Dr Yu Suk Choi

Research Fellow
Kolling Institute of Medical Research, Northern Clinical School

Telephone +61 2 9926 4907
Fax +61 2 9926 4050

Website Pubmed
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Biographical details

Yu Suk Choi is a Research Fellow (Level B) at the Cardiac Technology Centre / Cardiology at the University of Sydney / Royal North Shore Hospital / Kolling Institute. He studies stem cell fate decision, especially in cell - cell and cell - extracellular matrix (ECM) interaction using cellular, molecular and bioengineering tools to regenerate multiple tissues including cardiac and skeletal muscle in tissue engineering and regenerative medicine setting. He graduated from Yonsei University (South Korea) with B.E degree in Biotechnology and M.Sc degree in Nanobiomedical Technology. Yu Suk moved to University of Melbourne, Dept. of Surgery for his Ph.D in cardiac tissue engineering with supervision from Profs. Wayne Morrison, Greg Dusting, and Rod Dilley.
After awarding Ph.D in early 2010, Dr. Choi then moved to University of California, San Diego, Bioengineering as a Postdoctoral Scholar, sponsored by supervisor Dr. Adam Engler. Dr. Choi is the recipient of Muscular Dystrophy Association Grant (US$390,000 for 3 years) with Dr. Adam Engler an has been a co-author on 16 peer-reviewed papers (8 as first) in journals including Stem Cells (IF 7.701), Biomaterials (IF 7.604), Tissue Engineering (IF 4.065), and Journal of Cellular Molecular Medicine (IF 4.753) among others. He has high h-index (9) and h10-index (8) as an early career researcher with total of 447 citations. Dr. Choi also wrote book chapters including 'Stem Cells and Cancer Stem Cells v2, 2012, Springer Netherlands' and 'Biology of Extracellular Matix, 2013, Springer Heidelberg'. He has been invited for lectures or presentations by international institutes including Institute of Molecular Cardiology, University of Louisville (Prof. Roberto Bolli: Editor-in-chief for journal Circulation Research), Institute of Radioprotection and Nuclear Safety (IRNS Paris), and Tokyo Medical and Dental University, Global Centre of Excellence Program (Prof. Masaki Noda) and was selected for oral presentations in various conferences such as World Biomaterials Congress, Biomedical Engineering Society (BMES), and Australian Society of Stem Cell Research (ASSCR). Yu Suk serves as a reviewer for many prestigious journals including Advanced Materials (IF 14.829), Stem Cells, Tissue Engineering, and Plos ONE(IF 3.730). Dr. Choi's research expertise is mainly in stem cell biology, tissue engineering, extracellular matrix biology, and hydrogel material science. He has worked on differentiating adult stem cells (bone marrow-derived and adipose-derived) to beating cardiomyocytes, functional myotube, smooth muscle cells, and fat cells for cardiac, skeletal, and adipose tissue engineering approaches. Mechanobiology experience from his UCSD postdoctoral years will provide unique insights for cardiac regeneration coupled with conventional approaches. Important pre-2007 Publications: Kim M, Choi YS, Yang SH, Hong HN, Cho SW, Cha SM, Pak JH, Kim CW, Kwon SW, Park CJ. Muscle regeneration by adipose tissue-derived adult stem cells attached to injectable PLGA spheres. Biochem Biophys Res Commun. 2006;22:348(2):386-392. (co-first author) Choi YS, Cha SM, Lee YY, Kwon SW, Park CJ, Kim M. Adipogenic differentiation of adipose tissue derived adult stem cells in nude mouse. Biochem Biophys Res Commun. 2006:30;345(2):631-7. Choi YS, Park SN, Suh H. Adipose tissue engineering using mesenchymal stem cells attached to injectable PLGA spheres. Biomaterials. 2005;26(29):5855-63.

Research interests

  • Adult stem cell (especially differentiation, migration, and proliferation)
  • Tissue engineering and regenerative medicine
  • mechanotransduction
  • Target areas are cardiac, skeletal muscle, adipose, and cancer
  • Tools: advanced biomaterial fabrication (mechanically patterned hydrogel, micro-contact printing, soft lithography, and photopolymerization

Teaching and supervision

PhD Project (Heart Research Australia scholarship opportunity)

http://agile2.ucc.usyd.edu.au/ro/opportunities/scholarships/1333

Mechnosensitivity of stem cells on heart tissue stiffness-mimicked hydrogel

After myocardial infarct (MI), the microenvironments of the damaged heart muscle become stiffer than healthy cardiac muscle. This stiffened extracellular matrix (ECM) may misdirect stem cells to differentiate into other lineage cell types than cardiomyocytes when injected into scarred area. Stem cells have mechanosensing capability, which allow stem cells feel the stiffness of surrounding ECM. Intracellularly, stem cells transduce these biophysical signals into biochemical signals from cell membrane to nucleus and this process is called mechanotransduction. In this project, we will fabricate polymer hydrogels to mimic heart tissue stiffness at various stages (healthy vs. diseased after MI) and study stem cell behaviors including proliferation and cardiac differentiation. This reductionist’s approach will enhance our understanding how stem cell – ECM stiffness interact in heart tissue with or without MI and give us better insight to make natural ECM mimicked biomaterials for cardiac regeneration.

