Dr William Ritchie

Senior Research Fellow
Centenary Institute of Cancer Medicine & Cell Biology, Central Clinical School

Telephone +61 2 9565 6262

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Selected grants

2015

  • Investigating widespread regulation of gene expression through intron retention; Rasko J, Ritchie W, Wong J; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • Intron retention regulation in granulopoiesis and leukaemia; Rasko J, Ritchie W; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Small non-coding RNAs control alternative splicing in Chronic Myeloid Leukaemia; Ritchie W; Cancer Institute New South Wales/Career Development Fellowship.

2009

  • Exploring roles for micro RNAs in cancer using bioinformatics and gene expression tools; Ritchie W; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

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Book Chapters

  • Ritchie, W., Rasko, J., Flamant, S. (2013). MicroRNA Target Prediction and Validation. In Ulf Schmitz, Olaf Wolkenhauer, Julio Vera (Eds.), MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools, (pp. 39-53). Dordrecht: Springer.
  • Ritchie, W., Rasko, J. (2012). Integrated miRNA expression analysis and target prediction. In Jian-Bing Fan (Eds.), Methods in Molecular Biology: Next-Generation MicroRNA Expression Profiling Technology: Methods and Protocols, (pp. 289-293). New York, United States: Springer.

Journals

  • Wang, K., Hardie, R., Hoy, A., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M., Balaban, S., Nagarajah, R., Wong, J., Metierre, C., Pinello, N., Otte, N., Bailey, C., Ritchie, W., Rasko, J., Holst, J., et al (2015). Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. Journal of Pathology, 236(3), 278-289. [More Information]
  • Hancock, D., Shklovskaya, E., Guy, T., Falsafi, R., Fjell, C., Ritchie, W., Hancock, R., Fazekas de St Groth, B. (2014). A Systems Biology Approach to the Analysis of Subset-Specific Responses to Lipopolysaccharide in Dendritic Cells. PloS One, 9(6), 1-16. [More Information]
  • Hussein, S., Puri, M., Tonge, P., Benevento, M., Corso, A., Clancy, J., Mosbergen, R., Li, M., Lee, D., Cloonan, N., Middleton, R., Ritchie, W., Rasko, J., et al (2014). Genome-wide characterization of the routes to pluripotency. Nature, 516(7530), 198-206. [More Information]
  • Wong, J., Ritchie, W., Gao, D., Lau, K., Gonzalez, M., Choudhary, A., Taft, R., Rasko, J., Holst, J. (2014). Identification of nuclear-enriched miRNAs during mouse granulopoiesis. Journal of Hematology & Oncology, 7(1), 1-15. [More Information]
  • Ritchie, W., Rasko, J. (2014). Refining microRNA target predictions: sorting the wheat from the chaff. Biochemical and Biophysical Research Communications, 445(4), 780-784. [More Information]
  • Gao, D., Middleton, R., Rasko, J., Ritchie, W. (2013). miREval 2.0: a web tool for simple microRNA prediction in genome sequences. Bioinformatics, 29(24), 3225-3226. [More Information]
  • Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]
  • Wang, K., Tiffen, J., Bailey, C., Lehman, M., Ritchie, W., Fazli, L., Metierre, C., Feng, Y., Li, E., Gleave, M., Rasko, J., Holst, J., et al (2013). Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development. Journal of the National Cancer Institute, 105(19), 1463-1473. [More Information]
  • Ritchie, W., Gao, D., Rasko, J. (2012). Defining and providing robust controls for microRNA prediction. Bioinformatics, 28(8), 1058-1061. [More Information]
  • Bagnall, R., Tsoutsman, T., Shephard, R., Ritchie, W., Semsarian, C. (2012). Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure. PloS One, 7(9), 1-8. [More Information]
  • Flamant, S., Ritchie, W., Guilhot, J., Holst, J., Bonnet, M., Chomel, J., Guilhot, F., Turhan, A., Rasko, J. (2010). Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia. Haematologica: the hematology journal, 95(8), 1325-1333. [More Information]
  • Taft, R., Simons, C., Nahkuri, S., Oey, H., Korbie, D., Mercer, T., Holst, J., Ritchie, W., Wong, J., Rasko, J., et al (2010). Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nature Structural and Molecular Biology, 17(8), 1030-1035. [More Information]
  • Ritchie, W., Rajasekhar, M., Flamant, S., Rasko, J. (2009). Conserved expression patterns predict microRNA targets. PLoS Computational Biology, 5(9), e1000513 - 1-e1000513 - 8. [More Information]
  • Ritchie, W., Flamant, S., Rasko, J. (2009). mimiRNA: a microRNA expression profiler and classification resource designed to identify functional correlations between microRNAs and their targets. Bioinformatics, 26(2), 223-227. [More Information]
  • Ritchie, W., Flamant, S., Rasko, J. (2009). Predicting microRNA targets and functions: traps for the unwary. Nature Methods, 6(6), 397-398. [More Information]
  • Ritchie, W., Rasko, J., Marcucci, G., Radmacher, M., Bloomfield, C. (2008). MicroRNA in Acute Myeloid Leukemia. The New England Journal of Medicine, 359(6), 653-654. [More Information]
  • Ritchie, W., Theodule, F., Gautheret, D. (2008). Mireval: a web tool for simple microRNA prediction in genome sequences. Bioinformatics, 24(11), 1394-1396. [More Information]
  • Ritchie, W., Legendre, M., Gautheret, D. (2007). RNA stem-loops: to be or not to be cleaved by RNAse III. RNA, 13(4), 457-462. [More Information]
  • Ara, T., Lopez, F., Ritchie, W., Benech, P., Gautheret, D. (2006). Conservation of alternative polyadenylation patterns in mammalian genes. BMC Genomics, 7, 189-1-189-11. [More Information]
  • Legendre, M., Ritchie, W., Lopez, F., Gautheret, D. (2006). Differential repression of alternative transcripts: a screen for miRNA targets. PLoS Computational Biology, 2(5), e43-333-342. [More Information]
  • Desagher, S., Severac, D., Lipkin, A., Bernis, C., Ritchie, W., Le Digarcher, A., Journot, L. (2005). Genes regulated in neurons undergoing transcription-dependent apoptosis belong to signaling pathways rather than the apoptotic machinery. Journal of Biological Chemistry, 280(7), 5693-5702. [More Information]

