Dr Yuyi You

NHMRC Early Career Research Fellow
Save Sight Institute


Map

Selected grants

2017

  • Trans-synaptic degeneration in the visual pathways in glaucoma: an MRI Study; You Y, Klistorner A; Ophthalmic Research Institute of Australia (ORIA)/Research Grant.

2016

  • Differential patterns and underlying mechanisms of axonal loss in the visual pathways in optic neuritis; You Y; University of Sydney/Kickstart Grants Program.

2015

  • Glaucoma causes secondary neurodegeneration in the brain; You Y; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

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Book Chapters

  • You, Y., Klistorner, A., Graham, S. (2013). Visual Evoked Potential Recording in Rodents. In Paul M Pilowsky, Melissa M J Farnham, Angelina Y Fong (Eds.), Stimulation and Inhibition of Neurons, (pp. 275-285). New York: Springer Science+Business Media. [More Information]

Journals

  • Liu, S., Stuart, G., Schulz, A., Kalloniatis, M., Zangerl, B., Cai, W., Gao, Y., Chua, B., Arvind Srinivasan, H., Grigg, J., Klistorner, A., You, Y., et al (2018). A Deep Learning-Based Algorithm Identifies Glaucomatous Discs Using Monoscopic Fundus Photographs. Ophthalmology Glaucoma, 1(1), 15-22. [More Information]
  • Shen, T., You, Y., Joseph, C., Mirzaei, M., Klistorner, A., Graham, S., Gupta, V. (2018). BDNF Polymorphism: A Review of Its Diagnostic and Clinical Relevance in Neurodegenerative Disorders. Aging and Disease, 9(3), 523-536. [More Information]
  • Klistorner, A., Wang, C., Yiannikas, C., Parratt, J., Barton, J., You, Y., Graham, S., Barnett, M. (2018). Diffusivity in the core of chronic multiple sclerosis lesions. PloS One, 13(4), 1-20. [More Information]
  • Klistorner, A., Wang, C., Yiannikas, C., Parratt, J., Dwyer, M., Barton, J., Graham, S., You, Y., Liu, S., Barnett, M. (2018). Evidence of progressive tissue loss in the core of chronic MS lesions: A longitudinal DTI study. NeuroImage: Clinical, 17, 1028-1035. [More Information]
  • Schulz, A., Graham, E., You, Y., Klistorner, A., Graham, S. (2018). Performance of iPad based threshold perimetry in glaucoma and controls. Clinical and Experimental Ophthalmology, 46(4), 346-355. [More Information]
  • You, Y., Graham, E., Shen, T., Yiannikas, K., Parratt, J., Gupta, V., Barton, J., Dwyer, M., Barnett, M., Fraser, C., Graham, S., Klistorner, A. (2018). Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS. Neurology: Neuroimmunology and Neuroinflammation, 5(1), 1-9. [More Information]
  • Abbasi, M., Gupta, V., Chitranshi, N., You, Y., Dheer, Y., Mirzaei, M., Graham, S. (2018). Regulation of Brain-Derived Neurotrophic Factor and Growth Factor Signaling Pathways by Tyrosine Phosphatase Shp2 in the Retina: A Brief Review. Frontiers in Cellular Neuroscience, 12, 85. [More Information]
  • You, Y., Gupta, V. (2018). The Extracellular Matrix and Remyelination Strategies in Multiple Sclerosis. eNeuro, 1(5), 1-4. [More Information]
  • Mirzaei, M., Gupta, V., Chick, J., Greco, T., Wu, Y., Chitranshi, N., Vander Wall, R., Hone, E., Deng, L., Dheer, Y., You, Y., Graham, S., et al (2017). Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes. Scientific Reports, 7(1), 1-16. [More Information]
  • Gupta, V., Mirzaei, M., Gupta, V., Chitranshi, N., Dheer, Y., Wall, R., Abbasi, M., You, Y., Chung, R., Graham, S. (2017). Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin. Scientific Reports, 7(1), 1-18. [More Information]
  • Klistorner, A., Graham, E., Yiannikas, C., Barnett, M., Parratt, J., Garrick, R., Wang, C., You, Y., Graham, S. (2017). Progression of retinal ganglion cell loss in multiple sclerosis is associated with new lesions in the optic radiations. European Journal of Neurology, 24(11), 1392-1398. [More Information]
  • Chitranshi, N., Dheer, Y., Gupta, V., Abbasi, M., Mirzaei, M., You, Y., Chung, R., Graham, S., Gupta, V. (2017). PTPN11 induces endoplasmic stress and apoptosis in SH-SY5Y cells. Neuroscience, 364, 175-189. [More Information]
  • Klistorner, A., Wang, C., Fofanova, V., Barnett, M., Yiannikas, C., Parratt, J., You, Y., Graham, S. (2016). Diffusivity in multiple sclerosis lesions: At the cutting edge? NeuroImage: Clinical, 12, 219-226. [More Information]
