Dr Jacob Qi

Head, Diabetes Lipid Metabolism Laboratory, Centenary Institute of Cancer Medicine &
Cell Biology
Conjoint Lecturer, Sydney Medical School, The University of Sydney
Adjunct Lecturer, School of Biotechnology and Biomolecular Sciences, The University of NSW.

Telephone 02 8627 6045

Map

Biographical details

Dr Qi is an emerging young metabolism scientist. He is now heading the Diabetes Lipid Metabolism Laboratory at Centenary Institute of Cancer Medicine and Cell Biology and ACRF Centenary Cancer Research Centre, Charles Perkins Centre, The University of Sydney. Dr Qi commenced his research career at theSydney Pharmacy School, University of Sydney, Australia. He then received research training at the Graduate School of Endocrinology, Kyoto University, Japan. Dr Qi obtained his PhD at Sydney Medical School, University of Sydney. Most recently, he was a postdoctoral research fellow at the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Australia.

Dr Qi has strong research expertise in lipid metabolism and signalling, lipid droplet biology andadipose tissue biology. His current research focuses on the lipid metabolic causes ofliver diseases, includinghepatic insulin resistance, non-alcoholic fatty liver disease andhepatocellular carcinoma. Dr Qi’s research is highly regarded in the field of lipid studies.

Research interests

1. Type 2 Diabetes

Dysregulated lipid metabolism is a well-known risk factor in the development of type 2 diabetes. Ectopic lipid accumulation in the liver causes insulin resistance, while lipid overloading of pancreatic islets impairs insulin secretion due to lipotoxic stress. Our research focuses on multiple aspects of lipid metabolism: how sphingolipids and phospholipids regulate hepatic insulin resistance bothin vivoandin vitro; how sphingolipids determine pancreatic beta-cell viability; how neutral lipids are stored and mobilised in adipocytes; and how phospholipids are transported within cells.

In addition to lipid studies in the pathogenesis of type 2 diabetes, we also aim to identify lipid biomarkers for diabetes at early diagnosis. The majority of pre-diabetic subjects proceed to type 2 diabetes, however, prediabetes is usually unrecognised, which constitutes a major public health concern. Thus, identification of high-risk individuals via a biomarker is urgently needed. We will utilise the plasma sample bank from a cohort with over 6,000 subjects to screen the lipid species that is closely correlated to hepatic insulin resistance and prediabetes.

2. Hepatocellular carcinoma

Human hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and the second leading cause of cancer death worldwide. The liver is the principal organ of lipid metabolism. Dysregulated hepatic lipids are believed to provide an appropriate microenvironment for HCC progression. In recent years, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) are emerging as major risk factors for HCC, due to the prevalence of these two conditions. In contrast to the HCC derived from alcohol abuse and viral infection, diabetes and NAFLD can develop HCC bypassing the cirrhosis, indicating a unique pathogenic route. In human and mouse HCC, we identified a pair of sibling lipid metabolic enzymes, whose balance may determine the outcome of HCC development from diabetes and NAFLD. We are testing the novel chemotherapy and liver-specific gene therapy, targeting these sibling enzymes.

HCC is notoriously difficult to treat. Sorafenib and regorafenib are only two systemic therapies for the advanced HCC, however, both prolongs median survival by less than three months. Worse still, the current HCC diagnosis relies on the detection of cirrhosis that is absent in 30% of diabetes and NAFLD-related HCC. Thus, the prediction of HCC in non-cirrhotic diabetic and NAFLD subjects is crucial for the HCC management. Using a clinically relevant animal model, we have identified a candidate predictor, and we are now validating this predictor in collaboration with the AW Morrow Gastroenterology and Liver Centre and Director of the Australian National Liver Transplant unit at Royal Prince Alfred Hospital.

International links

China

(Fudan Univeristy) NHMRC-NSFC Collaboration Grant; Role of Sphingolipid Signaling in Hepatic Insulin Resistance.

