Dr Xia Wang

Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, St Leonards, NSW 2065
Doctor

Member of China Studies Centre

Telephone +61 02 94631787

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Biographical details

Dr. Wang (BPharm, MMed, PhD) completed her Ph.D. in clinical epidemiology at the University of Tasmania (2017), examining early imaging changes which occur in knee osteoarthritis and the effectiveness of vitamin D supplementation for people with knee osteoarthritis. She is a post-doc research fellow at the Institute of Bone and Joint Research, University of Sydney. Her current work includes clinical trials, epidemiology, health service and translational research in chronic musculoskeletal disorders, with a particular interest in osteoarthritis. Her research findings have been published in top-ranked journals such as JAMA, Ann Rheum Dis, Arthritis Rheumatol, Sci Rep etc.

Research interests

Clinical trials, epidemiology and translational research in musculoskeletal disorders; innovative health technology for chronic disease management.

Current research students

Project title Research student
Clinimetrics of ultrasonography in osteoarthritis Win Min Oo OO

Current projects

2019 Stem cell treatment for knee osteoarthritis - the SCUlpTOR trial.

2018 Knee joint force study: a population-based cohort study in identifying occupational risks in knee osteoarthritis and total knee arthroplasty

2018 National Osteoarthritis Strategy: an Australian health policy initiative and implementation recommendations for evidence-based osteoarthritis management

2017 Updating the RACGP clinical practice guideline and recommendation for the management of knee and hip osteoarthritis

Associations

RACGP clinical practice guideline working group

Awards and honours

2018 Helen Triantafyllou Conference Award (Top-ranked applicant), Sydney Medical School, University of Sydney.

2017 Award of the Infographic Competition NHMRC CRE in translational research in musculoskeletal pain.

2015 Ten of The Best Research Award, Menzies Institute for Medical Research, University of Tasmania.

2015 Chinese Government Award for Outstanding Self-Financed Student Abroad.

2014 Ten of The Best Research Award, Menzies Institute for Medical Research, University of Tasmania.

International links

United Kingdom

(University of Oxford) Collaborations with Professor Nigel Arden on a project of occupation risks in the knee osteoarthritis and individual patient data meta-analysis of RCTs of vitamin D supplement in knee osteoarthritis

Selected grants

2019

  • Stem Cells as a symptom- and strUcture-modifying Treatment for knee OsteoaRthritis- the SCUlpTOR trial; Hunter D, Ding C, Lohmander L, Gebski V, Wang X; National Health and Medical Research Council (NHMRC)/Project Grants.

2018

  • Knee osteoarthritis (OA) patients in occupations with excessive knee joint force and the speed of knee OA progression; Hunter D, Wang X; Merck KGaA/Research Support.

Selected publications

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Book Chapters

  • Deveza, L., Ding, C., Jin, X., Wang, X., Zhu, Z., Hunter, D. (2016). Laboratory tests. In M. Doherty, J. Bijlsma, N. Arden, D. J. Hunter, N. Dalbeth (Eds.), Oxford Textbook of Osteoarthritis and Crystal Arthropathy (3rd edition). Oxford: Oxford University Press. [More Information]

