Dr Yuyan Chen

Senior Lecturer
Paediatrics & Child Health, Children's Hospital, Westmead

Telephone +61 2 9845 3114

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Biographical details

Dr Chen graduated from the Shanghai Medical College of Fudan University in China with a Master’s Degree in Medicine in 1996 and then worked in the Shanghai No.1 Maternity and Child Care Hospital as a paediatrician during 1996-2000. Then she moved to Japan and started her research at the Haematology/Oncology Laboratory of the Department of Paediatrics in Graduate School of Medicine, University of Tokyo, Japan. Her PhD study focused on investigating candidate genes involved in the pathogenesis of paediatric cancers. In September 2007, Dr Chen was conferred her PhD degree by the University of Tokyo. Dr Chen continued her research in the same laboratory as a research fellow (2007-2008) and successfully identified the target oncogene anaplastic lymphoma kinase, ALK for neuroblastoma. Since April 2009, Dr Chen has joined the Molecular Oncology Group of the Children’s Cancer Research Unit (CCRU) at the Children’s Hospital at Westmead. Her main project is to investigate Tumor Protein D52 (TPD52) involvement in DNA damage repair. She is currently a Senior Research Officer within CCRU and has been appointed as Conjoint Senior Lecturer within the Discipline of Paediatrics and Child Health at the University of Sydney since January 2013.

Research interests

Dr Yuyan Chen's current research interests are to understand the roles of Tumor Protein PD52 (TPD52) in tumorigenesis; the molecular mechanisms by which TPD52 is involved in cancer development/ progression, with a focus on TPD52 involvement in the cellular response to DNA damage.

Selected grants

2011

  • Tumor protein D52 overexpression and DNA repair in cancer; Chen Y; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.

2010

  • Increased Tumour Protein D52 expression as a marker of tumor predisposition, and a possible role in DNA repair; Chen Y; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Book Chapters

  • Della-Franca, A., Chen, Y., Byrne, J. (2012). TPD52 (Tumor Protein D52). In Sangdun Choi (Eds.), Encyclopaedia of Signalling Molecules, (pp. 1906-1911). New York: Springer.

Journals

  • Takita, J., Chen, Y., Kato, M., Ohki, K., Sato, Y., Ohta, S., Sugita, K., Nishimura, R., Hoshino, N., Seki, M., et al (2014). Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays. Cancer science, 105(3), 258-264.
  • Shahheydari, H., Frost, S., Smith, B., Groblewski, G., Chen, Y., Byrne, J. (2014). Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening. Molecular Biology Reports, 41(7), 4565-4572. [More Information]
  • Roslan, N., Bieche, I., Bright, R., Lidereau, R., Chen, Y., Byrne, J. (2014). TPD52 Represents a Survival Factor in ERBB2-Amplified Breast Cancer Cells. Molecular Carcinogenesis, 53(10), 807-819. [More Information]
  • Byrne, J., Frost, S., Chen, Y., Bright, R. (2014). Tumor protein D52 (TPD52) and cancer-oncogene understudy or understudied oncogene? Tumor Biology, 35(8), 7369-7382. [More Information]
  • Chen, Y., Kamili, A., Hardy, J., Groblewski, G., Khanna, K., Byrne, J. (2013). Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle, 12(18), 3083-3097. [More Information]
  • Byrne, J., Chen, Y., Martin La Rotta, N., Peters, G. (2012). Challenges in Identifying Candidate Amplification Targets in Human Cancers: Chromosome 8q21 as a Case Study. Genes and Cancer, 3(2), 87-101. [More Information]
  • Takita, J., Chen, Y., Okubo, J., Sanada, M., Adachi, M., Ohki, K., Nishimura, R., Hanada, R., Igarashi, T., Hayashi, Y., et al (2011). Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma. Cancer science, 102(9), 1645-1650. [More Information]
  • Kato, M., Sanada, M., Kato, I., Sato, Y., Takita, J., Takeuchi, K., Niwa, A., Chen, Y., Nakazaki, K., Nomoto, J., et al (2009). Frequent inactivation of A20 in B-cell lymphomas. Nature, 459(7247), 712-716. [More Information]
  • Kato, M., Takita, J., Takahashi, K., Mimaki, M., Chen, Y., Koh, K., Ida, K., Oka, A., Mizuguchi, M., Ogawa, S., et al (2009). Hepatoblastoma in a Patient with Sotos Syndrome. Journal of Proteomics, 155(6), 937-939. [More Information]

2014

  • Takita, J., Chen, Y., Kato, M., Ohki, K., Sato, Y., Ohta, S., Sugita, K., Nishimura, R., Hoshino, N., Seki, M., et al (2014). Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays. Cancer science, 105(3), 258-264.
  • Shahheydari, H., Frost, S., Smith, B., Groblewski, G., Chen, Y., Byrne, J. (2014). Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening. Molecular Biology Reports, 41(7), 4565-4572. [More Information]
  • Roslan, N., Bieche, I., Bright, R., Lidereau, R., Chen, Y., Byrne, J. (2014). TPD52 Represents a Survival Factor in ERBB2-Amplified Breast Cancer Cells. Molecular Carcinogenesis, 53(10), 807-819. [More Information]
  • Byrne, J., Frost, S., Chen, Y., Bright, R. (2014). Tumor protein D52 (TPD52) and cancer-oncogene understudy or understudied oncogene? Tumor Biology, 35(8), 7369-7382. [More Information]

2013

  • Chen, Y., Kamili, A., Hardy, J., Groblewski, G., Khanna, K., Byrne, J. (2013). Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle, 12(18), 3083-3097. [More Information]

2012

  • Byrne, J., Chen, Y., Martin La Rotta, N., Peters, G. (2012). Challenges in Identifying Candidate Amplification Targets in Human Cancers: Chromosome 8q21 as a Case Study. Genes and Cancer, 3(2), 87-101. [More Information]
  • Della-Franca, A., Chen, Y., Byrne, J. (2012). TPD52 (Tumor Protein D52). In Sangdun Choi (Eds.), Encyclopaedia of Signalling Molecules, (pp. 1906-1911). New York: Springer.

2011

  • Takita, J., Chen, Y., Okubo, J., Sanada, M., Adachi, M., Ohki, K., Nishimura, R., Hanada, R., Igarashi, T., Hayashi, Y., et al (2011). Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma. Cancer science, 102(9), 1645-1650. [More Information]

2009

  • Kato, M., Sanada, M., Kato, I., Sato, Y., Takita, J., Takeuchi, K., Niwa, A., Chen, Y., Nakazaki, K., Nomoto, J., et al (2009). Frequent inactivation of A20 in B-cell lymphomas. Nature, 459(7247), 712-716. [More Information]
  • Kato, M., Takita, J., Takahashi, K., Mimaki, M., Chen, Y., Koh, K., Ida, K., Oka, A., Mizuguchi, M., Ogawa, S., et al (2009). Hepatoblastoma in a Patient with Sotos Syndrome. Journal of Proteomics, 155(6), 937-939. [More Information]

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