Publications list for Associate Professor Clare Hawkins

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008

2014

   
  • Hawkins, C., Davies, M. (2014), Detection and characterisation of radicals in biological materials using EPR methodology. Biochimica et Biophysica Acta. 1840(2), 708-721. [Abstract]

2013

   
  • Lloyd, M., Grima, M., Rayner, B., Hadfield, K., Davies, M., Hawkins, C. (2013), Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid (HOCl) and hypothiocyanous acid (HOSCN) with human coronary artery endothelial cells. Free Radical Biology & Medicine. 65C, 1352-1362. [Abstract]
  • Hadfield, K., Pattison, D., Brown, B., Hou, L., Rye, K., Davies, M., Hawkins, C. (2013), Myeloperoxidase-derived oxidants modify apolipoprotein a-i and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (hoscn) with hypochlorous acid (hocl). The Biochemical Journal. 449(2), 531-542. [Abstract]

2012

   
  • Pattison, D., Davies, M., Hawkins, C. (2012), Reactions and reactivity of myeloperoxidase-derived oxidants: Differential biological effects of hypochlorous and hypothiocyanous acids. Free Radical Research. 46(8), 975-995. [Abstract]
  • Summers, F., Forsman-Quigley, A., Hawkins, C. (2012), Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines. Biochemical and Biophysical Research Communications. 425(2), 157-161. [Abstract]
  • Boon, A., Hawkins, C., Bisht, K., Coombes, J., Bakrania, B., Wagner, K., Bulmer, A. (2012), Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. Free Radical Biology & Medicine. 52(10), 2120-2127. [Abstract]
  • Barrett, T., Pattison, D., Leonard, S., Carroll, K., Davies, M., Hawkins, C. (2012), Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates. Free Radical Biology & Medicine. 52(6), 1075-1085. [Abstract]
  • Barrett, T., Hawkins, C. (2012), Hypothiocyanous Acid: Benign or Deadly?. Chemical Research in Toxicology. 25(2), 263-273. [Abstract]
  • Lok, H., Suryo Rahmanto, Y., Hawkins, C., Kalinowski, D., Morrow, C., Townsend, A., Ponka, P., Richardson, D. (2012), Nitric oxide storage and transport in cells is mediated by glutathione-S-transferase P1-1 and Multidrug Resistant Protein 1 via Dinitrosyl iron complexes. Journal of Biological Chemistry. 287(1), 607-618. [Abstract]

2011

   
  • Morgan, P., Pattison, D., Talib, J., Summer, F., Harmer, J., Celermajer, D., Hawkins, C., Davies, M. (2011), High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase. Free radical biology & medicine. 51(9), 1815-22. [Abstract]
  • Yu, Y., Suryo Rahmanto, Y., Hawkins, C., Richardson, D. (2011), The Potent and Novel Thiosemicarbazone Chelators, Dp44mT and Bp44mT, Affect Crucial Thiol Systems Required for Ribonucleotide Reductase Activity. Molecular pharmacology. 79(6), 921-31. [Abstract]
  • Gracanin, M., Lam, M., Morgan, P., Rodgers, K., Hawkins, C., Davies, M. (2011), Amino acids, peptide and protein hydroperoxides, and their decomposition products, modify the activity of the 26S proteasome. Free radical biology & medicine. 50(2), 389-99. [Abstract]

2010

   
  • Rahmanto, A., Morgan, P., Hawkins, C., Davies, M. (2010), Cellular effects of photo-generated oxidants and long-lived, reactive, hydroperoxide photoproducts. Free radical biology & medicine. 49(10), 1505-15. [Abstract]
  • Jansson, P., Hawkins, C., Lovejoy, D., Richardson, D. (2010), The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study. Journal of inorganic biochemistry. 104(11), 1224-8. [Abstract]
  • Lane, A., Tan, J., Hawkins, C., Heather, A., Davies, M. (2010), The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages. The Biochemical journal. 430(1), 161-9. [Abstract]
  • Stanley, N., Pattison, D., Hawkins, C. (2010), Ability of Hypochlorous Acid and N-Chloramines to Chlorinate DNA and Its Constituents. Chemical research in toxicology. 23(7), 1293-302. [Abstract]
  • Koelsch, M., Mallak, R., Graham, G., Kajer, T., Milligan, M., Nguyen, L., Newsham, D., Keh, J., Kettle, A., Scott, K., Ziegler, J., Pattison, D., Fu, S., Hawkins, C., Rees, M., Davies, M. (2010), Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically-achievable concentrations. Biochemical pharmacology. 79(8), 1156-64. [Abstract]
  • Rahmanto, A., Morgan, P., Hawkins, C., Davies, M. (2010), Cellular effects of peptide and protein hydroperoxides. Free radical biology & medicine. 48(8), 1071-8. [Abstract]

2009

   
  • Hawkins, C. (2009), The role of hypothiocyanous acid (HOSCN) in biological systems. Free Radical Research. 43(12), 1147-1158. [Abstract]
  • Gracanin, M., Hawkins, C., Pattison, D., Davies, M. (2009), Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products. Free radical biology & medicine. 47(1), 92-102. [Abstract]
  • Pattison, D., Hawkins, C., Davies, M. (2009), What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach. Chemical Research in Toxicology. 22(5), 807-817. [Abstract]
  • Hawkins, C., Morgan, P., Davies, M. (2009), Quantification of protein modification by oxidants. Free Radical Biology & Medicine. 46(8), 965-988. [Abstract]

2008

   
  • Hawkins, C., Pattison, D., Stanley, N., Davies, M. (2008), Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation. Biochemical Journal. 416(3), 441-452. [Abstract]
  • Morgan, P., Pattison, D., Hawkins, C., Davies, M. (2008), Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins. Free radical biology & medicine. 45(9), 1279-89. [Abstract]
  • Szuchman-Sapir, A., Pattison, D., Ellis, N., Hawkins, C., Davies, M., Witting, P. (2008), Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin. Free radical biology & medicine. 45(6), 789-98. [Abstract]
  • Lloyd, M., van Reyk, D., Davies, M., Hawkins, C. (2008), Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid. The Biochemical Journal. 414(2), 271-280. [Abstract]
  • Summers, F., Morgan, P., Davies, M., Hawkins, C. (2008), Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines. Chemical Research in Toxicology. 21(9), 1832-1840. [Abstract]
  • Davies, M., Hawkins, C., Pattison, D., Rees, M. (2008), Mammalian heme peroxidases: from molecular mechanisms to health implications. Antioxidants & Redox Signaling. 10(7), 1199-1234. [Abstract]