2015

  • Wang, K., Hardie, R., Hoy, A., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M., Balaban, S., Nagarajah, R., Wong, J., Metierre, C., Pinello, N., Otte, N., Bailey, C., Ritchie, W., Rasko, J., Holst, J., et al (2015). Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. Journal of Pathology, 236(3), 278-289. [More Information]

2014

  • Hancock, D., Shklovskaya, E., Guy, T., Falsafi, R., Fjell, C., Ritchie, W., Hancock, R., Fazekas de St Groth, B. (2014). A Systems Biology Approach to the Analysis of Subset-Specific Responses to Lipopolysaccharide in Dendritic Cells. PloS One, 9(6), 1-16. [More Information]
  • Hussein, S., Puri, M., Tonge, P., Benevento, M., Corso, A., Clancy, J., Mosbergen, R., Li, M., Lee, D., Cloonan, N., Middleton, R., Ritchie, W., Rasko, J., et al (2014). Genome-wide characterization of the routes to pluripotency. Nature, 516(7530), 198-206. [More Information]
  • Wong, J., Ritchie, W., Gao, D., Lau, K., Gonzalez, M., Choudhary, A., Taft, R., Rasko, J., Holst, J. (2014). Identification of nuclear-enriched miRNAs during mouse granulopoiesis. Journal of Hematology & Oncology, 7(1), 1-15. [More Information]
  • Ritchie, W., Rasko, J. (2014). Refining microRNA target predictions: sorting the wheat from the chaff. Biochemical and Biophysical Research Communications, 445(4), 780-784. [More Information]

