Dr Jacob Qi

Head, Diabetes Lipid Metabolism Laboratory, Centenary Institute of Cancer Medicine &
Cell Biology
Conjoint Lecturer, Sydney Medical School, The University of Sydney
Adjunct Lecturer, School of Biotechnology and Biomolecular Sciences, The University of NSW.

Telephone 02 8627 6045

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Biographical details

Dr Qi is an emerging young lipid biologist. He is now heading the Diabetes Lipid Metabolism Laboratory at Centenary Institute of Cancer Medicine and Cell Biology and ACRF Centenary Cancer Research Centre, Charles Perkins Centre, The University of Sydney.

Dr Qi commenced his research career at the Sydney Pharmacy School, University of Sydney, Australia. He then received research training at the Graduate School of Endocrinology, Kyoto University, Japan. Dr Qi obtained his PhD at Sydney Medical School, University of Sydney. Most recently, he was a postdoctoral research fellow at the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Australia.

Dr Qi's current research focuses on the lipid metabolic causes of liver diseases, including hepatic insulin resistance, non-alcoholic fatty liver disease and hepatocellular carcinoma. His research is highly regarded and well funded with an NHMRC project grant (sole chief investigator), an NHMRC-NSFC joint research grant (lead investigator) and a USYD Kickstart grant.

Research interests

1. Hepatic insulin resistance and prediabetes

2. NAFLD-related liver cancer

3. Molecular lipid biology

4. Other interests and expertise in autophagy, ubiquitination, adipose tissue biology and islet biology.

Teaching and supervision

1. Supporting the Chinese Scholarship Council (CSC) exchange PhD scholarship application

2. Recruiting Honous and PhD students

Student Supervision History

1. Primary supervisor ofMin Li, PhD candidate (funded by CSC scholarship) and Jerry Huang, Honors student (funded by University scholarship);

Auxiliary supervisor of Collin Tran, PhD candidate (UNSW) andSheena Nunag, Honors student (USYD).

Awards and honours

1. NHMRC project grant as thesole chief investigator

2. NHMRC-NSFC joint research grant as thelead investigator

3. USYD Kickstart grant.

International links

China

(Fudan Univeristy) NHMRC-NSFC Collaboration Grant; Role of Sphingolipid Signaling in Hepatic Insulin Resistance.

Selected publications

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Journals

  • Du, X., Zadoorian, A., Lukmantara, I., Qi, J., Brown, A., Yang, H. (2018). Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling. Journal of Biological Chemistry, 293(10), 3806-3818. [More Information]
  • Qi, Y., Sun, L., Yang, H. (2017). Lipid Droplet Growth and Adipocyte Development: Mechanistically Distinct Processes Connected by Phospholipids. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862 (10 Part B), 1273-1283. [More Information]
  • Wang, M., Gao, M., Liao, J., Qi, Y., Du, X., Wang, Y., Li, L., Liu, G., Yang, H. (2016). Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861 (5), 410-418. [More Information]
  • Qi, Y., Kapterian, T., Du, X., Ma, Q., Fei, W., Zhang, Y., Huang, X., Dawes, I., Yang, H. (2016). CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of Lipid Research, 57(5), 767-780. [More Information]
  • Chen, J., Wang, W., Qi, Y., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
  • Pagac, M., Cooper, D., Qi, Y., Lukmantara, I., Mak, H., Wu, Z., Tian, Y., Liu, Z., Lei, M., et al (2016). SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Cell Reports, 17(6), 1546-1559. [More Information]
  • Liu, X., Xie, B., Qi, Y., Du, X., Wang, S., Zhang, Y., Paxinos, G., Yang, H., Liang, H. (2016). The expression of SEIPIN in the mouse central nervous system. Brain Structure and Function, 221(8), 4111-4127. [More Information]
  • Du, X., Zhang, Y., Jo, S., Liu, X., Qi, Y., Osborne, B., Byrne, F., Smith, G., Turner, N., Hoehn, K., et al (2015). Akt Activation Increases Cellular Cholesterol by Promoting the Proteasomal Degradation of Niemann-Pick C1. The Biochemical Journal, 471(2), 243-253. [More Information]
  • Qi, Y., Wang, W., Chen, J., Dai, L., Kaczorowski, D., Gao, X., Xia, P. (2015). Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1alpha Protein Expression. Journal of Biological Chemistry, 290(38), 23282-23290. [More Information]
  • Xia, P., Qi, Y. (2014). Cellular inhibitor of apoptosis protein-1 and survival of beta cells undergoing endoplasmic reticulum stress. Vitamins and Hormones, 95, 269-298. [More Information]
  • Dai, L., Qi, Y., Chen, J., Kaczorowski, D., Di, W., Wang, W., Xia, P. (2014). Sphingosine kinase (SphK) 1 and SphK2 play equivalent roles in mediating insulin's mitogenic action. Molecular Endocrinology, 28(2), 197-207. [More Information]
  • Zhang, N., Dai, L., Qi, Y., Di, W., Xia, P. (2013). Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: Role of autophagy. International Journal of Oncology, 42(6), 2053-2059. [More Information]
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]
  • Qi, Y., Xia, P. (2012). Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Plays A Critical Role in B-Cell Survival under Endoplasmic Reticulum Stress: Promoting Ubiquitination and Degradation of C/EBP Homologous Protein (CHOP). Journal of Biological Chemistry, 287(38), 32236-32245. [More Information]
  • Zhang, N., Qi, Y., Wadham, C., Wang, L., Warren, A., Di, W., Xia, P. (2010). FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy. Autophagy, 6(8), 1157-1167. [More Information]
  • Millar, A., Qi, Y., Rong, X., Jiang, J., Yang, Q., Yamahara, J., Murray, M., Li, Y. (2009). The Ayurvedic medicine Salacia oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling. Evidence-Based Complementary and Alternative Medicine, , 1 of 13-13 of 13. [More Information]