Previously

Dr. Choi has co-lectured 2 classes (Stem cell biology - Freshmen seminar, Tissue engineering lab module) with Drs. Adam Engler and Karen Christman at UCSD bioengineering. He has also mentored undergraduates, postgraduates, postdocs, and surgeons in lab setting at University of Mebourne and UCSD. His teaching interests are in stem cell biology, tissue engineering and regenerative medicine, advanced materials, biomaterials, molecular biology, mechanobiology, and cell biology.

International links

Korea South

(Hanyang University) Professor Heung Soo Shin and Dr. Yu Suk Choi collaborated on temperature sensitive hydrogel project.

United States

(University of California, Merced) Drs. Kara McCloskey and Yu Suk Choi are currently collaborating on endothelial lineage decision on smart hydrogel with mechanical pattern.

United States

(University of California, San Diego) Drs. Adam Engler and Yu Suk Choi shared several publications in stem cell / mechanotransduction.

Selected grants

2014

  • ECM stiffness driven cardiac induction of stem cells; Choi Y, Hunyor S, Cooper-White J, Engler A; Heart Research Australia/Research Support.

Selected publications

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Book Chapters

  • Choi, Y., Holle, A., Engler, A. (2013). Engineered ECM microenvironments and their regulation of stem cells. In Douglas W. DeSimone and Robert P. Mecham (Eds.), Extracellular Matrix in Development, (pp. 133-162). Heidelberg: Springer.
  • Dilley, R., Choi, Y., Dusting, G. (2012). Generating Human Cardiac Muscle Cells from Adipose-Derived Stem Cells. In M.A. Hayat (Eds.), Stem Cells and Cancer Stem Cells, (pp. 269-275). Netherlands: Springer Netherlands.
  • Kim, M., Choi, Y. (2011). Skeletal Muscle Tissue Engineering using Adipose Tissue derived Stem Cells. In Alexander L. Greene (Eds.), Encyclopedia of Stem Cell Research. Nova Science Publishers.
  • Kim, M., Choi, Y. (2008). Tissue engineering using adipose tissue derived adult stem cells for skeletal muscle repair. In Bernard N. Kennedy (Eds.), Stem Cell Transplantation, Tissue Engineering anc Cancer Applications, (pp. 159-174). Nova Science Publishers.
  • Kim, M., Choi, Y. (2008). Tissue Engineering Using Adipose Tissue-Derived Adult Stem Cells for Skeletal Muscle Repair. In Steven J. Barnes and Lawrence P. Harris (Eds.), Tissue Engineering: Roles, Materials and Applications, (pp. 287-301). Nova Science Publishers.