  • Graham, E., You, Y., Yiannikas, C., Garrick, R., Parratt, J., Barnett, M., Klistorner, A. (2016). Progressive Loss of Retinal Ganglion Cells and Axons in Nonoptic Neuritis Eyes in Multiple Sclerosis: A Longitudinal Optical Coherence Tomography Study. Investigative Ophthalmology and Visual Science, 57(4), 2311-2317. [More Information]
  • You, Y., Gupta, V., Chitranshi, N., Reedman, B., Klistorner, A., Graham, S. (2015). Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination. Journal of Visualized Experiments, 2015 (101), 1-5. [More Information]
  • Gupta, V., You, Y., Li, J., Gupta, V., Golzan, S., Klistorner, A., van den Buuse, M., Graham, S. (2014). BDNF impairment is associated with age-related changes in the inner retina and exacerbates experimental glaucoma. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1842 (9), 1567-1578. [More Information]
  • Gupta, V., Chitranshi, N., You, Y., Gupta, V., Klistorner, A., Graham, S. (2014). Brain derived neurotrophic factor is involved in the regulation of glycogen synthase kinase 3 beta (GSK3beta) signalling. Biochemical and Biophysical Research Communications, 454(3), 381-386. [More Information]
  • You, Y., Gupta, V., Li, J., Al-Adawy, N., Klistorner, A., Graham, S. (2014). FTY720 protects retinal ganglion cells in experimental glaucoma. Investigative Ophthalmology and Visual Science, 55(5), 3060-3066. [More Information]
  • Li, J., You, Y., Graham, S. (2013). Nighttime physician staffing in an intensive care unit. New England Journal of Medicine, 369(11), 1074-1074. [More Information]
  • You, Y., Gupta, V., Li, J., Klistorner, A., Graham, S. (2013). Optic neuropathies: characteristic features and mechanisms of retinal ganglion cell loss. Reviews in the Neurosciences, 24(3), 301-321. [More Information]
  • Gupta, V., You, Y., Li, J., Klistorner, A., Graham, S. (2013). Protective Effects of 7,8-Dihydroxyflavone on Retinal Ganglion and RGC-5 Cells Against Excitotoxic and Oxidative Stress. Journal of Molecular Neuroscience, 49(1), 96-104. [More Information]
  • Li, J., Gupta, V., You, Y., Ng, K., Graham, S. (2013). The dynamic response of intraocular pressure and ocular pulse amplitude to acute hemodynamic changes in normal and glaucomatous eyes. Investigative Ophthalmology and Visual Science, 54(10), 6960-6967. [More Information]
  • Gupta, V., You, Y., Gupta, V., Klistorner, A., Graham, S. (2013). TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders. International Journal of Molecular Sciences, 14(5), 10122-10142. [More Information]
  • You, Y., Gupta, V., Graham, S., Klistorner, A. (2012). Anterograde Degeneration along the Visual Pathway after Optic Nerve Injury. PloS One, 7(12), 1-11. [More Information]
  • You, Y., Klistorner, A., Thie, J., Gupta, V., Graham, S. (2012). Axonal Loss in a Rat Model of Optic Neuritis Is Closely Correlated with Visual Evoked Potential Amplitudes Using Electroencephalogram-based Scaling. Investigative Ophthalmology and Visual Science, 53(7), 3662-3662. [More Information]
  • Gupta, V., You, Y., Klistorner, A., Graham, S. (2012). Focus on molecules: Sphingosine 1 phosphate (S1P). Experimental Eye Research, 103, 119-120. [More Information]
  • You, Y., Thie, J., Klistorner, A., Gupta, V., Graham, S. (2012). Normalization of visual evoked potentials using underlying electroencephalogram levels improves amplitude reproducibility in rats. Investigative Ophthalmology and Visual Science, 53(3), 1473-1478. [More Information]
  • Gupta, V., You, Y., Klistorner, A., Graham, S. (2012). Shp-2 regulates the TrkB receptor activity in the retinal ganglion cells under glaucomatous stress. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1822 (11), 1643-1649. [More Information]
  • You, Y., Klistorner, A., Thie, J., Graham, S. (2011). Improving reproducibility of VEP recording in rats: electrodes, stimulus source and peak analysis. Documenta Ophthalmologica, 123(2), 109-119. [More Information]
  • You, Y., Klistorner, A., Thie, J., Graham, S. (2011). Latency delay of visual evoked potential is a real measurement of demyelination in a rat model of optic neuritis. Investigative Ophthalmology and Visual Science, 52(9), 6911-6918. [More Information]

