Dr Xin-Ming Chen

Research Only Academic Level C
Medicine, Northern Clinical School
Kolling Institute of Medical Research

Telephone 9926 4780
Fax 9926 5715

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International links

China

(Research Center of the 1st Teaching Hospital of Kunming University of Medical Sciences) collaboration

Selected grants

2014

  • KCa3.1 as a therapeutic target in diabetic nephropathy; Pollock C, Chen X; Juvenile Diabetes Research Foundation International (JDRF)/Research Support.

2013

  • A high-throughput, bright-field and fluorescence digital slide scanning platform and service that is both research and teaching-focused and available University-wide.; King N, Graeber M, Naylor M, Slapeta J, Quinnell R, Charles (nee Slaviero) K, Owens T, Bourne R, Braet F, Hambly B, Overall R, Stone J, Twigg S, Hardikar A, Halliday G, Richardson D, Byrne M, Keay K, Marsh D, Howell V, Pollock C, Chen X; DVC Research/Equipment Grant.

2012

  • Targeting KCa3.1 in diabetic nephropathy; Pollock C, Chen X, Shen S; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • The Krupple-like transcription factor 4 regulates endothelial activation in diabetic nephropathy.; Chen X; Kidney Health Australia/Seeding Grants.

2008

  • TGFbeta isoforms differentially regulate fibrosis and inflammation in diabetic nephropathy via KLF transcription factors; Pollock C, Chen X, Qi W; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Epithelial-mesenchymal transformation in diabetic nephropathy: Role of oxidative stress and KLF transcription factors; Pollock C, Kelly D, Chen X, Kelly D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Fiberlite: Carbon fiber composite rotors; Firth S, Chen X, Marsh D, Benn D; University of Sydney/Research Support.

2005

  • Automated Precision Liquid Handling System; Benn D, Chen X, Chung L, Baxter R, Marsh D, Robinson B, Firth S; University of Sydney/Research Support.
  • Multifunction Imaging System; Firth S, McCracken S, Marsh D, Chen X; University of Sydney/Research Support.
  • The role of SGK-1 and SGK-2 in hypertension and nephropathy in diabetes mellitus; Pollock C, Chen X; Australian Research Council (ARC)/Linkage Projects (LP).

2004

  • The role of peroxisome proliferator activated receptor gamma in progressive diabetic nephropathy; Chen X; Diabetes Australia/Research Grant.

Selected publications

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Book Chapters

  • Chen, X., Weier, Q., Pollock, C. (2010). Kruppel-like factors in vascular endothelial cells. In K. Yoshida (Eds.), Focus on Zinc Finger Protein Research, (pp. 65-80). United States: Research Signpost.

