Dr Ya Wang

Research Fellow
The Westmead Institute for Medical Research

Telephone +61 2 8627 3510

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Selected grants

2018

  • Targeting LAG-3 by IMP321 in reprogramming immune cells from sepsis patients; Wang Y; Sydney Medical School Foundation/Nepean Medical Research Fund Grant.

2017

  • Mitochondrial transplantation; Wang Y; Sydney Medical School Foundation/NMRF Seed Funding Grant.

Selected publications

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Journals

  • Sabanayagam, C., Banu Binte Mohammed Abdul, R., Chee, M., Lee, R., Wang, Y., Tan, G., Jonas, J., Lamoureux, E., Cheng, C., Klein, B., Mitchell, P., et al (2019). Incidence and progression of diabetic retinopathy: a systematic review. The Lancet Diabetes & Endocrinology, 7(2), 140-149. [More Information]
  • Shah, R., Li, Q., Zhao, W., Tedja, M., Tideman, J., Khawaja, A., Fan, Q., Yazar, S., Williams, K., Verhoeven, V., Mitchell, P., et al (2018). A genome-wide association study of corneal astigmatism: The CREAM Consortium. Molecular Vision, 24, 127-142.
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Tan, T., Harris, D., Alexander, S., Durkan, A. (2018). DEC205-DC targeted DNA vaccine against CX3CR1 protects against atherogenesis in mice. PloS One, 13(4), e0195657. [More Information]
  • Huang, D., Wang, Y., Hawthorne, W., Hu, M., Hawkes, J., Burns, H., Davies, S., Gao, F., Chew, Y., Yi, S., O'Connell, P. (2017). Ex vivo-expanded baboon CD39�+� regulatory T cells prevent rejection of porcine islet xenografts in NOD-SCID IL-2ry(-/-) mice reconstituted with baboon peripheral blood mononuclear cells. Xenotransplantation, 24(6), 1-11. [More Information]
  • Wang, Y., Zhang, G., Wang, Y., Hu, M., Zhou, J., Sawyer, A., Cao, Q., Wang, Y., Zheng, G., Lee, V., Harris, D., Alexander, S. (2017). Exacerbation of spontaneous autoimmune nephritis following regulatory T cell depletion in B cell lymphoma 2-interacting mediator knock-out mice. Clinical and Experimental Immunology, 188(2), 195-207. [More Information]
  • Springelkamp, H., Iglesias, A., Mishra, A., Hohn, R., Wojciechowski, R., Khawaja, A., Nag, A., Wang, Y., Wang, J., Cuellar-Partida, G., Mitchell, P., et al (2017). New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Human Molecular Genetics, 26(2), 438-453. [More Information]
  • Zheng, G., Zhang, J., Zhao, H., Wang, H., Pang, M., Qiao, X., Lee, S., Hsu, T., Tan, T., Lyons, G., Zhao, Y., Loebel, D., Wang, Y., Wang, Y., Wang, Y., Cao, Q., Wang, C., Lee, V., Tam, P., Harris, D., et al (2016). a3 Integrin of Cell-Cell Contact Mediates Kidney Fibrosis by Integrin-Linked Kinase in Proximal Tubular E-Cadherin Deficient Mice. American Journal of Pathology, 186(7), 1847-1860. [More Information]
  • Wang, Y., Ghali, J., Zhang, G., Hu, M., Wang, Y., Sawyer, A., Zhou, J., Hapudeniya, D., Wang, Y., Cao, Q., Zheng, G., Harris, D., Alexander, S. (2016). Development and function of Foxp3+ regulatory T cells. Nephrology, 21(2), 81-85. [More Information]
  • Zhao, Y., Qiao, X., Wang, L., Tan, T., Zhao, H., Zhang, Y., Zhang, J., Rao, P., Cao, Q., Wang, Y., Wang, Y., Wang, Y., Lee, V., Harris, D., Zheng, G., et al (2016). Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells. BMC Cell Biology, 17(1), 1-11. [More Information]
  • Sun, Y., Wang, Y., Cao, Q., Yu, H., Zheng, D., Wang, Y., Harris, D. (2015). Expression and Role of CD166 in the Chronic Kidney Disease. Iranian Journal of Pediatrics, 25(5), 1-8. [More Information]
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, C., Wang, X., Lee, V., Wang, Y., Wang, Y., Zheng, G., Tan, T., Harris, D., et al (2014). Failed renoprotection by alternatively activated macrophages from bone marrow due to proliferation-dependent phenotype switch in vivo. Kidney International, 85(4), 794-806. [More Information]
  • Zhao, Y., Zhao, H., Zhang, Y., Tsatralis, T., Cao, Q., Wang, Y., Wang, Y., Wang, Y., Alexander, S., Harris, D., Zheng, G. (2014). Isolation and epithelial co-culture of mouse renal peritubular endothelial cells. BMC Cell Biology, 15(1), 1-10. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Tan, T., Lee, S., Zhang, J., Zhang, G., Hu, M., Wang, C., Cao, Q., Zhao, Y., Harris, D., et al (2014). Regulatory T cells require renal antigen recognition through the TCR to protect against injury in nephritis. International Journal of Clinical and Experimental Pathology, 7(1), 38-47.
