005

  • Gervasio, O., Phillips, W. (2005). Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse. The Journal of Physiology, 562(3), 673-685.

2004

  • Ngo, S., Balke, C., Phillips, W., Noakes, P. (2004). Neuregulin potentiates agrin-induced acetylcholine receptor clustering in myotubes. NeuroReport, 15(16), 2501-2505. [More Information]

2003

  • Knight, D., D'Arbe, M., Liang, S., Phillips, W., Lavidis, N. (2003). Regional differences in sympathetic purinergic transmission along the length of the mouse vas deferens. Synapse (New York), 47, 225-235. [More Information]

2002

  • Phillips, W., Froehner, S. (2002). GABARAP and GABAa receptor clustering. Neuron, 33(1), 1-2.

2001

  • Jiang, L., Tsubakihara, M., Heinke, M., Phillips, W., Dos Remedios, C., Nosworthy, N., Yao, M. (2001). Heart failure and apoptosis: Electrophoretic methods support data from micro- and macro-arrays. A critical review of genomics and proteomics. Proteomics, 1 (12), 1481-1488.
  • Liang, S., Phillips, W., Moussa, C., Motin, L., Lavidis,, N. (2001). Spatial Distribution and developmental appearance of Postjunctional P2X1 Receptors on smooth muscle cells of the mouse vas deferencs. Synapse (New York), 42, 1-11.
  • Liang, S., Phillips, W., Jenkins, N., Gilbert, D., Copeland, N. (2001). Structure and chromosome location of the mouse P2X1 purinoceptor gene (P2rx1). Cytogenetics and Cell Genetics, 92, 333-336.

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