Journals

  • Wang, X., Hunter, D., Jin, X., Ding, C. (2018). The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials. Osteoarthritis and Cartilage, 26(2), 165-174. [More Information]
  • Wang, X., Jin, X. (2018). Using total knee arthroplasty as a primary outcome measure is too "hard" in lifestyle intervention trials in osteoarthritis. American Journal of Clinical Nutrition, 107(4), 673. [More Information]
  • Zheng, S., Wang, B., Han, W., Zhu, Z., Wang, X., Jin, X., Antony, B., Cicuttini, F., Wluka, A., Winzenberg, T., et al (2018). Vitamin D supplementation and inflammatory and metabolic biomarkers in patients with knee osteoarthritis: post hoc analysis of a randomised controlled trial. British Journal of Nutrition, 120(1), 41-48. [More Information]
  • Wang, X., Oo, W., Linklater, J. (2018). What is the role of imaging in the clinical diagnosis of osteoarthritis and disease management? Rheumatology, 57, iv51-iv60. [More Information]
  • Zhu, Z., Laslett, L., Jin, X., Han, W., Antony, B., Wang, X., Lu, M., Cicuttini, F., Jones, G., Ding, C. (2017). Association between MRI-detected osteophytes and changes in knee structures and pain in older adults: a cohort study. Osteoarthritis and Cartilage, 25(7), 1084-1092. [More Information]
  • Jin, X., Wang, B., Wang, X., Antony, B., Zhu, Z., Han, W., Cicuttini, F., Wluka, A., Winzenburg, T., Blizzard, L., et al (2017). Associations between endogenous sex hormones and MRI structural changes in patients with symptomatic knee osteoarthritis. Osteoarthritis and Cartilage, 25(7), 1100-1106. [More Information]
  • Wang, X., Jin, X., Blizzard, L., Antony, B., Han, W., Zhu, Z., Cicuttini, F., Wluka, A., Winzenburg, T., Jones, G., et al (2017). Associations Between Knee Effusion-synovitis and Joint Structural Changes in Patients with Knee Osteoarthritis. Journal of Rheumatology, 44(11), 1644-1651. [More Information]
  • Zhu, Z., Otahal, P., Wang, B., Lin, X., Laslett, L., Wluka, A., Antony, B., Han, W., Wang, X., Winzenburg, T., et al (2017). Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis. Osteoarthritis and Cartilage, 25(4), 499-505. [More Information]
  • Wang, X., Cicuttini, F., Jin, X., Wluka, A., Han, W., Zhu, Z., Blizzard, L., Antony, B., Winzenburg, T., Jones, G., et al (2017). Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis. Osteoarthritis and Cartilage, 25(8), 1304-1312. [More Information]
  • Zheng, S., Jin, X., Cicuttini, F., Wang, X., Zhaohua, Z., Wluka, A., Han, W., Winzenburg, T., Antony, B., Aitken, D., et al (2017). Maintaining Vitamin D Sufficiency Is Associated with Improved Structural and Symptomatic Outcomes in Knee Osteoarthritis. The American Journal of Medicine, 130(10), 1211-1218. [More Information]
  • Wang, X., Blizzard, L., Halliday, A., Han, W., Jin, X., Cicuttini, F., Jones, G., Ding, C. (2016). Association between MRI-detected knee joint regional effusion-synovitis and structural changes in older adults: a cohort study. Annals of the Rheumatic Diseases, 75(3), 519-525. [More Information]
  • Wang, X., Jin, X., Han, W., Cao, Y., Halliday, A., Blizzard, L., Pan, F., Antony, B., Cicuttini, F., Jones, G., et al (2016). Cross-sectional and Longitudinal Associations between Knee Joint Effusion Synovitis and Knee Pain in Older Adults. Journal of Rheumatology, 43(1), 121-130. [More Information]
  • Jin, X., Jones, G., Cicuttini, F., Wluka, A., Zhu, Z., Han, W., Antony, B., Wang, X., Winzenberg, T., Blizzard, L., et al (2016). Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial. JAMA, 315(10), 1005-1013. [More Information]
  • Han, W., Aitken, D., Zhu, Z., Halliday, A., Wang, X., Antony, B., Cicuttini, F., Jones, G., Ding, C. (2016). Hypointense signals in the infrapatellar fat pad assessed by magnetic resonance imaging are associated with knee symptoms and structure in older adults: a cohort study. Arthritis Research and Therapy, 18(1), 234. [More Information]
  • Jin, X., Ding, C., Wang, X., Antony, B., Laslett, L., Blizzard, L., Cicuttini, F., Jones, G. (2016). Longitudinal associations between adiposity and change in knee pain: Tasmanian older adult cohort study. Seminars in Arthritis and Rheumatism, 45(5), 564-569. [More Information]
  • Wang, X., Blizzard, L., Jin, X., Chen, Z., Zhu, Z., Han, W., Halliday, A., Cicuttini, F., Jones, G., Ding, C. (2016). Quantitative Assessment of Knee Effusion-Synovitis in Older Adults: Association With Knee Structural Abnormalities. Arthritis & Rheumatology, 68(4), 837-844. [More Information]
  • Pan, F., Han, W., Wang, X., Liu, Z., Jin, X., Antony, B., Cicuttini, F., Jones, G., Ding, C. (2016). Response to 'Infrapatellar fat pad maximal area and changes in knee symptoms: gender-related difference or gender difference in reporting?' by Bai et al. Annals of the Rheumatic Diseases, 75(1), e4. [More Information]
  • Han, W., Aitken, D., Zhu, Z., Halliday, A., Wang, X., Antony, B., Cicuttini, F., Jones, G., Ding, C. (2016). Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study. Annals of the Rheumatic Diseases, 75(10), 1783-1788. [More Information]
  • Wang, J., Antony, B., Zhu, Z., Han, W., Pan, F., Wang, X., Jin, X., Liu, Z., Cicuttini, F., Jones, G., et al (2015). Association of patellar bone marrow lesions with knee pain, patellar cartilage defect and patellar cartilage volume loss in older adults: a cohort study. Osteoarthritis and Cartilage, 23(8), 1330-1336. [More Information]
  • Chen, L., Feng, L., Wang, X., Du, J., Chen, Y., Yang, W., Zhou, C., Cheng, L., Shen, Y., Fang, S., et al (2015). Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-κB pathway. Scientific Reports, 5, 1-13. [More Information]
  • Wang, X., Hunter, D., Xu, J., Ding, C. (2015). Metabolic triggered inflammation in osteoarthritis. Osteoarthritis and Cartilage, 23(1), 22-30. [More Information]
  • Wang, J., Cheng, Q., Wang, X., Zu, B., Xu, J., Xu, Y., Zuo, X., Shen, Y., Wang, J., Shen, Y. (2014). Deficiency of IRE1 and PERK signal pathways in systemic lupus erythematosus. American Journal of the Medical Sciences, 348(6), 465-473. [More Information]
  • Han, W., Cai, S., Liu, Z., Jin, X., Wang, X., Antony, B., Cao, Y., Aitken, D., Cicuttini, F., Jones, G., et al (2014). Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis? Arthritis Research and Therapy, 16(4), 1-8. [More Information]
  • Cao, Y., Jones, G., Han, W., Antony, B., Wang, X., Cicuttini, F., Ding, C. (2014). Popliteal cysts and subgastrocnemius bursitis are associated with knee symptoms and structural abnormalities in older adults: a cross-sectional study. Arthritis Research and Therapy, 16(2), R59. [More Information]