  • Tian, X., Zhang, J., Tan, T., Lyons, G., Zhao, H., Niu, B., Lee, S., Tsatralis, T., Zhao, Y., Wang, Y., Cao, Q., Wang, C., Wang, Y., Lee, V., Zheng, G., Harris, D., et al (2013). Association of beta catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF- beta1. Journal of Cell Science, 126(1), 67-76. [More Information]
  • Wang, Y., Zhou, J., Wang, Y., Watson, D., Zhang, G., Hu, M., Wu, H., Zheng, G., Wang, Y., Durkan, A., Harris, D., Alexander, S. (2013). Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease. International Journal of Clinical and Experimental Pathology, 6(3), 326-333. [More Information]
  • Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V., Zheng, G., Tan, T., Wang, X., Harris, D., Wang, Y., et al (2013). Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney International, 84(4), 745-755. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Zhang, G., Zhou, J., Tan, T., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Harris, D., et al (2013). DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney International, 83(2), 223-232. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Lee, S., Zhang, J., Zhao, Y., Tian, X., Wang, Y., Wang, Y., Cao, Q., Wang, Y., Lee, V., Wang, C., Zheng, D., Alexander, S., Harris, D., et al (2013). Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage. Laboratory Investigation, 93(4), 434-449. [More Information]
  • Wang, Y., Zhang, G., Hu, M., Polhill, T., Sawyer, A., Zhou, J., Saito, M., Watson, D., Wu, H., Wang, Y., Wang, X., Wang, Y., Harris, D., Alexander, S. (2012). CD8+ Regulatory T Cells Induced by T Cell Vaccination Protect Against Autoimmune Nephritis. Journal of the American Society of Nephrology, 23(6), 1058-1067. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Phoon, R., Zhang, G., Wang, Y., Tan, T., Hu, M., Wang, D., Saito, M., Harris, D., Durkan, A., et al (2012). DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. International Journal of Clinical and Experimental Medicine, 5(1), 24-33. [More Information]
  • Polhill, T., Zhang, G., Hu, M., Sawyer, A., Zhou, J., Saito, M., Webster, K., Wang, Y., Wang, Y., Grey, S., Harris, D., Alexander, S., Wang, Y., et al (2012). IL-2/IL-2Ab Complexes Induce Regulatory T Cell Expansion and Protect against Proteinuric CKD. Journal of the American Society of Nephrology, 23(8), 1303-1308. [More Information]
  • Zheng, D., Cao, Q., Lee, V., Wang, Y., Zheng, G., Wang, Y., Tan, T., Wang, C., Alexander, S., Harris, D., Wang, Y. (2012). Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney International, 81(9), 892-902. [More Information]
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Harris, D., Alexander, S., et al (2012). Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology, 42(9), 2441-2451. [More Information]
  • Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011). IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology, 22(7), 1229-1239. [More Information]
  • Sun, Y., Yu, H., Zheng, D., Cao, Q., Wang, Y., Harris, D., Wang, Y. (2011). Sudan Black B Reduces Autofluorescence in Murine Renal Tissue. Archives of Pathology & Laboratory Medicine, 135(10), 1335-1342. [More Information]
  • Zheng, D., Wang, Y., Cao, Q., Lee, V., Zheng, G., Sun, Y., Tan, T., Wang, Y., Alexander, S., Harris, D. (2011). Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus. Nephron Experimental Nephrology, 118(4), e87-e99. [More Information]
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010). IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology, 21(6), 933-942. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Wang, Y., Lee, V., Tian, X., Wang, Y., Cao, Q., Wang, Y., Harris, D. (2010). Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells. American Journal of Pathology, 176(3), 1256-1270. [More Information]
  • Lee, V., Qin, X., Wang, Y., Zheng, G., Wang, Y., Wang, Y., Ince, J., Tan, T., Kairaitis, L., Alexander, S., Harris, D. (2010). The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrology, Dialysis, Transplantation, 25(3), 717-730. [More Information]
  • Wang, Y., Hu, M., Wang, Y., Polhill, T., Zhang, G., Wang, Y., Lee, V., Harris, D., Alexander, S. (2008). Regulatory T Cells in Renal Disease. International Journal of Clinical and Experimental Medicine, 1(4), 294-304. [More Information]

