Publications list for Professor Mark Cooper

2013 | 2012 | 2011 | 2010 | 2009


  • Cooper, M., Thickett, D., Stewart, P. (2013), Reduced cortisol metabolism during critical illness. New England Journal of Medicine. , 480. [Abstract]
  • Tiganescu, A., Tahrani, A., Morgan, S., Otranto, M., Desmoulière, A., Abrahams, L., Hassan-Smith, Z., Walker, E., Rabbitt, E., Cooper, M., Amrein, K., Lavery, G., Stewart, P. (2013), 11[beta]-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. The Journal of Clinical Investigation. 123(7), 3051-3060. [Abstract]
  • Hardy, R., Seibel, M., Cooper, M. (2013), Targeting 11beta-hydroxysteroid dehydrogenases: a novel approach to manipulating local glucocorticoid levels with implications for rheumatic disease. Current Opinion in Pharmacology. 13(3), 440-444. [Abstract]
  • Gathercole, L., Lavery, G., Morgan, S., Cooper, M., Sinclair, A., Tomlinson, J., Stewart, P. (2013), 11 beta-hydroxysteroid dehydrogenase 1: translational and therapeutic aspects. Endocrine Reviews. 34(4), 525-555. [Abstract]
  • Parekh, D., Dancer, R., Lax, S., Cooper, M., Martineau, A., Fraser, W., Tucker, O., Alderson, D., Perkins, G., Gao-Smith, F., Thickett, D. (2013), Vitamin D to prevent acute lung injury following oesophagectomy (VINDALOO): study protocol for a randomised placebo controlled trial. Trials. 14(1), 100. [Abstract]
  • Crabtree, N., Högler, W., Cooper, M., Shaw, N. (2013), Diagnostic evaluation of bone densitometric size adjustment techniques in children with and without low trauma fractures. Osteoporosis International. 24(7), 2015-2024. [Abstract]
  • Seibel, M., Cooper, M., Zhou, H. (2013), Glucocorticoid-induced osteoporosis: Mechanisms, management, and future perspectives. Lancet Diabetes and Endocrinology. 1(1), 59-70.


  • Cooper, M., Zhou, H., Seibel, M. (2012), Selective glucocorticoid receptor agonists: Glucocorticoid therapy with no regrets?. Journal of Bone and Mineral Research. 27(11), 2238-2241. [Abstract]
  • Hardy, R., Juarez, M., Naylor, A., Tu, J., Rabbitt, E., Filer, A., Stewart, P., Buckley, C., Raza, K., Cooper, M. (2012), Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis. Arthritis Research & Therapy. 14(5), R226. [Abstract]
  • Naylor, A., Azzam, E., Smith, S., Croft, A., Poyser, C., Duffield, J., Huso, D., Gay, S., Ospelt, C., Cooper, M., Isacke, C., Goodyear, S., Rogers, M., Buckley, C. (2012), The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice. Arthritis and Rheumatism. 64(10), 3334-3343. [Abstract]
  • de Pablo, P., Cooper, M., Buckley, C. (2012), Association between bone mineral density and C-reactive protein in a large population-based sample. Arthritis and Rheumatism. 64(8), 2624-2631. [Abstract]
  • Patel, P., Hardy, R., Sumathi, V., Bartle, G., Kindblom, L., Grimer, R., Bujalska, I., Stewart, P., Rabbitt, E., Gittoes, N., Cooper, M. (2012), Expression of 11β-hydroxysteroid dehydrogenase enzymes in human osteosarcoma: potential role in pathogenesis and as targets for treatments. Endocrine-Related Cancer. 19(4), 589-598. [Abstract]
  • Ahasan, M., Hardy, R., Jones, C., Kaur, K., Nanus, D., Juarez, M., Morgan, S., Hassan-Smith, Z., Bénézech, C., Caamaño, J., Hewison, M., Lavery, G., Rabbitt, E., Clark, A., Filer, A., Buckley, C., Raza, K., Stewart, P., Cooper, M. (2012), Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells. Arthritis and Rheumatism. 64(7), 2404-2413. [Abstract]
  • Cooper, M. (2012), Glucocorticoids in bone and joint disease: the good, the bad and the uncertain. Clinical Medicine. 12(3), 261-265. [Abstract]
  • Hassan-Smith, Z., Sherlock, M., Reulen, R., Arlt, W., Ayuk, J., Toogood, A., Cooper, M., Johnson, A., Stewart, P. (2012), Outcome of Cushing's disease following transsphenoidal surgery in a single center over 20 years. The Journal of Clinical Endocrinology and Metabolism. 97(4), 1194-1201. [Abstract]
  • Hardy, R., Raza, K., Cooper, M. (2012), Endogenous glucocorticoids in inflammation: contributions of systemic and local responses. Swiss Medical Weekly. 142, w13650. [Abstract]
  • Cooper, M., Palmer, A., Seibel, M. (2012), Cost-effectiveness of the Concord Minimal Trauma Fracture Liaison service, a prospective, controlled fracture prevention study. Osteoporosis International. 23(1), 97-107. [Abstract]


