Publications list for Dr Danuta Kalinowski

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008


  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014), Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta. 1845(1), 1-19. [Abstract]
  • Ellis, S., Kalinowski, D., Leotta, L., Huang, M., Jelfs, P., Sintchenko, V., Richardson, D., Triccas, J. (2014), Potent Anti-Mycobacterial Activity of the Pyridoxal Isonicotinoyl Hydrazone Analogue, 2-Pyridylcarboxaldehyde Isonicotinoyl Hydrazone: A Lipophilic Transport Vehicle for Isonicotinic Acid Hydrazide. Molecular Pharmacology. 85(2), 269-278. [Abstract]


  • Stefani, C., Jansson, P., Gutierrez, E., Bernhardt, P., Richardson, D., Kalinowski, D. (2013), Alkyl Substituted 2'-Benzoylpyridine Thiosemicarbazone Chelators with Potent and Selective Anti-Neoplastic Activity: Novel Ligands that Limit Methemoglobin Formation. Journal of Medicinal Chemistry. 56(1), 357-370. [Abstract]
  • Lukmantara, A., Kalinowski, D., Kumar, N., Richardson, D. (2013), Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: Novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy. Bioorganic & Medicinal Chemistry Letters. 23(4), 967-974. [Abstract]
  • Walcourt, A., Kurantsin-Mills, J., Kwagyan, J., Adenuga, B., Kalinowski, D., Lovejoy, D., Lane, D., Richardson, D. (2013), Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool. Journal of Inorganic Biochemistry. 129, 43-51. [Abstract]
  • Lui, G., Obeidy, P., Ford, S., Tselepis, C., Sharp, D., Jansson, P., Kalinowski, D., Kovacevic, Z., Lovejoy, D., Richardson, D. (2013), The Iron Chelator, Deferasirox, as a Novel Strategy for Cancer Treatment: Oral Activity Against Human Lung Tumor Xenografts and Molecular Mechanism of Action. Molecular Pharmacology. 83(1), 179-190. [Abstract]
  • Merlot, A., Pantarat, N., Menezes, S., Sahni, S., Richardson, D., Kalinowski, D. (2013), Cellular Uptake of the Anti-Tumor and Anti-Metastatic Agent, Dp44mT, Occurs via a Saturable, Temperature-Dependent Mechanism Consistent with Carrier/Receptor-Mediated Transport. Molecular Pharmacology. 84(6), 911-924. [Abstract]
  • Lukmantara, A., Kalinowski, D., Kumar, N., Richardson, D. (2013), Structure-activity studies of 4-phenyl-substituted 2'-benzoylpyridine thiosemicarbazones with potent and selective anti-tumour activity. Organic & Biomolecular Chemistry. 11(37), 6414-6425. [Abstract]
  • Bae, D., Jansson, P., Huang, M., Kovacevic, Z., Kalinowski, D., Lee, C., Sahni, S., Richardson, D. (2013), The role of NDRG1 in the pathology and potential treatment of human cancers. Journal of Clinical Pathology. 66(11), 911-917. [Abstract]
  • Merlot, A., Kalinowski, D., Richardson, D. (2013), Novel Chelators for Cancer Treatment: Where Are We Now?. Antioxidants & Redox Signaling. 18(8), 973-1006. [Abstract]
  • Ford, S., Obeidy, P., Lovejoy, D., Bedford, M., Nichols, L., Chadwick, C., Tucker, O., Lui, G., Kalinowski, D., Jansson, P., Iqbal, T., Alderson, D., Richardson, D., Tselepis, C. (2013), Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo. British Journal of Pharmacology. 168(6), 1316-1328. [Abstract]
  • Stariat, J., Kovaſíková, P., Kučera, R., KlimeÅ¡, J., Kalinowski, D., Richardson, D., Ketola, R. (2013), Identification of in vitro metabolites of the novel anti-tumor thiosemicarbazone, DpC, using ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. Analytical and Bioanalytical Chemistry. 405(5), 1651-1661. [Abstract]
  • Kalinowski, D., Jansson, P., Kovacevic, Z., Richardson, D. (2013), The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism. Redox Report. 18(2), 48-50. [Abstract]