Selected publications

Download citations: PDF RTF Endnote

Journals

  • Qi, Y., Sun, L., Yang, H. (2017). Lipid Droplet Growth and Adipocyte Development: Mechanistically Distinct Processes Connected by Phospholipids. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862 (10 Part B), 1273-1283. [More Information]
  • Wang, M., Gao, M., Liao, J., Qi, Y., Du, X., Wang, Y., Li, L., Liu, G., Yang, H. (2016). Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861 (5), 410-418. [More Information]
  • Qi, Y., Kapterian, T., Du, X., Ma, Q., Fei, W., Zhang, Y., Huang, X., Dawes, I., Yang, H. (2016). CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of Lipid Research, 57(5), 767-780. [More Information]
  • Chen, J., Wang, W., Qi, Y., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
  • Pagac, M., Cooper, D., Qi, Y., Lukmantara, I., Mak, H., Wu, Z., Tian, Y., Liu, Z., Lei, M., et al (2016). SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Cell Reports, 17(6), 1546-1559. [More Information]
  • Liu, X., Xie, B., Qi, Y., Du, X., Wang, S., Zhang, Y., Paxinos, G., Yang, H., Liang, H. (2016). The expression of SEIPIN in the mouse central nervous system. Brain Structure and Function, 221(8), 4111-4127. [More Information]
  • Du, X., Zhang, Y., Jo, S., Liu, X., Qi, Y., Osborne, B., Byrne, F., Smith, G., Turner, N., Hoehn, K., et al (2015). Akt Activation Increases Cellular Cholesterol by Promoting the Proteasomal Degradation of Niemann-Pick C1. The Biochemical Journal, 471(2), 243-253. [More Information]
  • Qi, Y., Wang, W., Chen, J., Dai, L., Kaczorowski, D., Gao, X., Xia, P. (2015). Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1alpha Protein Expression. Journal of Biological Chemistry, 290(38), 23282-23290. [More Information]
  • Xia, P., Qi, Y. (2014). Cellular inhibitor of apoptosis protein-1 and survival of beta cells undergoing endoplasmic reticulum stress. Vitamins and Hormones, 95, 269-298. [More Information]
  • Dai, L., Qi, Y., Chen, J., Kaczorowski, D., Di, W., Wang, W., Xia, P. (2014). Sphingosine kinase (SphK) 1 and SphK2 play equivalent roles in mediating insulin's mitogenic action. Molecular Endocrinology, 28(2), 197-207. [More Information]
  • Zhang, N., Dai, L., Qi, Y., Di, W., Xia, P. (2013). Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: Role of autophagy. International Journal of Oncology, 42(6), 2053-2059. [More Information]
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]
  • Qi, Y., Xia, P. (2012). Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Plays A Critical Role in B-Cell Survival under Endoplasmic Reticulum Stress: Promoting Ubiquitination and Degradation of C/EBP Homologous Protein (CHOP). Journal of Biological Chemistry, 287(38), 32236-32245. [More Information]
  • Zhang, N., Qi, Y., Wadham, C., Wang, L., Warren, A., Di, W., Xia, P. (2010). FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy. Autophagy, 6(8), 1157-1167. [More Information]
  • Millar, A., Qi, Y., Rong, X., Jiang, J., Yang, Q., Yamahara, J., Murray, M., Li, Y. (2009). The Ayurvedic medicine Salacia oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling. Evidence-Based Complementary and Alternative Medicine, , 1 of 13-13 of 13. [More Information]

2017

  • Qi, Y., Sun, L., Yang, H. (2017). Lipid Droplet Growth and Adipocyte Development: Mechanistically Distinct Processes Connected by Phospholipids. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862 (10 Part B), 1273-1283. [More Information]

2016

  • Wang, M., Gao, M., Liao, J., Qi, Y., Du, X., Wang, Y., Li, L., Liu, G., Yang, H. (2016). Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861 (5), 410-418. [More Information]
  • Qi, Y., Kapterian, T., Du, X., Ma, Q., Fei, W., Zhang, Y., Huang, X., Dawes, I., Yang, H. (2016). CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of Lipid Research, 57(5), 767-780. [More Information]
  • Chen, J., Wang, W., Qi, Y., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
  • Pagac, M., Cooper, D., Qi, Y., Lukmantara, I., Mak, H., Wu, Z., Tian, Y., Liu, Z., Lei, M., et al (2016). SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Cell Reports, 17(6), 1546-1559. [More Information]
  • Liu, X., Xie, B., Qi, Y., Du, X., Wang, S., Zhang, Y., Paxinos, G., Yang, H., Liang, H. (2016). The expression of SEIPIN in the mouse central nervous system. Brain Structure and Function, 221(8), 4111-4127. [More Information]

2015

  • Du, X., Zhang, Y., Jo, S., Liu, X., Qi, Y., Osborne, B., Byrne, F., Smith, G., Turner, N., Hoehn, K., et al (2015). Akt Activation Increases Cellular Cholesterol by Promoting the Proteasomal Degradation of Niemann-Pick C1. The Biochemical Journal, 471(2), 243-253. [More Information]
  • Qi, Y., Wang, W., Chen, J., Dai, L., Kaczorowski, D., Gao, X., Xia, P. (2015). Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1alpha Protein Expression. Journal of Biological Chemistry, 290(38), 23282-23290. [More Information]

2014

  • Xia, P., Qi, Y. (2014). Cellular inhibitor of apoptosis protein-1 and survival of beta cells undergoing endoplasmic reticulum stress. Vitamins and Hormones, 95, 269-298. [More Information]
  • Dai, L., Qi, Y., Chen, J., Kaczorowski, D., Di, W., Wang, W., Xia, P. (2014). Sphingosine kinase (SphK) 1 and SphK2 play equivalent roles in mediating insulin's mitogenic action. Molecular Endocrinology, 28(2), 197-207. [More Information]

2013

  • Zhang, N., Dai, L., Qi, Y., Di, W., Xia, P. (2013). Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: Role of autophagy. International Journal of Oncology, 42(6), 2053-2059. [More Information]
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]

2012

  • Qi, Y., Xia, P. (2012). Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Plays A Critical Role in B-Cell Survival under Endoplasmic Reticulum Stress: Promoting Ubiquitination and Degradation of C/EBP Homologous Protein (CHOP). Journal of Biological Chemistry, 287(38), 32236-32245. [More Information]

2010

  • Zhang, N., Qi, Y., Wadham, C., Wang, L., Warren, A., Di, W., Xia, P. (2010). FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy. Autophagy, 6(8), 1157-1167. [More Information]

2009

  • Millar, A., Qi, Y., Rong, X., Jiang, J., Yang, Q., Yamahara, J., Murray, M., Li, Y. (2009). The Ayurvedic medicine Salacia oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling. Evidence-Based Complementary and Alternative Medicine, , 1 of 13-13 of 13. [More Information]

To update your profile click here. For support on your academic profile contact .