Journals

  • Rao, N., Grover, G., Vincent, L., Evans, S., Choi, Y., Spencer, K., Hui, E., Engler, A., Christman, K. (2013). A co-culture device with a tunable stiffness to understand combinatorial cell-cell and cell-matrix interactions. Integrative Biology, 5(11), 1344-1354. [More Information]
  • Matsuda, K., Flakenberg, K., Woods, A., Choi, Y., Morrison, W., Dilley, R. (2013). Adipose-derived stem cells promote angiogenesis and tissue formation for in vivo tissue engineering. Tissue Engineering. Part A, 19(11), 1327-1335. [More Information]
  • Holle, A., Tang, X., Vijayraghavan, D., Vincent, L., Fuhrmann, A., Choi, Y., del Alamo, J., Engler, A. (2013). In situ mechanotransduction via vinculin regulates stem cell differentiation. Stem Cells, 31(11), 2467-2477. [More Information]
  • Vincent, L., Choi, Y., Alonso-Latorre, B., del Alamo, J., Engler, A. (2013). Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength. Biotechnology Journal, 8(4), 472-484. [More Information]
  • Young, D., Choi, Y., Engler, A., Christman, K. (2013). Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue. Biomaterials, 34(34), 8581-8588. [More Information]
  • Kim, M., Kim, C., Choi, Y., Kim, M., Park, C., Suh, Y. (2012). Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: implication to age-associated bone diseases and defects. Mechanisms of ageing and development, 133(5), 215-225. [More Information]
  • Choi, Y., Vincent, L., Lee, A., Dobke, M., Engler, A. (2012). Mechanical derivation of functional myotubes from adipose-derived stem cells. Biomaterials, 33(8), 2482-2491. [More Information]
  • Choi, Y., Vincent, L., Lee, A., Kretchmer, K., Chirasatitsin, S., Dobke, M., Engler, A. (2012). The alignment and fusion assembly of adipose-derived stem cells on mechanically patterned matrices. Biomaterials. [More Information]
  • Tee, R., Morrison, W., Dusting, G., Liu, G., Choi, Y., Hsiao, S., Dilley, R. (2012). Transplantation of engineered cardiac muscle flaps in syngeneic rats. Tissue Engineering. Part A, 18(19-20), 1992-1999. [More Information]
  • Choi, Y., Dusting, G., Stubbs, S., Arunothayaraj, S., Han, X., Collas, P., Morrison, W., Dilley, R. (2010). Differentiation of human adipose-derived stem cells into beating cardiomyocytes. Journal of Cellular and Molecular Medicine, 14(4), 878-889. [More Information]
  • Choi, Y., Matsuda, K., Dusting, G., Morrison, W., Dilley, R. (2010). Engineering cardiac tissue in vivo from human adipose-derived stem cells. Biomaterials, 31(8), 2236-2242. [More Information]
  • Choi, Y., Park, S., Suh, H. (2008). The effect of PLGA sphere diameter on rabbit mesenchymal stem cells in adipose tissue engineering. Journal of Materials Science: Materials in Medicine, 19(5), 2165-71. [More Information]
  • Park, S., Jang, H., Choi, Y., Cha, J., Son, S., Han, S., Kim, J., Lee, W., Suh, H. (2007). Preparation and characterization of biodegradable anti-adhesive membrane for peritoneal wound healing. Journal of Materials Science: Materials in Medicine, 18(3), 475-482. [More Information]
  • Choi, Y., Cha, S., Lee, Y., Kwon, S., Park, C., Kim, M. (2006). Adipogenic differentiation of adipose tissue derived adult stem cells in nude mouse. Biochemical and Biophysical Research Communications, 345(2), 631-637. [More Information]

Conferences

  • Choi, Y., Vincent, L., Lee, A., Marek, D., Engler, A. (2012). Controlling Stem Cell Fate with Spatially Varying Extracellular Matrix Stiffness. Biomedical Engineering Society Meeting, USA: Biomedical Engineering Society.
  • Choi, Y., Vincent, L., Lee, A., Marek, D., Engler, A. (2012). Mechanical Derivation of Functional Myotubes from Adipose-Derived Stem Cells. Biomedical Engineering Society Meeting, USA: Biomedical Engineering Society.
  • Choi, Y., Vincent, L., Lee, A., Marek, D., Engler, A. (2012). Mechanical Derivation of Functional Myotubes from Adipose-Derived Stem Cells. 244th National Meeting of the American Chemical Society,  :  .
  • Choi, Y., Matsuda, K., Dusting, G., Morrison, W., Dilley, R. (2009). Engineering human cardiac tissue in vivo from adipose-dervied stem cells. Australian Society for Stem Cell Research 2nd annual meeting, Australia: Australian Society for Stem Cell Research.

2013

  • Rao, N., Grover, G., Vincent, L., Evans, S., Choi, Y., Spencer, K., Hui, E., Engler, A., Christman, K. (2013). A co-culture device with a tunable stiffness to understand combinatorial cell-cell and cell-matrix interactions. Integrative Biology, 5(11), 1344-1354. [More Information]
  • Matsuda, K., Flakenberg, K., Woods, A., Choi, Y., Morrison, W., Dilley, R. (2013). Adipose-derived stem cells promote angiogenesis and tissue formation for in vivo tissue engineering. Tissue Engineering. Part A, 19(11), 1327-1335. [More Information]
  • Choi, Y., Holle, A., Engler, A. (2013). Engineered ECM microenvironments and their regulation of stem cells. In Douglas W. DeSimone and Robert P. Mecham (Eds.), Extracellular Matrix in Development, (pp. 133-162). Heidelberg: Springer.
  • Holle, A., Tang, X., Vijayraghavan, D., Vincent, L., Fuhrmann, A., Choi, Y., del Alamo, J., Engler, A. (2013). In situ mechanotransduction via vinculin regulates stem cell differentiation. Stem Cells, 31(11), 2467-2477. [More Information]
  • Vincent, L., Choi, Y., Alonso-Latorre, B., del Alamo, J., Engler, A. (2013). Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength. Biotechnology Journal, 8(4), 472-484. [More Information]
  • Young, D., Choi, Y., Engler, A., Christman, K. (2013). Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue. Biomaterials, 34(34), 8581-8588. [More Information]