2019

  • Sabanayagam, C., Banu Binte Mohammed Abdul, R., Chee, M., Lee, R., Wang, Y., Tan, G., Jonas, J., Lamoureux, E., Cheng, C., Klein, B., Mitchell, P., et al (2019). Incidence and progression of diabetic retinopathy: a systematic review. The Lancet Diabetes & Endocrinology, 7(2), 140-149. [More Information]

2018

  • Shah, R., Li, Q., Zhao, W., Tedja, M., Tideman, J., Khawaja, A., Fan, Q., Yazar, S., Williams, K., Verhoeven, V., Mitchell, P., et al (2018). A genome-wide association study of corneal astigmatism: The CREAM Consortium. Molecular Vision, 24, 127-142.
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Tan, T., Harris, D., Alexander, S., Durkan, A. (2018). DEC205-DC targeted DNA vaccine against CX3CR1 protects against atherogenesis in mice. PloS One, 13(4), e0195657. [More Information]

2017

  • Huang, D., Wang, Y., Hawthorne, W., Hu, M., Hawkes, J., Burns, H., Davies, S., Gao, F., Chew, Y., Yi, S., O'Connell, P. (2017). Ex vivo-expanded baboon CD39�+� regulatory T cells prevent rejection of porcine islet xenografts in NOD-SCID IL-2ry(-/-) mice reconstituted with baboon peripheral blood mononuclear cells. Xenotransplantation, 24(6), 1-11. [More Information]
  • Wang, Y., Zhang, G., Wang, Y., Hu, M., Zhou, J., Sawyer, A., Cao, Q., Wang, Y., Zheng, G., Lee, V., Harris, D., Alexander, S. (2017). Exacerbation of spontaneous autoimmune nephritis following regulatory T cell depletion in B cell lymphoma 2-interacting mediator knock-out mice. Clinical and Experimental Immunology, 188(2), 195-207. [More Information]
  • Springelkamp, H., Iglesias, A., Mishra, A., Hohn, R., Wojciechowski, R., Khawaja, A., Nag, A., Wang, Y., Wang, J., Cuellar-Partida, G., Mitchell, P., et al (2017). New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Human Molecular Genetics, 26(2), 438-453. [More Information]

2016

  • Zheng, G., Zhang, J., Zhao, H., Wang, H., Pang, M., Qiao, X., Lee, S., Hsu, T., Tan, T., Lyons, G., Zhao, Y., Loebel, D., Wang, Y., Wang, Y., Wang, Y., Cao, Q., Wang, C., Lee, V., Tam, P., Harris, D., et al (2016). a3 Integrin of Cell-Cell Contact Mediates Kidney Fibrosis by Integrin-Linked Kinase in Proximal Tubular E-Cadherin Deficient Mice. American Journal of Pathology, 186(7), 1847-1860. [More Information]
  • Wang, Y., Ghali, J., Zhang, G., Hu, M., Wang, Y., Sawyer, A., Zhou, J., Hapudeniya, D., Wang, Y., Cao, Q., Zheng, G., Harris, D., Alexander, S. (2016). Development and function of Foxp3+ regulatory T cells. Nephrology, 21(2), 81-85. [More Information]
  • Zhao, Y., Qiao, X., Wang, L., Tan, T., Zhao, H., Zhang, Y., Zhang, J., Rao, P., Cao, Q., Wang, Y., Wang, Y., Wang, Y., Lee, V., Harris, D., Zheng, G., et al (2016). Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells. BMC Cell Biology, 17(1), 1-11. [More Information]

2015

  • Sun, Y., Wang, Y., Cao, Q., Yu, H., Zheng, D., Wang, Y., Harris, D. (2015). Expression and Role of CD166 in the Chronic Kidney Disease. Iranian Journal of Pediatrics, 25(5), 1-8. [More Information]

2014

  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, C., Wang, X., Lee, V., Wang, Y., Wang, Y., Zheng, G., Tan, T., Harris, D., et al (2014). Failed renoprotection by alternatively activated macrophages from bone marrow due to proliferation-dependent phenotype switch in vivo. Kidney International, 85(4), 794-806. [More Information]
  • Zhao, Y., Zhao, H., Zhang, Y., Tsatralis, T., Cao, Q., Wang, Y., Wang, Y., Wang, Y., Alexander, S., Harris, D., Zheng, G. (2014). Isolation and epithelial co-culture of mouse renal peritubular endothelial cells. BMC Cell Biology, 15(1), 1-10. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Tan, T., Lee, S., Zhang, J., Zhang, G., Hu, M., Wang, C., Cao, Q., Zhao, Y., Harris, D., et al (2014). Regulatory T cells require renal antigen recognition through the TCR to protect against injury in nephritis. International Journal of Clinical and Experimental Pathology, 7(1), 38-47.