Journals

  • Huang, C., Day, M., Poronnik, P., Pollock, C., Chen, X. (2014). Inhibition of KCa3.1 suppresses TGF-Beta1 induced MCP-1 expression in human proximal tubular cells through Smad3, p38 and ERK1/2 signaling pathways. The International Journal of Biochemistry and Cell Biology, 47(1), 1-10. [More Information]
  • Huang, C., Shen, S., Ma, Q., Gill, A., Pollock, C., Chen, X. (2014). KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis. Nephrology, Dialysis, Transplantation, 29(2), 313-324. [More Information]
  • Huang, C., Lin, Z., Cheng, D., Braet, F., Pollock, C., Chen, X. (2014). Thioredoxin-interacting protein mediates dysfunction of tubular autophagy in diabetic kidneys through inhibiting autophagic flux. Laboratory Investigation, 94(3), 309-320. [More Information]
  • Cheng, D., Shen, S., Chen, X., Pollock, C., Braet, F. (2013). Application of transmission electron tomography for modeling the renal corpuscle. Pathology, Research and Practice, 209(11), 731-734. [More Information]
  • Huang, C., Shen, S., Ma, Q., Chen, J., Gill, A., Pollock, C., Chen, X. (2013). Blockade of KCa3.1 Ameliorates Renal Fibrosis Through the TGF-β1/Smad Pathway in Diabetic Mice. Diabetes, 62(8), 2923-2934. [More Information]
  • Tang, O., Chen, X., Shen, S., Hahn, M., Pollock, C. (2013). MiRNA-200b represses transforming growth factor-β1-induced EMT and fibronectin expression in kidney proximal tubular cells. American Journal of Physiology: Renal Physiology (Print), 304(10), F1266-F1273. [More Information]
  • Yong, R., Chen, X., Shen, S., Vijayaraj, S., Ma, Q., Pollock, C., Saad, S. (2013). Plumbagin Ameliorates Diabetic Nephropathy via Interruption of Pathways that Include NOX4 Signalling. PLoS One, 8(8), 1-13. [More Information]
  • Saad, S., Zhang, J., Yong, R., Yaghobian, D., Wong, M., Kelly, D., Chen, X., Pollock, C. (2013). Role of the EGF receptor in PPARgamma-mediated sodium and water transport in human proximal tubule cells. Diabetologia: clinical and experimental diabetes and metabolism, 56(5), 1174-1182. [More Information]
  • Wong, M., Panchapakesan, U., Qi, W., Silva, D., Chen, X., Pollock, C. (2011). Cation-independent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-B1. American Journal of Physiology: Renal Physiology (Print), 301(1), F84-F93. [More Information]
  • Qi, W., Holian, J., Tan, C., Kelly, D., Chen, X., Pollock, C. (2011). The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-γ in the regulation of macrophage inflammatory protein-3α at early onset of diabetes. The International Journal of Biochemistry and Cell Biology, 43(3), 383-392. [More Information]
  • Sumual, S., Saad, S., Tang, O., Yong, R., McGinn, C., Chen, X., Pollock, C. (2010). Differential Regulation of Snail by Hypoxia and Hyperglycemia in Human Proximal Tubule Cells. The International Journal of Biochemistry and Cell Biology, 42(10), 1689-1697. [More Information]
  • Chen, X., Qi, W., Pollock, C. (2009). CTGF and chronic kidney fibrosis. Frontiers in Bioscience, 1, 132-141. [More Information]
  • Mather, A., Chen, X., McGinn, C., Field, M., Sumual, S., Mangiafico, S., Zhang, Y., Kelly, D., Pollock, C. (2009). High glucose induced endothelial cell growth inhibition is associated with an increase in TGF-{beta}(1) secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway. The International Journal of Biochemistry and Cell Biology, 41(3), 561-569. [More Information]
  • Vesey, D., Qi, W., Chen, X., Pollock, C., Johnson, D. (2009). Isolation and primary culture of human proximal tubule cells. Methods in Molecular Biology, 466, 19-24. [More Information]
  • Qi, W., Chen, X., Holian, J., Tan, C., Kelly, D., Pollock, C. (2009). Transcription Factors Kruppel-Like Factor 6 and Peroxisome Proliferator-Activated Receptor-gamma Mediate High Glucose-Induced Thioredoxin-Interacting Protein. The American Journal of Pathology: cellular and molecular biology of disease, 175(5), 1858-1867. [More Information]
  • Holian, J., Qi, W., Kelly, D., Zhang, Y., Mreich, E., Pollock, C., Chen, X. (2008). The Role of Kruppel-like factor 6 in Transforming Growth Factor-Beta-1-induced Epithelial-Mesenchymal Transition of Proximal Tubule Cells. American Journal of Physiology: Renal Physiology (Print), 295(5), F1388-F1396. [More Information]