2012

  • Kim, M., Kim, C., Choi, Y., Kim, M., Park, C., Suh, Y. (2012). Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: implication to age-associated bone diseases and defects. Mechanisms of ageing and development, 133(5), 215-225. [More Information]
  • Choi, Y., Vincent, L., Lee, A., Marek, D., Engler, A. (2012). Controlling Stem Cell Fate with Spatially Varying Extracellular Matrix Stiffness. Biomedical Engineering Society Meeting, USA: Biomedical Engineering Society.
  • Dilley, R., Choi, Y., Dusting, G. (2012). Generating Human Cardiac Muscle Cells from Adipose-Derived Stem Cells. In M.A. Hayat (Eds.), Stem Cells and Cancer Stem Cells, (pp. 269-275). Netherlands: Springer Netherlands.
  • Choi, Y., Vincent, L., Lee, A., Marek, D., Engler, A. (2012). Mechanical Derivation of Functional Myotubes from Adipose-Derived Stem Cells. Biomedical Engineering Society Meeting, USA: Biomedical Engineering Society.
  • Choi, Y., Vincent, L., Lee, A., Marek, D., Engler, A. (2012). Mechanical Derivation of Functional Myotubes from Adipose-Derived Stem Cells. 244th National Meeting of the American Chemical Society,  :  .
  • Choi, Y., Vincent, L., Lee, A., Dobke, M., Engler, A. (2012). Mechanical derivation of functional myotubes from adipose-derived stem cells. Biomaterials, 33(8), 2482-2491. [More Information]
  • Choi, Y., Vincent, L., Lee, A., Kretchmer, K., Chirasatitsin, S., Dobke, M., Engler, A. (2012). The alignment and fusion assembly of adipose-derived stem cells on mechanically patterned matrices. Biomaterials. [More Information]
  • Tee, R., Morrison, W., Dusting, G., Liu, G., Choi, Y., Hsiao, S., Dilley, R. (2012). Transplantation of engineered cardiac muscle flaps in syngeneic rats. Tissue Engineering. Part A, 18(19-20), 1992-1999. [More Information]

2011

  • Kim, M., Choi, Y. (2011). Skeletal Muscle Tissue Engineering using Adipose Tissue derived Stem Cells. In Alexander L. Greene (Eds.), Encyclopedia of Stem Cell Research. Nova Science Publishers.

2010

  • Choi, Y., Dusting, G., Stubbs, S., Arunothayaraj, S., Han, X., Collas, P., Morrison, W., Dilley, R. (2010). Differentiation of human adipose-derived stem cells into beating cardiomyocytes. Journal of Cellular and Molecular Medicine, 14(4), 878-889. [More Information]
  • Choi, Y., Matsuda, K., Dusting, G., Morrison, W., Dilley, R. (2010). Engineering cardiac tissue in vivo from human adipose-derived stem cells. Biomaterials, 31(8), 2236-2242. [More Information]

2009

  • Choi, Y., Matsuda, K., Dusting, G., Morrison, W., Dilley, R. (2009). Engineering human cardiac tissue in vivo from adipose-dervied stem cells. Australian Society for Stem Cell Research 2nd annual meeting, Australia: Australian Society for Stem Cell Research.

2008

  • Choi, Y., Park, S., Suh, H. (2008). The effect of PLGA sphere diameter on rabbit mesenchymal stem cells in adipose tissue engineering. Journal of Materials Science: Materials in Medicine, 19(5), 2165-71. [More Information]
  • Kim, M., Choi, Y. (2008). Tissue engineering using adipose tissue derived adult stem cells for skeletal muscle repair. In Bernard N. Kennedy (Eds.), Stem Cell Transplantation, Tissue Engineering anc Cancer Applications, (pp. 159-174). Nova Science Publishers.
  • Kim, M., Choi, Y. (2008). Tissue Engineering Using Adipose Tissue-Derived Adult Stem Cells for Skeletal Muscle Repair. In Steven J. Barnes and Lawrence P. Harris (Eds.), Tissue Engineering: Roles, Materials and Applications, (pp. 287-301). Nova Science Publishers.

2007

  • Park, S., Jang, H., Choi, Y., Cha, J., Son, S., Han, S., Kim, J., Lee, W., Suh, H. (2007). Preparation and characterization of biodegradable anti-adhesive membrane for peritoneal wound healing. Journal of Materials Science: Materials in Medicine, 18(3), 475-482. [More Information]

2006

  • Choi, Y., Cha, S., Lee, Y., Kwon, S., Park, C., Kim, M. (2006). Adipogenic differentiation of adipose tissue derived adult stem cells in nude mouse. Biochemical and Biophysical Research Communications, 345(2), 631-637. [More Information]

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