Publications list for Professor David Little

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008


  • El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014), Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone. 59C, 151-161. [Abstract]
  • Gray, K., Burns, J., Little, D., Bellemore, M., Gibbons, P. (2014), Is tibialis anterior tendon transfer effective for recurrent clubfoot?. Clinical Orthopaedics and Related Research. 472(2), 750-758. [Abstract]


  • Sousa, D., McDonald, M., Mikulec, K., Peacock, L., Herzog, H., Lamghari, M., Little, D., Baldock, P. (2013), Neuropeptide Y modulates fracture healing through Y1 receptor signaling. Journal of Orthopaedic Research. 31(10), 1570-1578. [Abstract]
  • Padhye, B., Dalla-Pozza, L., Little, D., Munns, C. (2013), Use of Zoledronic Acid for Treatment of Chemotherapy Related Osteonecrosis in Children and Adolescents: A Retrospective Analysis. Pediatric Blood & Cancer. 60(9), 1539-1545. [Abstract]
  • Stevenson, D., Little, D., Armstrong, L., Crawford, A., Eastwood, D., Friedman, J., Greggi, T., Gutierrez, G., Hunter-Schaedle, K., Kendler, D., Kolanczyk, M., Monsell, F., Oetgen, M., Richards, B., Schindeler, A., Schorry, E., Wilkes, D., Viskochil, D., Yang, F., Elefteriou, F. (2013), Approaches to Treating NF1 Tibial Pseudarthrosis: Consensus From the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. Journal of Pediatric Orthopedics. 33(3), 269-275. [Abstract]
  • Schindeler, A., Kolind, M., Little, D. (2013), Cellular transitions and tissue engineering. Cellular Reprogramming. 15(2), 101-106. [Abstract]
  • McDonald, M., Morse, A., Mikulec, K., Peacock, L., Baldock, P., Kostenuik, P., Little, D. (2013), MMP driven endochondral fracture union proceeds independently of osteoclast activity. Journal of Bone and Mineral Research. 28(7), 1550-1560. [Abstract]
  • Bosemark, P., Isaksson, H., McDonald, M., Little, D. (2013), Augmentation of autologous bone graft by a combination of bone morphogenic protein and bisphosphonate increased both callus volume and strength. Acta Orthopaedica. 84(1), 106-111. [Abstract]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Fitzpatrick, J., Ruys, A., Cooper-White, J., Little, D. (2013), Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation. European Cells & Materials. 25, 190-203. [Abstract]
  • Bobyn, J., Rasch, A., Little, D., Schindeler, A. (2013), Posterolateral inter-transverse lumbar fusion in a mouse model. Journal of Orthopaedic Surgery and Research. 8(1), 2. [Abstract]
  • Cheng, T., Valtchev, P., Murphy, C., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2013), A sugar-based phase-transitioning delivery system for bone tissue engineering. European Cells & Materials. 26, 208-221. [Abstract]
  • Murphy, C., O'Brien, F., Little, D., Schindeler, A. (2013), Cell-scaffold interactions in the bone tissue engineering triad. European Cells & Materials. 26, 120-132. [Abstract]


  • Young, M., Little, D., Kim, H. (2012), Evidence for using bisphosphonate to treat Legg-Calvé-Perthes disease. Clinical Orthopaedics and Related Research. 470(9), 2462-2475. [Abstract]
  • McDonald, M., Morse, A., Mikulec, K., Peacock, L., Yu, N., Baldock, P., Birke, O., Liu, M., Ke, H., Little, D. (2012), Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats. Journal of Orthopaedic Research. 30(10), 1541-1548. [Abstract]
  • Yu, N., Schindeler, A., Tagil, M., Ruys, A., Little, D. (2012), Use of BMPs and bisphosphonates to improve bone fracture healing. Frontiers in Bioscience. 4, 2647-2653. [Abstract]
  • Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012), Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells. PLoS one. 7(7), e39642. [Abstract]
  • Gray, K., Pacey, V., Gibbons, P., Little, D., Frost, C., Burns, J. (2012), Interventions for congenital talipes equinovarus (clubfoot). Cochrane Database of Systematic Reviews. 4, CD008602. [Abstract]