2013

  • Tian, X., Zhang, J., Tan, T., Lyons, G., Zhao, H., Niu, B., Lee, S., Tsatralis, T., Zhao, Y., Wang, Y., Cao, Q., Wang, C., Wang, Y., Lee, V., Zheng, G., Harris, D., et al (2013). Association of beta catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF- beta1. Journal of Cell Science, 126(1), 67-76. [More Information]
  • Wang, Y., Zhou, J., Wang, Y., Watson, D., Zhang, G., Hu, M., Wu, H., Zheng, G., Wang, Y., Durkan, A., Harris, D., Alexander, S. (2013). Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease. International Journal of Clinical and Experimental Pathology, 6(3), 326-333. [More Information]
  • Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V., Zheng, G., Tan, T., Wang, X., Harris, D., Wang, Y., et al (2013). Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney International, 84(4), 745-755. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Zhang, G., Zhou, J., Tan, T., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Harris, D., et al (2013). DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney International, 83(2), 223-232. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Lee, S., Zhang, J., Zhao, Y., Tian, X., Wang, Y., Wang, Y., Cao, Q., Wang, Y., Lee, V., Wang, C., Zheng, D., Alexander, S., Harris, D., et al (2013). Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage. Laboratory Investigation, 93(4), 434-449. [More Information]

2012

  • Wang, Y., Zhang, G., Hu, M., Polhill, T., Sawyer, A., Zhou, J., Saito, M., Watson, D., Wu, H., Wang, Y., Wang, X., Wang, Y., Harris, D., Alexander, S. (2012). CD8+ Regulatory T Cells Induced by T Cell Vaccination Protect Against Autoimmune Nephritis. Journal of the American Society of Nephrology, 23(6), 1058-1067. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Phoon, R., Zhang, G., Wang, Y., Tan, T., Hu, M., Wang, D., Saito, M., Harris, D., Durkan, A., et al (2012). DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. International Journal of Clinical and Experimental Medicine, 5(1), 24-33. [More Information]
  • Polhill, T., Zhang, G., Hu, M., Sawyer, A., Zhou, J., Saito, M., Webster, K., Wang, Y., Wang, Y., Grey, S., Harris, D., Alexander, S., Wang, Y., et al (2012). IL-2/IL-2Ab Complexes Induce Regulatory T Cell Expansion and Protect against Proteinuric CKD. Journal of the American Society of Nephrology, 23(8), 1303-1308. [More Information]
  • Zheng, D., Cao, Q., Lee, V., Wang, Y., Zheng, G., Wang, Y., Tan, T., Wang, C., Alexander, S., Harris, D., Wang, Y. (2012). Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney International, 81(9), 892-902. [More Information]
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Harris, D., Alexander, S., et al (2012). Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology, 42(9), 2441-2451. [More Information]

2011

  • Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011). IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology, 22(7), 1229-1239. [More Information]
  • Sun, Y., Yu, H., Zheng, D., Cao, Q., Wang, Y., Harris, D., Wang, Y. (2011). Sudan Black B Reduces Autofluorescence in Murine Renal Tissue. Archives of Pathology & Laboratory Medicine, 135(10), 1335-1342. [More Information]
  • Zheng, D., Wang, Y., Cao, Q., Lee, V., Zheng, G., Sun, Y., Tan, T., Wang, Y., Alexander, S., Harris, D. (2011). Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus. Nephron Experimental Nephrology, 118(4), e87-e99. [More Information]

2010

  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010). IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology, 21(6), 933-942. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Wang, Y., Lee, V., Tian, X., Wang, Y., Cao, Q., Wang, Y., Harris, D. (2010). Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells. American Journal of Pathology, 176(3), 1256-1270. [More Information]
  • Lee, V., Qin, X., Wang, Y., Zheng, G., Wang, Y., Wang, Y., Ince, J., Tan, T., Kairaitis, L., Alexander, S., Harris, D. (2010). The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrology, Dialysis, Transplantation, 25(3), 717-730. [More Information]

2008

  • Wang, Y., Hu, M., Wang, Y., Polhill, T., Zhang, G., Wang, Y., Lee, V., Harris, D., Alexander, S. (2008). Regulatory T Cells in Renal Disease. International Journal of Clinical and Experimental Medicine, 1(4), 294-304. [More Information]

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