  • Debebe, Z., Nekhai, S., Ashenafi, M., Lovejoy, D., Kalinowski, D., Gordeuk, V., Byrnes, W., Richardson, D., Karla, P. (2012), Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 906, 25-32. [Abstract]
  • Serda, M., Kalinowski, D., Mrozek-Wilczkiewicz, A., Musiol, R., Szurko, A., Ratuszna, A., Pantarat, N., Kovacevic, Z., Merlot, A., Richardson, D., Polanski, J. (2012), Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy. Bioorganic & Medicinal Chemistry Letters. 22(17), 5527-5531. [Abstract]
  • Lovejoy, D., Sharp, D., Seebacher, N., Obeidy, P., Prichard, T., Stefani, C., Basha, M., Sharpe, P., Jansson, P., Kalinowski, D., Bernhardt, P., Richardson, D. (2012), Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo. Journal of Medicinal Chemistry. 55(16), 7230-7244. [Abstract]
  • Basha, M., Chartres, J., Pantarat, N., Ali, M., Mirza, A., Kalinowski, D., Richardson, D., Bernhardt, P. (2012), Heterocyclic dithiocarbazate iron chelators: Fe coordination chemistry and biological activity. Dalton Transactions. 41(21), 6536-6548. [Abstract]
  • Quach, P., Gutierrez, E., Basha, M., Kalinowski, D., Sharpe, P., Lovejoy, D., Bernhardt, P., Jansson, P., Richardson, D. (2012), Methemoglobin Formation by 3-AP, Dp44mT and Other Anti-Cancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics that Prevent this Effect. Molecular Pharmacology. 82(1), 105-114. [Abstract]
  • Stariat, J., Sestak, V., Vavrova, K., Nobilis, M., Kollarova, Z., Klimes, J., Kalinowski, D., Richardson, D., Kovarikova, P. (2012), LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT. Analytical and bioanalytical chemistry. 403(1), 309-321. [Abstract]
  • Suryo Rahmanto, Y., Kalinowski, D., Lane, D., Lok, H., Richardson, V., Richardson, D. (2012), Nitrogen Monoxide (NO) Storage and Transport by Dinitrosyl-Dithiol-Iron Complexes: Long-Lived NO that is Trafficked by Interacting Proteins. The Journal of Biological Chemistry. 287(10), 6960-6968. [Abstract]
  • Lok, H., Suryo Rahmanto, Y., Hawkins, C., Kalinowski, D., Morrow, C., Townsend, A., Ponka, P., Richardson, D. (2012), Nitric oxide storage and transport in cells is mediated by glutathione-S-transferase P1-1 and Multidrug Resistant Protein 1 via Dinitrosyl iron complexes. Journal of Biological Chemistry. 287(1), 607-618. [Abstract]
  • Brychtova, K., Dvorakova, L., Opatrilova, R., Raich, I., Kacerova, S., Placek, L., Kalinowski, D., Richardson, D., Jampilek, J. (2012), Investigation of substituted 6-aminohexanoates as skin penetration enhancers. Bioorganic & Medicinal Chemistry. 20(1), 86-95. [Abstract]