  • Sullivan, K., El-Hoss, J., Little, D., Schindeler, A. (2011), JNK inhibitors increase osteogenesis in Nf1-deficient cells. Bone. 49(6), 1311-6. [Abstract]
  • Simm, P., Johannesen, J., Briody, J., McQuade, M., Hsu, B., Bridge, C., Little, D., Cowell, C., Munns, C. (2011), Zoledronic acid improves bone mineral density, reduces bone turnover and improves skeletal architecture over 2years of treatment in children with secondary osteoporosis. Bone. 49(5), 939-943. [Abstract]
  • Yang, N., Schindeler, A., McDonald, M., Seto, J., Houweling, P., Lek, M., Hogarth, M., Morse, A., Raftery, J., Balasuriya, D., Macarthur, D., Berman, Y., Quinlan, K., Eisman, J., Nguyen, T., Center, J., Prince, R., Wilson, S., Zhu, K., Little, D., North, K. (2011), α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone. 49(4), 790-798. [Abstract]
  • El-Hoss, J., Sullivan, K., Cheng, T., Yu, N., Bobyn, J., Peacock, L., Mikulec, K., Baldock, P., Alexander, I., Schindeler, A., Little, D. (2011), A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. Journal of Bone and Mineral Research. 27(1), 68-78. [Abstract]
  • Little, D., Kim, H. (2011), Potential for bisphosphonate treatment in legg-calve-perthes disease. Journal of Pediatric Orthopedics. 31(2 Suppl), S182-S188. [Abstract]
  • Schindeler, A., Birke, O., Yu, N., Morse, A., Ruys, A., Baldock, P., Little, D. (2011), Distal tibial fracture repair in a neurofibromatosis type 1-deficient mouse treated with recombinant bone morphogenetic protein and a bisphosphonate. The Journal of Bone and Joint Surgery. British Volume. 93(8), 1134-1139. [Abstract]
  • Wilkinson, J., Little, D. (2011), Bisphosphonates in orthopedic applications. Bone. 49(1), 95-102. [Abstract]
  • Little, D., Kim, H. (2011), Future biologic treatments for perthes disease. Orthopedic Clinics of North America. 42(3), 423-427. [Abstract]
  • Birke, O., Davies, N., Latimer, M., Little, D., Bellemore, M. (2011), Experience With the Fassier-Duval Telescopic Rod: First 24 Consecutive Cases With a Minimum of 1-Year Follow-up. Journal of Pediatric Orthopedics. 31(4), 458-464. [Abstract]
  • Birke, O., Mitchell, P., Onikul, E., Little, D. (2011), The effect of hip position upon the location of the sciatic nerve: an MRI Study. Journal of Pediatric Orthopedics. 31(2), 165-169. [Abstract]
  • Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011), Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders. 12, 288. [Abstract]
  • El-Hoss, J., Micallef, A., Fairfull-Smith, K., Bottle, S., Little, D., Schindeler, A. (2011), Assessment of Tumor Prevention in Type 1 Neurofibromatosis using a Nitroxide Compound. Free Radicals and Antioxidants. 1(3), 13-18.


  • McDonald, M., Morse, A., Peacock, L., Mikulec, K., Schindeler, A., Little, D. (2010), Characterization of the bone phenotype and fracture repair in osteopetrotic Incisors absent rats. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. (5). [Abstract]
  • Zreiqat, H., Ramaswamy, Y., Wu, C., Paschalidis, A., Lu, Z., James, B., Birke, O., McDonald, M., Little, D., Dunstan, C. (2010), The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials. 31(12), 3175-3184. [Abstract]
  • Yu, N., Schindeler, A., Little, D., Ruys, A. (2010), Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering. Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 93(1), 285-295. [Abstract]
  • Liu, R., Schindeler, A., Little, D. (2010), The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions. 10(1), 71-76. [Abstract]
  • Tägil, M., McDonald, M., Morse, A., Peacock, L., Mikulec, K., Amanat, N., Godfrey, C., Little, D. (2010), Intermittent PTH (1-34) Does Not Increase Union Rates in Open Rat Femoral Fractures and Exhibits Attenuated Anabolic Effects Compared to Closed Fractures. Bone. 46(3), 852-9. [Abstract]
  • Ferri-de-Barros, F., Little, D., Bridge, C., Cummine, J., Cree, A. (2010), Atlantoaxial and Craniocervical Arthrodesis in Children A Tomographic Study Comparing Suitability of C2 Pedicles and C2 Laminae for Screw Fixation. Spine. 35(3), 291-293. [Abstract]
  • Goldhahn, J., Little, D., Mitchell, P., Fazzalari, N., Reid, I., Aspenberg, P., Marsh, D. (2010), Evidence for anti-osteoporosis therapy in acute fracture situations-Recommendations of a multidisciplinary workshop of the International Society for Fracture Repair. Bone. 46(2), 267-271. [Abstract]
  • Kumar, J., Ramachandran, M., Little, D., Zenios, M. (2010), Pelvic osteomyelitis in children. Journal of pediatric orthopaedics. Part B. 19(1), 38-41. [Abstract]
  • Yu, N., Schindeler, A., Peacock, L., Mikulec, K., Baldock, P., Ruys, A., Little, D. (2010), In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid. European Cells & Materials. 20, 431-442. [Abstract]
  • Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010), Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders. 11, 105. [Abstract]
  • Gray, K., Pacey, V., Gibbons, P., Little, D., Burns, J. (2010), Interventions for congenital talipes equinovarus. Cochrane Database of Systematic Reviews. 7(CD008602), 1-9.
  • Birke, O., Schindeler, A., Ramachandran, M., Cowell, C., Munns, C., Bellemore, M., Little, D. (2010), Preliminary experience with the combined use of recombinant bone morphogenetic protein and bisphosphonates in the treatment of congenital pseudarthrosis of the tibia. Journal of Children's Orthopaedics. 4(6), 507–517.


