Dr Yuhong Fu

Research Fellow
Central Clinical School

Member of the Brain and Mind Centre

Telephone 02 93510886

Map

Biographical details

My Ph.D. was granted for the completion of a neuroscience project on “experimental autoimmune encephalomyelitis” in 2002. With MD granted in 1996, I was employed as a neurologist (2002 – 2005) in a full-time position in The Department of Neurology, The Second Affiliated Hospital, Harbin Medical University, China. This clinical experience paved my research path to Parkinson’s Disease (PD).

In 2005, I was awarded a visiting scientist scholarship by the World Health Organization, which offered me the great opportunity to study the pathogenesis of PD using transgenic mouse models at the Garvan Institute of Medical Research, Sydney.

In 2007, I joined Professor Paxinos’ lab at the Neuroscience Research Australia to continue research in neural pathway and cytoarchitecture of the dopamine system. In the following eight years, I took neuroanatomy as a platform to seek the answer to why dopaminergic neurons are diverse in their vulnerability to PD and whether adult neurogenesis may be the option for replacing the loss of neurons in the progression of neurodegeneration.

In 2015, I joined Professor Halliday’s neurodegeneration lab at the Neuroscience Research Australia and moved to The University of Sydney in 2017. My current research direction is to study the glial involvement in the initiation of neurodegeneration. I believe our projects will offer the great opportunity for those who have enthusiasm in neuroscience to gain knowledge in neuroanatomy and neuropathology, as well as to learn laboratory skills in histology, microscopy, animal models, and molecular biology.

Research interests

Neurodegeneration, glia, Parkinson’s disease, a-synuclein, ageing

Teaching and supervision

Teaching interests in Neuroanatomy and Neuroscience (neurodegeneration)

Current projects

Improve targeted and individualised treatments for neurodegenerative disorders through reading the matrix of astrocytes

When astrocytes express proper protein profile, they protect those neurons that are vulnerable to neurodegenerative disorders. To the opposite, the dysfunction of astrocytes contributes to the pathogenesis of neurodegenerative disorders, e.g., Parkinson's disease. In addition, brain scanning may offerthe possibility to in vivo monitor astroglial function and neuropathy progression in response to the treatment, which however requires knowing the level of proteins expressed by astrocytes in different neurodegenerative disorders as a reference for the proper interpretation.

In this project, we aim to reveal the astroglial protein profiles in neurodegenerative disorders by taking advantage of the newly available astroglial biomarkers and microscopy methods. This study is needed for proceeding to targeted and individualised treatment. The project is composed of parallel studies in examining the different astroglial biomarkers and relevant neuropathy.

Selected grants

2018

  • Nix mediated mitophagy: A new therapeutic approach to Parkinson's disease; Sue C, Klein C, Fu Y; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Sillitoe, R., Fu, Y., Watson, C. (2012). Cerebellum. In C Watson, G Paxinos, L Puelles (Eds.), The Mouse Nervous System, (pp. 360-397). London: Elsevier. [More Information]