  • Saad, S., Agapiou, D., Chen, X., Stevens, V., Pollock, C. (2008). The role of Sgk-1 in the upregulation of transport proteins by PPAR-{gamma} agonists in human proximal tubule cells. Nephrology, Dialysis, Transplantation, doi: 10.1093/ndt/gfn614, 1-12. [More Information]
  • Qi, W., Chen, X., Zhang, Y., Holian, J., Mreich, E., Gilbert, R., Kelly, D., Pollock, C. (2007). High glucose induces macrophage inflammatory protein-3{alpha} in renal proximal tubule cells via a transforming growth factor-{beta}1 dependent mechanism. Nephrology, Dialysis, Transplantation, 22(11), 3147-3153. [More Information]
  • Qi, W., Chen, X., Gilbert, R., Zhang, Y., Waltham, M., Schache, M., Kelly, D., Pollock, C. (2007). High Glucose-Induced Thioredoxin-Interacting Protein in Renal Proximal Tubule Cells Is Independent of Transforming Growth Factor-{beta}1. The American Journal of Pathology: cellular and molecular biology of disease, 171(3), 744-754. [More Information]
  • Qi, W., Johnson, D., Vesey, D., Pollock, C., Chen, X. (2007). Isolation, propagation and characterization of primary tubule cell culture from human kidney. Nephrology, 12(2), 155-159. [More Information]
  • Qi, W., Chen, X., Twigg, S., Zhang, Y., Gilbert, R., Kelly, D., Pollock, C. (2007). The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1. Nephrology, 12(3), 267-274. [More Information]
  • Stevens, V., Saad, S., Chen, X., Pollock, C. (2007). The interdependence of EGF-R and SGK-1 in fibronectin expression in primary kidney cortical fibroblast cells. The International Journal of Biochemistry and Cell Biology, 39(5), 1047-1054. [More Information]
  • Whitney, E., Ghaleb, A., Chen, X., Yang, V. (2007). Transcriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis. Gene Expression, 13(2), 85-96. [More Information]
  • Qi, W., Chen, X., Poronnik, P., Pollock, C. (2007). Transforming growth factor-beta/connective tissue growth factor axis in the kidney. The International Journal of Biochemistry and Cell Biology, 40(1 available online 20 Jan 2007), 9-13. [More Information]
  • Qi, W., Chen, X., Polhill, T., Sumual, S., Twigg, S., Gilbert, R., Pollock, C. (2006). TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. American Journal of Physiology: Renal Physiology (Print), 290(3), F703-F709. [More Information]
  • Qi, W., Chen, X., Poronnik, P., Pollock, C. (2006). The renal cortical fibroblast in renal tubulointerstitial fibrosis. The International Journal of Biochemistry and Cell Biology, 38(1), 1-5. [More Information]
  • Qi, W., Chen, X., Twigg, S., Polhill, T., Gilbert, R., Pollock, C. (2006). Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells. Kidney International, 69(6), 989-995. [More Information]
  • Qi, W., Twigg, S., Pollock, C., Holian, J., Mreich, E., Gilbert, R., Chen, X. (2006). Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells. American Journal of Physiology: Renal Physiology (Print), 291, F1070-F1077. [More Information]
  • Panchapakesan, U., Chen, X., Pollock, C. (2005). Drug insight: thiazolidinediones and diabetic nephropathy--relevance to renoprotection. Nature Clinical Practice. Nephrology, 1(1), 33-43. [More Information]
  • Qi, W., Twigg, S., Chen, X., Polhill, T., Poronnik, P., Gilbert, R., Pollock, C. (2005). Integrated actions of transforming growth factor-beta(1) and connective tissue growth factor in renal fibrosis. American Journal of Physiology: Renal Physiology (Print), 288(4), F800-F809.
  • Panchapakesan, U., Sumual, S., Pollock, C., Chen, X. (2005). PPAR gamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose. American Journal of Physiology: Renal Physiology (Print), 289(5), F1153-F1158. [More Information]
  • Panchapakesan, U., Pollock, C., Chen, X. (2004). The Effect Of High Glucose And Ppar-Gamma Agonists On Ppar-Gamma Expression And Function In Hk-2 Cells. American Journal of Physiology: Renal Physiology (Print), 287(3), F528-F534.
  • Yoon, H., Chen, X., Yang, V. (2003). Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. Journal of Biological Chemistry, 278(4), 2101-2105.
  • Dang, D., Chen, X., Feng, J., Torbenson, M., Long H, D., Vincent, Y. (2003). Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene, 22(22), 3424-3430.
  • Chen, X., Whitney, E., Gao, S., Yang, V. (2003). Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. Journal of Molecular Biology, 326(3), 665-677.

