Publications list for Professor Christopher Little

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008


  • El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014), Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone. 59C, 151-161. [Abstract]


  • Melrose, J., Smith, M., Smith, S., Ravi, V., Young, A., Dart, A., Sonnabend, D., Little, C. (2013), Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy. Tissue & Cell. 45(1), 77-82. [Abstract]
  • Malfait, A., Little, C., McDougall, J. (2013), A commentary on modelling osteoarthritis pain in small animals. Osteoarthritis and Cartilage. 21(9), 1316-1326. [Abstract]
  • Gossan, N., Zeef, L., Hensman, J., Hughes, A., Bateman, J., Rowley, L., Little, C., Piggins, H., Rattray, M., Boot-Handford, R., Meng, Q. (2013), The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis. Arthritis and Rheumatism. 65(9), 2334-2345. [Abstract]
  • Smith, M., Russell, A., Schiavinato, A., Little, C. (2013), A hexadecylamide - derivative of hyaluronan (HYMOVIS(R)) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan. Journal of Inflammation. 10(1), 26. [Abstract]
  • Shu, C., Hughes, C., Smith, S., Smith, M., Hayes, A., Caterson, B., Little, C., Melrose, J. (2013), The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal. 30(7), 717-725. [Abstract]
  • Smith, M., Jacobson, E., Dart, A., Little, C. (2013), Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine. 47(9), e2. [Abstract]
  • Smith, M., Ravi, V., Dart, A., Sonnabend, D., Little, C. (2013), Factors affecting tendinopathogenesis. British Journal of Sports Medicine. 47(9), e2. [Abstract]
  • Bateman, J., Rowley, L., Belluoccio, D., Chan, B., Bell, K., Fosang, A., Little, C. (2013), Transcriptomics of Wild-Type Mice and Mice Lacking ADAMTS-5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage Destruction. Arthritis and Rheumatism. 65(6), 1547-1560. [Abstract]
  • Little, C., Hunter, D. (2013), Post-traumatic osteoarthritis: from mouse models to clinical trials. Nature Reviews Rheumatology. 9(8), 485-497. [Abstract]
  • Shu, C., Smith, S., Little, C., Melrose, J. (2013), Comparative immunolocalisation of perlecan, heparan sulphate, fibroblast growth factor-18, and fibroblast growth factor receptor-3 and their prospective roles in chondrogenic and osteogenic development of the human foetal spine. European Spine Journal. 22(8), 1774-1784. [Abstract]
  • Cake, M., Read, R., Corfield, G., Daniel, A., Burkhardt, D., Smith, M., Little, C. (2013), Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep. Osteoarthritis and Cartilage. 21(1), 226-236. [Abstract]
  • Belluoccio, D., Rowley, L., Little, C., Bateman, J. (2013), Maintaining mRNA integrity during decalcification of mineralized tissues. PloS One. 8(3), e58154. [Abstract]


  • Maher, A., Coles, C., White, J., Bateman, J., Fuller, E., Burkhardt, D., Little, C., Cake, M., Read, R., McDonagh, M., Rochfort, S. (2012), 1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep. Journal of Proteome Research. 11(8), 4261-4268. [Abstract]
  • Chan, B., Little, C. (2012), The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis. Arthritis Research & Therapy. 14(3), 119. [Abstract]
  • Melrose, J., Isaacs, M., Smith, S., Hughes, C., Little, C., Caterson, B., Hayes, A. (2012), Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development. Histochemistry and Cell Biology. 138(3), 461-475. [Abstract]
  • Little, C., Zaki, S. (2012), What constitutes an "animal model of osteoarthritis"--the need for consensus?. Osteoarthritis and Cartilage. 20(4), 261-267. [Abstract]
  • Melrose, J., Shu, C., Young, C., Ho, R., Smith, M., Young, A., Smith, S., Gooden, B., Dart, A., Podadera, J., Appleyard, R., Little, C. (2012), Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration. Spine. 37(1), 18-25. [Abstract]
  • Fuller, E., Smith, M., Little, C., Melrose, J. (2012), Zonal differences in meniscus matrix turnover and cytokine response. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 20(1), 49-59. [Abstract]
  • Boeuf, S., Graf, F., Fischer, J., Moradi, B., Little, C., Richter, W. (2012), Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells. European Cells & Materials. 23, 320-332. [Abstract]