Journals

  • Betzer, C., Lassen, L., Olsen, A., Kofoed, R., Riemer, L., Gregersen, E., Zheng, J., Cali, T., Gai, W., Chen, T., Fu, Y., Halliday, G., et al (2018). Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation. EMBO Reports, 19(5), e44617. [More Information]
  • Kim, W., Fu, Y., Dobson-Stone, C., Hsiao, J., Shang, K., Hallupp, M., Schofield, P., Garner, B., Karl, T., Kwok, J. (2018). Effect of Fluvoxamine on Amyloid-beta Peptide Generation and Memory. Journal of Alzheimer's Disease, 62(4), 1777-1787. [More Information]
  • Zhao, Y., Keshiya, S., Atashrazm, F., Gao, J., Ittner, L., Alessi, D., Halliday, G., Fu, Y., Dzamko, N. (2018). Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice. Neurobiology of Disease, 120, 76-87. [More Information]
  • Bhatia, S., Fu, Y., Hsiao, J., Halliday, G., Kim, W. (2017). Deletion of Alzheimer's Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels. Journal of Alzheimer's Disease Reports, 1, 237-247. [More Information]
  • Dzamko, N., Gysbers, A., Perera, G., Bahar, A., Shankar, A., Gao, J., Fu, Y., Halliday, G. (2017). Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology. Acta Neuropathologica Communications, 133(2), 303-319. [More Information]
  • Fu, Y., Hsiao, J., Paxinos, G., Halliday, G., Kim, W. (2016). ABCA7 Mediates Phagocytic Clearance of Amyloid-(beta) in the Brain. Journal of Alzheimer's Disease, 54(2), 569-584. [More Information]
  • Fu, Y., Hsiao, J., Paxinos, G., Halliday, G., Kim, W. (2015). ABCA5 Regulates amyloid-beta peptide production and is associated with Alzheimer's disease neuropathology. Journal of Alzheimer's Disease, 43(3), 857-869. [More Information]
  • Fu, Y., Yu, Y., Paxinos, G., Watson, C., Rusznak, Z. (2015). Aging-dependent changes in the cellular composition of the mouse brain and spinal cord. Neuroscience, 290, 406-420. [More Information]
  • Rusznak, Z., Kim, W., Hsiao, J., Halliday, G., Paxinos, G., Fu, Y. (2015). Early in vivo effects of the human mutant amyloid-? protein precursor (hA?PPSwInd) on the mouse olfactory bulb. Journal of Alzheimer's Disease, 49(2), 443-457. [More Information]
  • Fu, Y., Rusznak, Z., Kwok, J., Kim, W., Paxinos, G. (2014). Age-Dependent Alterations of the Hippocampal Cell Composition and Proliferative Potential in the hA-Beta-PPSwInd-J20 Mouse. Journal of Alzheimer's Disease, 41(4), 1177-1192. [More Information]
  • Sengul, G., Fu, Y., Yu, Y., Paxinos, G. (2014). Spinal cord projections to the cerebellum in the mouse. Brain Structure and Function, 220(5), 2997-3009. [More Information]
  • Fu, Y., Rusznak, Z., Herculano-Houzel, S., Watson, C., Paxinos, G. (2013). Cellular composition characterizing postnatal development and maturation of the mouse brain and spinal cord. Brain Structure and Function, 218(5), 1337-1354. [More Information]
  • Hsiao, J., Fu, Y., Hill, A., Halliday, G., Kim, W. (2013). Elevation in Sphingomyelin Synthase Activity Is Associated with Increases in Amyloid-Beta Peptide Generation. PloS One, 8(8), 1-10. [More Information]
  • Bacskai, T., Fu, Y., Sengul, G., Rusznak, Z., Paxinos, G., Watson, C. (2013). Musculotopic organization of the motor neurons supplying forelimb and shoulder girdle muscles in the mouse. Brain Structure and Function, 218(1), 221-238. [More Information]
  • Duan, D., Fu, Y., Paxinos, G., Watson, C. (2013). Spatiotemporal expression patterns of Pax6 in the brain of embryonic, newborn, and adult mice. Brain Structure and Function, 218(2), 353-372. [More Information]
  • Koszeghy, A., Vincze, J., Rusznak, Z., Fu, Y., Paxinos, G., Csernoch, L., Szucs, G. (2012). Activation of muscarinic receptors increases the activity of the granule neurones of the rat dorsal cochlear nucleus - A calcium imaging study. Pfluegers Archiv: European journal of physiology, 463(6), 829-844. [More Information]
  • Fu, Y., Watson, C. (2012). The arcuate nucleus of the C57BL/6J mouse hindbrain is a displaced part of the inferior olive. Brain, Behavior and Evolution, 79(3), 191-204. [More Information]
  • Fu, Y., Sengul, G., Paxinos, G., Watson, C. (2012). The spinal precerebellar nuclei: Calcium binding proteins and gene expression profile in the mouse. Neuroscience Letters, 518(2), 161-166. [More Information]
  • Fu, Y., Tvrdik, P., Makki, N., Paxinos, G., Watson, C. (2011). Precerebellar Cell Groups in the Hindbrain of the Mouse Defined by Retrograde Tracing and Correlated with Cumulative Wnt1-Cre Genetic Labeling. Cerebellum, 10(3), 570-584. [More Information]

2018

  • Betzer, C., Lassen, L., Olsen, A., Kofoed, R., Riemer, L., Gregersen, E., Zheng, J., Cali, T., Gai, W., Chen, T., Fu, Y., Halliday, G., et al (2018). Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation. EMBO Reports, 19(5), e44617. [More Information]
  • Kim, W., Fu, Y., Dobson-Stone, C., Hsiao, J., Shang, K., Hallupp, M., Schofield, P., Garner, B., Karl, T., Kwok, J. (2018). Effect of Fluvoxamine on Amyloid-beta Peptide Generation and Memory. Journal of Alzheimer's Disease, 62(4), 1777-1787. [More Information]
  • Zhao, Y., Keshiya, S., Atashrazm, F., Gao, J., Ittner, L., Alessi, D., Halliday, G., Fu, Y., Dzamko, N. (2018). Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice. Neurobiology of Disease, 120, 76-87. [More Information]