  • Stefani, C., Punnia-Moorthy, G., Lovejoy, D., Jansson, P., Kalinowski, D., Sharpe, P., Bernhardt, P., Richardson, D. (2011), Halogenated 2'-Benzoylpyridine Thiosemicarbazone (XBpT) Chelators with Potent and Selective Anti-Neoplastic Activity: Relationship to Intracellular Redox Activity. Journal of medicinal chemistry. 54(19), 6936-48. [Abstract]
  • Debebe, Z., Ammosova, T., Breuer, D., Lovejoy, D., Kalinowski, D., Karla, P., Kumar, K., Jerebtsova, M., Ray, P., Kashanchi, F., Gordeuk, V., Richardson, D., Nekhai, S. (2011), Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9. Molecular Pharmacology. 79(1), 185-196. [Abstract]
  • Kovacevic, Z., Kalinowski, D., Lovejoy, D., Yu, Y., Rahmanto, Y., Sharpe, P., Bernhardt, P., Richardson, D. (2011), The Medicinal Chemistry of Novel Iron Chelators for the Treatment of Cancer. Current topics in medicinal chemistry. 11(5), 483-99. [Abstract]
  • Sharpe, P., Richardson, D., Kalinowski, D., Bernhardt, P. (2011), Synthetic and natural products as iron chelators. Current Topics in Medicinal Chemistry. 11(5), 591-607. [Abstract]


  • Merlot, A., Pantarat, N., Lovejoy, D., Kalinowski, D., Richardson, D. (2010), Membrane Transport and Intracellular Sequestration of Novel Thiosemicarbazone Chelators for the Treatment of Cancer. Molecular pharmacology. 78(4), 675-84. [Abstract]
  • Bendova, P., Mackova, E., Haskova, P., Vavrova, A., Jirkovsky, E., Sterba, M., Popelova, O., Kalinowski, D., Kovarikova, P., Vavrova, K., Richardson, D., Simunek, T. (2010), Comparison of Clinically Used and Experimental Iron Chelators for Protection against Oxidative Stress-Induced Cellular Injury. Chemical research in toxicology. 23(6), 1105-14. [Abstract]
  • Kovacevic, Z., Kalinowski, D., Lovejoy, D., Quach, P., Wong, J., Richardson, D. (2010), Iron Chelators: Development of Novel Compounds with High and Selective Anti-Tumour Activity. Current Drug Delivery. 7(3), 194-207. [Abstract]
  • Stariat, J., Kovaríková, P., Klimes, J., Kalinowski, D., Richardson, D. (2010), Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT. Analytical and Bioanalytical Chemistry. 397(1), 161-171. [Abstract]
  • Mrozek-Wilczkiewicz, A., Kalinowski, D., Musiol, R., Finster, J., Szurko, A., Serafin, K., Knas, M., Kamalapuram, S., Kovacevic, Z., Jampilek, J., Ratuszna, A., Rzeszowska-Wolny, J., Richardson, D., Polanski, J. (2010), Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones. Bioorganic & medicinal chemistry. 18(7), 2664-2671. [Abstract]
  • Liu, J., Obando, D., Schipanski, L., Groebler, L., Witting, P., Kalinowski, D., Richardson, D., Codd, R. (2010), Conjugates of Desferrioxamine B (DFOB) with Derivatives of Adamantane or with Orally Available Chelators as Potential Agents for Treating Iron Overload. Journal of medicinal chemistry. 53(3), 1370-82. [Abstract]
  • Brychtova, K., Opatrilova, R., Raich, I., Kalinowski, D., Dvorakova, L., Placek, L., Csollei, J., Richardson, D., Jampilek, J. (2010), Investigating the activity of 2-substituted alkyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoates as skin penetration enhancers. Bioorganic & Medicinal Chemistry. 18(24), 8556-8565. [Abstract]
  • Miao, Q., Xu, D., Wang, Z., Xu, L., Wang, T., Wu, Y., Lovejoy, D., Kalinowski, D., Richardson, D., Nie, G., Zhao, Y. (2010), Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents. Biomaterials. 31(28), 7364-7375. [Abstract]
  • Otevrel, J., Mandelova, Z., Pesko, M., Guo, J., Kralova, K., Sersen, F., Vejsova, M., Kalinowski, D., Kovacevic, Z., Coffey, A., Csollei, J., Richardson, D., Jampilek, J. (2010), Investigating the Spectrum of Biological Activity of Ring-Substituted Salicylanilides and Carbamoylphenylcarbamates. Molecules. 15(11), 8122-8142. [Abstract]
  • Kalinowski, D., Richardson, D. (2010), Cellular and Molecular Biology of Iron-Binding Proteins. In: Cellular and Molecular Biology of Metals. (pp.167-180).United States: Taylor and Francis.