Conferences

  • Qi, W., Chen, X., Holian, J., Twigg, S., Gilbert, R., Pollock, C. (2006). Transforming growth factor-beta1 differentially mediates fibrosis and immunomodulation in kidney tubular cells. XLIII ERA-EDTA Congress, United Kingdom: Oxford University Press.

2014

  • Huang, C., Day, M., Poronnik, P., Pollock, C., Chen, X. (2014). Inhibition of KCa3.1 suppresses TGF-Beta1 induced MCP-1 expression in human proximal tubular cells through Smad3, p38 and ERK1/2 signaling pathways. The International Journal of Biochemistry and Cell Biology, 47(1), 1-10. [More Information]
  • Huang, C., Shen, S., Ma, Q., Gill, A., Pollock, C., Chen, X. (2014). KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis. Nephrology, Dialysis, Transplantation, 29(2), 313-324. [More Information]
  • Huang, C., Lin, Z., Cheng, D., Braet, F., Pollock, C., Chen, X. (2014). Thioredoxin-interacting protein mediates dysfunction of tubular autophagy in diabetic kidneys through inhibiting autophagic flux. Laboratory Investigation, 94(3), 309-320. [More Information]

2013

  • Cheng, D., Shen, S., Chen, X., Pollock, C., Braet, F. (2013). Application of transmission electron tomography for modeling the renal corpuscle. Pathology, Research and Practice, 209(11), 731-734. [More Information]
  • Huang, C., Shen, S., Ma, Q., Chen, J., Gill, A., Pollock, C., Chen, X. (2013). Blockade of KCa3.1 Ameliorates Renal Fibrosis Through the TGF-β1/Smad Pathway in Diabetic Mice. Diabetes, 62(8), 2923-2934. [More Information]
  • Tang, O., Chen, X., Shen, S., Hahn, M., Pollock, C. (2013). MiRNA-200b represses transforming growth factor-β1-induced EMT and fibronectin expression in kidney proximal tubular cells. American Journal of Physiology: Renal Physiology (Print), 304(10), F1266-F1273. [More Information]
  • Yong, R., Chen, X., Shen, S., Vijayaraj, S., Ma, Q., Pollock, C., Saad, S. (2013). Plumbagin Ameliorates Diabetic Nephropathy via Interruption of Pathways that Include NOX4 Signalling. PLoS One, 8(8), 1-13. [More Information]
  • Saad, S., Zhang, J., Yong, R., Yaghobian, D., Wong, M., Kelly, D., Chen, X., Pollock, C. (2013). Role of the EGF receptor in PPARgamma-mediated sodium and water transport in human proximal tubule cells. Diabetologia: clinical and experimental diabetes and metabolism, 56(5), 1174-1182. [More Information]

2011

  • Wong, M., Panchapakesan, U., Qi, W., Silva, D., Chen, X., Pollock, C. (2011). Cation-independent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-B1. American Journal of Physiology: Renal Physiology (Print), 301(1), F84-F93. [More Information]
  • Qi, W., Holian, J., Tan, C., Kelly, D., Chen, X., Pollock, C. (2011). The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-γ in the regulation of macrophage inflammatory protein-3α at early onset of diabetes. The International Journal of Biochemistry and Cell Biology, 43(3), 383-392. [More Information]

2010

  • Sumual, S., Saad, S., Tang, O., Yong, R., McGinn, C., Chen, X., Pollock, C. (2010). Differential Regulation of Snail by Hypoxia and Hyperglycemia in Human Proximal Tubule Cells. The International Journal of Biochemistry and Cell Biology, 42(10), 1689-1697. [More Information]
  • Chen, X., Weier, Q., Pollock, C. (2010). Kruppel-like factors in vascular endothelial cells. In K. Yoshida (Eds.), Focus on Zinc Finger Protein Research, (pp. 65-80). United States: Research Signpost.

2009

  • Chen, X., Qi, W., Pollock, C. (2009). CTGF and chronic kidney fibrosis. Frontiers in Bioscience, 1, 132-141. [More Information]
  • Mather, A., Chen, X., McGinn, C., Field, M., Sumual, S., Mangiafico, S., Zhang, Y., Kelly, D., Pollock, C. (2009). High glucose induced endothelial cell growth inhibition is associated with an increase in TGF-{beta}(1) secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway. The International Journal of Biochemistry and Cell Biology, 41(3), 561-569. [More Information]
  • Vesey, D., Qi, W., Chen, X., Pollock, C., Johnson, D. (2009). Isolation and primary culture of human proximal tubule cells. Methods in Molecular Biology, 466, 19-24. [More Information]
  • Qi, W., Chen, X., Holian, J., Tan, C., Kelly, D., Pollock, C. (2009). Transcription Factors Kruppel-Like Factor 6 and Peroxisome Proliferator-Activated Receptor-gamma Mediate High Glucose-Induced Thioredoxin-Interacting Protein. The American Journal of Pathology: cellular and molecular biology of disease, 175(5), 1858-1867. [More Information]

2008

  • Holian, J., Qi, W., Kelly, D., Zhang, Y., Mreich, E., Pollock, C., Chen, X. (2008). The Role of Kruppel-like factor 6 in Transforming Growth Factor-Beta-1-induced Epithelial-Mesenchymal Transition of Proximal Tubule Cells. American Journal of Physiology: Renal Physiology (Print), 295(5), F1388-F1396. [More Information]
  • Saad, S., Agapiou, D., Chen, X., Stevens, V., Pollock, C. (2008). The role of Sgk-1 in the upregulation of transport proteins by PPAR-{gamma} agonists in human proximal tubule cells. Nephrology, Dialysis, Transplantation, doi: 10.1093/ndt/gfn614, 1-12. [More Information]