  • Cooper, M. (2011), Disorders of calcium metabolism and parathyroid disease. Best Practice & Research. Clinical Endocrinology & Metabolism. 25(6), 975-983. [Abstract]
  • Hidalgo, E., Essex, S., Yeo, L., Curnow, S., Filer, A., Cooper, M., Thomas, A., McGettrick, H., Salmon, M., Buckley, C., Raza, K., Scheel-Toellner, D. (2011), The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue. Arthritis and Rheumatism. 63(11), 3284-3293. [Abstract]
  • Cooper, M., Venkatesh, B. (2011), Endocrine management in the intensive care unit. Preface. Best Practice & Research. Clinical Endocrinology & Metabolism. 25(5), 703-704. [Abstract]
  • Hassan-Smith, Z., Cooper, M. (2011), Overview of the endocrine response to critical illness: how to measure it and when to treat. Best Practice & Research. Clinical Endocrinology & Metabolism. 25(5), 705-717. [Abstract]
  • Cooper, M., Kriel, H., Sayers, A., Fraser, W., Williams, A., Stewart, P., Probert, C., Tobias, J. (2011), Can 11β-hydroxysteroid dehydrogenase activity predict the sensitivity of bone to therapeutic glucocorticoids in inflammatory bowel disease?. Calcified Tissue International. 89(3), 246-251. [Abstract]
  • Hardy, R., Cooper, M. (2011), Glucocorticoid-induced osteoporosis - a disorder of mesenchymal stromal cells?. Frontiers in Endocrinology. 2, 24. [Abstract]


  • Hardy, R., Cooper, M. (2010), Adrenal gland and bone. Archives of Biochemistry and Biophysics. 503(1), 137-145. [Abstract]
  • Raza, K., Hardy, R., Cooper, M. (2010), The 11beta-hydroxysteroid dehydrogenase enzymes--arbiters of the effects of glucocorticoids in synovium and bone. Rheumatology. 49(11), 2016-2023. [Abstract]
  • Cooper, M. (2010), Thyroid gland: Variation in 'normal' thyroid function--effect on bone health?. Nature Reviews. Endocrinology. 6(11), 599-600. [Abstract]
  • Crabtree, N., Bebbington, N., Chapman, D., Wahid, Y., Ayuk, J., Boivin, C., Cooper, M., Gittoes, N. (2010), Impact of UK National Guidelines based on FRAX®--comparison with current clinical practice. Clinical Endocrinology. 73(4), 452-456. [Abstract]
  • Ayuk, J., Cooper, M., Gittoes, N. (2010), New perspectives in the management of primary hyperparathyroidism. Therapeutic Advances in Endocrinology and Metabolism. 1(5), 197-205. [Abstract]
  • Kaur, K., Hardy, R., Ahasan, M., Eijken, M., van Leeuwen, J., Filer, A., Thomas, A., Raza, K., Buckley, C., Stewart, P., Rabbitt, E., Hewison, M., Cooper, M. (2010), Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss. Annals of the Rheumatic Diseases. 69(6), 1185-1190. [Abstract]
  • Gittoes, N., Cooper, M. (2010), Primary hyperparathyroidism--is mild disease worth treating?. Clinical Medicine. 10(1), 45-49. [Abstract]
  • Cooper, M. (2010), Glucocorticoid-induced osteoporosis: how best to avoid fractures. Therapeutic Advances in Chronic Disease. 1(1), 17-23. [Abstract]


  • Cooper, M., Stewart, P. (2009), 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation. The Journal of Clinical Endocrinology and Metabolism. 94(12), 4645-4654. [Abstract]
  • Hardy, R., Cooper, M. (2009), Bone loss in inflammatory disorders. The Journal of Endocrinology. 201(3), 309-320. [Abstract]