  • Johannesen, J., Briody, J., McQuade, M., Little, D., Cowell, C., Munns, C. (2009), Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease. Bone. 45(5), 898-902. [Abstract]
  • Kakar, S., Little, D., Einhorn, T. (2009), Can we improve fixation and outcomes in the treatment of femoral neck fractures? The use of pharmaceuticals. Journal of Orthopaedic Trauma. 23(6), 413-421. [Abstract]
  • Little, D. (2009), Humanising a Mouse Gene for Human Therapeutics - Lessons From Denosumab. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 24(0), 179-81. [Abstract]
  • Baldock, P., Lee, N., Driessler, F., Lin, S., Allison, S., Stehrer, B., Lin, E., Zhang, L., Enriquez, R., Wong, I., McDonald, M., During, M., Pierroz, D., Slack, K., Shi, Y., Yulyaningsih, E., Aljanova, A., Little, D., Ferrari, S., Sainsbury, A., Eisman, J., Herzog, H. (2009), Neuropeptide Y Knockout Mice Reveal a Central Role of NPY in the Coordination of Bone Mass to Body Weight. PLoS One. 4(12), e8415. [Abstract]
  • Schindeler, A., Liu, R., Little, D. (2009), The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation. 77(1), 12-18. [Abstract]
  • Elefteriou, F., Kolanczyk, M., Schindeler, A., Viskochil, D., Hock, J., Schorry, E., Crawford, A., Friedman, J., Little, D., Peltonen, J., Carey, J., Feldman, D., Yu, X., Armstrong, L., Birch, P., Kendler, D., Mundlos, S., Yang, F., Agiostratidou, G., Hunter-Schaedle, K., Stevenson, D. (2009), Skeletal Abnormalities in Neurofibromatosis Type 1: Approaches to Therapeutic Options. American Journal of Medical Genetics Part A. 149A(10), 2327-2338. [Abstract]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009), Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1a. BMC musculoskeletal disorders. 10(0), 51. [Abstract]


  • Yu, N., Ruys, A., Zenios, M., Godfrey, C., McDonald, M., Kiely, P., Mikulec, K., Little, D., Schindeler, A. (2008), Bisphosphonate-laden acrylic bone cement: Mechanical properties, elution performance, and in vivo activity. Journal of biomedical materials research. Part B, Applied biomaterials. 87(2), 482-91. [Abstract]
  • Schindeler, A., McDonald, M., Bokko, P., Little, D. (2008), Bone remodeling during fracture repair: The cellular picture. Seminars in cell & developmental biology. 19(5), 459-66. [Abstract]
  • McDonald, M., Dulai, S., Godfrey, C., Amanat, N., Sztynda, T., Little, D. (2008), Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling. Bone. 43(4), 653-62. [Abstract]
  • Amanata, N., He, L., Swain, M., Little, D. (2008), The effect of zoledronic acid on the intrinsic material properties of healing bone: an indentation study. Medical Engineering and Physics. 30(7), 843-847. [Abstract]
  • Schindeler, A., Morse, A., Harry, L., Godfrey, C., Mikulec, K., McDonald, M., Gasser, J., Little, D. (2008), Models of tibial fracture healing in normal and Nf1-deficient mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 26(8), 1053-60. [Abstract]
  • Chang, A., Hook, J., Lemckert, F., McDonald, M., Nguyen, M., Hardeman, E., Little, D., Gunning, P., Reddel, R. (2008), The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology. 149(5), 2403-2410. [Abstract]
  • Schindeler, A., Little, D. (2008), Recent insights into bone development, homeostasis, and repair in type 1 neurofibromatosis (NF1). Bone. 42(4), 616-622. [Abstract]
  • Schindeler, A., Ramachandran, M., Godfrey, C., Morse, A., McDonald, M., Mikulec, K., Little, D. (2008), Modeling bone morphogenetic protein and bisphosphonate combination therapy in wild-type and Nf1 haploinsufficient mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 26(1), 65-74. [Abstract]