2018

  • Liu, S., Stuart, G., Schulz, A., Kalloniatis, M., Zangerl, B., Cai, W., Gao, Y., Chua, B., Arvind Srinivasan, H., Grigg, J., Klistorner, A., You, Y., et al (2018). A Deep Learning-Based Algorithm Identifies Glaucomatous Discs Using Monoscopic Fundus Photographs. Ophthalmology Glaucoma, 1(1), 15-22. [More Information]
  • Shen, T., You, Y., Joseph, C., Mirzaei, M., Klistorner, A., Graham, S., Gupta, V. (2018). BDNF Polymorphism: A Review of Its Diagnostic and Clinical Relevance in Neurodegenerative Disorders. Aging and Disease, 9(3), 523-536. [More Information]
  • Klistorner, A., Wang, C., Yiannikas, C., Parratt, J., Barton, J., You, Y., Graham, S., Barnett, M. (2018). Diffusivity in the core of chronic multiple sclerosis lesions. PloS One, 13(4), 1-20. [More Information]
  • Klistorner, A., Wang, C., Yiannikas, C., Parratt, J., Dwyer, M., Barton, J., Graham, S., You, Y., Liu, S., Barnett, M. (2018). Evidence of progressive tissue loss in the core of chronic MS lesions: A longitudinal DTI study. NeuroImage: Clinical, 17, 1028-1035. [More Information]
  • Schulz, A., Graham, E., You, Y., Klistorner, A., Graham, S. (2018). Performance of iPad based threshold perimetry in glaucoma and controls. Clinical and Experimental Ophthalmology, 46(4), 346-355. [More Information]
  • You, Y., Graham, E., Shen, T., Yiannikas, K., Parratt, J., Gupta, V., Barton, J., Dwyer, M., Barnett, M., Fraser, C., Graham, S., Klistorner, A. (2018). Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS. Neurology: Neuroimmunology and Neuroinflammation, 5(1), 1-9. [More Information]
  • Abbasi, M., Gupta, V., Chitranshi, N., You, Y., Dheer, Y., Mirzaei, M., Graham, S. (2018). Regulation of Brain-Derived Neurotrophic Factor and Growth Factor Signaling Pathways by Tyrosine Phosphatase Shp2 in the Retina: A Brief Review. Frontiers in Cellular Neuroscience, 12, 85. [More Information]
  • You, Y., Gupta, V. (2018). The Extracellular Matrix and Remyelination Strategies in Multiple Sclerosis. eNeuro, 1(5), 1-4. [More Information]

2017

  • Mirzaei, M., Gupta, V., Chick, J., Greco, T., Wu, Y., Chitranshi, N., Vander Wall, R., Hone, E., Deng, L., Dheer, Y., You, Y., Graham, S., et al (2017). Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes. Scientific Reports, 7(1), 1-16. [More Information]
  • Gupta, V., Mirzaei, M., Gupta, V., Chitranshi, N., Dheer, Y., Wall, R., Abbasi, M., You, Y., Chung, R., Graham, S. (2017). Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin. Scientific Reports, 7(1), 1-18. [More Information]
  • Klistorner, A., Graham, E., Yiannikas, C., Barnett, M., Parratt, J., Garrick, R., Wang, C., You, Y., Graham, S. (2017). Progression of retinal ganglion cell loss in multiple sclerosis is associated with new lesions in the optic radiations. European Journal of Neurology, 24(11), 1392-1398. [More Information]
  • Chitranshi, N., Dheer, Y., Gupta, V., Abbasi, M., Mirzaei, M., You, Y., Chung, R., Graham, S., Gupta, V. (2017). PTPN11 induces endoplasmic stress and apoptosis in SH-SY5Y cells. Neuroscience, 364, 175-189. [More Information]

2016

  • Klistorner, A., Wang, C., Fofanova, V., Barnett, M., Yiannikas, C., Parratt, J., You, Y., Graham, S. (2016). Diffusivity in multiple sclerosis lesions: At the cutting edge? NeuroImage: Clinical, 12, 219-226. [More Information]
  • Graham, E., You, Y., Yiannikas, C., Garrick, R., Parratt, J., Barnett, M., Klistorner, A. (2016). Progressive Loss of Retinal Ganglion Cells and Axons in Nonoptic Neuritis Eyes in Multiple Sclerosis: A Longitudinal Optical Coherence Tomography Study. Investigative Ophthalmology and Visual Science, 57(4), 2311-2317. [More Information]