  • Stanton, H., Melrose, J., Little, C., Fosang, A. (2011), Proteoglycan degradation by the ADAMTS family of proteinases. Biochimica et Biophysica Acta. 1812(12), 1616-1629. [Abstract]
  • Lamandé, S., Yuan, Y., Gresshoff, I., Rowley, L., Belluoccio, D., Kaluarachchi, K., Little, C., Botzenhart, E., Zerres, K., Amor, D., Cole, W., Savarirayan, R., McIntyre, P., Bateman, J. (2011), Mutations in TRPV4 cause an inherited arthropathy of hands and feet. Nature Genetics. 43(11), 1142-1146. [Abstract]
  • Bernardo, B., Belluoccio, D., Rowley, L., Little, C., Hansen, U., Bateman, J. (2011), Cartilage Intermediate Layer Protein 2 (CILP-2) Is Expressed in Articular and Meniscal Cartilage and Down-regulated in Experimental Osteoarthritis. The Journal of Biological Chemistry. 286(43), 37758-37767. [Abstract]
  • Glasson, S., Little, C. (2011), The recent paper "Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilization of the medial meniscus and increased joint laxity". Osteoarthritis and Cartilage. , 1076-1077. [Abstract]
  • Chan, B., Fuller, E., Russell, A., Smith, S., Smith, M., Jackson, M., Cake, M., Read, R., Bateman, J., Sambrook, P., Little, C. (2011), Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis and Cartilage. 19(7), 874-885. [Abstract]
  • Stanton, H., Golub, S., Rogerson, F., Last, K., Little, C., Fosang, A. (2011), Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage. Nature Protocols. 6(3), 388-404. [Abstract]


  • Schollum, M., Appleyard, R., Little, C., Melrose, J. (2010), A Detailed Microscopic Examination of Alterations in Normal Anular Structure Induced by Mechanical Destabilization in an Ovine Model of Disc Degeneration. Spine. 35(22), 1965-1973. [Abstract]
  • Glasson, S., Chambers, M., Van Den Berg, W., Little, C. (2010), The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 18 Suppl 3, S17-23. [Abstract]
  • Little, C., Smith, M., Cake, M., Read, R., Murphy, M., Barry, F. (2010), The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats. Osteoarthritis and Cartilage. 18(Suppl 3), S80-S92. [Abstract]
  • Melrose, J., Little, C. (2010), Immunolocalization of lymphatic vessels in human fetal knee joint tissues. Connective tissue research. 51(4), 289-305. [Abstract]
  • Nguyen, T., Little, C., Yenson, V., Jackson, C., McCracken, S., Warning, J., Stevens, V., Gallery, E., Morris, J. (2010), Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. Journal of autoimmunity. 35(1), 86-97. [Abstract]
  • Little, C., Fosang, A. (2010), Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis?. Current Drug Targets. 11(5), 561-575. [Abstract]
  • Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010), S100A8 and S100A9 in experimental osteoarthritis. Arthritis research & therapy. 12(1), R16. [Abstract]
  • Little, C., Kim, Y. (2010), Targeting Cartilage Breakdown in Osteoarthritis. Journal of American Academy of Orthopaedic Surgeons. 18(4), 243-246.
  • Fosang, A., Last, K., Stanton, H., Golub, S., Little, C., Brown, L., Jackson, D. (2010), Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan. Methods in molecular biology (Clifton, N.J.). 622, 312-47. [Abstract]


