Dr Jacob Qi

Head, Diabetes Lipid Metabolism Laboratory, Centenary Institute of Cancer Medicine &
Cell Biology
Conjoint Lecturer, Sydney Medical School, The University of Sydney
Adjunct Lecturer, School of Biotechnology and Biomolecular Sciences, The University of NSW.

Telephone 02 8627 6045

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Biographical details

Dr Qi commenced his research career at the University of Sydney, Australia, where he studied the pharmacology of lipid-lowering drugs. He then continued in the field of lipid reesearch as a foreign co-researcher in the Department of Endocrinology, Kyoto University, Japan. Dr Qi obtained his PhD at Sydney Medical School, University of Sydney, where his PhD focused on lipids, with emphasis on sphingolipid signaling and lipotoxicity. Most recently, he was research fellow at School of Biotechnology and Biomolecular Sciences, University of New South Wales, where his research focused on cellular lipid mobilisation and storage.He has been appointed as Head of Diabetes Lipid Metabolism Laboratory at Centenary Institute, The University of Sydney since 2017. His current research focuses on lipid metabolism and signaling in selective hepatic insulin resistance. Dr Qi’s research is highly regarded in the field of lipid research.

Research interests

Dysregulated lipid metabolism is a well-known risk factor in the development of type 2 diabetes. Ectopic lipid accumulation in the liver causes insulin resistance, while lipid overloading of pancreatic islets impairs insulin secretion due to lipotoxic stress. Our research focuses on multiple aspects of lipid metabolism: how sphingolipids and phospholipids regulate hepatic insulin resistance both in vivo and in vitro; how sphingolipids determine pancreatic beta-cell viability; how neutral lipids are stored and mobilised in adipocytes; and how phospholipids are transported within cells.

In addition to lipid studies in the pathogenesis of type 2 diabetes, we also aim to identify lipid biomarkers for diabetes at early diagnosis. The majority of pre-diabetic subjects proceed to type 2 diabetes, however, prediabetes is usually unrecognised, which constitutes a major public health concern. Thus, identification of high-risk individuals via a biomarker is urgently needed. We will utilise the plasma sample bank from a cohort with over 6,000 subjects to screen the lipid species that is closely correlated to insulin resistance and prediabetes.

Keywords

Obesity & overweight; Lipid metabolism; Diabetes; Hepatology

Clinical Specialty

Endocrinology

International links

China

(Fudan Univeristy) NHMRC-NSFC Collaboration Grant; Role of Sphingolipid Signaling in Hepatic Insulin Resistance.

Selected publications

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Journals

  • Qi, Y., Sun, L., Yang, H. (2017). Lipid Droplet Growth and Adipocyte Development: Mechanistically Distinct Processes Connected by Phospholipids. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862 (10 Part B), 1273-1283. [More Information]
  • Wang, M., Gao, M., Liao, J., Qi, Y., Du, X., Wang, Y., Li, L., Liu, G., Yang, H. (2016). Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861 (5), 410-418. [More Information]
  • Qi, Y., Kapterian, T., Du, X., Ma, Q., Fei, W., Zhang, Y., Huang, X., Dawes, I., Yang, H. (2016). CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of Lipid Research, 57(5), 767-780. [More Information]
  • Chen, J., Wang, W., Qi, Y., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
  • Pagac, M., Cooper, D., Qi, Y., Lukmantara, I., Mak, H., Wu, Z., Tian, Y., Liu, Z., Lei, M., et al (2016). SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Cell Reports, 17(6), 1546-1559. [More Information]
  • Liu, X., Xie, B., Qi, Y., Du, X., Wang, S., Zhang, Y., Paxinos, G., Yang, H., Liang, H. (2016). The expression of SEIPIN in the mouse central nervous system. Brain Structure and Function, 221(8), 4111-4127. [More Information]
  • Du, X., Zhang, Y., Jo, S., Liu, X., Qi, Y., Osborne, B., Byrne, F., Smith, G., Turner, N., Hoehn, K., et al (2015). Akt Activation Increases Cellular Cholesterol by Promoting the Proteasomal Degradation of Niemann-Pick C1. The Biochemical Journal, 471(2), 243-253. [More Information]
  • Qi, Y., Wang, W., Chen, J., Dai, L., Kaczorowski, D., Gao, X., Xia, P. (2015). Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1alpha Protein Expression. Journal of Biological Chemistry, 290(38), 23282-23290. [More Information]
  • Xia, P., Qi, Y. (2014). Cellular inhibitor of apoptosis protein-1 and survival of beta cells undergoing endoplasmic reticulum stress. Vitamins and Hormones, 95, 269-298. [More Information]
  • Dai, L., Qi, Y., Chen, J., Kaczorowski, D., Di, W., Wang, W., Xia, P. (2014). Sphingosine kinase (SphK) 1 and SphK2 play equivalent roles in mediating insulin's mitogenic action. Molecular Endocrinology, 28(2), 197-207. [More Information]
  • Zhang, N., Dai, L., Qi, Y., Di, W., Xia, P. (2013). Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: Role of autophagy. International Journal of Oncology, 42(6), 2053-2059. [More Information]
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]
  • Qi, Y., Xia, P. (2012). Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Plays A Critical Role in B-Cell Survival under Endoplasmic Reticulum Stress: Promoting Ubiquitination and Degradation of C/EBP Homologous Protein (CHOP). Journal of Biological Chemistry, 287(38), 32236-32245. [More Information]
  • Zhang, N., Qi, Y., Wadham, C., Wang, L., Warren, A., Di, W., Xia, P. (2010). FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy. Autophagy, 6(8), 1157-1167. [More Information]
  • Millar, A., Qi, Y., Rong, X., Jiang, J., Yang, Q., Yamahara, J., Murray, M., Li, Y. (2009). The Ayurvedic medicine Salacia oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling. Evidence-Based Complementary and Alternative Medicine, , 1 of 13-13 of 13. [More Information]

