Dr William Ritchie

Senior Research Fellow
Centenary Institute of Cancer Medicine & Cell Biology, Central Clinical School

Telephone +61 2 9565 6262

Map

Selected grants

2015

  • Investigating widespread regulation of gene expression through intron retention; Ritchie W, Rasko J, Wong J; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • Intron retention regulation in granulopoiesis and leukaemia; Rasko J, Ritchie W; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Small non-coding RNAs control alternative splicing in Chronic Myeloid Leukaemia; Ritchie W; Cancer Institute New South Wales/Career Development Fellowship.

2009

  • Exploring roles for micro RNAs in cancer using bioinformatics and gene expression tools; Ritchie W; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Book Chapters

  • Ritchie, W., Rasko, J., Flamant, S. (2013). MicroRNA Target Prediction and Validation. In Ulf Schmitz, Olaf Wolkenhauer, Julio Vera (Eds.), MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools, (pp. 39-53). Dordrecht: Springer.
  • Ritchie, W., Rasko, J. (2012). Integrated miRNA expression analysis and target prediction. In Jian-Bing Fan (Eds.), Methods in Molecular Biology: Next-Generation MicroRNA Expression Profiling Technology: Methods and Protocols, (pp. 289-293). New York, United States: Springer.

Journals

  • Hancock, D., Shklovskaya, E., Guy, T., Falsafi, R., Fjell, C., Ritchie, W., Hancock, R., Fazekas de St Groth, B. (2014). A Systems Biology Approach to the Analysis of Subset-Specific Responses to Lipopolysaccharide in Dendritic Cells. PloS One, 9(6), 1-16. [More Information]
  • Wong, J., Ritchie, W., Gao, D., Lau, K., Gonzalez, M., Choudhary, A., Taft, R., Rasko, J., Holst, J. (2014). Identification of nuclear-enriched miRNAs during mouse granulopoiesis. Journal of Hematology & Oncology, 7(1), 42. [More Information]
  • Ritchie, W., Rasko, J. (2014). Refining microRNA target predictions: sorting the wheat from the chaff. Biochemical and Biophysical Research Communications, 445(4), 780-784. [More Information]
  • Gao, D., Middleton, R., Rasko, J., Ritchie, W. (2013). miREval 2.0: a web tool for simple microRNA prediction in genome sequences. Bioinformatics, 29(24), 3225-3226. [More Information]
  • Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]
  • Wang, K., Tiffen, J., Bailey, C., Lehman, M., Ritchie, W., Fazli, L., Metierre, C., Feng, Y., Li, E., Gleave, M., Rasko, J., Holst, J., et al (2013). Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development. Journal of the National Cancer Institute, 105(19), 1463-1473. [More Information]
  • Ritchie, W., Gao, D., Rasko, J. (2012). Defining and providing robust controls for microRNA prediction. Bioinformatics, 28(8), 1058-1061. [More Information]
  • Bagnall, R., Tsoutsman, T., Shephard, R., Ritchie, W., Semsarian, C. (2012). Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure. PloS One, 7(9), 1-8. [More Information]
  • Flamant, S., Ritchie, W., Guilhot, J., Holst, J., Bonnet, M., Chomel, J., Guilhot, F., Turhan, A., Rasko, J. (2010). Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia. Haematologica: the hematology journal, 95(8), 1325-1333. [More Information]
  • Taft, R., Simons, C., Nahkuri, S., Oey, H., Korbie, D., Mercer, T., Holst, J., Ritchie, W., Wong, J., Rasko, J., et al (2010). Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nature Structural and Molecular Biology, 17(8), 1030-1035. [More Information]
  • Ritchie, W., Rajasekhar, M., Flamant, S., Rasko, J. (2009). Conserved expression patterns predict microRNA targets. PLoS Computational Biology, 5(9), e1000513 - 1-e1000513 - 8. [More Information]
  • Ritchie, W., Flamant, S., Rasko, J. (2009). mimiRNA: a microRNA expression profiler and classification resource designed to identify functional correlations between microRNAs and their targets. Bioinformatics, 26(2), 223-227. [More Information]
  • Ritchie, W., Flamant, S., Rasko, J. (2009). Predicting microRNA targets and functions: traps for the unwary. Nature Methods, 6(6), 397-398. [More Information]
  • Ritchie, W., Rasko, J., Marcucci, G., Radmacher, M., Bloomfield, C. (2008). MicroRNA in Acute Myeloid Leukemia. The New England Journal of Medicine, 359(6), 653-654. [More Information]
  • Ritchie, W., Theodule, F., Gautheret, D. (2008). Mireval: a web tool for simple microRNA prediction in genome sequences. Bioinformatics, 24(11), 1394-1396. [More Information]
  • Ritchie, W., Legendre, M., Gautheret, D. (2007). RNA stem-loops: to be or not to be cleaved by RNAse III. RNA, 13(4), 457-462. [More Information]
  • Ara, T., Lopez, F., Ritchie, W., Benech, P., Gautheret, D. (2006). Conservation of alternative polyadenylation patterns in mammalian genes. BMC Genomics, 7, 189-1-189-11. [More Information]
  • Legendre, M., Ritchie, W., Lopez, F., Gautheret, D. (2006). Differential repression of alternative transcripts: a screen for miRNA targets. PLoS Computational Biology, 2(5), e43-333-342. [More Information]
  • Desagher, S., Severac, D., Lipkin, A., Bernis, C., Ritchie, W., Le Digarcher, A., Journot, L. (2005). Genes regulated in neurons undergoing transcription-dependent apoptosis belong to signaling pathways rather than the apoptotic machinery. Journal of Biological Chemistry, 280(7), 5693-5702. [More Information]