2018

  • Wang, X., Hunter, D., Jin, X., Ding, C. (2018). The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials. Osteoarthritis and Cartilage, 26(2), 165-174. [More Information]
  • Wang, X., Jin, X. (2018). Using total knee arthroplasty as a primary outcome measure is too "hard" in lifestyle intervention trials in osteoarthritis. American Journal of Clinical Nutrition, 107(4), 673. [More Information]
  • Zheng, S., Wang, B., Han, W., Zhu, Z., Wang, X., Jin, X., Antony, B., Cicuttini, F., Wluka, A., Winzenberg, T., et al (2018). Vitamin D supplementation and inflammatory and metabolic biomarkers in patients with knee osteoarthritis: post hoc analysis of a randomised controlled trial. British Journal of Nutrition, 120(1), 41-48. [More Information]
  • Wang, X., Oo, W., Linklater, J. (2018). What is the role of imaging in the clinical diagnosis of osteoarthritis and disease management? Rheumatology, 57, iv51-iv60. [More Information]

2017

  • Zhu, Z., Laslett, L., Jin, X., Han, W., Antony, B., Wang, X., Lu, M., Cicuttini, F., Jones, G., Ding, C. (2017). Association between MRI-detected osteophytes and changes in knee structures and pain in older adults: a cohort study. Osteoarthritis and Cartilage, 25(7), 1084-1092. [More Information]
  • Jin, X., Wang, B., Wang, X., Antony, B., Zhu, Z., Han, W., Cicuttini, F., Wluka, A., Winzenburg, T., Blizzard, L., et al (2017). Associations between endogenous sex hormones and MRI structural changes in patients with symptomatic knee osteoarthritis. Osteoarthritis and Cartilage, 25(7), 1100-1106. [More Information]
  • Wang, X., Jin, X., Blizzard, L., Antony, B., Han, W., Zhu, Z., Cicuttini, F., Wluka, A., Winzenburg, T., Jones, G., et al (2017). Associations Between Knee Effusion-synovitis and Joint Structural Changes in Patients with Knee Osteoarthritis. Journal of Rheumatology, 44(11), 1644-1651. [More Information]
  • Zhu, Z., Otahal, P., Wang, B., Lin, X., Laslett, L., Wluka, A., Antony, B., Han, W., Wang, X., Winzenburg, T., et al (2017). Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis. Osteoarthritis and Cartilage, 25(4), 499-505. [More Information]
  • Wang, X., Cicuttini, F., Jin, X., Wluka, A., Han, W., Zhu, Z., Blizzard, L., Antony, B., Winzenburg, T., Jones, G., et al (2017). Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis. Osteoarthritis and Cartilage, 25(8), 1304-1312. [More Information]
  • Zheng, S., Jin, X., Cicuttini, F., Wang, X., Zhaohua, Z., Wluka, A., Han, W., Winzenburg, T., Antony, B., Aitken, D., et al (2017). Maintaining Vitamin D Sufficiency Is Associated with Improved Structural and Symptomatic Outcomes in Knee Osteoarthritis. The American Journal of Medicine, 130(10), 1211-1218. [More Information]