2017

  • Qi, Y., Sun, L., Yang, H. (2017). Lipid Droplet Growth and Adipocyte Development: Mechanistically Distinct Processes Connected by Phospholipids. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862 (10 Part B), 1273-1283. [More Information]

2016

  • Wang, M., Gao, M., Liao, J., Qi, Y., Du, X., Wang, Y., Li, L., Liu, G., Yang, H. (2016). Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861 (5), 410-418. [More Information]
  • Qi, Y., Kapterian, T., Du, X., Ma, Q., Fei, W., Zhang, Y., Huang, X., Dawes, I., Yang, H. (2016). CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of Lipid Research, 57(5), 767-780. [More Information]
  • Chen, J., Wang, W., Qi, Y., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
  • Pagac, M., Cooper, D., Qi, Y., Lukmantara, I., Mak, H., Wu, Z., Tian, Y., Liu, Z., Lei, M., et al (2016). SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Cell Reports, 17(6), 1546-1559. [More Information]
  • Liu, X., Xie, B., Qi, Y., Du, X., Wang, S., Zhang, Y., Paxinos, G., Yang, H., Liang, H. (2016). The expression of SEIPIN in the mouse central nervous system. Brain Structure and Function, 221(8), 4111-4127. [More Information]

2015

  • Du, X., Zhang, Y., Jo, S., Liu, X., Qi, Y., Osborne, B., Byrne, F., Smith, G., Turner, N., Hoehn, K., et al (2015). Akt Activation Increases Cellular Cholesterol by Promoting the Proteasomal Degradation of Niemann-Pick C1. The Biochemical Journal, 471(2), 243-253. [More Information]
  • Qi, Y., Wang, W., Chen, J., Dai, L., Kaczorowski, D., Gao, X., Xia, P. (2015). Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1alpha Protein Expression. Journal of Biological Chemistry, 290(38), 23282-23290. [More Information]

2014

  • Xia, P., Qi, Y. (2014). Cellular inhibitor of apoptosis protein-1 and survival of beta cells undergoing endoplasmic reticulum stress. Vitamins and Hormones, 95, 269-298. [More Information]
  • Dai, L., Qi, Y., Chen, J., Kaczorowski, D., Di, W., Wang, W., Xia, P. (2014). Sphingosine kinase (SphK) 1 and SphK2 play equivalent roles in mediating insulin's mitogenic action. Molecular Endocrinology, 28(2), 197-207. [More Information]

2013

  • Zhang, N., Dai, L., Qi, Y., Di, W., Xia, P. (2013). Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: Role of autophagy. International Journal of Oncology, 42(6), 2053-2059. [More Information]
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]

2012

  • Qi, Y., Xia, P. (2012). Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Plays A Critical Role in B-Cell Survival under Endoplasmic Reticulum Stress: Promoting Ubiquitination and Degradation of C/EBP Homologous Protein (CHOP). Journal of Biological Chemistry, 287(38), 32236-32245. [More Information]

2010

  • Zhang, N., Qi, Y., Wadham, C., Wang, L., Warren, A., Di, W., Xia, P. (2010). FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy. Autophagy, 6(8), 1157-1167. [More Information]

2009

  • Millar, A., Qi, Y., Rong, X., Jiang, J., Yang, Q., Yamahara, J., Murray, M., Li, Y. (2009). The Ayurvedic medicine Salacia oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling. Evidence-Based Complementary and Alternative Medicine, , 1 of 13-13 of 13. [More Information]

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