  • Yu, Y., Kalinowski, D., Kovacevic, Z., Siafakas, A., Jansson, P., Stefani, C., Lovejoy, D., Sharpe, P., Bernhardt, P., Richardson, D. (2009), Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors. Journal of medicinal chemistry. 52(17), 5271-94. [Abstract]
  • Kalinowski, D., Quach, P., Richardson, D. (2009), Thiosemicarbazones: the new wave in cancer treatment. Future Medicinal Chemistry. 1(6), 1143-1151. [Abstract]
  • Richardson, D., Kalinowski, D., Lau, S., Jansson, P., Lovejoy, D. (2009), Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents. Biochimica et biophysica acta. 1790(0), 702-17. [Abstract]
  • Richardson, D., Kalinowski, D., Richardson, V., Sharpe, P., Lovejoy, D., Islam, M., Bernhardt, P. (2009), 2-Acetylpyridine Thiosemicarbazones are Potent Iron Chelators and Antiproliferative Agents: Redox Activity, Iron Complexation and Characterization of their Antitumor Activity. Journal of medicinal chemistry. 52(5), 1459-70. [Abstract]
  • Bernhardt, P., Sharpe, P., Islam, M., Lovejoy, D., Kalinowski, D., Richardson, D. (2009), Iron Chelators of the Dipyridylketone Thiosemicarbazone Class: Precomplexation and Transmetalation Effects on Anticancer Activity. Journal of medicinal chemistry. 52(2), 407-15. [Abstract]
  • Stariat, J., Kovaríková, P., Klimes, J., Lovejoy, D., Kalinowski, D., Richardson, D. (2009), HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 877(3), 316-322. [Abstract]
  • Mladĕnka, P., Kalinowski, D., Haskova, P., Bobrovová, Z., Hrdina, R., Simůnek, T., Nachtigal, P., Semecký, V., Vávrová, J., Holeckova, M., Palicka, V., Mazurová, Y., Jansson, P., Richardson, D. (2009), The novel iron chelator, 2-pyridylcarboxaldehyde 2-thiophenecarboxyl hydrazone, reduces catecholamine-mediated myocardial toxicity. Chemical research in toxicology. 22(1), 208-217. [Abstract]
  • Noulsri, E., Richardson, D., Lerdwana, S., Fucharoen, S., Yamagishi, T., Kalinowski, D., Pattanapanyasat, K. (2009), Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells. American Journal of Hematology. 84(3), 170-176. [Abstract]


  • Opletalova��, V., Kalinowski, D., Vejsova��, M., Kunes, J., Pour, M., Jampi��lek, J., Buchta, V., Richardson, D. (2008), Identification and Characterization of Thiosemicarbazones with Antifungal and Antitumor Effects: Cellular Iron Chelation Mediating Cytotoxic Activity. Chemical research in toxicology. 21(9), 1878-89. [Abstract]
  • Lim, C., Kalinowski, D., Richardson, D. (2008), Protection Against Hydrogen Peroxide-Mediated Cytotoxicity in Friedreich's Ataxia Fibroblasts using Novel Iron Chelators of the PCIH Class. Molecular pharmacology. 74(1), 225-35. [Abstract]
  • Kalinowski, D., Sharpe, P., Bernhardt, P., Richardson, D. (2008), Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series. Journal of Medicinal Chemistry. 51(2), 331-344. [Abstract]
  • Bernhardt, P., Wilson, G., Sharpe, P., Kalinowski, D., Richardson, D. (2008), Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 13(1), 107-19. [Abstract]