2015

  • You, Y., Gupta, V., Chitranshi, N., Reedman, B., Klistorner, A., Graham, S. (2015). Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination. Journal of Visualized Experiments, 2015 (101), 1-5. [More Information]

2014

  • Gupta, V., You, Y., Li, J., Gupta, V., Golzan, S., Klistorner, A., van den Buuse, M., Graham, S. (2014). BDNF impairment is associated with age-related changes in the inner retina and exacerbates experimental glaucoma. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1842 (9), 1567-1578. [More Information]
  • Gupta, V., Chitranshi, N., You, Y., Gupta, V., Klistorner, A., Graham, S. (2014). Brain derived neurotrophic factor is involved in the regulation of glycogen synthase kinase 3 beta (GSK3beta) signalling. Biochemical and Biophysical Research Communications, 454(3), 381-386. [More Information]
  • You, Y., Gupta, V., Li, J., Al-Adawy, N., Klistorner, A., Graham, S. (2014). FTY720 protects retinal ganglion cells in experimental glaucoma. Investigative Ophthalmology and Visual Science, 55(5), 3060-3066. [More Information]

2013

  • Li, J., You, Y., Graham, S. (2013). Nighttime physician staffing in an intensive care unit. New England Journal of Medicine, 369(11), 1074-1074. [More Information]
  • You, Y., Gupta, V., Li, J., Klistorner, A., Graham, S. (2013). Optic neuropathies: characteristic features and mechanisms of retinal ganglion cell loss. Reviews in the Neurosciences, 24(3), 301-321. [More Information]
  • Gupta, V., You, Y., Li, J., Klistorner, A., Graham, S. (2013). Protective Effects of 7,8-Dihydroxyflavone on Retinal Ganglion and RGC-5 Cells Against Excitotoxic and Oxidative Stress. Journal of Molecular Neuroscience, 49(1), 96-104. [More Information]
  • Li, J., Gupta, V., You, Y., Ng, K., Graham, S. (2013). The dynamic response of intraocular pressure and ocular pulse amplitude to acute hemodynamic changes in normal and glaucomatous eyes. Investigative Ophthalmology and Visual Science, 54(10), 6960-6967. [More Information]
  • Gupta, V., You, Y., Gupta, V., Klistorner, A., Graham, S. (2013). TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders. International Journal of Molecular Sciences, 14(5), 10122-10142. [More Information]
  • You, Y., Klistorner, A., Graham, S. (2013). Visual Evoked Potential Recording in Rodents. In Paul M Pilowsky, Melissa M J Farnham, Angelina Y Fong (Eds.), Stimulation and Inhibition of Neurons, (pp. 275-285). New York: Springer Science+Business Media. [More Information]

2012

  • You, Y., Gupta, V., Graham, S., Klistorner, A. (2012). Anterograde Degeneration along the Visual Pathway after Optic Nerve Injury. PloS One, 7(12), 1-11. [More Information]
  • You, Y., Klistorner, A., Thie, J., Gupta, V., Graham, S. (2012). Axonal Loss in a Rat Model of Optic Neuritis Is Closely Correlated with Visual Evoked Potential Amplitudes Using Electroencephalogram-based Scaling. Investigative Ophthalmology and Visual Science, 53(7), 3662-3662. [More Information]
  • Gupta, V., You, Y., Klistorner, A., Graham, S. (2012). Focus on molecules: Sphingosine 1 phosphate (S1P). Experimental Eye Research, 103, 119-120. [More Information]
  • You, Y., Thie, J., Klistorner, A., Gupta, V., Graham, S. (2012). Normalization of visual evoked potentials using underlying electroencephalogram levels improves amplitude reproducibility in rats. Investigative Ophthalmology and Visual Science, 53(3), 1473-1478. [More Information]
  • Gupta, V., You, Y., Klistorner, A., Graham, S. (2012). Shp-2 regulates the TrkB receptor activity in the retinal ganglion cells under glaucomatous stress. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1822 (11), 1643-1649. [More Information]

2011

  • You, Y., Klistorner, A., Thie, J., Graham, S. (2011). Improving reproducibility of VEP recording in rats: electrodes, stimulus source and peak analysis. Documenta Ophthalmologica, 123(2), 109-119. [More Information]
  • You, Y., Klistorner, A., Thie, J., Graham, S. (2011). Latency delay of visual evoked potential is a real measurement of demyelination in a rat model of optic neuritis. Investigative Ophthalmology and Visual Science, 52(9), 6911-6918. [More Information]

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