  • Little, C., Barai, A., Burkhardt, D., Smith, S., Fosang, A., Werb, Z., Shah, M., Thompson, E. (2009), Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis and rheumatism. 60(12), 3723-33. [Abstract]
  • Smith, S., Whitelock, J., Iozzo, R., Little, C., Melrose, J. (2009), Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development. Histochemistry and Cell Biology. 132(5), 491-503. [Abstract]
  • Melrose, J., Burkhardt, D., Taylor, T., Dillon, C., Read, R., Cake, M., Little, C. (2009), Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 18(0), 479-89. [Abstract]
  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009), Activated Protein C Mediates a Healing Phenotype In Cultured Tenocytes. Journal of cellular and molecular medicine. 13(4), 749-57. [Abstract]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009), Activation of cartilage matrix metalloproteinases by activated protein C. Arthritis and Rheumatism. 60(3), 780-791. [Abstract]


  • Cake, M., Read, R., Edwards, S., Smith, M., Burkhardt, D., Little, C., Ghosh, P. (2008), Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations. Journal of Orthopaedic Science. 13(6), 514-523. [Abstract]
  • Fitzgerald, J., Rich, C., Burkhardt, D., Allen, J., Herzka, A., Little, C. (2008), Evidence for articular cartilage regeneration in MRL/MpJ mice. Osteoarthritis and Cartilage. 16(11), 1319-1326. [Abstract]
  • Wilson, R., Belluoccio, D., Little, C., Fosang, A., Bateman, J. (2008), Proteomic characterization of mouse cartilage degradation in vitro. Arthritis and Rheumatism. 58(10), 3120-3131. [Abstract]
  • Melrose, J., Smith, S., Little, C., Moore, R., Vernon-Roberts, B., Fraser, R. (2008), Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 17(9), 1131-48. [Abstract]
  • Fosang, A., Little, C. (2008), Drug insight: aggrecanases as therapeutic targets for osteoarthritis. Nature clinical practice. Rheumatology. 4(8), 420-427. [Abstract]
  • Smith, M., Cake, M., Ghosh, P., Schiavinato, A., Read, R., Little, C. (2008), Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy. Rheumatology (Oxford, England). 47(8), 1172-8. [Abstract]
  • Melrose, J., Hayes, A., Whitelock, J., Little, C. (2008), Perlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues. BioEssays : news and reviews in molecular, cellular and developmental biology. 30(5), 457-469. [Abstract]
  • Smith, M., Sakurai, G., Smith, S., Young, A., Melrose, J., Stewart, C., Appleyard, R., Peterson, J., Gillies, R., Dart, A., Sonnabend, D., Little, C. (2008), Modulation of aggrecan and ADAMTS expression in ovine tendinopathy induced by altered strain. Arthritis and rheumatism. 58(4), 1055-1066. [Abstract]
  • Melrose, J., Smith, S., Smith, M., Little, C. (2008), The use of Histochoice for histological examination of articular and growth plate cartilages, intervertebral disc and meniscus. Biotechnic & Histochemistry. 83(1), 47-53. [Abstract]
  • Melrose, J., Smith, S., Appleyard, R., Little, C. (2008), Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 17(0), 314-24. [Abstract]
  • Gauci, S., Golub, S., Tutolo, L., Little, C., Sims, N., Lee, E., Mackie, E., Fosang, A. (2008), Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage. Journal of musculoskeletal & neuronal interactions. 8(4), 308-10. [Abstract]
  • Alini, M., Eisenstein, S., Ito, K., Little, C., Kettler, A., Masuda, K., Melrose, J., Ralphs, J., Stokes, I., Wilke, H. (2008), Are animal models useful for studying human disc disorders/degeneration?. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 17(0), 2-19. [Abstract]
  • Little, C., Smith, M. (2008), Animal models of osteoarthritis. Current Rheumatology Reviews. 4, 175-182.
  • Melrose, J., Fuller, E., Roughley, P., Smith, M., Kerr, B., Hughes, C., Caterson, B., Little, C. (2008), Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis research & therapy. 10(4), R79. [Abstract]