2017

  • Bhatia, S., Fu, Y., Hsiao, J., Halliday, G., Kim, W. (2017). Deletion of Alzheimer's Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels. Journal of Alzheimer's Disease Reports, 1, 237-247. [More Information]
  • Dzamko, N., Gysbers, A., Perera, G., Bahar, A., Shankar, A., Gao, J., Fu, Y., Halliday, G. (2017). Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology. Acta Neuropathologica Communications, 133(2), 303-319. [More Information]

2016

  • Fu, Y., Hsiao, J., Paxinos, G., Halliday, G., Kim, W. (2016). ABCA7 Mediates Phagocytic Clearance of Amyloid-(beta) in the Brain. Journal of Alzheimer's Disease, 54(2), 569-584. [More Information]

2015

  • Fu, Y., Hsiao, J., Paxinos, G., Halliday, G., Kim, W. (2015). ABCA5 Regulates amyloid-beta peptide production and is associated with Alzheimer's disease neuropathology. Journal of Alzheimer's Disease, 43(3), 857-869. [More Information]
  • Fu, Y., Yu, Y., Paxinos, G., Watson, C., Rusznak, Z. (2015). Aging-dependent changes in the cellular composition of the mouse brain and spinal cord. Neuroscience, 290, 406-420. [More Information]
  • Rusznak, Z., Kim, W., Hsiao, J., Halliday, G., Paxinos, G., Fu, Y. (2015). Early in vivo effects of the human mutant amyloid-? protein precursor (hA?PPSwInd) on the mouse olfactory bulb. Journal of Alzheimer's Disease, 49(2), 443-457. [More Information]

2014

  • Fu, Y., Rusznak, Z., Kwok, J., Kim, W., Paxinos, G. (2014). Age-Dependent Alterations of the Hippocampal Cell Composition and Proliferative Potential in the hA-Beta-PPSwInd-J20 Mouse. Journal of Alzheimer's Disease, 41(4), 1177-1192. [More Information]
  • Sengul, G., Fu, Y., Yu, Y., Paxinos, G. (2014). Spinal cord projections to the cerebellum in the mouse. Brain Structure and Function, 220(5), 2997-3009. [More Information]

2013

  • Fu, Y., Rusznak, Z., Herculano-Houzel, S., Watson, C., Paxinos, G. (2013). Cellular composition characterizing postnatal development and maturation of the mouse brain and spinal cord. Brain Structure and Function, 218(5), 1337-1354. [More Information]
  • Hsiao, J., Fu, Y., Hill, A., Halliday, G., Kim, W. (2013). Elevation in Sphingomyelin Synthase Activity Is Associated with Increases in Amyloid-Beta Peptide Generation. PloS One, 8(8), 1-10. [More Information]
  • Bacskai, T., Fu, Y., Sengul, G., Rusznak, Z., Paxinos, G., Watson, C. (2013). Musculotopic organization of the motor neurons supplying forelimb and shoulder girdle muscles in the mouse. Brain Structure and Function, 218(1), 221-238. [More Information]
  • Duan, D., Fu, Y., Paxinos, G., Watson, C. (2013). Spatiotemporal expression patterns of Pax6 in the brain of embryonic, newborn, and adult mice. Brain Structure and Function, 218(2), 353-372. [More Information]

2012

  • Koszeghy, A., Vincze, J., Rusznak, Z., Fu, Y., Paxinos, G., Csernoch, L., Szucs, G. (2012). Activation of muscarinic receptors increases the activity of the granule neurones of the rat dorsal cochlear nucleus - A calcium imaging study. Pfluegers Archiv: European journal of physiology, 463(6), 829-844. [More Information]
  • Sillitoe, R., Fu, Y., Watson, C. (2012). Cerebellum. In C Watson, G Paxinos, L Puelles (Eds.), The Mouse Nervous System, (pp. 360-397). London: Elsevier. [More Information]
  • Fu, Y., Watson, C. (2012). The arcuate nucleus of the C57BL/6J mouse hindbrain is a displaced part of the inferior olive. Brain, Behavior and Evolution, 79(3), 191-204. [More Information]
  • Fu, Y., Sengul, G., Paxinos, G., Watson, C. (2012). The spinal precerebellar nuclei: Calcium binding proteins and gene expression profile in the mouse. Neuroscience Letters, 518(2), 161-166. [More Information]

2011

  • Fu, Y., Tvrdik, P., Makki, N., Paxinos, G., Watson, C. (2011). Precerebellar Cell Groups in the Hindbrain of the Mouse Defined by Retrograde Tracing and Correlated with Cumulative Wnt1-Cre Genetic Labeling. Cerebellum, 10(3), 570-584. [More Information]

To update your profile click here. For support on your academic profile contact .