2013

  • Ritchie, W., Rasko, J., Flamant, S. (2013). MicroRNA Target Prediction and Validation. In Ulf Schmitz, Olaf Wolkenhauer, Julio Vera (Eds.), MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools, (pp. 39-53). Dordrecht: Springer.
  • Gao, D., Middleton, R., Rasko, J., Ritchie, W. (2013). miREval 2.0: a web tool for simple microRNA prediction in genome sequences. Bioinformatics, 29(24), 3225-3226. [More Information]
  • Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]
  • Wang, K., Tiffen, J., Bailey, C., Lehman, M., Ritchie, W., Fazli, L., Metierre, C., Feng, Y., Li, E., Gleave, M., Rasko, J., Holst, J., et al (2013). Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development. Journal of the National Cancer Institute, 105(19), 1463-1473. [More Information]

2012

  • Ritchie, W., Gao, D., Rasko, J. (2012). Defining and providing robust controls for microRNA prediction. Bioinformatics, 28(8), 1058-1061. [More Information]
  • Bagnall, R., Tsoutsman, T., Shephard, R., Ritchie, W., Semsarian, C. (2012). Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure. PloS One, 7(9), 1-8. [More Information]
  • Ritchie, W., Rasko, J. (2012). Integrated miRNA expression analysis and target prediction. In Jian-Bing Fan (Eds.), Methods in Molecular Biology: Next-Generation MicroRNA Expression Profiling Technology: Methods and Protocols, (pp. 289-293). New York, United States: Springer.

2010

  • Flamant, S., Ritchie, W., Guilhot, J., Holst, J., Bonnet, M., Chomel, J., Guilhot, F., Turhan, A., Rasko, J. (2010). Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia. Haematologica: the hematology journal, 95(8), 1325-1333. [More Information]
  • Taft, R., Simons, C., Nahkuri, S., Oey, H., Korbie, D., Mercer, T., Holst, J., Ritchie, W., Wong, J., Rasko, J., et al (2010). Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nature Structural and Molecular Biology, 17(8), 1030-1035. [More Information]

2009

  • Ritchie, W., Rajasekhar, M., Flamant, S., Rasko, J. (2009). Conserved expression patterns predict microRNA targets. PLoS Computational Biology, 5(9), e1000513 - 1-e1000513 - 8. [More Information]
  • Ritchie, W., Flamant, S., Rasko, J. (2009). mimiRNA: a microRNA expression profiler and classification resource designed to identify functional correlations between microRNAs and their targets. Bioinformatics, 26(2), 223-227. [More Information]
  • Ritchie, W., Flamant, S., Rasko, J. (2009). Predicting microRNA targets and functions: traps for the unwary. Nature Methods, 6(6), 397-398. [More Information]

2008

  • Ritchie, W., Rasko, J., Marcucci, G., Radmacher, M., Bloomfield, C. (2008). MicroRNA in Acute Myeloid Leukemia. The New England Journal of Medicine, 359(6), 653-654. [More Information]
  • Ritchie, W., Theodule, F., Gautheret, D. (2008). Mireval: a web tool for simple microRNA prediction in genome sequences. Bioinformatics, 24(11), 1394-1396. [More Information]

2007

  • Ritchie, W., Legendre, M., Gautheret, D. (2007). RNA stem-loops: to be or not to be cleaved by RNAse III. RNA, 13(4), 457-462. [More Information]

2006

  • Ara, T., Lopez, F., Ritchie, W., Benech, P., Gautheret, D. (2006). Conservation of alternative polyadenylation patterns in mammalian genes. BMC Genomics, 7, 189-1-189-11. [More Information]
  • Legendre, M., Ritchie, W., Lopez, F., Gautheret, D. (2006). Differential repression of alternative transcripts: a screen for miRNA targets. PLoS Computational Biology, 2(5), e43-333-342. [More Information]

2005

  • Desagher, S., Severac, D., Lipkin, A., Bernis, C., Ritchie, W., Le Digarcher, A., Journot, L. (2005). Genes regulated in neurons undergoing transcription-dependent apoptosis belong to signaling pathways rather than the apoptotic machinery. Journal of Biological Chemistry, 280(7), 5693-5702. [More Information]

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