2018

  • Du, X., Zadoorian, A., Lukmantara, I., Qi, J., Brown, A., Yang, H. (2018). Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling. Journal of Biological Chemistry, 293(10), 3806-3818. [More Information]

2017

  • Qi, Y., Sun, L., Yang, H. (2017). Lipid Droplet Growth and Adipocyte Development: Mechanistically Distinct Processes Connected by Phospholipids. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862 (10 Part B), 1273-1283. [More Information]

2016

  • Wang, M., Gao, M., Liao, J., Qi, Y., Du, X., Wang, Y., Li, L., Liu, G., Yang, H. (2016). Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861 (5), 410-418. [More Information]
  • Qi, Y., Kapterian, T., Du, X., Ma, Q., Fei, W., Zhang, Y., Huang, X., Dawes, I., Yang, H. (2016). CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. Journal of Lipid Research, 57(5), 767-780. [More Information]
  • Chen, J., Wang, W., Qi, Y., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
  • Pagac, M., Cooper, D., Qi, Y., Lukmantara, I., Mak, H., Wu, Z., Tian, Y., Liu, Z., Lei, M., et al (2016). SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Cell Reports, 17(6), 1546-1559. [More Information]
  • Liu, X., Xie, B., Qi, Y., Du, X., Wang, S., Zhang, Y., Paxinos, G., Yang, H., Liang, H. (2016). The expression of SEIPIN in the mouse central nervous system. Brain Structure and Function, 221(8), 4111-4127. [More Information]

2015

  • Du, X., Zhang, Y., Jo, S., Liu, X., Qi, Y., Osborne, B., Byrne, F., Smith, G., Turner, N., Hoehn, K., et al (2015). Akt Activation Increases Cellular Cholesterol by Promoting the Proteasomal Degradation of Niemann-Pick C1. The Biochemical Journal, 471(2), 243-253. [More Information]
  • Qi, Y., Wang, W., Chen, J., Dai, L., Kaczorowski, D., Gao, X., Xia, P. (2015). Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1alpha Protein Expression. Journal of Biological Chemistry, 290(38), 23282-23290. [More Information]

2014

  • Xia, P., Qi, Y. (2014). Cellular inhibitor of apoptosis protein-1 and survival of beta cells undergoing endoplasmic reticulum stress. Vitamins and Hormones, 95, 269-298. [More Information]
  • Dai, L., Qi, Y., Chen, J., Kaczorowski, D., Di, W., Wang, W., Xia, P. (2014). Sphingosine kinase (SphK) 1 and SphK2 play equivalent roles in mediating insulin's mitogenic action. Molecular Endocrinology, 28(2), 197-207. [More Information]

2013

  • Zhang, N., Dai, L., Qi, Y., Di, W., Xia, P. (2013). Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: Role of autophagy. International Journal of Oncology, 42(6), 2053-2059. [More Information]
  • Qi, Y., Chen, J., Lay, A., Don, A., Vadas, M., Xia, P. (2013). Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. The FASEB Journal, 27(10), 4294-4304. [More Information]

2012

  • Qi, Y., Xia, P. (2012). Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Plays A Critical Role in B-Cell Survival under Endoplasmic Reticulum Stress: Promoting Ubiquitination and Degradation of C/EBP Homologous Protein (CHOP). Journal of Biological Chemistry, 287(38), 32236-32245. [More Information]

2010

  • Zhang, N., Qi, Y., Wadham, C., Wang, L., Warren, A., Di, W., Xia, P. (2010). FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy. Autophagy, 6(8), 1157-1167. [More Information]

2009

  • Millar, A., Qi, Y., Rong, X., Jiang, J., Yang, Q., Yamahara, J., Murray, M., Li, Y. (2009). The Ayurvedic medicine Salacia oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling. Evidence-Based Complementary and Alternative Medicine, , 1 of 13-13 of 13. [More Information]

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