Dr Yu Zheng

Senior Research Fellow
ANZAC Research Institute, Concord Clinical School

Telephone +61 2 9767 9163
Fax +61 2 9767 9101

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Research interests

Breast Cancer, Prostate Cancer, Bone Metastasis, Bone Biology

Selected grants

2014

  • EVOS FL Auto cell imaging system; Nicholson G, Clark G, Zhou H, Jessup W, Le Couteur D, McMahon A, McLachlan A, Allan C, Handelsman D, Hart D, Walters K, Kritharides L, Kockx M, Kennerson M, Cooper M, Seibel M, Verma N, Silveira P, Fromm P, Simanainen U, Cogger V, Zheng Y; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Mechanisms of self-amplification and tumour growth in breast and prostate cancer metastases to bone; Zheng Y; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.
  • Novel Cytoplasmic Functions of the Vitamin D Receptor in Bone Metastases; Seibel M, Zheng Y, Croucher P, Zhou H, Guise T, Dunstan C; Cancer Council New South Wales/Research Project Grants.
  • IVIS Lumina II in vivo Imaging System; Seibel M, Handelsman D, Le Couteur D, Hart D, Nicholson G, Freedman B, Kritharides L, Jessup W, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, McMahon A, Simanainen U, Kockx M, Speranza T, Zheng Y; DVC Research/Equipment Grant.
  • Automacs Pro Seperator; Hart D, Handelsman D, Le Couteur D, Nicholson G, Kritharides L, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, Simanainen U, Zheng Y, Seibel M; DVC Research/Equipment Grant.

2012

  • Vitamin D Deficiency and Breast Cancer Metastasis to the Bone; Zheng Y; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Book Chapters

  • Zheng, Y., Seibel, M., Zhou, H. (2011). Methods in Bone Biology: Cancer and Bone. In Gustavo Duque, Ken Watanabe (Eds.), Osteoporosis Research: Animal Models, (pp. 83-91). London: Springer.

Journals

  • Zheng, Y., Chow, S., Boernert, K., Basel, D., Mikuscheva, A., Kim, S., Fong�?Yee, C., Trivedi, T., Buttgereit, F., Sutherland, R., Dunstan, C., Zhou, H., Seibel, M. (2014). Direct Cross-Talk between Cancer and Osteoblast Lineage Cells Fuels Metastatic Growth in Bone via Auto-Amplification of IL-6 and RANKL Signaling Pathways. Journal of Bone and Mineral Research, 29(9), 1938-1949. [More Information]
  • Zheng, Y., Zhou, H., Dunstan, C., Sutherland, R., Seibel, M. (2013). The role of the bone microenvironment in skeletal metastasis. Journal of Bone Oncology, 2(1), 47-57. [More Information]
  • Ooi, L., Zheng, Y., Stalgis-Bilinski, K., Dunstan, C. (2011). The bone remodeling environment is a factor in breast cancer bone metastasis. Bone, 48(1), 66-70. [More Information]
  • Ooi, L., Zheng, Y., Zhou, H., Trivedi, T., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone, 47(4), 795-803. [More Information]
  • Ooi, L., Zhou, H., Kalak, R., Zheng, Y., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research, 70(5), 1835-1844. [More Information]
  • Zheng, Y., Zhou, H., Ooi, L., Snir, A., Dunstan, C., Seibel, M. (2010). Vitamin D deficiency promotes prostate cancer growth in bone. The Prostate, , 1-10. [More Information]
  • Zhou, H., Mak, W., Kalak, R., Street, J., Fong-Yee, C., Zheng, Y., Dunstan, C., Seibel, M. (2009). Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice. Development (Cambridge), 136(3), 427-436. [More Information]
  • Wang, M., Wu, L., Zheng, Y., Zhang, Q., Li, C. (2009). The Chinese QOLIE-AD-48: Translation, validity, and reliability. Epilepsy and Behavior, 14(3), 476-480. [More Information]
  • Zheng, Y., Zhou, H., Fong-Yee, C., Modzelewski, J., Seibel, M., Dunstan, C. (2008). Bone Resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis. Clinical and Experimental Metastasis, 25(5), 559-567. [More Information]
  • Zhou, H., Mak, W., Zheng, Y., Dunstan, C., Seibel, M. (2008). Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through WNT signaling. Journal of Biological Chemistry, 283(4), 1936-1945. [More Information]
  • Zheng, Y., Zhou, H., Modzelewski, J., Kalak, R., Blair, J., Seibel, M., Dunstan, C. (2007). Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone. Cancer Research, 67(19), 9542-9548. [More Information]
  • Zheng, Y., Brennan, K., Blair, J., Modzelewski, J., Seibel, M., Dunstan, C. (2006). Inhibition of bone resorption, rather than direct cytotoxicity, mediates the anti-tumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis. Bone, 40(2), 471-478. [More Information]
  • Blair, J., Zheng, Y., Dunstan, C. (2006). RANK ligand. The International Journal of Biochemistry and Cell Biology, 39(6), 1077-1081. [More Information]