2007

  • Qi, W., Chen, X., Zhang, Y., Holian, J., Mreich, E., Gilbert, R., Kelly, D., Pollock, C. (2007). High glucose induces macrophage inflammatory protein-3{alpha} in renal proximal tubule cells via a transforming growth factor-{beta}1 dependent mechanism. Nephrology, Dialysis, Transplantation, 22(11), 3147-3153. [More Information]
  • Qi, W., Chen, X., Gilbert, R., Zhang, Y., Waltham, M., Schache, M., Kelly, D., Pollock, C. (2007). High Glucose-Induced Thioredoxin-Interacting Protein in Renal Proximal Tubule Cells Is Independent of Transforming Growth Factor-{beta}1. The American Journal of Pathology: cellular and molecular biology of disease, 171(3), 744-754. [More Information]
  • Qi, W., Johnson, D., Vesey, D., Pollock, C., Chen, X. (2007). Isolation, propagation and characterization of primary tubule cell culture from human kidney. Nephrology, 12(2), 155-159. [More Information]
  • Qi, W., Chen, X., Twigg, S., Zhang, Y., Gilbert, R., Kelly, D., Pollock, C. (2007). The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1. Nephrology, 12(3), 267-274. [More Information]
  • Stevens, V., Saad, S., Chen, X., Pollock, C. (2007). The interdependence of EGF-R and SGK-1 in fibronectin expression in primary kidney cortical fibroblast cells. The International Journal of Biochemistry and Cell Biology, 39(5), 1047-1054. [More Information]
  • Whitney, E., Ghaleb, A., Chen, X., Yang, V. (2007). Transcriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis. Gene Expression, 13(2), 85-96. [More Information]
  • Qi, W., Chen, X., Poronnik, P., Pollock, C. (2007). Transforming growth factor-beta/connective tissue growth factor axis in the kidney. The International Journal of Biochemistry and Cell Biology, 40(1 available online 20 Jan 2007), 9-13. [More Information]

2006

  • Qi, W., Chen, X., Polhill, T., Sumual, S., Twigg, S., Gilbert, R., Pollock, C. (2006). TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. American Journal of Physiology: Renal Physiology (Print), 290(3), F703-F709. [More Information]
  • Qi, W., Chen, X., Poronnik, P., Pollock, C. (2006). The renal cortical fibroblast in renal tubulointerstitial fibrosis. The International Journal of Biochemistry and Cell Biology, 38(1), 1-5. [More Information]
  • Qi, W., Chen, X., Twigg, S., Polhill, T., Gilbert, R., Pollock, C. (2006). Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells. Kidney International, 69(6), 989-995. [More Information]
  • Qi, W., Twigg, S., Pollock, C., Holian, J., Mreich, E., Gilbert, R., Chen, X. (2006). Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells. American Journal of Physiology: Renal Physiology (Print), 291, F1070-F1077. [More Information]
  • Qi, W., Chen, X., Holian, J., Twigg, S., Gilbert, R., Pollock, C. (2006). Transforming growth factor-beta1 differentially mediates fibrosis and immunomodulation in kidney tubular cells. XLIII ERA-EDTA Congress, United Kingdom: Oxford University Press.

2005

  • Panchapakesan, U., Chen, X., Pollock, C. (2005). Drug insight: thiazolidinediones and diabetic nephropathy--relevance to renoprotection. Nature Clinical Practice. Nephrology, 1(1), 33-43. [More Information]
  • Qi, W., Twigg, S., Chen, X., Polhill, T., Poronnik, P., Gilbert, R., Pollock, C. (2005). Integrated actions of transforming growth factor-beta(1) and connective tissue growth factor in renal fibrosis. American Journal of Physiology: Renal Physiology (Print), 288(4), F800-F809.
  • Panchapakesan, U., Sumual, S., Pollock, C., Chen, X. (2005). PPAR gamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose. American Journal of Physiology: Renal Physiology (Print), 289(5), F1153-F1158. [More Information]

2004

  • Panchapakesan, U., Pollock, C., Chen, X. (2004). The Effect Of High Glucose And Ppar-Gamma Agonists On Ppar-Gamma Expression And Function In Hk-2 Cells. American Journal of Physiology: Renal Physiology (Print), 287(3), F528-F534.

2003

  • Yoon, H., Chen, X., Yang, V. (2003). Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. Journal of Biological Chemistry, 278(4), 2101-2105.
  • Dang, D., Chen, X., Feng, J., Torbenson, M., Long H, D., Vincent, Y. (2003). Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene, 22(22), 3424-3430.
  • Chen, X., Whitney, E., Gao, S., Yang, V. (2003). Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. Journal of Molecular Biology, 326(3), 665-677.

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