2016

  • Wang, X., Blizzard, L., Halliday, A., Han, W., Jin, X., Cicuttini, F., Jones, G., Ding, C. (2016). Association between MRI-detected knee joint regional effusion-synovitis and structural changes in older adults: a cohort study. Annals of the Rheumatic Diseases, 75(3), 519-525. [More Information]
  • Wang, X., Jin, X., Han, W., Cao, Y., Halliday, A., Blizzard, L., Pan, F., Antony, B., Cicuttini, F., Jones, G., et al (2016). Cross-sectional and Longitudinal Associations between Knee Joint Effusion Synovitis and Knee Pain in Older Adults. Journal of Rheumatology, 43(1), 121-130. [More Information]
  • Jin, X., Jones, G., Cicuttini, F., Wluka, A., Zhu, Z., Han, W., Antony, B., Wang, X., Winzenberg, T., Blizzard, L., et al (2016). Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial. JAMA, 315(10), 1005-1013. [More Information]
  • Han, W., Aitken, D., Zhu, Z., Halliday, A., Wang, X., Antony, B., Cicuttini, F., Jones, G., Ding, C. (2016). Hypointense signals in the infrapatellar fat pad assessed by magnetic resonance imaging are associated with knee symptoms and structure in older adults: a cohort study. Arthritis Research and Therapy, 18(1), 234. [More Information]
  • Deveza, L., Ding, C., Jin, X., Wang, X., Zhu, Z., Hunter, D. (2016). Laboratory tests. In M. Doherty, J. Bijlsma, N. Arden, D. J. Hunter, N. Dalbeth (Eds.), Oxford Textbook of Osteoarthritis and Crystal Arthropathy (3rd edition). Oxford: Oxford University Press. [More Information]
  • Jin, X., Ding, C., Wang, X., Antony, B., Laslett, L., Blizzard, L., Cicuttini, F., Jones, G. (2016). Longitudinal associations between adiposity and change in knee pain: Tasmanian older adult cohort study. Seminars in Arthritis and Rheumatism, 45(5), 564-569. [More Information]
  • Wang, X., Blizzard, L., Jin, X., Chen, Z., Zhu, Z., Han, W., Halliday, A., Cicuttini, F., Jones, G., Ding, C. (2016). Quantitative Assessment of Knee Effusion-Synovitis in Older Adults: Association With Knee Structural Abnormalities. Arthritis & Rheumatology, 68(4), 837-844. [More Information]
  • Pan, F., Han, W., Wang, X., Liu, Z., Jin, X., Antony, B., Cicuttini, F., Jones, G., Ding, C. (2016). Response to 'Infrapatellar fat pad maximal area and changes in knee symptoms: gender-related difference or gender difference in reporting?' by Bai et al. Annals of the Rheumatic Diseases, 75(1), e4. [More Information]
  • Han, W., Aitken, D., Zhu, Z., Halliday, A., Wang, X., Antony, B., Cicuttini, F., Jones, G., Ding, C. (2016). Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study. Annals of the Rheumatic Diseases, 75(10), 1783-1788. [More Information]

2015

  • Wang, J., Antony, B., Zhu, Z., Han, W., Pan, F., Wang, X., Jin, X., Liu, Z., Cicuttini, F., Jones, G., et al (2015). Association of patellar bone marrow lesions with knee pain, patellar cartilage defect and patellar cartilage volume loss in older adults: a cohort study. Osteoarthritis and Cartilage, 23(8), 1330-1336. [More Information]
  • Chen, L., Feng, L., Wang, X., Du, J., Chen, Y., Yang, W., Zhou, C., Cheng, L., Shen, Y., Fang, S., et al (2015). Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-κB pathway. Scientific Reports, 5, 1-13. [More Information]
  • Wang, X., Hunter, D., Xu, J., Ding, C. (2015). Metabolic triggered inflammation in osteoarthritis. Osteoarthritis and Cartilage, 23(1), 22-30. [More Information]

2014

  • Wang, J., Cheng, Q., Wang, X., Zu, B., Xu, J., Xu, Y., Zuo, X., Shen, Y., Wang, J., Shen, Y. (2014). Deficiency of IRE1 and PERK signal pathways in systemic lupus erythematosus. American Journal of the Medical Sciences, 348(6), 465-473. [More Information]
  • Han, W., Cai, S., Liu, Z., Jin, X., Wang, X., Antony, B., Cao, Y., Aitken, D., Cicuttini, F., Jones, G., et al (2014). Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis? Arthritis Research and Therapy, 16(4), 1-8. [More Information]
  • Cao, Y., Jones, G., Han, W., Antony, B., Wang, X., Cicuttini, F., Ding, C. (2014). Popliteal cysts and subgastrocnemius bursitis are associated with knee symptoms and structural abnormalities in older adults: a cross-sectional study. Arthritis Research and Therapy, 16(2), R59. [More Information]

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