2014

  • Zheng, Y., Chow, S., Boernert, K., Basel, D., Mikuscheva, A., Kim, S., Fong�?Yee, C., Trivedi, T., Buttgereit, F., Sutherland, R., Dunstan, C., Zhou, H., Seibel, M. (2014). Direct Cross-Talk between Cancer and Osteoblast Lineage Cells Fuels Metastatic Growth in Bone via Auto-Amplification of IL-6 and RANKL Signaling Pathways. Journal of Bone and Mineral Research, 29(9), 1938-1949. [More Information]

2013

  • Zheng, Y., Zhou, H., Dunstan, C., Sutherland, R., Seibel, M. (2013). The role of the bone microenvironment in skeletal metastasis. Journal of Bone Oncology, 2(1), 47-57. [More Information]

2011

  • Zheng, Y., Seibel, M., Zhou, H. (2011). Methods in Bone Biology: Cancer and Bone. In Gustavo Duque, Ken Watanabe (Eds.), Osteoporosis Research: Animal Models, (pp. 83-91). London: Springer.
  • Ooi, L., Zheng, Y., Stalgis-Bilinski, K., Dunstan, C. (2011). The bone remodeling environment is a factor in breast cancer bone metastasis. Bone, 48(1), 66-70. [More Information]

2010

  • Ooi, L., Zheng, Y., Zhou, H., Trivedi, T., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone, 47(4), 795-803. [More Information]
  • Ooi, L., Zhou, H., Kalak, R., Zheng, Y., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research, 70(5), 1835-1844. [More Information]
  • Zheng, Y., Zhou, H., Ooi, L., Snir, A., Dunstan, C., Seibel, M. (2010). Vitamin D deficiency promotes prostate cancer growth in bone. The Prostate, , 1-10. [More Information]

2009

  • Zhou, H., Mak, W., Kalak, R., Street, J., Fong-Yee, C., Zheng, Y., Dunstan, C., Seibel, M. (2009). Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice. Development (Cambridge), 136(3), 427-436. [More Information]
  • Wang, M., Wu, L., Zheng, Y., Zhang, Q., Li, C. (2009). The Chinese QOLIE-AD-48: Translation, validity, and reliability. Epilepsy and Behavior, 14(3), 476-480. [More Information]

2008

  • Zheng, Y., Zhou, H., Fong-Yee, C., Modzelewski, J., Seibel, M., Dunstan, C. (2008). Bone Resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis. Clinical and Experimental Metastasis, 25(5), 559-567. [More Information]
  • Zhou, H., Mak, W., Zheng, Y., Dunstan, C., Seibel, M. (2008). Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through WNT signaling. Journal of Biological Chemistry, 283(4), 1936-1945. [More Information]

2007

  • Zheng, Y., Zhou, H., Modzelewski, J., Kalak, R., Blair, J., Seibel, M., Dunstan, C. (2007). Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone. Cancer Research, 67(19), 9542-9548. [More Information]

2006

  • Zheng, Y., Brennan, K., Blair, J., Modzelewski, J., Seibel, M., Dunstan, C. (2006). Inhibition of bone resorption, rather than direct cytotoxicity, mediates the anti-tumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis. Bone, 40(2), 471-478. [More Information]
  • Blair, J., Zheng, Y., Dunstan, C. (2006). RANK ligand. The International Journal of Biochemistry and Cell Biology, 39(6), 1077-1081. [More Information]

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