2014

  • Hancock, D., Shklovskaya, E., Guy, T., Falsafi, R., Fjell, C., Ritchie, W., Hancock, R., Fazekas de St Groth, B. (2014). A Systems Biology Approach to the Analysis of Subset-Specific Responses to Lipopolysaccharide in Dendritic Cells. PloS One, 9(6), 1-16. [More Information]
  • Wong, J., Ritchie, W., Gao, D., Lau, K., Gonzalez, M., Choudhary, A., Taft, R., Rasko, J., Holst, J. (2014). Identification of nuclear-enriched miRNAs during mouse granulopoiesis. Journal of Hematology & Oncology, 7(1), 42. [More Information]
  • Ritchie, W., Rasko, J. (2014). Refining microRNA target predictions: sorting the wheat from the chaff. Biochemical and Biophysical Research Communications, 445(4), 780-784. [More Information]

2013

  • Ritchie, W., Rasko, J., Flamant, S. (2013). MicroRNA Target Prediction and Validation. In Ulf Schmitz, Olaf Wolkenhauer, Julio Vera (Eds.), MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools, (pp. 39-53). Dordrecht: Springer.
  • Gao, D., Middleton, R., Rasko, J., Ritchie, W. (2013). miREval 2.0: a web tool for simple microRNA prediction in genome sequences. Bioinformatics, 29(24), 3225-3226. [More Information]
  • Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]
  • Wang, K., Tiffen, J., Bailey, C., Lehman, M., Ritchie, W., Fazli, L., Metierre, C., Feng, Y., Li, E., Gleave, M., Rasko, J., Holst, J., et al (2013). Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development. Journal of the National Cancer Institute, 105(19), 1463-1473. [More Information]

2012

  • Ritchie, W., Gao, D., Rasko, J. (2012). Defining and providing robust controls for microRNA prediction. Bioinformatics, 28(8), 1058-1061. [More Information]
  • Bagnall, R., Tsoutsman, T., Shephard, R., Ritchie, W., Semsarian, C. (2012). Global MicroRNA Profiling of the Mouse Ventricles during Development of Severe Hypertrophic Cardiomyopathy and Heart Failure. PloS One, 7(9), 1-8. [More Information]
  • Ritchie, W., Rasko, J. (2012). Integrated miRNA expression analysis and target prediction. In Jian-Bing Fan (Eds.), Methods in Molecular Biology: Next-Generation MicroRNA Expression Profiling Technology: Methods and Protocols, (pp. 289-293). New York, United States: Springer.

2010

  • Flamant, S., Ritchie, W., Guilhot, J., Holst, J., Bonnet, M., Chomel, J., Guilhot, F., Turhan, A., Rasko, J. (2010). Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia. Haematologica: the hematology journal, 95(8), 1325-1333. [More Information]
  • Taft, R., Simons, C., Nahkuri, S., Oey, H., Korbie, D., Mercer, T., Holst, J., Ritchie, W., Wong, J., Rasko, J., et al (2010). Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nature Structural and Molecular Biology, 17(8), 1030-1035. [More Information]

2009

  • Ritchie, W., Rajasekhar, M., Flamant, S., Rasko, J. (2009). Conserved expression patterns predict microRNA targets. PLoS Computational Biology, 5(9), e1000513 - 1-e1000513 - 8. [More Information]
  • Ritchie, W., Flamant, S., Rasko, J. (2009). mimiRNA: a microRNA expression profiler and classification resource designed to identify functional correlations between microRNAs and their targets. Bioinformatics, 26(2), 223-227. [More Information]
  • Ritchie, W., Flamant, S., Rasko, J. (2009). Predicting microRNA targets and functions: traps for the unwary. Nature Methods, 6(6), 397-398. [More Information]

2008

  • Ritchie, W., Rasko, J., Marcucci, G., Radmacher, M., Bloomfield, C. (2008). MicroRNA in Acute Myeloid Leukemia. The New England Journal of Medicine, 359(6), 653-654. [More Information]
  • Ritchie, W., Theodule, F., Gautheret, D. (2008). Mireval: a web tool for simple microRNA prediction in genome sequences. Bioinformatics, 24(11), 1394-1396. [More Information]

2007

  • Ritchie, W., Legendre, M., Gautheret, D. (2007). RNA stem-loops: to be or not to be cleaved by RNAse III. RNA, 13(4), 457-462. [More Information]

2006

  • Ara, T., Lopez, F., Ritchie, W., Benech, P., Gautheret, D. (2006). Conservation of alternative polyadenylation patterns in mammalian genes. BMC Genomics, 7, 189-1-189-11. [More Information]
  • Legendre, M., Ritchie, W., Lopez, F., Gautheret, D. (2006). Differential repression of alternative transcripts: a screen for miRNA targets. PLoS Computational Biology, 2(5), e43-333-342. [More Information]

2005

  • Desagher, S., Severac, D., Lipkin, A., Bernis, C., Ritchie, W., Le Digarcher, A., Journot, L. (2005). Genes regulated in neurons undergoing transcription-dependent apoptosis belong to signaling pathways rather than the apoptotic machinery. Journal of Biological Chemistry, 280(7), 5693-5702. [More Information]

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